108 completed, 44 unknown, 28 recruiting, 9 not yet recruiting. 54 Not applicable, 30 Phase 4, 18 Phase 2, 10 Phase 3, 3 Early Phase 1.
Follow Hypothyroidism: new trials by email Literature Review of Hypothyroidism trials Research Report on Hypothyroidism
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Discontinuation of Low-Dose Levothyroxine in Older Adults With Subclinical Hypothyroidism Levothyroxine Pill, Placebo - Hypothyroidism | Phase 4 | Not yet recruiting | Spyridoula Maraka | 138 | 2027-10-01 | 2026-08-26 |
| Evaluation of an Intensified Systematic Screening for Congenital Hypothyroidism in Premature Newborns Blood test - Congenital Hypothyroidism | Not yet recruiting | University Hospital, Lille | 1600 | 2027-03-01 | 2026-05-22 | |
| Vitamin E Add-On Therapy, Thyroid Function & Oxidative Stress in Levothyroxine-Treated Hypothyroidism vitamin E, placebo - Hypothyroidism | Not applicable | Enrolling by invitation | Bangladesh Medical University | 74 | 2027-02-01 | 2026-08-25 |
| T4/T3 Therapy in Hypothyroidism Liothyronine (L-T3), Levothyroxine Sodium (LT4) Tablets, Liothyronine (LT3) placebo - Hypothyroidism Primary | Phase 2 | Not yet recruiting | University of Pennsylvania | 60 | 2026-11-01 | 2026-08-20 |
| Impact of Overt and Subclinical Hypothyroidism on Liver Fibrosis in Patients With MASLD Metabolic Dysfunction-Associated Steatotic Liver Disease, Non-Alcoholic Fatty Liver Disease | Not yet recruiting | Assiut University | 120 | 2026-10-01 | 2026-09-18 | |
| Hypothyroidism and Liver Fibrosis Severity in MASLD Metabolic Dysfunction-Associated Steatotic Liver Disease, Hypothyroidism | Not yet recruiting | Assiut University | 85 | 2026-10-01 | 2026-08-28 | |
| Evaluation of Levothyroxine Replacement Therapy After Total Thyroidectomy Using a Smart Wristband Xiomi Smart Band 10 - Total Thyroidectomy, Hyperthyroidism | Not applicable | Recruiting | Yeditepe University Hospital | 40 | 2026-07-22 | 2026-09-25 |
| Prevalence and Associated Factors of High BMI and Periodontitis in Thai Adults Aged Under 60 Years Periodontal Examination, Questionnaire interview, Anthropometric measurements - Diabete Mellitus, Dyslipidaemia | Recruiting | Mahidol University | 93 | 2026-07-01 | 2026-10-19 | |
| An Open-Label, Single-Arm Study to Investigate the Efficacy and Safety of North Star Desiccated Porcine Thyroid Extract Tablets. Desiccated Porcine Thyroid Extract Tablets - Hypothyroidism | Phase 3 | Recruiting | Neuvosyn Laboratories, LLC | 466 | 2026-06-30 | 2026-08-05 |
| Effect of Medication Adherence-Based Digital Intervention on Fatigue Severity, Weight, and Thyroid Hormone Regulation medication adherence based digital intervention - Hypothyroidism | Not applicable | Not yet recruiting | University of Baghdad | 80 | 2026-06-01 | 2026-06-09 |
| Internal Organ and Musculoskeletal Assessment in Hypothyroidism (HYPOMORPH) Comprehensive Morphometric and Functional Assessment - Hypothyroidism | Recruiting | Andijan State Medical Institute | 500 | 2026-06-01 | 2026-08-28 | |
| ThyMoves: Screening and Exercise to Improve Muscle, Enhance Quality of Life, and Reduce Fall Risk in Thyroid Disease Rhythm- and Multitask-Based Activity (RYMA) and Activities of Daily Living (ADL) - Thyroid Disease, Hashimoto's Thyroiditis | Not applicable | Enrolling by invitation | Aalborg University Hospital | 148 | 2026-05-15 | 2026-04-17 |
| Ultrasound Measurement of Thyroid Volume in Term Newborns Thyroid ultrasound - Thyroid Volume, Thyroid Ultrasound | Not yet recruiting | IRCCS Ospedale San Raffaele | 400 | 2026-05-01 | 2026-05-12 | |
| Association Between Overt and Sub-clinical Primary Hypothyroidism and Metabolic Dysfunction-Associated Steatoic Liver Disease in Non-Diabetic Patients FibroScan, Thyroid Function Assessment - Overt, Sub-clinical | Recruiting | Sohag University | 200 | 2026-03-01 | 2026-06-02 | |
| Physical Activity, Fatigue, Social Support, and Psychological Well-Being in Women With Primary Hypothyroidism Women with primary hypothyroidism sample - Hypothyroidism Primary | Recruiting | University of Oviedo | 96 | 2026-02-16 | 2026-02-19 | |
| Infants With Primary Congenital Hypothyroidism and Development neurological status, sensory processing functions, Motor development - Congenital Hypothyroidism | Recruiting | Nigde Omer Halisdemir University | 40 | 2025-12-20 | 2026-02-12 | |
| Serum Adipokines and Metabolic Parameters With Hormone Replacement in Newly Diagnosed Hypothyroidism Hypothyroidism, Primary Hypothyroidism | Completed | Başakşehir Çam & Sakura City Hospital | 88 | 2025-12-10 | 2026-06-01 | |
| Levothyroxine Dosing in Neonatal Congenital Hypothyroidism Levothyroxine - Congenital Hypothyroidism | Phase 4 | Completed | Menoufia University | 101 | 2025-11-02 | 2026-08-10 |
| Walking for Hypothyroidism Trial (WHT) Supervised Walking Program - Hypothyroidism | Not applicable | Not yet recruiting | University of Karachi | 120 | 2025-11-01 | 2025-10-03 |
| Metabolic Risk Assessment in Prepubertal Children With Congenital Hypothyroidism prospective observational study (clinical, hormonal and auxological data) - Congenital Hypothyroidism, Metabolic Syndrome | Not yet recruiting | Buzzi Children's Hospital | 170 | 2025-09-01 | 2025-08-17 |
Showing 20 of 218. Sign in to see all of them.
Thyroid Diseases (28) · Congenital Hypothyroidism (26) · Hyperthyroidism (20) · Thyroid Neoplasms (12) · Diabetes Mellitus (11) · Hypertension (8) · Obesity (7) · Depression (6) · Insulin Resistance (6) · Fatigue (5) · Goiter (5) · Graves Disease (5) · Osteoporosis (5) · Anxiety Disorders (4)
Endocrine System Diseases (215) · Thyroid Diseases (190) · Pathological Conditions, Signs and Symptoms (35) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (34) · Musculoskeletal Diseases (34) · Nutritional and Metabolic Diseases (34) · Bone Diseases (32) · Genetic Diseases, Inborn (32) · Metabolic Diseases (31) · Bone Diseases, Developmental (26) · Bone Diseases, Endocrine (26) · Dwarfism (26) · Neoplasms (25) · Neoplasms by Site (25)
Thyroxine (63) · Triiodothyronine (12) · Blood Specimen Collection (5) · Thyroid (USP) (5) · Tablets (3) · Hematologic Tests (2) · Thyroid Function Tests (2) · Thyrotropin-Releasing Hormone (2) · Absorptiometry, Photon (1) · Acoustic Impedance Tests (1) · Activities of Daily Living (1) · Acupuncture Therapy (1) · Aging (1) · Antithyroid Agents (1) · Ascorbic Acid (1)
Assiut University (10) · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (6) · Cairo University (3) · HaEmek Medical Center, Israel (3) · IRCCS Azienda Ospedaliero-Universitaria di Bologna (3) · Seoul National University Bundang Hospital (3) · Sohag University (3) · University of Pennsylvania (3) · All India Institute of Medical Sciences, Bhubaneswar (2) · Azienda USL Modena (2) · Bayer (2) · Birte Nygaard (2) · Boston Children's Hospital (2) · Brigham and Women's Hospital (2) · Duzce University (2)
United States (54) · China (13) · Denmark (12) · Italy (12) · Egypt (11) · Turkey (Türkiye) (10) · Israel (7) · France (6) · India (5) · Pakistan (5) · South Korea (5) · Canada (4) · Germany (4) · Netherlands (4) · Switzerland (4)
Joanna Klubo-Gwiezdzinska, M.D. (2) · Murat Yassa, MD (2) · Rita Ortolano, MD (2) · Adam Wright, PhD (1) · Adnan Agha (1) · Ahmed Faysal, lecturer (1) · Andrea M Isidori, MD, PhD (1) · Angeliki M Stamatouli, MD (1) · Anne R Cappola, MD, ScM (1)
PMID 11172193, PMID 11239487, PMID 11580992, PMID 12390993, PMID 12919160, PMID 12985867, PMID 14749496, PMID 15247962, PMID 15309449, PMID 16205094, PMID 16275864, PMID 16957553, PMID 16984248, PMID 17433800, PMID 17711927, PMID 17728530, PMID 17932107, PMID 17964598, PMID 18279016, PMID 18296580, PMID 18407156, PMID 18787384, PMID 19554027, PMID 19682539, PMID 19690557, PMID 19846175, PMID 19897683, PMID 20427509, PMID 20463094, PMID 20823876, PMID 21258337, PMID 21335378, PMID 21424182, PMID 21568669, PMID 21586104, PMID 21705721, PMID 21765997, PMID 22134702, PMID 22215056, PMID 22730012, PMID 23124142, PMID 23264396, PMID 23448784, PMID 23710844, PMID 23773982, PMID 23856989, PMID 24157158, PMID 24281671, PMID 24423358, PMID 24446653
2015 (1), 2017 (1), 2025 (1), K24AG042765 (1), R01AG079833 (1), R01AG081698 (1), R01DK137207 (1), R01HD113778 (1), R01HL033959 (1), R01HL076645 (1), R18DP001148 (1), R21DK122310 (1), R21NS095723 (1), U10CA081920 (1), UL1TR001082 (1)