37 completed, 11 unknown, 8 recruiting, 3 not yet recruiting. 28 Not applicable, 8 Phase 4, 5 Phase 2, 4 Phase 1, 1 Early Phase 1.
Follow Muscle Hypotonia: new trials by email Literature Review of Muscle Hypotonia trials Research Report on Muscle Hypotonia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Aprepitant for the Treatment of CLIFAHDD Aprepitant Powder for Oral Suspension - CLIFAHDD, Congenital Contractures of the Limbs and Face, Hypotonia, and Developmental Delay | Early Phase 1 | Recruiting | The University of Texas Health Science Center at San Antonio | 5 | 2026-10-31 | 2026-10-05 |
| Efficacy and Safety of HRS-9190 in General Anesthesia Administration of intravenous HRS-9190, Administration of intravenous rocuronium - Adult Participants Requiring Tracheal Intubation Under General Anesthesia for Elective Surgery | Phase 3 | Enrolling by invitation | The Third Xiangya Hospital of Central South University | 320 | 2026-09-02 | 2026-09-09 |
| Orthosis to Improve Trunk Control in Infants Age 6-18 Months SPIO® Core-MAX® Expedition thoracolumbosacral orthosis, Standard Care Therapy option - Cerebral Palsy | Completed | Medical College of Wisconsin | 21 | 2026-08-06 | 2026-10-08 | |
| The Impact of Ventilator Synchrony on Muscle Relaxant Consumption and Surgeon Satisfaction During Laparoscopic Cholecystectomy. Non-Synchronized Group (Control), Synchronized group - Muscle Relaxant Consumption, Mechanical Ventilation | Not applicable | Not yet recruiting | Hitham Mohammed Aly Elsayed | 60 | 2026-08-01 | 2026-06-15 |
| Developing a Physiology-Pharmacodynamic Model of Rocuronium Dose and Cardiac Output to Investigate the Onset Time of Neuromuscular Relaxation Rocuronium dosing - Induction of Anaesthesia, Muscle Relaxants | Phase 4 | Not yet recruiting | Clare Hayes-Bradley | 32 | 2025-12-01 | 2025-11-25 |
| Test of Aquatic Mobility of SMA Infants Mobility study in dry conditions, Mobility study in water conditions - Infantile Spinal Muscular Atrophy | Not applicable | Recruiting | Assistance Publique - Hôpitaux de Paris | 15 | 2025-06-26 | 2025-11-21 |
| Muscle Relaxant Effect and Safety of Mivacurium Chloride and Succinylcholine for Bronchoscopy mivacurium chloride, succinylcholine - Anesthesia, Bronchoscopy | Not applicable | Not yet recruiting | Peng Liang | 240 | 2024-11-20 | 2024-11-29 |
| Long-term Evaluation of Nasopharyngeal Airway in Hypotonia Self-Supporting Nasopharyngeal Airway (ssNPA) - Hypotonia, Muscle, Obstructive Sleep Apnea | Not applicable | Enrolling by invitation | University of Michigan | 40 | 2024-10-23 | 2025-12-02 |
| The Association Between Residual Neuromuscular Block Risk Prediction Score and the Train-of-Four Ratio residual neuromuscular block risk prediction score - Muscle Relaxants | Recruiting | Assiut University | 91 | 2024-08-01 | 2025-03-27 | |
| The Potential Protective Effect of Using Muscle Relaxants During Electroporation Ablation (PFA) Propofol, Rocuronium - Kidney Failure, Acute, Myopathy; Drugs | Not applicable | Recruiting | 4th Military Clinical Hospital with Polyclinic, Poland | 32 | 2024-08-01 | 2024-11-27 |
| Patterns Of Floppy Infants Attending Assiut University Children Hospital Floppy Infant | Unknown | Assiut University | 50 | 2024-01-01 | 2023-12-28 | |
| Interindividual Variability in Duration of Action of Rocuronium in Pediatric Patients measurement of the depth of neuromuscular blockade - Muscle Relaxation | Completed | Brno University Hospital | 107 | 2022-09-05 | 2024-11-21 | |
| Myotonometer Intra- and Inter Examiner Reliability on Spinal Muscular Atrophy MyotonPRO - Muscle Tone Poor, Spinal Muscular Atrophy | Unknown | Istanbul Medipol University Hospital | 30 | 2022-08-26 | 2022-10-25 | |
| Use of Muscle Relaxants in Parotidectomy Operation With Neuromonitoring Group A - Muscle Relaxants Used, Group B - No Muscle Relaxants - Intubation; Difficult or Failed, Muscle Relaxation | Not applicable | Completed | Bezmialem Vakif University | 40 | 2022-06-30 | 2023-03-14 |
| Muscle Relaxants and Laryngeal Local Anesthetics for Laryngeal Mask Airway Insertion Decreasing Propofol in Elderly 10% lidocaine spray, Placebo of lidocaine spray, Cisatracurium - Anesthesia, General | Not applicable | Completed | Chang Gung Memorial Hospital | 96 | 2022-04-12 | 2024-02-06 |
| Pilot Study of a Self-Supporting Nasopharyngeal Airway in Hypotonia ssNPA - Sleep Apnea, Obstructive, Hypotonia | Not applicable | Completed | University of Michigan | 2 | 2021-09-01 | 2023-12-28 |
| Register for Patients With Thyroid Hormone Resistance. no intervention - Hypothyroidism, Global Developmental Delay | Recruiting | Charite University, Berlin, Germany | 200 | 2021-07-01 | 2024-08-22 | |
| Vestibular Stimulation and Neurodevelopmental Technique on Hypotonic Cerebral Palsy While Controlling the Gender Vestibular stimulation, Neck Control facilitation exercises - Cerebral Palsy, Hypotonia | Not applicable | Completed | Riphah International University | 24 | 2021-05-30 | 2022-02-22 |
| Down Syndrome and Effects of Foot Muscle Exercise Foot Muscle Exercise Protocol, Arch Support Insole and One Leg Balance Activities - Pes Planus Down Syndrome Patients | Not applicable | Completed | Ziauddin University | 47 | 2021-04-22 | 2022-02-23 |
| Neonatal Hypotonia Associated With in Utero Exposure to Antidepressant Antidepressant - Neonatal Hypotonia, Antidepressant Drug Adverse Reaction | Unknown | University Hospital, Caen | 10000 | 2021-03-25 | 2021-04-05 |
Showing 20 of 66. Sign in to see all of them.
Cerebral Palsy (4) · Intellectual Disability (4) · Learning Disabilities (4) · Down Syndrome (3) · Autism Spectrum Disorder (2) · Hypothyroidism (2) · Low Back Pain (2) · Microcephaly (2) · Muscle Hypertonia (2) · Neurodevelopmental Disorders (2) · Neuromuscular Diseases (2) · Pharyngitis (2) · Postoperative Complications (2) · Respiratory Insufficiency (2)
Nervous System Diseases (66) · Neurologic Manifestations (66) · Neuromuscular Manifestations (66) · Pathological Conditions, Signs and Symptoms (66) · Signs and Symptoms (66) · Musculoskeletal Diseases (10) · Neurobehavioral Manifestations (10) · Central Nervous System Diseases (9) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (9) · Pathologic Processes (9) · Genetic Diseases, Inborn (7) · Respiratory Tract Diseases (7) · Brain Diseases (6) · Mental Disorders (6) · Congenital Abnormalities (5)
Rocuronium (8) · Propofol (4) · cisatracurium (3) · Neostigmine (2) · Saline Solution (2) · Sevoflurane (2) · Sodium Chloride (2) · Succinylcholine (2) · Sugammadex (2) · Accelerometry (1) · Acupuncture Therapy (1) · Anesthesia (1) · Anesthesia, General (1) · Antidepressive Agents (1) · Aprepitant (1)
Assiut University (3) · Brno University Hospital (2) · Columbia University (2) · SMG-SNU Boramae Medical Center (2) · Technical University of Munich (2) · University of Michigan (2) · 4th Military Clinical Hospital with Polyclinic, Poland (1) · Air Force Military Medical University, China (1) · Algenis SpA (1) · Assistance Publique - Hôpitaux de Paris (1) · Assistance Publique Hopitaux De Marseille (1) · Bezmialem Vakif University (1) · Centre Hospitalier Intercommunal Creteil (1) · Chang Gung Memorial Hospital (1) · Charite University, Berlin, Germany (1)
United States (17) · Germany (6) · France (5) · Spain (5) · Brazil (4) · Canada (3) · South Korea (3) · Turkey (Türkiye) (3) · Belgium (2) · China (2) · Czechia (2) · Egypt (2) · Italy (2) · Pakistan (2) · Taiwan (2)
Manfred Blobner, M.D. (2) · Shashi Bhatt, MD (2) · Ahmed F Hegazy, MD, FRCPC (1) · Alessandra Haddad (1) · Ana Igric, MD, FRCSC (1) · Antonio Romero Berrocal, MD,PhD (1) · Arif HM Marsaban, Consultant (1) · Bryan Young, MD, FRCPC (1) · Carine Wiesiolek, PhD (1) · Carlos L Errando, MD, PhD (1) · Carolyn Benson, MD (1) · Chung Yung-Tai, MD (1) · David A Zopf, MD (1) · Doris M Hexsel (1)
PMID 19713169, PMID 20661199, PMID 20843245, PMID 23122973, PMID 24565391, PMID 24708453, PMID 27894328, PMID 28387017, PMID 28712602, PMID 28964314, PMID 30224322, PMID 30626406, PMID 30902907, PMID 31607388, PMID 33728377, PMID 34041634, PMID 34127041, PMID 34969638, PMID 37881807, PMID 38229914, PMID 39220267, PMID 39315524, PMID 40911819, PMID 41566470
R21DK077415 (1), R61HL151952 (1), U01HG006487 (1)