7 completed, 4 terminated, 2 unknown, 1 not yet recruiting. 15 Phase 2, 4 Phase 1, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 15 | Completed 7, Terminated 4, Unknown 2, Not yet recruiting 1, Withdrawn 1 |
| Phase 1 | 4 | Completed 1, Not yet recruiting 1, Terminated 1, Unknown 1 |
| Phase 3 | 1 | Completed 1 |
Follow Multiple Organ Failure: new trials by email Literature Review of Multiple Organ Failure trials Research Report on Multiple Organ Failure
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Point-of-Care AI Assistance and Critical Care Outcomes: A Randomized Trial Point-of-care large language model decision support (ChatGPT-5) - Critical Illness, Sepsis | Phase 1 / Phase 2 | Not yet recruiting | MetroWest Artificial Intelligence Research Workgroup | 1000 | 2026-01-01 | 2025-12-18 |
| TXA127 for the Treatment of Severe COVID-19 TXA127, Placebo - COVID-19 | Phase 2 | Completed | Columbia University | 22 | 2021-02-10 | 2022-07-27 |
| Red Cell Rejuvenation for the Attenuation of Transfusion Associated Organ Injury in Cardiac Surgery rejuvesol Solution, Standard Care - Organ Failure, Multiple, Inflammation | Phase 2 | Withdrawn | University of Leicester | 2020-12-01 | 2021-04-29 | |
| Clinical Use of Stem Cells for the Treatment of Covid-19 MSC Treatment, Saline Control - Covid19, Pneumonia | Phase 1 / Phase 2 | Completed | SBÜ Dr. Sadi Konuk Eğitim ve Araştırma Hastanesi | 30 | 2020-04-01 | 2021-05-25 |
| Early Metabolic Resuscitation for Septic Shock Best Practice, early metabolic resuscitation - Multiple Organ Failure, Septic Shock | Phase 2 | Terminated | M.D. Anderson Cancer Center | 2 | 2019-10-04 | 2024-10-29 |
| Infusion of Prostacyclin vs Placebo for 72-hours in Trauma Patients With Haemorrhagic Shock Suffering From Organ Failure Iloprost, Isotonic saline - Multi Organ Failure | Phase 2 | Completed | Pär Johansson | 228 | 2019-05-22 | 2024-05-08 |
| The Val-CARD Trial Sodium Valproate - Cardiac Valve Disease, Coronary Artery Disease | Phase 1 / Phase 2 | Terminated | University of Leicester | 45 | 2018-11-06 | 2026-08-17 |
| Eculizumab to Treat Thrombotic Microangiopathy/Atypical Hemolytic Uremic Syndrome -Associated Multiple Organ Dysfunction Syndrome in Hematopoietic Stem Cell Transplant Recipients Eculizumab - Thrombotic Microangiopathies, Atypical Hemolytic Uremic Syndrome | Phase 2 | Completed | Children's Hospital Medical Center, Cincinnati | 23 | 2018-08-03 | 2023-09-21 |
| Efficacy and Safety of FP-1201-lyo (Interferon Beta-1a) in Prevention of Multi-Organ Failure on Patients After Open Surgery for a RAAA Interferon Beta-1A, Placebo - Preventive Medicine, Multi Organ Failure | Phase 2 | Terminated | Faron Pharmaceuticals Ltd | 40 | 2017-02-18 | 2021-01-14 |
| Treatment of Septic Shock by Inhibiting Autodigestion and Preserving Gut Integrity With Enteric LB1148 LB1148, Placebo - Septic Shock | Phase 2 | Terminated | Leading BioSciences, Inc | 8 | 2015-04-01 | 2020-06-01 |
| Using Human Menstrual Blood Cells to Treat Acute Lung Injury Caused by H7N9 Bird Flu Virus Infection Menstrual blood stem cells - Acute Lung Injury, Acute Respiratory Distress Syndrome (ARDS) | Phase 1 / Phase 2 | Unknown | S-Evans Biosciences Co., Ltd. | 20 | 2014-03-01 | 2014-03-24 |
| Supplemental Parenteral Nutrition in Critically Ill Adults: A Pilot Randomised Controlled Trial Supplemental PN, Standard Care - Multiple Organ Failure, Critical Illness | Phase 2 / Phase 3 | Completed | Australian and New Zealand Intensive Care Research Centre | 100 | 2014-02-01 | 2016-08-02 |
| Reducing Elevated Heart Rate in Patients With Multiple Organ Dysfunction Syndrome (MODS) by Ivabradine ivabradine - Multiple Organ Dysfunction Syndrome | Phase 2 | Unknown | Martin-Luther-Universität Halle-Wittenberg | 70 | 2010-05-01 | 2010-09-08 |
| Intrapleural Methylprednisolone Injection for Multiple Organ Failure With Acute Respiratory Distress Syndrome conventional ECMO with intravenous steroid, solumedrol - Acute Respiratory Distress Syndrome (ARDS), Multiple Organ Failure | Phase 2 | Completed | National Taiwan University Hospital | 29 | 2005-06-01 | 2011-08-26 |
| Bovine Intestinal Alkaline Phosphatase for the Treatment of Patients With Sepsis Alkaline Phosphatase, Placebo - Sepsis, Multiple Organ Dysfunction Syndrome | Phase 2 | Completed | AM-Pharma | 37 | 2004-09-01 | 2012-04-02 |
Sepsis (6) · Acute Kidney Injury (2) · COVID-19 (2) · Critical Illness (2) · Respiratory Distress Syndrome (2) · Shock (2) · Shock, Septic (2) · Acute Lung Injury (1) · Atypical Hemolytic Uremic Syndrome (1) · Confusion (1) · Coronary Artery Disease (1) · Coronavirus Infections (1) · Heart Valve Diseases (1) · Hyperlactatemia (1)
Pathologic Processes (15) · Pathological Conditions, Signs and Symptoms (15) · Shock (13) · Infections (7) · Inflammation (5) · Systemic Inflammatory Response Syndrome (5) · Lung Diseases (4) · Respiratory Tract Diseases (4) · Female Urogenital Diseases (3) · Female Urogenital Diseases and Pregnancy Complications (3) · Kidney Diseases (3) · Male Urogenital Diseases (3) · Urogenital Diseases (3) · Urologic Diseases (3) · Cardiovascular Diseases (2)
Standard of Care (3) · Sodium Chloride (2) · 2-(3',4'-dihydroxyphenyl-1-azo)benzimidazole (1) · Alkaline Phosphatase (1) · Dietary Supplements (1) · Drugs, Investigational (1) · Glucose (1) · Iloprost (1) · Interferon beta-1a (1) · Ivabradine (1) · Methods (1) · Methylprednisolone Hemisuccinate (1) · Parenteral Nutrition (1) · Practice Guidelines as Topic (1) · Proteins (1)
University of Leicester (2) · AM-Pharma (1) · Australian and New Zealand Intensive Care Research Centre (1) · Children's Hospital Medical Center, Cincinnati (1) · Columbia University (1) · Faron Pharmaceuticals Ltd (1) · Leading BioSciences, Inc (1) · M.D. Anderson Cancer Center (1) · Martin-Luther-Universität Halle-Wittenberg (1) · MetroWest Artificial Intelligence Research Workgroup (1) · National Taiwan University Hospital (1) · Pär Johansson (1) · S-Evans Biosciences Co., Ltd. (1) · SBÜ Dr. Sadi Konuk Eğitim ve Araştırma Hastanesi (1)
United States (5) · United Kingdom (2) · Australia (1) · Belgium (1) · Canada (1) · China (1) · Denmark (1) · Estonia (1) · Finland (1) · Germany (1) · Lithuania (1) · Netherlands (1) · New Zealand (1) · Norway (1) · Taiwan (1)
Bart Wuurman, M.Sc. (1) · Charlie Xiang, Doctor (1) · Erdal Karaoz, Prof.Dr. (1) · Eric Silverman, M.D. (1) · Gavin J Murphy, Prof (1) · Gavin Murphy, MD (1) · Gokhan T Adas, Prof.Dr. (1) · Harri Hakovirta, MD (1) · Henning Ebelt, MD (1) · Jeanine D'Armiento, MD, PhD (1) · Joseph L. Nates, MBA,MD (1) · Karl Werdan, MD, Professor (1) · Maarit Venermo, MD (1) · Marius Roman, MD (1)
PMID 19048243, PMID 19114895, PMID 21638157, PMID 26703919, PMID 29361959, PMID 33393084, PMID 35115574, PMID 35902867, PMID 37946262
2014 (1), 2018 (1), 2019 (1), P30CA016672 (1)