16 completed, 5 recruiting, 1 terminated, 1 unknown. 4 Not applicable, 1 Phase 1, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 4 | Completed 4 |
| Phase 1 | 1 | Recruiting 1 |
| Phase 2 | 1 | Recruiting 1 |
Follow Microcephaly: new trials by email Literature Review of Microcephaly trials Research Report on Microcephaly
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| MEHMO Natural History and Biomarkers Intellectual Disability, Epilepsy | Recruiting | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | 150 | 2023-10-23 | 2026-06-25 | |
| Melpida: Recombinant Adeno-associated Virus (Serotype 9) Encoding a Codon Optimized Human AP4M1 Transgene (hAP4M1opt) MELPIDA - Spasticity, Muscle, Microcephaly | Phase 1 / Phase 2 | Recruiting | Elpida Therapeutics SPC | 4 | 2023-02-15 | 2026-07-08 |
| Summary of Infants Weighing 500 Grams or Less Microcephaly - Infant, Extremely Low Birth Weight, Microcephaly | Completed | Nagano Children's Hospital | 22 | 2022-04-05 | 2024-11-20 | |
| Register for Patients With Thyroid Hormone Resistance. no intervention - Hypothyroidism, Global Developmental Delay | Recruiting | Charite University, Berlin, Germany | 200 | 2021-07-01 | 2024-08-22 | |
| Surveillance of Zika-related Microcephaly in Sub-Saharan Africa and Asia Differential diagnosis for infectious causes of microcephaly - Microcephaly, Congenital Infection | Terminated | Institut Pasteur | 150 | 2019-05-20 | 2022-05-20 | |
| Intensive Therapy for Children With Microcephaly, Hyperkinetic Movements, or Global Developmental Delay Acquire Therapy - Microcephaly, Hyperkinesis With Developmental Delay | Not applicable | Completed | Virginia Polytechnic Institute and State University | 4 | 2019-04-30 | 2022-10-13 |
| North Carolina Genomic Evaluation by Next-generation Exome Sequencing, 2 Pre-visit prep, usual care + exome seq - Epilepsy; Seizure, Neuromuscular Diseases | Not applicable | Completed | University of North Carolina, Chapel Hill | 548 | 2018-09-28 | 2025-05-13 |
| Efficacy of Aquatic Physiotherapy in Children With Microcephaly by Zika Virus Congenital Syndrome aquatic physicotherapy, immersion - Zika Virus Infection, Microcephaly | Not applicable | Completed | Universidade Federal de Pernambuco | 12 | 2017-06-01 | 2019-05-07 |
| Guangzhou Surveillance and Clinical Study in Microcephaly (GSCSM) Microcephaly | Completed | Guangzhou Women and Children's Medical Center | 47369 | 2017-02-10 | 2024-10-01 | |
| Sensorimotor Outcomes of Children Exposed to Foetal Zika Virus Infection First trimester, Second trimester - Zika Virus Infection | Completed | University of Sao Paulo | 31 | 2016-08-02 | 2018-09-20 | |
| Zika Virus Infection's Neonatal and Pediatric Consequences in French Department of America fundus examination, Head ultrasound - Zika Virus Infection on Fetus and Child During the Pregnancy | Completed | Institut National de la Santé Et de la Recherche Médicale, France | 1180 | 2016-06-01 | 2026-09-30 | |
| Neurodevelopment Outcome of Newborns Exposed to Zika Virus (ZIKV) in Utero Symptomatic pregnant women with positive RT-PCR ZIKV in serum or urine, or a positive serologic test specific for ZIKV - Microcephaly, Mental Retardation | Completed | Universidad Industrial de Santander | 284 | 2016-05-01 | 2023-01-09 | |
| Zika Virus Infection's Pregnancy Consequences in French Department of America Incidence of ZIKV Infection on Fetus During the Pregnancy | Completed | Institut National de la Santé Et de la Recherche Médicale, France | 26980 | 2016-04-01 | 2025-12-04 | |
| Zika and Microcephaly: Case-control Study Questionary - Microcephaly | Completed | Laboratório Sabin | 110 | 2016-02-01 | 2017-02-23 | |
| Vertical Exposure to Zika Virus and Its Consequences for Child Neurodevelopment (ZIKVIRUSIFF) Child exposed Zika virus proved - ZIKA VIRUS INFECTION, Child Development | Unknown | Oswaldo Cruz Foundation | 500 | 2016-01-02 | 2018-05-03 | |
| Fetal and Maternal Head Circumference During Pregnancy in Israeli Population no intervention - Maternal-Fetal Relations, Microcephaly | Completed | Clalit Health Services | 188 | 2015-09-01 | 2017-02-14 | |
| Microcephaly Genetic Deficiency in Neural Progenitors Microcephaly | Completed | Assistance Publique - Hôpitaux de Paris | 98 | 2013-10-01 | 2018-03-02 | |
| The FBRI VTC Neuromotor Research Clinic ACQUIRE Therapy - Neuromotor Impairments, Cerebral Palsy | Recruiting | Virginia Polytechnic Institute and State University | 500 | 2013-01-01 | 2026-01-21 | |
| Postnatal HCMV Infection in Very Preterm Infants. Implications, Morbidity, Growth and Neurodevelopmental Outcomes. Hearing Loss, Mental Retardation | Withdrawn | Oslo University Hospital | 2010-08-01 | 2022-09-23 | ||
| COL4A1 Gene Related Cerebra-retinal Angiopathy COL4A1 genetic testing - Cerebra-retinal Angiopathy | Completed | Assistance Publique - Hôpitaux de Paris | 132 | 2010-02-01 | 2016-01-15 |
Showing 20 of 24. Sign in to see all of them.
Intellectual Disability (7) · Zika Virus Infection (6) · Congenital Abnormalities (5) · Learning Disabilities (4) · Epilepsy (3) · Seizures (3) · Cerebral Palsy (2) · Hearing Loss (2) · Muscle Hypotonia (2) · Porencephaly (2) · Allan-Herndon-Dudley syndrome (1) · Angelman Syndrome (1) · Ataxia (1) · Autism Spectrum Disorder (1)
Congenital, Hereditary, and Neonatal Diseases and Abnormalities (24) · Craniofacial Abnormalities (24) · Malformations of Cortical Development (24) · Musculoskeletal Abnormalities (24) · Musculoskeletal Diseases (24) · Nervous System Diseases (23) · Nervous System Malformations (23) · Malformations of Cortical Development, Group I (22) · Congenital Abnormalities (19) · Pathological Conditions, Signs and Symptoms (11) · Mental Disorders (10) · Neurologic Manifestations (10) · Signs and Symptoms (10) · Neurodevelopmental Disorders (9) · Neurobehavioral Manifestations (8)
Betaine (1) · Creatine (1) · Diagnosis, Differential (1) · Hydrotherapy (1) · Immersion (1) · Pregnancy Trimester, First (1) · Pregnancy Trimester, Second (1) · Urination (1) · Vitamin B 12 (1) · levomefolate calcium (1)
Assistance Publique - Hôpitaux de Paris (2) · Institut National de la Santé Et de la Recherche Médicale, France (2) · Virginia Polytechnic Institute and State University (2) · Charite University, Berlin, Germany (1) · Clalit Health Services (1) · Elpida Therapeutics SPC (1) · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (1) · Guangzhou Women and Children's Medical Center (1) · Harvard University Faculty of Medicine (1) · Institut Pasteur (1) · Laboratório Sabin (1) · Nagano Children's Hospital (1) · National Human Genome Research Institute (NHGRI) (1) · National Institute of Neurological Disorders and Stroke (NINDS) (1) · Oslo University Hospital (1)
United States (9) · Brazil (4) · France (3) · China (2) · French Guiana (2) · Guadeloupe (2) · Martinique (2) · Cameroon (1) · Colombia (1) · Côte d’Ivoire (1) · Germany (1) · Israel (1) · Japan (1) · Norway (1) · Sri Lanka (1)
An N Dang Do, M.D. (1) · Arnaud Fontanet (1) · Arthur L. Beaudet, MD (1) · Bruno Hoen (1) · Carlos A. Bacino, MD (1) · Carlos BM Monteiro, PhD (1) · Christopher A. Walsh, M.D., Ph.D. (1) · Gustavo B Barra, ph.D (1) · Heiko Krude, MD (1) · Jeannette T Bensen, Ph.D (1) · Jonathan S Berg, MD, PhD (1)
PMID 22002941, PMID 28715527, PMID 28877754, PMID 29258560, PMID 29539287, PMID 31640736, PMID 32015000, PMID 33472606, PMID 33657112, PMID 34127041, PMID 34969638, PMID 35144270, PMID 35255097, PMID 35726608, PMID 37881807, PMID 39315524, PMID 39610761, PMID 40151166, PMID 41491634
U01HG006487 (1)