86 completed, 25 unknown, 13 terminated, 9 recruiting. 139 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 139 | Completed 86, Unknown 25, Terminated 13, Recruiting 9, Not yet recruiting 4, Enrolling by invitation 1, Withdrawn 1 |
Follow Metabolic Syndrome: new trials by email Literature Review of Metabolic Syndrome trials Research Report on Metabolic Syndrome
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Assessing Trauma-related Links Between Affective and Metabolic Systems prazosin - Posttraumatic Stress Disorder, Metabolic Syndrome | Phase 4 | Not yet recruiting | VA Office of Research and Development | 70 | 2027-03-01 | 2026-10-15 |
| Metabolic Surgery for Atrial Fibrillation Elimination Roux-en-Y Gastric Bypass or Sleeve Gastrectomy, Anti-Obesity Medication (AOM) treatment - Atrial Fibrillation, Obesity and Obesity-related Medical Conditions | Phase 4 | Not yet recruiting | Ali Aminian | 100 | 2026-11-01 | 2026-04-17 |
| Mazdutide for Weight Management and Gout in Adults With Obesity Mazdutide - Gout, Obesity (BMI>30) | Phase 4 | Not yet recruiting | Hongwei Jiang | 30 | 2026-09-15 | 2026-09-17 |
| Efficacy, Safety, and Tolerability of Tirzepatide in Real-World Conditions in Paraguay. Tirzepatide (LIPOLESS de Laboratorio de Productos Eticos C.E.I.S.A.) - Obesity, Diabetes Mellitus, Type 2 | Phase 4 | Recruiting | Las Rías Medical Center | 160 | 2026-07-27 | 2026-05-19 |
| Tirzepatide's Effects on Epigenetic Aging and Metabolic Restoration in Virally Suppressed People With HIV Tirzepatide - Human Immunodeficiency Virus (HIV), Metabolic Dysfunction Associated Steatotic Liver Disease | Phase 4 | Enrolling by invitation | National Taiwan University Clinical Trial Center | 60 | 2026-06-25 | 2026-07-20 |
| Association Between Diastolic Dysfunction and Erectile Dysfunction and the Effect of Tadalafil and SGLT2 Inhibitors on Them in Men With Metabolic Syndrome Tadalafil 5 mg, SGLT-2 inhibitor, Tadalafil plus SGLT2 inhibitors - Erectile Dysfunction, Left Ventricular Diastolic Dysfunction | Phase 4 | Completed | Kafrelsheikh University | 60 | 2025-05-05 | 2026-05-04 |
| Eradication of Helicobacter Pylori Improves Metabolic Syndrome Through Modulation of Gut Microbiota. Vonoprazan-Amoxicillin Dual Therapy, Vonoprazan-Amoxicillin with Bifidobacterium tetravaccae, Vonoprazan-Amoxicillin with Berberine - HELICOBACTER PYLORI INFECTIONS, Metabolic Syndrome | Phase 4 | Recruiting | Nanjing First Hospital, Nanjing Medical University | 120 | 2025-04-17 | 2026-04-13 |
| LDL-C Optimization Using Inclisiran in Patients in Which Drug-Drug Interactions Limit LDL Lowering Inclisiran sodium 300 mg (equivalent to 284 mg inclisiran) in 1.5 mL - Drug Interactions, Primary Prevention | Phase 4 | Recruiting | University of California, San Diego | 100 | 2025-04-02 | 2026-07-13 |
| Safety, Tolerability and Effectiveness of DTG/3TC vs BIC/TAF/FTC in PWH Without Antiretroviral Experience DTG/3TC, Bictegravir (BIC) plus Emtricitabine (FTC) plus Tenofovir Alafenamide (TAF) - HIV Infection, Metabolic Syndrome | Phase 4 | Recruiting | Instituto Mexicano del Seguro Social | 124 | 2025-04-01 | 2025-06-26 |
| Evaluating the Effects of Adjunctive Aripiprazole on Weight and Metabolic Outcomes in Females Adjunctive Aripiprazole for improving Weight and Metabolic Outcomes in Females - Psychosis, Metabolic Syndrome | Phase 4 | Unknown | Universiti Putra Malaysia | 600 | 2024-09-15 | 2024-09-19 |
| Effectiveness of Weight Loss Methods on Lifespan for Metabolic Syndrome Semaglutide, Empagliflozin, Minigastric bypass, Analimentary detoxication - Metabolic Syndrome | Phase 4 | Recruiting | University Medical Center, Kazakhstan | 220 | 2024-03-01 | 2025-11-26 |
| Impact GLP-1 Agonists Following Bariatric GLP-1 receptor agonist - Morbid Obesity, Metabolic Syndrome | Phase 4 | Recruiting | University of Missouri-Columbia | 150 | 2024-02-01 | 2026-10-21 |
| A Study to Evaluate the Safety and Effectiveness of Saroglitazar 4 mg in Patients With NAFLD With Comorbidities Saroglitazar - NAFLD, Obesity | Phase 4 | Unknown | Zydus Lifesciences Limited | 1500 | 2023-07-20 | 2024-02-07 |
| High-intensity Statin and Ezetimibe Therapy for Asymptomatic Patients With Positive Coronary Calcium Guideline directed statin therapy, High intensity statin plus ezetimibe therapy - Coronary Artery Calcification, Metabolic Syndrome | Phase 4 | Recruiting | Samsung Medical Center | 6000 | 2023-07-03 | 2025-01-14 |
| Relationship Between Metformin Treatment, Anemia, and Erythropoietin Levels in Women With Polycystic Ovary Syndrome in Jordan Metformin - Polycystic Ovary Syndrome (PCOS) Women, Insulin Resistance Syndrome | Phase 4 | Completed | Jerash Private University | 25 | 2023-06-01 | 2026-08-12 |
| A Clinical Trial to Evaluate the Blood Pressure Control of Telmisartan or Losartan in Essential Hypertensive Patients With Metabolic Syndrome Telmisartan, Losartan - Essential Hypertension, Metabolic Syndrome | Phase 4 | Unknown | Chong Kun Dang Pharmaceutical | 116 | 2023-06-01 | 2023-05-06 |
| Topiramate vs Metformin on Cardio-Metabolic Profile in Schizophrenia on Atypical Antipsychotics Metformin, Topiramate - Metabolic Syndrome, Schizophrenia | Phase 4 | Completed | All India Institute of Medical Sciences, Bhubaneswar | 60 | 2022-09-20 | 2023-08-22 |
| Extended-Release Tacrolimus Following Liver Transplantation Envarsus Oral Product, Prograf (SOC) - Liver Transplant; Complications, Renal Insufficiency | Phase 4 | Recruiting | University of Alberta | 94 | 2022-05-15 | 2026-09-15 |
| Effect of Polysaccharide-based Complex Administration on the Gut Microbiome and Cardio-Metabolic Profile in Children With Obesity and Metabolic Syndrome. Polysaccharide-based complex - Childhood Obesity | Phase 4 | Completed | University of Milan | 36 | 2022-02-01 | 2026-01-06 |
| Comparison of Berberine and Metformin for the Treatment for MS in Schizophrenia Patients Berberine, Metformin - Schizophrenia, Metabolic Syndrome | Phase 4 | Unknown | Tianjin Anding Hospital | 100 | 2021-12-01 | 2022-02-16 |
Showing 20 of 139. Sign in to see all of them.
Obesity (27) · Insulin Resistance (25) · Hypertension (20) · Schizophrenia (16) · Diabetes Mellitus, Type 2 (13) · Diabetes Mellitus (10) · Cardiovascular Diseases (9) · Hypogonadism (7) · Psychotic Disorders (7) · Dyslipidemias (6) · Fatty Liver (5) · Atherosclerosis (4) · Inflammation (4) · Overweight (4)
Glucose Metabolism Disorders (139) · Hyperinsulinism (139) · Metabolic Diseases (139) · Nutritional and Metabolic Diseases (139) · Insulin Resistance (114) · Pathological Conditions, Signs and Symptoms (44) · Signs and Symptoms (40) · Body Weight (33) · Endocrine System Diseases (32) · Cardiovascular Diseases (31) · Nutrition Disorders (30) · Overnutrition (30) · Vascular Diseases (28) · Overweight (26) · Mental Disorders (23)
Hydrochlorothiazide (8) · Metformin (8) · Pioglitazone (7) · Aripiprazole (6) · Rosiglitazone (5) · Eplerenone (4) · Ezetimibe, Simvastatin Drug Combination (4) · Liraglutide (4) · Losartan (4) · Olanzapine (4) · Rosuvastatin Calcium (4) · Telmisartan (4) · Testosterone (4) · Valsartan (4) · ziprasidone (4)
Novartis (7) · Vanderbilt University (3) · Vanderbilt University Medical Center (3) · AstraZeneca (2) · Bristol-Myers Squibb (2) · Korea University Anam Hospital (2) · Leiden University Medical Center (2) · Seoul National University Hospital (2) · Taichung Veterans General Hospital (2) · UMC Utrecht (2) · Universita di Verona (2) · University of Florida (2) · University of Texas Southwestern Medical Center (2) · Abbott (1) · Aichi Gakuin University (1)
United States (44) · South Korea (11) · Italy (9) · Germany (8) · Netherlands (6) · Canada (5) · Taiwan (5) · China (4) · France (4) · Turkey (Türkiye) (4) · Denmark (3) · India (3) · Spain (3) · Australia (2) · Belgium (2)
Frank LJ Visseren, MD PhD (2) · Hildo J Lamb, MD PhD (2) · Ingrid M Jazet, MD PhD (2) · Ahmad Hatim Sulaiman, MBBS,MPM (1) · Albert M de Roos, MD PhD (1) · Albert de Roos, MD PhD (1) · Alberto Parabiaghi, M.D. (1) · Ali Aminani (1) · Alice PS Kong, M.B.,Ch.B. (1) · Alicja E. Grzegorzewska, MD, PhD (1) · Alison Berent-Spillson, PhD (1) · Anand Vaidya, MD (1) · Andrea Lenzi, MD, PhD (1)
PMID 33293204, PMID 36262060, PMID 39641307, PMID 39963952, PMID 15482620, PMID 17130190, PMID 17539698, PMID 17850473, PMID 18172212, PMID 18394022, PMID 18413332, PMID 18647805, PMID 18670365, PMID 18824462, PMID 19120715, PMID 19394149, PMID 19689921, PMID 19732305, PMID 19814947, PMID 20026785, PMID 20457512, PMID 20679179, PMID 20739421, PMID 20888102, PMID 20937657, PMID 21103669, PMID 21105792, PMID 21123449, PMID 21340022, PMID 21554991, PMID 21676394, PMID 21710401, PMID 21733334, PMID 21738005, PMID 21771281, PMID 21957032, PMID 22010203, PMID 22030226, PMID 22104550, PMID 22341881, PMID 22353614, PMID 22398127, PMID 22451451, PMID 22475524, PMID 22492381, PMID 22884685, PMID 22892157, PMID 23348658, PMID 23596158, PMID 23730808
2005 (2), 2008 (2), 2016 (1), K01MH095920 (1), K23HL086558 (1), K23MH074540 (1), R01DK061486 (1), R01DK071277 (1), R01DK125330 (1), R01HL075079 (1)