20 completed. 20 Early Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Early Phase 1 | 20 | Completed 20 |
Follow Mood Disorders: new trials by email Literature Review of Mood Disorders trials Research Report on Mood Disorders
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Mood Effects of Serotonin Agonists: Depression LSD, Placebo - LSD, Major Depressive Disorder | Early Phase 1 | Completed | University of Chicago | 41 | 2025-06-09 | 2026-07-10 |
| Feasibility Pilot of Accelerated Stimulation With TMS for Treatment of Major Depressive Disorder (FAST-MDD) aTMS utilizing the MagVenture TMS device - Major Depressive Disorder | Early Phase 1 | Completed | University of Minnesota | 11 | 2025-06-09 | 2026-02-09 |
| Testing a Transdiagnostic TMS Treatment Target transcranial magnetic stimulation - Major Depressive Disorder, Depression | Early Phase 1 | Completed | Brigham and Women's Hospital | 10 | 2024-09-09 | 2026-07-13 |
| Glutamate and Opioid Mechanisms of Antidepressant Response to Ketamine Naltrexone, Placebo, Ketamine - Depressive Disorder, Treatment-Resistant | Early Phase 1 | Completed | King's College London | 27 | 2021-09-27 | 2023-03-02 |
| Treatment of Bipolar Depression With Pentoxifylline Pentoxifylline 400 MG - Bipolar Depression | Early Phase 1 | Completed | University Health Network, Toronto | 6 | 2021-07-12 | 2022-04-15 |
| The Pharmacokinetics of Ketamine in the Breast Milk of Lactating Women ketamine in lactation - Ketamine, Lactation | Early Phase 1 | Completed | The Ketamine Research Foundation | 4 | 2019-12-20 | 2021-12-13 |
| Xenon Inhalation Therapy for Major Depressive Disorder and Bipolar Disorder Xenon, Nitrogen gas - Major Depressive Disorder, Bipolar Depression | Early Phase 1 | Completed | Massachusetts General Hospital | 13 | 2019-12-05 | 2026-10-09 |
| Investigate the Clinical Responses of Ethosuximide in Patients With Treatment-Resistant Depression. Ethosuximide, Placebo, Escitalopram - Depressive Disorder, Treatment-Resistant | Early Phase 1 | Completed | Zhejiang University | 16 | 2019-05-21 | 2025-06-18 |
| Brain Imaging to Understand the Role of Inflammation in N-Acetyl Cysteine (NAC) Treatment of Bipolar Depression N-acetyl cysteine (NAC) - Bipolar Disorder, Depression | Early Phase 1 | Completed | Martin Lan | 3 | 2018-11-01 | 2021-08-05 |
| Effect of Ketamine vs. Active Placebo on Suicidal Ideation in Depressed Inpatients With Major Depressive Disorder or Bipolar Depression. Ketamine, Midazolam, Treatment as usual (TAU) - Major Depressive Disorder, Bipolar I Disorder | Early Phase 1 | Completed | Sunnybrook Health Sciences Centre | 9 | 2016-01-01 | 2017-07-26 |
| Targeting a Genetic Mutation in Glycine Metabolism With D-cycloserine D-cycloserine, DCS or placebo - Schizophrenia, Bipolar Disorder | Early Phase 1 | Completed | Mclean Hospital | 2 | 2015-09-27 | 2017-09-19 |
| Biomarkers of Neuroinflammation and Anti-Inflammatory Treatments in Major Depressive Disorder Minocycline, Placebo, Celecoxib - Major Depressive Disorder | Early Phase 1 | Completed | Centre for Addiction and Mental Health | 115 | 2015-02-01 | 2019-05-23 |
| A Multimodal Neuroimaging Study of Brain Activation Patterns Under Ketamine Ketamine, Placebo - Major Depressive Disorder | Early Phase 1 | Completed | Psychiatric University Hospital, Zurich | 10 | 2015-01-01 | 2019-03-20 |
| A New Treatment Approach for Major Depressive Disorder Based Upon Targeting Monoamine Oxidase A (MAO-A) Sertraline, Citalopram, N-acetylcysteine (NAC) - Major Depressive Disorder | Early Phase 1 | Completed | Centre for Addiction and Mental Health | 10 | 2014-10-01 | 2019-05-24 |
| Effects of Methylphenidate, Modafinil, and MDMA on Emotion-processing in Humans: A Pharmaco-fMRI Study Methylphenidate, Modafinil, MDMA - Healthy, Substance-related Disorder | Early Phase 1 | Completed | University Hospital, Basel, Switzerland | 24 | 2013-10-01 | 2016-01-21 |
| Dose-Ranging Trial of Creatine Augmentation for Adolescent Females With Treatment-Resistant Major Depressive Disorder Creatine monohydrate or placebo - Major Depressive Disorder | Early Phase 1 | Completed | Perry Renshaw | 32 | 2012-06-01 | 2016-10-25 |
| Exploratory Study on the Mood and Cytokine Levels in Female Healthy Participants and Major Depressive Disorder Patients Placebo, Salmonella typhi vaccine (Typhim Vi) - Major Depressive Disorder | Early Phase 1 | Completed | Janssen Pharmaceutica N.V., Belgium | 40 | 2012-05-01 | 2014-03-28 |
| Pilot Study to Evaluate Individualized Choice of Antidepressants in Patients With Cancer Mirtazapine, Citalopram - Major Depressive Disorder, Neoplasms | Early Phase 1 | Completed | UNC Lineberger Comprehensive Cancer Center | 21 | 2011-01-01 | 2017-03-13 |
| Clinician Managed Interpersonal Psychotherapy Standard interpersonal psychotherapy (IPT), Clinician managed interpersonal psychotherapy (CM-IPT) - Depression, Depression, Postpartum | Early Phase 1 | Completed | University of Iowa | 140 | 2001-09-01 | 2013-09-26 |
| Transcranial Magnetic Treatment (TMS) in Unipolar Depression Transcranial Magnetic Stimulation (TMS) - Unipolar Depression | Early Phase 1 | Completed | St. Joseph's Healthcare Hamilton | 21 | 2000-12-01 | 2011-08-03 |
Depressive Disorder, Major (12) · Bipolar Disorder (5) · Depression (5) · Depression, Postpartum (2) · Depressive Disorder, Treatment-Resistant (2) · Anxiety Disorders (1) · Breast Feeding (1) · Depressive Disorder (1) · Inflammation (1) · Mental Disorders (1) · Neoplasms (1) · Psychotic Disorders (1) · Schizophrenia (1) · Stress Disorders, Post-Traumatic (1)
Mental Disorders (19) · Depressive Disorder (15) · Behavior (6) · Behavioral Symptoms (5) · Bipolar and Related Disorders (5) · Female Urogenital Diseases and Pregnancy Complications (2) · Pregnancy Complications (2) · Puerperal Disorders (2) · Urogenital Diseases (2) · Chemically-Induced Disorders (1) · Feeding Behavior (1) · Pathologic Processes (1) · Pathological Conditions, Signs and Symptoms (1) · Schizophrenia Spectrum and Other Psychotic Disorders (1)
Ketamine (4) · Acetylcysteine (2) · Citalopram (2) · Transcranial Magnetic Stimulation (2) · Celecoxib (1) · Creatine (1) · Cycloserine (1) · Dexmethylphenidate Hydrochloride (1) · Escitalopram (1) · Ethosuximide (1) · Lactation (1) · Lysergic Acid Diethylamide (1) · Methylphenidate (1) · Midazolam (1) · Minocycline (1)
Centre for Addiction and Mental Health (2) · Brigham and Women's Hospital (1) · Janssen Pharmaceutica N.V., Belgium (1) · King's College London (1) · Martin Lan (1) · Massachusetts General Hospital (1) · Mclean Hospital (1) · Perry Renshaw (1) · Psychiatric University Hospital, Zurich (1) · St. Joseph's Healthcare Hamilton (1) · Sunnybrook Health Sciences Centre (1) · The Ketamine Research Foundation (1) · UNC Lineberger Comprehensive Cancer Center (1) · University Health Network, Toronto (1) · University Hospital, Basel, Switzerland (1)
United States (9) · Canada (5) · Belgium (1) · China (1) · Switzerland (1) · United Kingdom (1)
Jeffrey H Meyer, MD, PhD (2) · Andrew Nierenberg, MD (1) · Deborah L. Levy, Ph.D. (1) · Douglas Kondo, MD (1) · Eliza Park, MD (1) · Gary Hasey, MD (1) · Hanna Molla (1) · Joseph J Taylor, MD, PhD (1) · Joshua D Rosenblat, MD, MSc (1) · Matthias E Liechti, MD, MAS (1) · Philip E Wolfson, MD (1) · Scott P. Stuart, MD (1) · Yi Xu, Doctor of Medicine (1)
PMID 15474895, PMID 28551715, PMID 29912955, PMID 30423462, PMID 30819549, PMID 31279534, PMID 33309459, PMID 35086123, PMID 36999619, PMID 40707608
R01DA002812 (1), R01MH059668 (1)