5 completed, 4 unknown, 2 terminated, 1 not yet recruiting. 13 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 13 | Completed 5, Unknown 4, Terminated 2, Not yet recruiting 1, Recruiting 1 |
Follow Multiple Organ Failure: new trials by email Literature Review of Multiple Organ Failure trials Research Report on Multiple Organ Failure
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Sivelestat Treatment for Postoperative Organ Protection in Type A Aortic Dissection Conventional treatment, Sivelestat sodium, Placebo - Type A Aortic Dissection, Organ Failure, Multiple | Phase 4 | Not yet recruiting | Shanghai Zhongshan Hospital | 236 | 2025-09-01 | 2025-09-05 |
| Rectal Indomethacin as Early Treatment for Acute Pancreatitis (INDOMAP Trial) Indomethacin SR, Placebos - Acute Pancreatitis, Complication | Phase 4 | Recruiting | Peking Union Medical College Hospital | 1504 | 2024-12-01 | 2025-06-15 |
| Efficacy of the Use of Vasopressin as a Primary Vasoconstrictor in Critically Ill Patients Initiation of vasopressine as a first vasoconstrictive drug, Initiation of noradrenaline as a first vasoconstrictive drug - Circulatory Shock | Phase 4 | Unknown | University of Thessaly | 145 | 2023-12-15 | 2024-03-06 |
| Role of Ulinastatin in Preventing Severe Sepsis and Consequent Morbidities and Mortality Ulinastatin - Severe Sepsis, Septic Shock | Phase 4 | Unknown | Jinnah Postgraduate Medical Centre | 175 | 2023-05-01 | 2023-06-08 |
| Efficacy of Dexamethasone Treatment for Patients With ARDS Caused by COVID-19 Dexamethasone - Acute Respiratory Distress Syndrome Caused by COVID-19 | Phase 4 | Terminated | Hospital Universitario de Gran Canaria Doctor Negrín | 19 | 2020-04-03 | 2021-02-03 |
| GM-CSF for Reversal of immunopAralysis in pediatriC sEpsis-induced MODS Study GM-CSF - Pediatric Sepsis-induced MODS | Phase 4 | Completed | Nationwide Children's Hospital | 75 | 2018-12-05 | 2026-05-05 |
| The Pharmacokinetics of Fentanyl in Intensive Care Patients Fentanyl - Multiple Organ Failure, Critical Care | Phase 4 | Unknown | Oslo University Hospital | 150 | 2015-10-01 | 2015-10-29 |
| Pharmacokinetics of Two Different High-dose Regimens of Intravenous Vitamin C in Critically Ill Patients Ascorbic Acid - Multiple Organ Failure, Sepsis | Phase 4 | Completed | Amsterdam UMC, location VUmc | 20 | 2015-03-01 | 2017-08-02 |
| Modulation of Systemic Inflammatory Response in Critically Ill Children After Glutamine Supplementation solution of amino acids supplemented with glutamine, amino acids not supplemented with glutamine - Inflammatory Response, Multi-organ Failure | Phase 4 | Completed | Hospital Sant Joan de Deu | 101 | 2010-04-01 | 2013-09-06 |
| Nadroparin Anticoagulation for Continuous Venovenous Hemofiltration CVVH 4 to 2 L/h, CVVH 2 to 4L/h - Kidney, Acute Renal Failure | Phase 4 | Completed | Onze Lieve Vrouwe Gasthuis | 14 | 2007-02-01 | 2009-08-25 |
| Ganciclovir Pharmacokinetics in Patients Undergoing Continuous Renal Replacement Therapy intravenous (IV) ganciclovir - Acute Renal Failure, Cytomegalovirus Infections | Phase 4 | Terminated | University of Oslo School of Pharmacy | 6 | 2005-12-01 | 2007-06-28 |
| 6-Methyl-Prednisolone for Multiple Organ Dysfunction Syndrome 6-methyl-prednisolone - Multiple Organ Dysfunction Syndrome | Phase 4 | Unknown | Hospital Universitario Principe de Asturias | 240 | 2005-08-01 | 2008-05-13 |
| Impact of Continuous Venovenous Haemofiltration on Organ Failure During the Early Phase of Severe Sepsis venovenous hemofiltration - Bacteremia, Gram-Negative Bacterial Infections | Phase 4 | Completed | Hopital Lariboisière | 400 | 1997-03-01 | 2006-12-04 |
Sepsis (4) · Acute Kidney Injury (2) · Shock, Septic (2) · Bacteremia (1) · COVID-19 (1) · Cytomegalovirus Infections (1) · Diabetes Insipidus (1) · Gram-Negative Bacterial Infections (1) · Gram-Positive Bacterial Infections (1) · Hyperphagia (1) · Pancreatitis (1) · Pneumonia, Bacterial (1) · Shock (1) · Systemic Inflammatory Response Syndrome (1)
Pathologic Processes (13) · Pathological Conditions, Signs and Symptoms (13) · Shock (12) · Infections (7) · Inflammation (4) · Female Urogenital Diseases (3) · Female Urogenital Diseases and Pregnancy Complications (3) · Kidney Diseases (3) · Male Urogenital Diseases (3) · Systemic Inflammatory Response Syndrome (3) · Urogenital Diseases (3) · Urologic Diseases (3) · Lung Diseases (2) · Pneumonia (2) · Renal Insufficiency (2)
Ascorbic Acid (1) · Colony-Stimulating Factors (1) · Continuous Renal Replacement Therapy (1) · Dexamethasone (1) · Fentanyl (1) · Ganciclovir (1) · Glutamine (1) · Granulocyte-Macrophage Colony-Stimulating Factor (1) · Hemofiltration (1) · Norepinephrine (1) · alanylglutamine (1) · amino-acid, glucose, and electrolyte solution (1) · methyl 11,17,21-trihydroxy-3,20-dioxopregna-1,4-diene-16-carboxylate (1) · salicylhydroxamic acid (1) · sargramostim (1)
Amsterdam UMC, location VUmc (1) · Hopital Lariboisière (1) · Hospital Sant Joan de Deu (1) · Hospital Universitario Principe de Asturias (1) · Hospital Universitario de Gran Canaria Doctor Negrín (1) · Jinnah Postgraduate Medical Centre (1) · Nationwide Children's Hospital (1) · Onze Lieve Vrouwe Gasthuis (1) · Oslo University Hospital (1) · Peking Union Medical College Hospital (1) · Shanghai Zhongshan Hospital (1) · University of Oslo School of Pharmacy (1) · University of Thessaly (1)
Spain (3) · China (2) · Netherlands (2) · Norway (2) · France (1) · Greece (1) · Pakistan (1) · United States (1)
Anders Hartmann, MD, Ph.D. (1) · Baofeng Zhu, MD (1) · Daoyuan Jing, MD (1) · Didier Payen, MD, PhD (1) · Dong Wu, M.D. (1) · H.M. Oudemans-van Straaten, MD, PhD (1) · Heleen Oudemans-van Straaten, MD.PhD (1) · Hong Liu, MD (1) · Iolanda Jordan, PhMD (1) · Jan F Bugge, MD, Ph.D. (1) · Jianzhong Yang, MD (1) · Mark W Hall, MD (1) · Mei Liu, M.D. (1)
PMID 12794416, PMID 18305265, PMID 19958532, PMID 25872171, PMID 27449641, PMID 27483065, PMID 28820036, PMID 29522710, PMID 29600824, PMID 32043986, PMID 32799933, PMID 33314078, PMID 34519356, PMID 34605781, PMID 36018257, PMID 36416787
2014 (1)