12 completed, 7 recruiting, 7 unknown, 2 active not recruiting. 9 Not applicable, 3 Phase 1, 3 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 9 | Completed 3, Recruiting 2, Unknown 2, Active not recruiting 1, Not yet recruiting 1 |
| Phase 1 | 3 | Completed 1, Recruiting 1, Unknown 1 |
| Phase 2 | 3 | Completed 3 |
Follow Neurodegeneration: new trials by email Literature Review of Neurodegeneration trials Research Report on Neurodegeneration
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Neuromodulation and fMRI in Neurodegenerative Diseases Study Transcranial Alternating Current Stimulation - Mild Cognitive Impairment, Traumatic Brain Injury | Not applicable | Not yet recruiting | Sunnybrook Health Sciences Centre | 30 | 2026-06-01 | 2026-05-01 |
| Kisspeptin to Quantify GnRH Neuronal Function in Health and Disease Kisspeptin 112-121 - Reproductive Disorder, Neurodegeneration | Phase 1 | Recruiting | Stephanie B. Seminara, MD | 40 | 2026-03-10 | 2026-07-13 |
| Home Transcranial Direct Current Stimulation (tDCS) to Enhance Functional Recovery Soterix® tDCS - Home treatment, Cognitive-linguistic therapy, Soterix® tDCS - Lab treatment - Stroke, Neurodegeneration | Not applicable | Active not recruiting | Mayo Clinic | 55 | 2026-01-16 | 2026-08-19 |
| Deciphering the Effect of Moderate Wine Consumption on Healthy Aging Through Postprandial Extracellular Vesicles. White Wine, Red Wine, Water - Atherosclerosis Cardiovascular Disease, Obesity | Not applicable | Recruiting | University of Seville | 8 | 2025-11-01 | 2026-01-23 |
| Moderate Versus High Volume Light-Moderate Intensity Exercise for People With Moderate Parkinson's Disease HV-PDAE: High Volume Partnered Dance Aerobic Exercise, MV-PDAE: Moderate Volume Partnered Dance Aerobic Exercise, MV-WALK: Moderate Volume Walking - Parkinson Disease, Movement Disorders | Not applicable | Recruiting | VA Office of Research and Development | 123 | 2025-01-25 | 2026-07-29 |
| Heading in Football: Impact on Neural Blood Biomarkers Head impact exposure - Head Injury, Minor, Concussion, Mild | Completed | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | 335 | 2024-08-13 | 2025-05-13 | |
| The Effects of the MIND Diet on Oxidative Stress, Inflammation and Neurodegenerative Risk Biomarkers MIND diet - Neurodegeneration, Inflammation | Not applicable | Completed | Bartu Eren Güneşliol | 24 | 2023-06-23 | 2025-06-25 |
| Serotonin Release in Premotor and Motor PD Positron Emission Tomography (PET) scan using CIMBI-36 tracer, Magnetic Resonance Imaging (MRI) Scan, Positron Emission Tomography (PET) scan using DASB tracer - Parkinson Disease, Parkinson's | Recruiting | University of Exeter | 42 | 2022-07-01 | 2025-10-07 | |
| Microbiome, Anxiety and Cognitive Orientation Study Anxiety, Microbiome | Unknown | Endominance | 2000 | 2022-06-01 | 2022-12-14 | |
| Periodontitis Provokes Retinal Neurodegenerative Effects of Metabolic Syndrome: A Cross-Sectional Study Clinical Periodontal Measurements (plaque index, gingival index, bleeding index, clinical attachment level), Optical Coherence Tomographic Measurements, Serum IL1-β, TNF-α, IL-10, TAS, TOS, OSİ levels - Periodontitis, Metabolic Syndrome | Completed | Recep Tayyip Erdogan University | 92 | 2022-05-01 | 2024-10-15 | |
| Longitudinal Investigation of I2BS in PD Positron Emission Tomography (PET) scan using BU99008 tracer, FP-CIT Single-photon Emission Computed Tomography (SPECT) scan, Magnetic Resonance Imaging (MRI) Scan - Parkinson's, Parkinson Disease | Recruiting | University of Exeter | 44 | 2021-11-01 | 2025-10-07 | |
| Retinal Neurodegeneration In Type 2 Diabetes Mellitus Detected by Optical Coherence Tomography Optical Coherence Tomography (OCT) - Retinal Neuropathy, Neurodegeneration | Unknown | Assiut University | 80 | 2021-06-01 | 2021-03-23 | |
| Comparison of Power Wheelchair Driving Performance Under Immersive and Non-immersive Conditions With Drivers With Neurological Disorders Immersive condition (CAVE), Immersive condition (HMD), Non Immersive condition (Screen alone) - Neurologic Disorder, Brain Injuries | Not applicable | Completed | Pôle Saint Hélier | 25 | 2021-05-10 | 2021-11-01 |
| Acute Effects of Vigorous-intensity Aerobic Exercise on Glymphatic Flow in Healthy Adults Cycle Ergometer Exercise - Glymphatic System, Neurodegeneration | Not applicable | Unknown | Turku University Hospital | 20 | 2021-02-08 | 2021-02-11 |
| China Longitudinal Aging and Cognitive Impairment Study None of intervention - Aging, Mild Cognitive Impairment | Recruiting | Second Affiliated Hospital, Zhejiang University, School of Medicine | 4000 | 2021-01-10 | 2022-07-21 | |
| Predicting Parkinson's Disease Before It Strikes: A Brain Imaging Study in At-Risk Individual Multiparametric clinical, neuropsychological, PSG and MRI assessment - Idiopathic REM Sleep Behavior Disorder, Parkinson Disease | Active not recruiting | IRCCS San Raffaele | 100 | 2020-12-04 | 2026-07-28 | |
| Safety, Tolerability and Pharmacokinetics of Inhaled Nanoparticle Formulation of Remdesivir (GS-5734) and NA-831 Drug: NA-831 - 0.10 mg/kg, Placebo- 0.10 mg/kg, Drug: NA-831 - 0.20 mg/kg - Covid19, Corona Virus Infection | Phase 1 | Unknown | Biomed Industries, Inc. | 45 | 2020-09-15 | 2020-07-21 |
| MCLENA-1: A Clinical Trial for the Assessment of Lenalidomide in Amnestic MCI Patients Lenalidomide 10 mg, Placebo - Cognitive Impairment, Mild, Cognitive Dysfunction | Phase 2 | Completed | St. Joseph's Hospital and Medical Center, Phoenix | 15 | 2020-07-22 | 2026-06-10 |
| Search for Biomarkers of Neurodegenerative Diseases in Idiopathic REM Sleep Behavior Disorder REM Sleep Behavior Disorder, Neurodegeneration | Unknown | Chinese University of Hong Kong | 182 | 2019-05-15 | 2021-08-06 | |
| Glycemic Control and Retinal Microvascular Changes Diabetic Retinopathy, Neurodegeneration | Unknown | Seoul National University Hospital | 259 | 2019-01-01 | 2023-11-29 |
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Nerve Degeneration (29) · Cognitive Dysfunction (4) · Neurodegenerative Diseases (4) · Parkinson Disease (4) · Alzheimer Disease (3) · REM Sleep Behavior Disorder (3) · Depression (2) · Diabetic Retinopathy (2) · Inflammation (2) · Metabolic Syndrome (2) · Anxiety Disorders (1) · Brain Concussion (1) · Brain Injuries (1) · Brain Injuries, Traumatic (1) · Brain Neoplasms (1)
Pathologic Processes (29) · Pathological Conditions, Signs and Symptoms (29) · Nervous System Diseases (17) · Brain Diseases (13) · Central Nervous System Diseases (13) · Mental Disorders (11) · Neurocognitive Disorders (6) · Neurodegenerative Diseases (6) · Behavior (5) · Basal Ganglia Diseases (4) · Cardiovascular Diseases (4) · Cognition Disorders (4) · Dementia (4) · Parkinsonian Disorders (4) · Synucleinopathies (4)
2-phenyl-6-(2'-(4'-(ethoxycarbonyl)thiazolyl))thiazolo(3,2-b)(1,2,4)triazole (2) · Magnetic Resonance Spectroscopy (2) · Spinal Puncture (2) · Tomography, Optical Coherence (2) · Drug Implants (1) · Early Detection of Cancer (1) · Goserelin (1) · Granulocyte Colony-Stimulating Factor (1) · Lenalidomide (1) · Sodium Chloride (1) · Transcranial Direct Current Stimulation (1) · Water (1) · remdesivir (1)
Chinese University of Hong Kong (2) · University of Exeter (2) · Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) (1) · Assiut University (1) · Bartu Eren Güneşliol (1) · Biomed Industries, Inc. (1) · Endominance (1) · Gitte Moos Knudsen (1) · Hadassah Medical Organization (1) · Hanyang University Seoul Hospital (1) · IRCCS San Raffaele (1) · Iuliu Hatieganu University of Medicine and Pharmacy (1) · Mayo Clinic (1) · Pôle Saint Hélier (1) · Recep Tayyip Erdogan University (1)
United States (7) · United Kingdom (3) · China (2) · Denmark (2) · Hong Kong (2) · Turkey (Türkiye) (2) · Finland (1) · France (1) · Israel (1) · Italy (1) · Netherlands (1) · Romania (1) · South Korea (1) · Spain (1)
Jihui Zhang, PhD (2) · Shirley Xin Li, PhD (2) · Vincent Chung Tong Mok, MBChB (2) · Yun Kwok Wing, MBChB (2) · Asiye Dikmen, PhD (1) · Bartu Gunesliol, Master (1) · Boris Decourt, PhD (1) · Huafeng Wei, MD (1) · Ilkka Heinonen, PhD (1) · Ioana Damian, MD (1) · Jaap Oosterlaan, Prof.Dr. (1) · Jeremy PE Spencer, PhD (1) · Lloyd Tran, PhD (1) · Madeleine E. Hackney, PhD (1) · Marios M Politis, Professor (1)
PMID 20402743, PMID 21554495, PMID 27649641, PMID 28109298, PMID 31099405, PMID 33317729, PMID 34764932
K01AG047279 (1), R01AG059008 (1), R37HD043341 (1)