389 completed, 102 unknown, 78 recruiting, 35 terminated. 352 Not applicable, 64 Phase 3, 54 Phase 2, 31 Phase 4, 28 Phase 1.
Follow Muscle Hypertonia: new trials by email Literature Review of Muscle Hypertonia trials Research Report on Muscle Hypertonia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Lateral Cord Stimulation as a New Treatment for Refractory Spastic Cerebral Palsy Lateral spinal cord surgical implant of electrodes - Cerebral Palsy, Spasticity | Not applicable | Not yet recruiting | Juan Carlos M. Andreani MD | 40 | 2027-06-01 | 2026-04-28 |
| A Study to Investigate Arbaclofen ER Tablets for the Treatment of Spasticity in Patients With Multiple Sclerosis Arbaclofen, Placebo - Spasticity | Phase 3 | Not yet recruiting | RVL Pharmaceuticals, Inc. | 442 | 2027-01-01 | 2025-12-03 |
| A Phase IIb Study of Nabiximols for Spasticity Due to Neuromyelitis Optica Spectrum Disorders Nabiximols, Placebo - NMO Spectrum Disorder, Spasticity, Muscle | Phase 2 | Withdrawn | Michael, Levy M.D.,Ph.D. | 2026-12-31 | 2025-07-16 | |
| Evaluating the Effects of the EXOPULSE Suit on Mobility, Walking Ability, and Balance in People With Multiple Sclerosis Electrostimulation suit - Multiple Sclerosis | Not applicable | Not yet recruiting | Otto Bock Healthcare Products GmbH | 100 | 2026-11-01 | 2026-10-27 |
| Addressing Spasticity and Motor Function With Epidural Spinal Cord Stimulation Epidural implant stimulation device - SCI - Spinal Cord Injury, Spasticity | Not applicable | Recruiting | Kessler Foundation | 8 | 2026-10-01 | 2026-10-22 |
| Spinal Mobility, Rigidity, and Kinesiophobia in PD and TMD PARKINSON DISEASE (Disorder), Rigidity | Recruiting | Mustafa Kemal University | 60 | 2026-09-23 | 2026-10-05 | |
| Extracorporeal Shockwave Therapy as an Additional Treatment for Spasticity Secondary to Spinal Cord Injury Focused extracorporeal shockwave therapy, Botulinum toxin, Sham - Spinal Cord Injury, Spasticity | Phase 2 | Recruiting | Kessler Foundation | 30 | 2026-09-21 | 2026-10-28 |
| Spinal Cord Stimulation for Poststroke Spasticity Active spinal cord stimulation, Sham spinal cord stimulation - Spasticity Post Stroke | Not applicable | Recruiting | Beijing Pins Medical Co., Ltd | 92 | 2026-09-09 | 2026-09-21 |
| A Pilot Study to Evaluate the Efficacy, Safety and Tolerability of BMS-986368, a FAAH/MAGL Inhibitor, in Participants With Post-Stroke Spasticity (The STIPS Study) Administration of BMS-986368, Placebo - Post-Stroke Spasticity | Phase 2 | Recruiting | Alberto Esquenazi | 42 | 2026-09-02 | 2026-10-01 |
| Collagenase Injection for Spasticity Management XIAFLEX Collagenase injection - Spasticity | Early Phase 1 | Not yet recruiting | The University of Texas Health Science Center, Houston | 15 | 2026-09-01 | 2026-07-09 |
| The Use of Photobiomodulation in the Treatment of Spasticity After Stroke. Photobiomodulation Therapy, Placebo PBM, Standard Multidisciplinary Rehabilitation Program for Spasticity - Stroke, Spasticity | Phase 1 / Phase 2 | Recruiting | University of Nove de Julho | 42 | 2026-08-28 | 2026-09-01 |
| Intermittent Theta-Burst Stimulation for Lower-Limb Spasticity and Pain in Multiple Sclerosis Active Intermittent Theta-Burst Stimulation (iTBS), Sham Intermittent Theta-Burst Stimulation - Multiple Sclerosis, Muscle Spasticity | Not applicable | Not yet recruiting | Comenius University | 40 | 2026-08-10 | 2026-08-26 |
| Orthosis to Improve Trunk Control in Infants Age 6-18 Months SPIO® Core-MAX® Expedition thoracolumbosacral orthosis, Standard Care Therapy option - Cerebral Palsy | Completed | Medical College of Wisconsin | 21 | 2026-08-06 | 2026-10-08 | |
| Co-contraction and Corticoreticular Excitability in Spinal Cord Injury Corticoreticular excitability and co-contraction measurement - Spinal Cord Injury, Spasticity | Not applicable | Enrolling by invitation | Taipei Veterans General Hospital, Taiwan | 20 | 2026-07-27 | 2026-10-14 |
| Extracorporeal Shock Wave Therapy in Botulinum Toxin-Treated Patients With Post-Stroke Ankle Plantar Flexor Spasticity Radial Extracorporeal Shock Wave Therapy (rESWT), Conventional Physical Therapy and Rehabilitation - Stroke, Post-stroke Spasticity of the Lower Limb | Not applicable | Not yet recruiting | Pamukkale University | 32 | 2026-07-20 | 2026-07-10 |
| Dorsal Root Electrical Stimulation in Children With Cerebral Palsy Constant Current Stimulator, Cadwell Guardian System - Cerebral Palsy (CP), Cerebral Palsy | Not applicable | Recruiting | Martin Piazza | 15 | 2026-07-16 | 2026-08-11 |
| Prospective Case Series Evaluating 6-Month and 12-Month Outcomes After Cryoneurolysis for Chronic Pain Chronic Pain, PERIPHERAL NEUROPATHY | Recruiting | Yale University | 80 | 2026-06-20 | 2026-08-21 | |
| Selective Dorsal Rhizotomy as a Cost Effective and Safe Procedure as a Alternative to Intrathecal Baclofen Pump in Patients With Post Traumatic Spasticity Selective dorsal rhizotomy with neuromonitoring - Post Traumatic Induced Spasticity | Not applicable | Not yet recruiting | Assiut University | 32 | 2026-06-01 | 2026-05-13 |
| Constraint-induced Movement Therapy Combined With Functional Electrical Stimulation in Children With Cerebral Palsy Constraint-Induced Movement Therapy Combined with Functional Electrical Stimulation, Constraint-Induced Movement Therapy - Cerebral Palsy (CP) | Not applicable | Completed | Montiha Azeem | 46 | 2026-05-18 | 2026-07-06 |
| Effects of Functional Electrical Stimulation on Spasticity, Quadriceps Muscle Strength and Functional Mobility in Individuals With Paraplegia Conventional Neurorehabilitation, Functional Electrical Stimulation (FES) of Quadriceps Muscle, Sham FES group: Conventional neurorehabilitation + sham/placebo FES - Spinal Cord Injury, Paraplegia | Not applicable | Withdrawn | Istanbul Medipol University Hospital | 2026-05-10 | 2026-10-28 |
Showing 20 of 673. Sign in to see all of them.
Muscle Spasticity (621) · Stroke (216) · Cerebral Palsy (148) · Multiple Sclerosis (76) · Spinal Cord Injuries (67) · Hemiplegia (44) · Muscle Rigidity (31) · Pain (28) · Paresis (22) · Brain Injuries, Traumatic (15) · Dystonia (14) · Brain Injuries (13) · Parkinson Disease (13) · Movement Disorders (11)
Pathological Conditions, Signs and Symptoms (673) · Signs and Symptoms (670) · Neuromuscular Manifestations (669) · Neurologic Manifestations (666) · Nervous System Diseases (665) · Muscular Diseases (645) · Musculoskeletal Diseases (645) · Central Nervous System Diseases (452) · Brain Diseases (389) · Cardiovascular Diseases (222) · Vascular Diseases (221) · Cerebrovascular Disorders (220) · Brain Damage, Chronic (150) · Wounds and Injuries (86)
Botulinum Toxins, Type A (73) · Dry Needling (17) · nabiximols (17) · Botulinum Toxins (15) · Extracorporeal Shockwave Therapy (14) · Baclofen (12) · Physical Therapy Modalities (11) · incobotulinumtoxinA (11) · abobotulinumtoxinA (10) · Muscle Stretching Exercises (7) · Rehabilitation (7) · Transcranial Direct Current Stimulation (7) · Control Groups (6) · Saline Solution (6) · Transcranial Magnetic Stimulation (6)
Riphah International University (19) · Allergan (17) · Ipsen (15) · Chang Gung Memorial Hospital (12) · Jazz Pharmaceuticals (10) · Kessler Foundation (8) · National Institute of Neurological Disorders and Stroke (NINDS) (8) · Shirley Ryan AbilityLab (7) · Vanderbilt University (7) · Assistance Publique - Hôpitaux de Paris (6) · GlaxoSmithKline (6) · Marmara University (6) · Medy-Tox (6) · Universitaire Ziekenhuizen KU Leuven (6) · Cairo University (5)
United States (181) · Turkey (Türkiye) (79) · France (42) · Spain (40) · Pakistan (34) · Canada (32) · Italy (28) · Taiwan (27) · United Kingdom (27) · Belgium (21) · Poland (21) · South Korea (19) · Brazil (17) · Germany (17) · Russia (17)
David Charles, M.D. (5) · Pong Ya-Ping, MD (4) · Jen-Wen Hung (3) · Mirza Obaid Baig, MSPT (3) · Monica A Gorassini, PhD (3) · William Z Rymer, MD, PhD (3) · Aiko K Thompson, PhD (2)
PMID 27149465, PMID 17370477, PMID 20358216, PMID 25475413, PMID 32232101, PMID 34721255, PMID 36706682, PMID 3809245, PMID 41491634, PMID 7192811, PMID 10077661, PMID 10641699, PMID 10695888, PMID 10811692, PMID 10896696, PMID 10946168, PMID 11689982, PMID 12088304, PMID 12167681, PMID 12525714, PMID 12529557, PMID 12593613, PMID 12929197, PMID 1392142, PMID 14179895, PMID 14506719, PMID 14515935, PMID 14684785, PMID 14970972, PMID 15037681, PMID 16108461, PMID 16777777, PMID 16780624, PMID 16785117, PMID 16914068, PMID 17084128, PMID 17086911, PMID 17209981, PMID 17355549, PMID 17979861, PMID 18292215, PMID 18355307, PMID 18977158, PMID 19011522, PMID 19083678, PMID 19416339, PMID 19480872, PMID 19597267, PMID 19834018, PMID 19854692
2019 (2), 2025 (2), 2005 (1), 2009 (1), 2014 (1), 2016 (1), 2018 (1), 2023 (1), I01RX002507 (1), I21RX004652 (1), K23NS044997 (1), P20GM109040 (1), R01HD039343 (1), R01HD075813 (1), R01HD112563 (1)