6 completed, 2 unknown, 2 withdrawn, 1 terminated. 11 Phase 3, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 11 | Completed 6, Unknown 2, Withdrawn 2, Terminated 1 |
| Phase 2 | 1 | Completed 1 |
Follow Multiple Organ Failure: new trials by email Literature Review of Multiple Organ Failure trials Research Report on Multiple Organ Failure
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Dalargin for Prevention of Organ Disfunction in High-Risk Abdominal Surgery Dalargin, 0.9 % NaCl - Postoperative Complications, Multiple Organ Failure | Phase 3 | Completed | Botkin Hospital | 200 | 2025-05-13 | 2026-09-23 |
| Efficacy of Coenzyme Q10 Supplementation on Multi-Organ Dysfunction in Severely Burned Patients CoQ10, Placebo - Multiple Organ Failure | Phase 3 | Withdrawn | American Burn Association | 2018-07-01 | 2023-07-20 | |
| Benefit of Clarithromycin in Patients With Severe Infections Through Modulation of the Immune System Clarithromycin, Water for injection - Sepsis, Pneumonia | Phase 3 | Completed | Hellenic Institute for the Study of Sepsis | 110 | 2017-12-15 | 2020-12-22 |
| Vitamin D Status in Patients With Severe Sepsis vitamin D3, Placebo - Sepsis, Severe Sepsis | Phase 3 | Withdrawn | Massachusetts General Hospital | 2017-12-01 | 2021-05-05 | |
| Trial of Enteral Glutamine on Clinical Outcomes in Critically Ill Patients Glutamin, Maltodextrin - Critical Illness, Enteral Nutrition | Phase 3 | Completed | Shahid Beheshti University | 200 | 2016-11-10 | 2018-10-16 |
| Supplemental Parenteral Nutrition in Critically Ill Adults: A Pilot Randomised Controlled Trial Supplemental PN, Standard Care - Multiple Organ Failure, Critical Illness | Phase 2 / Phase 3 | Completed | Australian and New Zealand Intensive Care Research Centre | 100 | 2014-02-01 | 2016-08-02 |
| Effect of C1-esterase Inhibitor on Systemic Inflammation in Trauma Patients With a Femur or Pelvic Fracture C1-esterase inhibitor, Saline 0.9% - Trauma, Inflammation | Phase 3 | Terminated | UMC Utrecht | 11 | 2012-04-01 | 2015-02-04 |
| L-citrulline Supplementation During Sepsis L-citrulline supplementation, L-alanine - Sepsis, Multiple Organ Failure | Phase 3 | Unknown | Maastricht University Medical Center | 48 | 2011-01-01 | 2010-09-03 |
| Cyclosporine A in Cardiac Arrest Cyclosporine A, cardio-pulmonary resuscitation - Non Shockable Out of Hospital Cardiac Arrest | Phase 3 | Completed | Hospices Civils de Lyon | 796 | 2010-06-01 | 2025-08-28 |
| Defibrotide for the Treatment of Severe Hepatic Veno-Occlusive Disease in Hematopoetic Stem Cell Transplant Patients Defibrotide - Severe Hepatic Veno-Occlusive Disease | Phase 3 | Completed | Jazz Pharmaceuticals | 134 | 2006-07-01 | 2017-01-30 |
| Effect of Rosiglitazone on ADMA in Critical Illness Rosiglitazone - Critical Illness, Multiple Organ Failure | Phase 3 | Unknown | Amsterdam UMC, location VUmc | 30 | 2006-04-01 | 2006-12-08 |
Critical Illness (4) · Sepsis (4) · Inflammation (2) · Angioedemas, Hereditary (1) · Gram-Negative Bacterial Infections (1) · Heart Arrest (1) · Hepatic Veno-Occlusive Disease (1) · Pneumonia (1) · Post-Cardiac Arrest Syndrome (1) · Postoperative Complications (1) · Respiratory Distress Syndrome (1) · Spinocerebellar ataxia 23 (1) · Wounds and Injuries (1)
Pathologic Processes (11) · Pathological Conditions, Signs and Symptoms (11) · Shock (11) · Disease Attributes (4) · Infections (4) · Systemic Inflammatory Response Syndrome (4) · Cardiovascular Diseases (3) · Inflammation (3) · Vascular Diseases (3) · Angioedema (1) · Bacterial Infections (1) · Bacterial Infections and Mycoses (1) · Brain Diseases (1) · Brain Injuries (1) · Central Nervous System Diseases (1)
Sodium Chloride (2) · Alanine (1) · Cardiopulmonary Resuscitation (1) · Cholecalciferol (1) · Clarithromycin (1) · Complement C1 Inhibitor Protein (1) · Cyclosporine (1) · Dietary Supplements (1) · Glutamine (1) · Injections (1) · Rosiglitazone (1) · Saline Solution (1) · Standard of Care (1) · Water (1) · coenzyme Q10 (1)
American Burn Association (1) · Amsterdam UMC, location VUmc (1) · Australian and New Zealand Intensive Care Research Centre (1) · Botkin Hospital (1) · Hellenic Institute for the Study of Sepsis (1) · Hospices Civils de Lyon (1) · Jazz Pharmaceuticals (1) · Maastricht University Medical Center (1) · Massachusetts General Hospital (1) · Shahid Beheshti University (1) · UMC Utrecht (1)
Netherlands (3) · United States (3) · Australia (1) · Belgium (1) · Canada (1) · France (1) · Greece (1) · Iran (1) · New Zealand (1) · Russia (1)
Apostolos Armaganidis, MD, PhD (1) · Herb Phelan, MD (1) · Luke P Leenen, MD, PhD (1) · Martijn Poeze, MD, PhD (1) · Paul Richardson, M.D. (1) · Sadeq A Quraishi, MD (1) · Zahra Vahdat Shariatpanahi, MD, PhD (1)
PMID 10933646, PMID 18444850, PMID 20610825, PMID 21988742, PMID 22564837, PMID 24292991, PMID 26703919, PMID 26825712, PMID 27044546, PMID 27433815, PMID 29361959, PMID 34116828, PMID 35717241
2009 (1)