136 completed, 21 terminated, 10 unknown, 6 withdrawn. 52 Phase 3, 37 Phase 4, 36 Phase 2, 27 Phase 1, 23 Not applicable.
Follow this drug Literature Review of Rosiglitazone trials Research Report on Rosiglitazone
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Comparative Effectiveness and Safety of Four Second Line Pharmacological Strategies in Type 2 Diabetes Study SGLT2 inhibitor, DPP-4 inhibitor, GLP-1RA - Cardiovascular Events, Type2 Diabetes | Active not recruiting | Brigham and Women's Hospital | 781430 | 2021-08-01 | 2026-08-13 | |
| Anti-PD-1 mAb Plus Metabolic Modulator in Solid Tumor Malignancies Nivolumab or Pembrolizumab (dependent upon approved indication), Metformin, Rosiglitazone - Melanoma, NSCLC | Phase 2 | Recruiting | Dan Zandberg | 72 | 2020-09-14 | 2026-06-23 |
| A Pilot Study of Rosiglitazone in the Treatment of GH Secreting Pituitary Adenomas Rosiglitazone - Pituitary Tumor | Not applicable | Unknown | Zhaoyun Zhang | 24 | 2016-10-16 | 2017-10-13 |
| Rosiglitazone Adjunctive Therapy for Severe Malaria in Children Rosiglitazone, Placebo - Malaria | Not applicable | Completed | Centro de Investigacao em Saude de Manhica | 210 | 2016-02-01 | 2024-02-21 |
| Incretin-based Drugs and the Risk of Heart Failure DPP-4 inhibitors, GLP-1 analogs, Insulins - Type 2 Diabetes Mellitus | Completed | Canadian Network for Observational Drug Effect Studies, CNODES | 1499650 | 2014-03-01 | 2016-04-19 | |
| Incretin-based Drugs and Acute Pancreatitis DPP-4 inhibitors, GLP-1 analogs, Insulins - Diabetes Mellitus, Type 2 | Completed | Canadian Network for Observational Drug Effect Studies, CNODES | 1417914 | 2014-03-01 | 2016-11-03 | |
| Incretin-based Drugs and Pancreatic Cancer DPP-4 inhibitors, GLP-1 analogs, Sulfonylureas - Diabetes Mellitus, Type 2 | Completed | Canadian Network for Observational Drug Effect Studies, CNODES | 886172 | 2014-03-01 | 2016-03-14 | |
| BAY73-4506 Probe Substrate Study Regorafenib (Stivarga, BAY73-4506), Warfarin, Omeprazole - Neoplasms | Phase 1 | Completed | Bayer | 41 | 2011-08-02 | 2019-07-10 |
| A Study to Assess the Effect Tasimelteon on the Cytochrome P450 3A4 and 2C8 Enzymes in Healthy Subjects Tasimelteon, Rosiglitazone, Midazolam - Healthy Volunteers | Phase 1 | Completed | Vanda Pharmaceuticals | 24 | 2011-08-01 | 2014-02-17 |
| A Study of Pharmacokinetic Drug Interaction Study of the Hedgehog Pathway Inhibitor GDC-0449 in Combination With Rosiglitazone or Combined Oral Contraceptive in Patients With Locally Advanced or Metastatic Solid Tumors That Are Refractory to Standard Therapy or for Whom No Standard Therapy Exists Vismodegib, Rosiglitazone, Norethindrone/ethinyl estradiol - Solid Cancers | Phase 1 | Completed | Genentech, Inc. | 52 | 2010-11-01 | 2015-06-29 |
| A Drug-Drug Interaction Study of the Effects of XL184 (Cabozantinib) on Rosiglitazone in Subjects With Solid Tumors rosiglitazone, XL184 - Papillary Thyroid Cancer, Follicular Thyroid Cancer | Phase 1 | Completed | Exelixis | 40 | 2010-04-01 | 2013-09-19 |
| Compare the Pharmacokinetics of Omeprazole, Rosiglitazone, and Desipramine When Administered With Avanafil in Healthy Male Subjects Omeprazole, Rosiglitazone, Desipramine - Erectile Dysfunction | Phase 1 | Completed | VIVUS LLC | 60 | 2010-04-01 | 2011-08-11 |
| An Efficacy and Safety Study of Fixed-dose Rosiglitazone/Glimepiride to Treat Chinese Type 2 Diabetes Patients rosiglitazone/glimepiride fix dose combination, glimepiride - Diabetes Mellitus, Type 2 | Phase 3 | Terminated | GlaxoSmithKline | 86 | 2010-04-01 | 2012-03-27 |
| A Methodological Study To Evaluate The Effects of Single Oral Doses Of Pioglitazone 45 mg And Rosiglitazone 8 mg On Sodium Balance In Healthy Male Volunteers pioglitazone/rosiglitazone/placebo, rosiglitazone/pioglitazone/placebo, placebo/pioglitazone/rosiglitazone - Type 2 Diabetes Mellitus | Phase 1 | Completed | Solvay Pharmaceuticals | 12 | 2010-02-01 | 2010-03-17 |
| Avandamet Bioequivalence Study Brazil - Fed Administration Rosiglitazone Maleate + Metformin 2 miligrams (mg) + 500 mg, Rosiglitazone Maleate + Metformin 4 miligrams (mg) + 1000 mg - Diabetes Mellitus, Type 2 | Phase 1 | Completed | GlaxoSmithKline | 26 | 2009-11-24 | 2017-07-12 |
| Malignancy Meta Analysis for BRL49653 allocation of treatment with metformin or rosiglitazone - Diabetes Mellitus, Type 2 | Completed | GlaxoSmithKline | 1 | 2009-10-01 | 2013-10-28 | |
| Validation Study of Multiple Probe Compounds for Drug Interaction Evaluation Caffeine, Rosiglitazone, Flurbiprofen - Drug Interactions | Phase 1 | Completed | GlaxoSmithKline | 87 | 2009-08-26 | 2018-01-04 |
| The Impact of Obesity and Obesity Treatments on Breast Cancer Exemestane, Avandamet - Breast Cancer | Phase 1 | Completed | M.D. Anderson Cancer Center | 25 | 2009-07-01 | 2016-02-19 |
| Thiazolidinedione Intervention With Vitamin D Evaluation pioglitazone, rosiglitazone, placebo - Diabetes Mellitus, Type 2 | Phase 4 | Terminated | GlaxoSmithKline | 1332 | 2009-05-01 | 2017-04-18 |
| A First Time in Human Study in Healthy Volunteers to Investigate a New Medicine to Treat Malaria GSK932121; Rosiglitazone; Rosuvastatin - Malaria | Phase 1 | Terminated | GlaxoSmithKline | 12 | 2008-12-11 | 2017-08-03 |
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Diabetes Mellitus, Type 2 (74) · Insulin Resistance (32) · Diabetes Mellitus (28) · Glucose Intolerance (12) · Metabolic Syndrome (12) · HIV Infections (8) · Alzheimer Disease (7) · Atherosclerosis (7) · Obesity (6) · Fatty Liver (5) · Cardiovascular Diseases (4) · Coronary Artery Disease (4) · Lipodystrophy (4) · Non-alcoholic Fatty Liver Disease (4) · Asthma (3)
GlaxoSmithKline (35) · Novo Nordisk A/S (6) · AstraZeneca (4) · Aristotle University Of Thessaloniki (3) · Canadian Network for Observational Drug Effect Studies, CNODES (3) · National Center for Research Resources (NCRR) (3) · National Institute of Allergy and Infectious Diseases (NIAID) (3) · Stanford University (3) · US Department of Veterans Affairs (3) · University of Glasgow (3) · Baskent University (2) · Brooke Army Medical Center (2) · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (2) · Gerstein, Hertzel, MD (2) · James Lewis (2)
United States (86) · Canada (23) · United Kingdom (15) · Netherlands (14) · Germany (13) · France (10) · Spain (9) · Greece (8) · Australia (7) · Denmark (7) · Finland (7) · Italy (7) · Mexico (7) · Philippines (7) · South Korea (7)
Pierre Ernst, MD, MSc (3) · Anthony Heaney, MD (2) · Carlos Abraira, MD (2) · James D Lewis, MD, MSCE (2) · Naveed Sattar, MBChB PhD (2) · Stuart M Cobbe, MBChB MD (2) · Abdul Rashid A Rahman, MRCP, PhD (1) · Alan J Bank, M.D. (1) · Alexander JM Rennings, MD (1) · Alfonso Perez, MD (1)
PMID 32501595, PMID 19245711, PMID 19491536, PMID 19878259, PMID 19898642, PMID 21209033, PMID 21883806, PMID 22055210, PMID 22193143, PMID 22862847, PMID 23010561, PMID 23186975, PMID 24561125, PMID 25504028, PMID 33367811, PMID 11347758, PMID 11815513, PMID 12351470, PMID 12803733, PMID 14583175, PMID 15561950, PMID 15983299, PMID 16043738, PMID 16504835, PMID 16627388, PMID 16784922, PMID 16873701, PMID 16980380, PMID 16997664, PMID 17093067, PMID 17116177, PMID 17145742, PMID 17192117, PMID 17305652, PMID 17486315, PMID 17586747, PMID 17592102, PMID 17595249, PMID 17595355, PMID 18223031, PMID 18268075, PMID 18325386, PMID 18406632, PMID 18413173, PMID 18539917, PMID 18623174, PMID 18671796, PMID 19092145, PMID 19196814, PMID 19205754
2005 (3), K23HD043952 (2), R01DK059961 (2), 2004 (1), 2009 (1), K24HD001357 (1), M01RR000096 (1), N01CN35159 (1), N01HC95178 (1), N01HC95179 (1), N01HC95180 (1), N01HC95181 (1), N01HC95182 (1), N01HC95183 (1), N01HC95184 (1)