12 completed, 5 unknown, 2 recruiting, 1 not yet recruiting. 6 Not applicable, 6 Phase 2, 4 Phase 3, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 6 | Completed 4, Terminated 1, Unknown 1 |
| Phase 2 | 6 | Unknown 3, Completed 1, Not yet recruiting 1, Recruiting 1 |
| Phase 3 | 4 | Completed 4 |
| Phase 4 | 1 | Withdrawn 1 |
Follow Hepatic Veno-Occlusive Disease: new trials by email Literature Review of Hepatic Veno-Occlusive Disease trials Research Report on Hepatic Veno-Occlusive Disease
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| SAMe in Prevention of Oxaliplatin-associated Liver Injury Standard of care oxaliplatin-based chemotherapy, S-adenosylmethionine (SAMe) supplement, Surgery - Colorectal Cancer, Liver Metastases | Phase 2 | Not yet recruiting | Cedars-Sinai Medical Center | 30 | 2026-10-01 | 2026-09-30 |
| Defibrotide Dose-escalation for SOS Post-HSCT Defibrotide - Sinusoidal Obstruction Syndrome, Veno-occlusive Disease | Phase 2 | Recruiting | New York Medical College | 20 | 2024-03-20 | 2026-04-15 |
| Cell Free DNA Profiling As a Tool to Monitor Clinically-Relevant Events in Allogeneic Hematopoietic Stem Cell Transplantation Sample collation for cfDNA methylation analysis, Sample collection for EV phenotype analysis - GVHD - Graft-Versus-Host Disease, Infections After HSCT | Recruiting | University of Turin, Italy | 30 | 2024-01-31 | 2024-12-04 | |
| Clinical Diagnosis and Pathological Spectrum of Porto-sinusoidal Vascular Disease in India Portal Hypertension, Budd-Chiari Syndrome | Unknown | Post Graduate Institute of Medical Education and Research, Chandigarh | 210 | 2023-08-01 | 2024-04-25 | |
| Efficacy of N-acetylcysteine Versus Placebo as Prophylaxis of Sinusoidal Obstruction Syndrome in Patients Undergoing Hematopoietic Stem Cell Transplantation N-acetylcysteine, Placebo - Sinusoidal Obstruction Syndrome (SOS), Hematopoietic Stem Cell Transplant (HSCT) | Phase 2 | Unknown | Instituto Brasileiro de Controle do Cancer | 80 | 2021-04-01 | 2021-03-09 |
| 5-day Defibrotide Treatment for Hepatic SOS/VOD Defibrotide - Sinusoidal Obstruction Syndrome, Veno-occlusive Disease | Phase 2 | Unknown | Loyola University | 24 | 2021-03-11 | 2021-04-23 |
| Validating Ultrasound Biomarkers for Hepatic Sinusoidal Obstruction Syndrome in Pediatric Hematopoietic Cell Transplant Patients Ultrasound Elastography, Contrast Enhanced Ultrasound (CEUS) - Sinusoidal Obstruction Syndrome, Veno Occlusive Disease, Hepatic | Phase 4 | Withdrawn | Children's Mercy Hospital Kansas City | 2020-04-01 | 2020-01-13 | |
| Pharmacogenetic Study of Antimitotic Therapies Involved in Hepatic VOD in Children With Nephroblastoma or ALL Blood test for genetic analysis - Hepatic Veno-Occlusive Disease, Nephroblastoma | Not applicable | Completed | University Hospital, Angers | 85 | 2020-01-01 | 2026-06-29 |
| Using Ultrasound Elastography to Predict Development of Hepatic Sinusoidal Obstruction Syndrome Ultrasound Elastography - Bone Marrow Transplant Complications, Sinusoidal Obstruction Syndrome | Not applicable | Completed | Children's Mercy Hospital Kansas City | 250 | 2019-04-01 | 2026-07-14 |
| Ultrasound Elastography to Predict Development of SOS Ultrasound Examination - Bone Marrow Transplant Complications, Sinusoidal Obstruction Syndrome | Not applicable | Terminated | Children's Mercy Hospital Kansas City | 21 | 2018-05-01 | 2024-09-04 |
| Sinusoidal Obstruction Syndrome for Stem Cell Transplant Patients Biomarker Study Serial Blood Draws - Sinusoidal Obstruction Syndrome | Completed | Indiana University | 80 | 2017-04-01 | 2023-12-19 | |
| Detection of Sinusoidal Obstruction Syndrome With Ultrasound After Allogeneic HSCT ultrasound - Sinusoidal Obstruction Syndrome | Completed | Central Hospital, Nancy, France | 114 | 2016-09-01 | 2025-09-26 | |
| Study Comparing Efficacy and Safety of Defibrotide vs Best Supportive Care in the Prevention of Hepatic Veno-Occlusive Disease in Adult and Pediatric Patients Defibrotide, Best Supportive Care - Veno-occlusive Disease | Phase 3 | Completed | Jazz Pharmaceuticals | 372 | 2016-09-01 | 2022-03-02 |
| Using Ultrasound Elastography to Predict Development of SOS shear wave ultrasound elastography - Sinusoidal Obstruction Syndrome, Complications of Bone Marrow Transplant | Not applicable | Completed | Children's Mercy Hospital Kansas City | 45 | 2015-08-01 | 2024-02-14 |
| Liver Stiffness Measurement Predicts VOD/SOS Development (ELASTOVOD ITALIAN MULTICENTRIC STUDY) LSM assessed by Elastographic Techniques - Veno Occlusive Disease, Hepatic, Sinusoidal Obstruction Syndrome | Not applicable | Completed | IRCCS Azienda Ospedaliero-Universitaria di Bologna | 1101 | 2015-04-28 | 2022-04-14 |
| European VOD Registry Hepatic Veno-Occlusive Disease | Completed | Jazz Pharmaceuticals | 176 | 2015-04-24 | 2019-10-16 | |
| Antithrombin-III for Patients With Hepatic Veno-occlusive Diseases Following Hematopoietic Stem Cell Transplantation Freeze-dried Concentrated Human Antithrombin Ⅲ 500 IU - Hepatic Veno-Occlusive Disease | Phase 2 | Unknown | Seoul National University Hospital | 32 | 2013-06-01 | 2021-03-30 |
| Prevention of the Hepatic Sinusoidal Obstruction Syndrome by Means of Anticoagulants Sinusoidal Obstruction Syndrome, Colorectal Liver Metastases | Completed | Maastricht University Medical Center | 80 | 2008-01-01 | 2014-02-04 | |
| Defibrotide for Patients With Hepatic Veno-occlusive Disease: A Treatment IND Study Defibrotide - Hepatic Veno-Occlusive Disease | Phase 3 | Completed | Jazz Pharmaceuticals | 1206 | 2007-12-01 | 2017-11-30 |
| Defibrotide for the Treatment of Severe Hepatic Veno-Occlusive Disease in Hematopoetic Stem Cell Transplant Patients Defibrotide - Severe Hepatic Veno-Occlusive Disease | Phase 3 | Completed | Jazz Pharmaceuticals | 134 | 2006-07-01 | 2017-01-30 |
Showing 20 of 23. Sign in to see all of them.
Budd-Chiari Syndrome (1) · Chemical and Drug Induced Liver Injury (1) · Colorectal Neoplasms (1) · Graft vs Host Disease (1) · Hypertension, Portal (1) · Idiopathic Noncirrhotic Portal Hypertension (1) · Mucositis (1) · Multiple Organ Failure (1) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (1) · Pulmonary Veno-Occlusive Disease (1) · Wilms Tumor (1)
Cardiovascular Diseases (23) · Digestive System Diseases (23) · Liver Diseases (23) · Vascular Diseases (23) · Gastrointestinal Diseases (2) · Immune System Diseases (2) · Neoplasms (2) · Neoplasms by Site (2) · Chemically-Induced Disorders (1) · Colonic Diseases (1) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (1) · Digestive System Neoplasms (1) · Drug-Related Side Effects and Adverse Reactions (1) · Embolism and Thrombosis (1) · Female Urogenital Diseases (1)
defibrotide (7) · Acetylcysteine (1) · Antithrombin III (1) · Genetic Testing (1) · Glutamine (1) · Hematologic Tests (1) · S-Adenosylmethionine (1) · Specimen Handling (1) · Surgical Procedures, Operative (1) · Ultrasonography (1)
Children's Mercy Hospital Kansas City (4) · Jazz Pharmaceuticals (4) · Cedars-Sinai Medical Center (1) · Central Hospital, Nancy, France (1) · European Society for Blood and Marrow Transplantation (1) · Hospital Authority, Hong Kong (1) · IRCCS Azienda Ospedaliero-Universitaria di Bologna (1) · Indiana University (1) · Instituto Brasileiro de Controle do Cancer (1) · Loyola University (1) · Maastricht University Medical Center (1) · New York Medical College (1) · Post Graduate Institute of Medical Education and Research, Chandigarh (1) · Seoul National University Hospital (1) · St. Jude Children's Research Hospital (1)
United States (12) · Italy (5) · France (4) · United Kingdom (3) · Canada (2) · Germany (2) · Israel (2) · Netherlands (2) · South Korea (2) · Australia (1) · Austria (1) · Belgium (1) · Brazil (1) · China (1) · India (1)
Paul Richardson, M.D. (2) · Sherwin S Chan, MD, PhD (2) · Albert Lie, Dr (1) · Alexandra Gangi, MD (1) · Andrea Passion, Prof. M.D. (1) · Antonio Colecchia, M.D. (1) · Dr Madhumita Premkumar, DM (1) · Francesca Bonifazi, Ph.D. M.D. (1) · Hyoung Jin Kang, MD, Ph.D (1) · Isabelle Pellier, MD (1) · Jamilla N Cavalcante, MD (1) · Maud D'Aveni, MD, PhD (1) · Mitchell Cairo, MD (1) · Patrick A Hagen, MD (1)
PMID 37231094, PMID 12134100, PMID 12393437, PMID 22364685, PMID 26825712, PMID 27183098, PMID 29335626, PMID 29767845, PMID 32950693, PMID 34059801, PMID 37001534, PMID 37071469, PMID 40253530