6 completed, 2 recruiting, 2 terminated, 2 unknown. 6 Phase 2, 3 Phase 3, 1 Early Phase 1, 1 Phase 1, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 6 | Completed 3, Terminated 2, Unknown 1 |
| Phase 3 | 3 | Recruiting 2, Completed 1 |
| Early Phase 1 | 1 | Completed 1 |
| Phase 1 | 1 | Terminated 1 |
| Phase 4 | 1 | Unknown 1 |
Follow Ethosuximide: new trials by email Literature Review of Ethosuximide trials Research Report on Ethosuximide
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Evaluation of the Efficacy and Tolerance of Low Doses of Ethosuximide in the Treatment of Peripheral Neuropathic Pain Ethosuximide, Placebo - Peripheral Neuropathic Pain | Phase 2 | Unknown | University Hospital, Clermont-Ferrand | 64 | 2020-11-01 | 2023-01-06 |
| Ketogenic Diet for New-Onset Absence Epilepsy Modified Atkins Diet, Absence epilepsy medications - Absence Epilepsy, Ketogenic Dieting | Phase 3 | Recruiting | Johns Hopkins University | 40 | 2020-08-10 | 2026-05-07 |
| Ethosuximide and Pentoxifylline in the Treatment of Abdominal Pain Related to Irritable Bowel Syndrome pentoxyifylline, Mebeverine, ethosuximide - IBS - Irritable Bowel Syndrome | Phase 3 | Recruiting | Tanta University | 60 | 2019-11-01 | 2020-01-03 |
| Investigate the Clinical Responses of Ethosuximide in Patients With Treatment-Resistant Depression. Ethosuximide, Placebo, Escitalopram - Depressive Disorder, Treatment-Resistant | Early Phase 1 | Completed | Zhejiang University | 16 | 2019-05-21 | 2025-06-18 |
| Ethosuximide to Treat IBS Ethosuximide, Placebo - Irritable Bowel Syndrome | Phase 2 | Completed | University Hospital, Clermont-Ferrand | 162 | 2018-02-08 | 2026-04-21 |
| Population Pharmacokinetics of Antiepileptic in Pediatrics Valproic acid, carbamazepine, phenobarbital - Epilepsy | Completed | Assistance Publique - Hôpitaux de Paris | 753 | 2017-06-19 | 2025-11-20 | |
| Ketogenic Diet in Infants With Epilepsy (KIWE) Ketogenic diet, Antiepileptic drug therapy - Epilepsy | Phase 4 | Unknown | University College, London | 160 | 2015-01-01 | 2017-05-04 |
| Assessment of the Effectiveness of Ethosuximide in the Treatment of Peripheral Neuropathic Pain. Zarontin® (ethosuximide) and Stodal® - Neuropathic Traumatic Pain, Pain NRS ≥ 4 | Phase 2 | Completed | University Hospital, Clermont-Ferrand | 114 | 2014-03-01 | 2026-04-21 |
| Comparison of a Drug and Placebo in the Prevention of Migraine Headaches ethosuximide, placebo comparator - Headache, Migraine | Phase 1 / Phase 2 | Terminated | US Department of Veterans Affairs | 5 | 2011-12-01 | 2015-08-19 |
| Chemotherapy Induced Painful Peripheral Neuropathy Ethosuximide (The CIN-E Study) Ethosuximide, Placebo - Cancer, Peripheral Neuropathy | Phase 2 | Completed | Royal Marsden NHS Foundation Trust | 15 | 2010-05-01 | 2016-05-26 |
| Safety and Efficacy Study of Ethosuximide for the Treatment of Complex Regional Pain Syndrome (CRPS) Placebo, Ethosuximide - Complex Regional Pain Syndromes | Phase 2 | Terminated | McGill University Health Centre/Research Institute of the McGill University Health Centre | 4 | 2008-09-01 | 2011-05-13 |
| Childhood Absence Epilepsy Rx PK-PD-Pharmacogenetics Study Ethosuximide, Lamotrigine, Valproic acid - Childhood Absence Epilepsy, Petit Mal Epilepsy | Phase 3 | Completed | Children's Hospital Medical Center, Cincinnati | 453 | 2004-07-01 | 2020-10-14 |
Epilepsy (3) · Epilepsy, Absence (2) · Irritable Bowel Syndrome (2) · Neuralgia (2) · Pain (2) · Chronic Pain (1) · Complex Regional Pain Syndromes (1) · Depression (1) · Depressive Disorder, Treatment-Resistant (1) · Migraine Disorders (1) · Neoplasms (1) · Peripheral Nervous System Diseases (1) · Reflex Sympathetic Dystrophy (1) · Seizures (1) · Weight Gain (1)
University Hospital, Clermont-Ferrand (3) · Assistance Publique - Hôpitaux de Paris (1) · Children's Hospital Medical Center, Cincinnati (1) · Johns Hopkins University (1) · McGill University Health Centre/Research Institute of the McGill University Health Centre (1) · Royal Marsden NHS Foundation Trust (1) · Tanta University (1) · US Department of Veterans Affairs (1) · University College, London (1) · Zhejiang University (1)
France (4) · United States (3) · United Kingdom (2) · Canada (1) · China (1) · Egypt (1)
Avital Cnaan, PhD (1) · Eric H Kossoff, MD (1) · Helen Cross, FRCP(UK) (1) · Kathy L Gardner, MD (1) · Mark A Ware, MD (1) · Peter Adamson, MD (1) · Sahar El-Haggar, Prof (1) · Sahar Hegazy, Prof. (1) · Sherief Abd-Elsalam, Ass. Prof. (1) · Tracy A. Glauser, MD (1) · Yi Xu, Doctor of Medicine (1)
PMID 20200383, PMID 27986742, PMID 28446244, PMID 28720615, PMID 28916534, PMID 29577519, PMID 34726293, PMID 35221706, PMID 41505133
2016 (1), U01NS045803 (1)