277 completed, 68 unknown, 26 recruiting, 12 withdrawn. 417 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 417 | Completed 277, Unknown 68, Recruiting 26, Withdrawn 12, Active not recruiting 11, Not yet recruiting 10, Terminated 10, Enrolling by invitation 3 |
Follow Mouth Diseases: new trials by email Literature Review of Mouth Diseases trials Research Report on Mouth Diseases
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Endodontic Microsurgery Platelet rich fibrin - Apical Periodontitis | Phase 4 | Not yet recruiting | Mark Schachman | 20 | 2026-10-01 | 2026-07-29 |
| Intraoperative Methadone for the Management of Postoperative Pain in Patients With Head and Neck Cancers Electronic Health Record Review, Fentanyl, Laryngoscopy - Head and Neck Carcinoma, Hypopharyngeal Carcinoma | Phase 4 | Recruiting | OHSU Knight Cancer Institute | 58 | 2026-09-22 | 2026-10-05 |
| Oral Hygiene Assistance Training Program Stannous Fluoride Toothpaste (SnF), sodium fluoride 5000 ppm, cetylpyridinium chloride (0.075%) and zinc alcohol free mouthwash - Elderly, Periodontal Disease | Phase 4 | Not yet recruiting | Colgate Palmolive | 500 | 2026-09-20 | 2026-09-08 |
| Investigation of the Interplay Between Local Oral Inflammation, Microbiota and Systemic Immune Responses. Stannous Fluoride Toothpaste (SnF) - Gingival Inflammation | Phase 4 | Not yet recruiting | Colgate Palmolive | 20 | 2026-09-01 | 2026-09-03 |
| Nanozymes in Endodontics Nanozyme treatment, Control (Standard treatment) - Apical Periodontitis, Endodontic Disease | Phase 4 | Enrolling by invitation | University of Pennsylvania | 72 | 2026-08-24 | 2026-10-13 |
| An Open-label, Single-arm Study of Prophylaxis for Datopotamab Deruxtecan (Dato-DXd) -Related Stomatitis in Eligible Patients With Metastatic or Inoperable Locally Recurrent Breast Cancer or Locally Advanced or Metastatic Epidermal Growth Factor Receptor-Mutated Non-small Cell Lung Cancer. Dexamethasone mouthwash, Datopotamab Deruxtecan (Dato-DXd) - Stomatitis | Phase 4 | Recruiting | AstraZeneca | 100 | 2026-06-24 | 2026-10-28 |
| Clinical and Radiographic Evaluation of Doxycycline and Atorvastatin Loaded Chitosan Nanoparticles as an Adjunctive to Scaling and Root Planning in the Management of Chronic Periodontitis. A Randomized Controlled Clinical Trial. Doxycycline and Atorvastatin loaded Chitosan nanoparticles local drug - Chronic Periodontitis | Phase 4 | Not yet recruiting | Fayoum University | 80 | 2026-06-01 | 2026-06-08 |
| Evaluate the Efficacy of an Oral Health Behavioral Intervention in People With Diabetes Diabetes Oral Health Program, Stannous Fluoride Dentifrice, Cetylpyridinium Chloride (CPC) and Zinc Lactate Mouthwash - Diabetes Type 2, Periodontal Disease | Phase 4 | Enrolling by invitation | Colgate Palmolive | 10000 | 2026-05-26 | 2026-09-03 |
| This a Clinical Trial to Evaluate the Efficacy of I-PRF, Povidone-Iodine and Laser as Adjuncts to Non-surgical Periodontal Treatment in Smokers and Non-Smokers Periodontitis Patients Injectable Platelet-Rich Fibrin (I-PRF), Diode Laser Activation, Povidone-Iodine Irrigation (1%) - Periodontitis, Smokers | Phase 4 | Recruiting | Military Hospital of Tunis | 50 | 2026-05-25 | 2026-07-16 |
| Clinical Study to Collect and Analyze Dental Plaque and Oral Health Measures in a Population With High Plaque/Low Gingivitis and High Plaque/High Gingivitis sodium monofluorophosphate toothpaste - Gingivitis, Plaque | Phase 4 | Recruiting | Colgate Palmolive | 100 | 2026-04-20 | 2026-05-29 |
| Using a Steroid Mouthwash to Prevent Mouth Sores During Chemotherapy Dexamethasone Mouthwash - Oral Mucositis Due to Chemotherapy | Phase 4 | Recruiting | Woman's | 45 | 2026-04-02 | 2026-06-25 |
| Low Level Laser Therapy With Injectable Platelet Rich Fibrin in Management of Oral Lichen Planus Injectable Platelet Rich Fibrin, Low Level Laser Therapy, Triamcinolone acetonide (injection) - Oral Lichen Planus | Phase 4 | Active not recruiting | Ain Shams University | 39 | 2026-03-15 | 2026-09-29 |
| Evaluation of the Anti-plaque Effect of a Bioflavonoid-based Antiseptic Mouthwash Bioflavonoid mouthwash, Chlorhexidine 0.12% mouthwash - Gingival Inflammation, Dental Plaque Accumulation | Phase 4 | Completed | University of Barcelona | 24 | 2026-03-02 | 2026-09-17 |
| Oral Health Outcomes With Amphion Mouthwash as an Adjunct to Non-Surgical Periodontal Therapy Amphion® Mouthwash, Placebo Mouthwash - Periodontitis, Mouthwash | Phase 4 | Not yet recruiting | Second Affiliated Hospital, Zhejiang University, School of Medicine | 60 | 2026-03-01 | 2026-02-11 |
| TREATMENT OF VAGINAL DRYNESS IN SJÖGREN'S DISEASE WITH CO2-LASER VERSUS TOPICAL PROMESTRIENE Fractional CO2 laser (vaginal), Promestriene Vaginal - Sjogren Syndrome, Sjogren Disease | Phase 4 | Recruiting | University of Sao Paulo General Hospital | 60 | 2026-02-27 | 2026-03-03 |
| Comparison Between the Effect of Triclosan Toothpaste and Chlorhexidine Mouthwash on Gingival Health in a Group of Fixed Orthodontic Patients: A Randomized Controlled Clinical Trial Triclosan 0.3% toothpaste, sodium fluoride 0.24% toothpaste, Chlorhexidine 0.2% mouthwash - Gingival Inflammation | Phase 4 | Completed | University of Science and Technology, Yemen | 60 | 2026-02-14 | 2026-09-11 |
| Calcium Hydroxide Versus Triple Antibiotic Paste for Pain After Root Canal Treatment Calcium Hydroxide (CH), Triple Antibiotic Paste - Apical Periodontitis, Pulp Necrosis | Phase 4 | Completed | Rehman Medical Institute - RMI | 138 | 2026-02-01 | 2026-11-06 |
| 6-month Clinical Investigation Assessing the Efficacy of an Antimicrobial Mouthrinse in Reducing Established Plaque and Improving Gum Health Test Mouthrinse, Control Mouthrinse - Gingivitis, Dental Plaque Accumulation | Phase 4 | Recruiting | Colgate Palmolive | 90 | 2026-01-28 | 2026-02-17 |
| HLA-B*58:01-Guided Therapy for Gout: Effectiveness, Safety, and Cost-Effectiveness HLA-B*58:01 Genotyping, Allopurinol Tablet, Febuxostat - Gout Initiating Urate-loweringUrate-lowering Therapy, Gout Arthritis | Phase 4 | Not yet recruiting | Haiphong University of Medicine and Pharmacy | 228 | 2026-01-20 | 2026-01-27 |
| Effectiveness of a Sodium Hyaluronate 0.01% and Sh-Oligopeptide-85 SP Mouthwash for the Treatment of Symptomatic Oral Lichen Planus Sodium hyaluronate 0.01% and Sh-Oligopeptide-85 SP Mouthwash, Placebo - Oral Lichen Planus | Phase 4 | Not yet recruiting | Universidad Complutense de Madrid | 40 | 2026-01-08 | 2026-01-16 |
Showing 20 of 417. Sign in to see all of them.
Periodontitis (65) · Chronic Periodontitis (50) · Gingivitis (48) · Periodontal Diseases (48) · Gingival Recession (27) · Lichen Planus, Oral (17) · Peri-Implantitis (17) · Sjogren's Syndrome (17) · Mumps (16) · Measles (15) · Rubella (14) · Stomatitis (14) · Xerostomia (13) · Dental Plaque (12) · Mucositis (11)
Stomatognathic Diseases (417) · Periodontal Diseases (207) · Pathological Conditions, Signs and Symptoms (99) · Infections (89) · Gingival Diseases (78) · Pathologic Processes (73) · Periodontitis (57) · Disease Attributes (53) · Chronic Disease (50) · Musculoskeletal Diseases (50) · Salivary Gland Diseases (49) · Skin and Connective Tissue Diseases (47) · Periodontal Atrophy (40) · Tooth Diseases (39)
Chlorhexidine (17) · Tooth Exfoliation (17) · Amoxicillin (15) · Metronidazole (14) · Root Planing (14) · Sodium Chloride (8) · Triamcinolone Acetonide (8) · enamel matrix proteins (8) · Alloderm (6) · Doxycycline (6) · Hyaluronic Acid (6) · Mouthwashes (6) · Oils, Volatile (6) · Photochemotherapy (6) · Botulinum Toxins, Type A (5)
Ain Shams University (17) · Colgate Palmolive (14) · University of Sao Paulo (11) · Tatyasaheb Kore Dental College (8) · University of Campinas, Brazil (8) · University of Oslo (7) · GlaxoSmithKline (6) · University of Santiago de Compostela (6) · University of Taubate (6) · Procter and Gamble (5) · The University of Texas Health Science Center, Houston (5) · Al-Azhar University (4) · Cairo University (4) · Proed, Torino, Italy (4) · University of Guarulhos (4)
United States (66) · Brazil (37) · Egypt (32) · India (20) · China (18) · Spain (18) · Italy (16) · Germany (12) · Turkey (Türkiye) (12) · Canada (10) · Pakistan (9) · France (8) · United Kingdom (8) · Norway (7) · Switzerland (7)
Enilson A Sallum, PhD (5) · Daniele Cardaropoli, DDS (4) · Ahmed Y Gamal, Professor (2) · Chhaju Ram Goyal, DDS (2) · Fernando O Costa, PhD (2) · Girish D Deore, BDS (2) · Gustavo Avila-Ortiz, DDS, MS, PhD (2) · Hans R Preus, PhD (2) · Jose R Cortelli, PhD (2) · Michael Lynch, DMD, PhD (2) · Ronaldo B Santana, DDS,MScD,DSc (2) · Aaron Biesbrock, DMD, PhD (1) · Abdullah AlAlwani, DDS (1)
PMID 33197289, PMID 16018754, PMID 19968743, PMID 25981528, PMID 26285807, PMID 34790237, PMID 5237684, PMID 10328647, PMID 10435146, PMID 10630935, PMID 10775736, PMID 10865927, PMID 11208206, PMID 11276867, PMID 11393894, PMID 11514795, PMID 11516756, PMID 11702237, PMID 11737510, PMID 11989392, PMID 12108756, PMID 12190139, PMID 12622859, PMID 12666710, PMID 12673463, PMID 12787214, PMID 1298430, PMID 14121956, PMID 14296927, PMID 14489483, PMID 14697016, PMID 14710766, PMID 14742657, PMID 15109507, PMID 15225944, PMID 15341352, PMID 15346752, PMID 15455740, PMID 15464564, PMID 15655026, PMID 15703760, PMID 15712851, PMID 15766375, PMID 16022079, PMID 16190504, PMID 16243238, PMID 16424527, PMID 16460251, PMID 16480503, PMID 16553634
2014 (2), 2015 (2), 2023 (2), 2008 (1), 2017 (1), P20RR017696 (1), R01CA091912 (1)