281 completed, 26 unknown, 11 terminated, 11 withdrawn. 122 Phase 4, 89 Phase 3, 50 Phase 1, 37 Not applicable, 21 Phase 2.
Follow Hydrochlorothiazide: new trials by email Literature Review of Hydrochlorothiazide trials Research Report on Hydrochlorothiazide
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| SPIRO-First: A Pragmatic Primary Care-Embedded Pilot Trial of Renin-Guided First-Line Antihypertensive Therapy Spironolactone (drug), Candesartan 8mg, Hydrochlorothiazide (HCTZ) 25 milligrams. - Hypertension | Phase 4 | Not yet recruiting | Ottawa Hospital Research Institute | 30 | 2027-01-01 | 2026-10-14 |
| TACTIC-HF: Sequential Diuretic Strategies in Ambulatory Worsening Heart Failure Intravenous furosemide bolus injections, ACETAZOLAMIDE oral capsule, Hydrochlorothiazide (HCT) - Acute Heart Failure (AHF) | Phase 4 | Not yet recruiting | Lucrecia Maria Burgos | 60 | 2026-06-15 | 2026-05-18 |
| POcus INTERvention for Tailoring Diuretic Strategy in Acute Decompensated Heart Failure Furosemide 40 Milligrams., Hydrochlorothiazide (HCTZ) 25 milligrams., Acetazolamide 250 milligrams. - Acute Heart Failure (AHF), Congestive Heart Failure Acute | Phase 2 / Phase 3 | Not yet recruiting | Hospital de Clinicas de Porto Alegre | 128 | 2026-03-23 | 2026-03-18 |
| Triple Antihypertensive Medication After Intracerebral Hemorrhage for Blood Pressure Control Exforge HCT® or Three Individual drug amlodipine + valsartan + hydrochlorothiazide - Intracerebral Hemorrhage | Not applicable | Recruiting | The University of Hong Kong | 140 | 2026-03-01 | 2026-03-09 |
| Effectiveness of Valsartan Alone vs Combination Therapy in Hypertensive Heart Disease Valsartan + Hydrochlorothiazide - Heart Diseases, Hypertension | Phase 1 | Completed | Shaikh Zayed Hospital, Lahore | 118 | 2025-11-01 | 2026-04-22 |
| The Role of Skin Sodium Accumulation in Chronic Kidney Disease Hydrochlorothiazide, Spironolactone, Lercanidipine - Chronic Kidney Diseases | Not applicable | Recruiting | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | 60 | 2025-01-07 | 2025-06-13 |
| Indapamide and Chlorthalidone to Reduce Urine Supersaturation for Kidney Stone Prevention Indapamide 2.5 MG, Hydrochlorothiazide 50Mg, Chlorthalidone 25mg - Kidney Stone | Phase 2 | Recruiting | Insel Gruppe AG, University Hospital Bern | 99 | 2024-10-01 | 2026-05-06 |
| HYDROchlorothiazide to PROTECT Polycystic Kidney Disease Patients and Improve Their Quality of Life Hydrochlorothiazide 25 mg, Placebo - ADPKD | Phase 3 | Recruiting | University Medical Center Groningen | 300 | 2024-07-31 | 2026-08-25 |
| EU Sites: Fluid Management of Acute Decompensated Heart Failure With Reprieve Decongestion Management System (FASTR-EU) Reprieve Decongestion Management System, Diuretic (furosemide, bumetanide, torsemide, hydrochlorothiazide, and/or acetazolamide) - Acute Decompensated Heart Failure | Not applicable | Completed | Reprieve Cardiovascular, Inc | 12 | 2024-05-17 | 2025-03-10 |
| Multi-Omics to Predict the Blood Pressure Response to Antihypertensives Amlodipine, Olmesartan, Hydrochlorothiazide - Primary Hypertension | Phase 4 | Unknown | Radboud University Medical Center | 96 | 2024-04-04 | 2024-06-10 |
| Dapagliflozin and Hydrochlorothiazide in Recurring Kidney Stone Patients Dapagliflozin, Hydrochlorothiazide - Urolithiasis, Hyperoxaluria | Phase 4 | Unknown | Medical University of Vienna | 32 | 2024-03-04 | 2023-10-23 |
| A Study to Learn How the Body Processes Spironolactone and Hydrochlorothiazide Film Coated Tablets Manufactured at Two Sites: Viatris and Neolpharma Spironolactone/Hydrochlorothiazide (25 mg/25 mg) film coated tablets from Viatris, Spironolactone/Hydrochlorothiazide (25 mg/25 mg) film coated tablets from Neolpharma. - Healthy Participants | Phase 1 | Completed | Pfizer | 42 | 2023-12-26 | 2025-03-21 |
| Study to Evaluate the Efficacy and Safety of TEL/AML/CTD in Elderly Patients With Essential Hypertension Telmisartan/Amlodipine/Chlorthalidone 40/5/12.5 mg, Telmisartan/Amlodipine/Hydrochlorothiazide 40/5/25 mg - Essential Hypertension | Phase 4 | Active not recruiting | Yuhan Corporation | 198 | 2023-10-18 | 2026-02-13 |
| Candesartan Cilexetil + Chlorthalidone + Amlodipine Versus Exforge HCT®️ for Systemic Arterial Hypertension candesartan cilexetil + chlorthalidone + amlodipine, Exforge HCT® (valsartan 160mg + hydrochlorothiazide 12.5mg + amlodipine 5mg) - Hypertension | Phase 3 | Completed | Hospital Israelita Albert Einstein | 702 | 2023-08-22 | 2025-07-09 |
| Diuretics and Volume Overload in Early CKD Diuretic augmentation (hydrochlorothiazide, chlorthalidone, furosemide, torsemide, or bumetanide) - Chronic Kidney Disease, Hypertension | Phase 4 | Completed | VA Office of Research and Development | 49 | 2023-02-01 | 2026-09-21 |
| Bioequivalence Study of Two Formulations of Tablets Ramipril/Hydrochlorothiazide 10 mg/25 mg in Healthy Volunteers Under Fasting Conditions Ramipril/Hydrochlorothiazide tablet 10 mg/25 mg, Tritace® Plus tablet 10 mg/25 mg - Bioequivalence | Phase 1 | Completed | Pharmtechnology LLC | 50 | 2022-12-28 | 2024-01-08 |
| Effects and Safety of Sacubitril/Valsartan on Refractory Hypertension Sacubitril/valsartan, valsartan - Resistant Hypertension | Phase 3 | Unknown | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | 138 | 2022-09-24 | 2022-09-19 |
| Efficacy and Safety of Losartan/Chlorthalidone vs Losartan/Hydrochlorothiazide in Essential Arterial Hypertension Losartan/Chlorthalidone in fixed dose, Losartan + hydrochlorothiazide in fixed dose - Essential Arterial Hypertension | Phase 3 | Completed | Laboratorios Silanes S.A. de C.V. | 163 | 2022-06-30 | 2025-03-13 |
| Comparison of the Medication Adherence of Patients Treated With Telmisartan/Hydrochlorothiazide or Telmisartan/Amlodipine Fixed Dose Combination (FDC) Versus Double-pill Combination Therapy in Real-world Japanese Therapeutic Practice subjects treated with telmisartan/hydrochlorothiazide, Subjects treated with Telmisartan and amlodipine, subjects treated with Telmisartan+hydrochlorothiazide double-pill combination group - Hypertension | Withdrawn | Boehringer Ingelheim | 2022-06-01 | 2022-06-28 | ||
| Improving Pain Management Via Spinal Cord Stimulation and Blood Pressure Reduction Hydrochlorothiazide 12.5mg, Placebo - Chronic Pain, Hypertension | Early Phase 1 | Active not recruiting | University of Kansas Medical Center | 36 | 2022-02-08 | 2026-08-20 |
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Hypertension (219) · Essential Hypertension (34) · Diabetes Mellitus, Type 2 (21) · Diabetes Mellitus (16) · Cardiovascular Diseases (9) · Metabolic Syndrome (9) · Renal Insufficiency, Chronic (8) · Nephrolithiasis (6) · Obesity (6) · Heart Failure (5) · Insulin Resistance (5) · Isolated Systolic Hypertension (5) · Obesity, Abdominal (4) · Vascular Diseases (4) · Albuminuria (3)
Novartis (40) · Boehringer Ingelheim (28) · Daiichi Sankyo (14) · Novartis Pharmaceuticals (12) · Organon and Co (11) · Mylan Pharmaceuticals Inc (9) · Takeda (9) · Ranbaxy Laboratories Limited (7) · Sanofi (6) · AstraZeneca (5) · Merck Sharp & Dohme LLC (5) · Boryung Pharmaceutical Co., Ltd (4) · Brigham and Women's Hospital (4) · Damanhour University (4) · GlaxoSmithKline (4)
United States (116) · Germany (42) · Netherlands (23) · Switzerland (23) · South Korea (21) · China (20) · France (19) · Spain (18) · Canada (17) · Japan (17) · Italy (14) · India (12) · Poland (12) · Brazil (11) · Taiwan (11)
James D Carlson, Pharm. D. (6) · Alan K Copa, Pharm. D. (2) · Dr. Tarang Girishbhai Shah, M. D. (Pharmacology) (2) · Gail K Adler, MD, PhD (2) · John Shea, MS (2)
PMID 20606150, PMID 22114906, PMID 22440088, PMID 30753254, PMID 32905623, PMID 36398903, PMID 38353215, PMID 10851208, PMID 11927799, PMID 12119802, PMID 12923400, PMID 14657064, PMID 15320564, PMID 15364899, PMID 15381674, PMID 15539615, PMID 15553310, PMID 15738343, PMID 15911902, PMID 16075824, PMID 16278523, PMID 16391172, PMID 16458134, PMID 16533484, PMID 16569807, PMID 16644338, PMID 16785477, PMID 16996868, PMID 17093067, PMID 17130190, PMID 17324745, PMID 17339868, PMID 17389151, PMID 17488800, PMID 17531579, PMID 17566313, PMID 17606861, PMID 17627399, PMID 17700361, PMID 17904457, PMID 17922981, PMID 18162623, PMID 18326958, PMID 18375982, PMID 18426998, PMID 18463672, PMID 18475165, PMID 18539917, PMID 18593517, PMID 18615004
2009 (7), 2008 (3), 2016 (2), 1IK2CX002368-01A1 (1), 2005 (1), 2023 (1), 5KL2TR000370 (1), K23AG030057 (1), K23HL086558 (1), K23HL090505 (1), N01HC95178 (1), N01HC95179 (1), N01HC95180 (1), N01HC95181 (1), N01HC95182 (1)