279 completed, 41 unknown, 39 recruiting, 27 terminated. 100 Phase 2, 79 Phase 4, 72 Phase 3, 47 Not applicable, 44 Phase 1.
Follow Hypogonadism: new trials by email Literature Review of Hypogonadism trials Research Report on Hypogonadism
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Testosterone Therapy With or Without Finasteride After Spinal Cord Injury: TRT-SCI Trial testosterone cypionate, finasteride, placebo injection - Spinal Cord Injury, Spinal Cord Injuries | Phase 2 / Phase 3 | Not yet recruiting | VA Office of Research and Development | 300 | 2027-10-01 | 2026-08-04 |
| A Dose Ranging Study to Examine TDS-Testosterone 5% Testosterone, Pump Sprayer - Hypogonadotropism | Phase 2 | Not yet recruiting | Transdermal Delivery Solutions Corp | 48 | 2027-06-01 | 2026-09-30 |
| Product Transference Study of Testagen™ TDS®-Testosterone Testagen® TDS Testosterone 5% HypoSpray® - Hypogonadotropism | Phase 2 | Not yet recruiting | Transdermal Delivery Solutions Corp | 96 | 2027-01-05 | 2026-05-27 |
| Clinical Trial to Observe the Effects of Tamoxifen on Testosterone Recovery in Medically Castrated Prostate Cancer Patients Tamoxifen - Hypogonadism, Prostate Cancer | Phase 2 | Recruiting | University Health Network, Toronto | 96 | 2026-12-31 | 2026-10-22 |
| Testosterone Replacement Therapy in Hypogonadal Patients With Prostate Cancer Under Active Surveillance Testosterone cypionate - Prostate Cancer, Hypogonadism, Male | Phase 4 | Recruiting | University of Miami | 35 | 2026-11-30 | 2026-11-02 |
| Hematological Profile in Children With Numerical Chromosomal Disorders Down Syndrome, Turner Syndrome | Not yet recruiting | Assiut University | 158 | 2026-11-02 | 2026-10-29 | |
| SEMAFORCRANIO : Multicenter, Double-blind, Parallel, Randomized Controlled Trial of the Efficacy of Semaglutide in Hypothalamic Obesity Secondary to Craniopharyngioma in Children Aged 12 to 17 Years Semaglutide (Wegovy) weekly injection, Placebo weekly Injection - Craniopharyngioma, Child | Phase 3 | Not yet recruiting | University Hospital, Angers | 50 | 2026-11-01 | 2026-09-29 |
| Anticipated Stigma, Illness Identity, and Quality of Life in Male Hypogonadism Hypogonadism, Male, Endocrine Disease | Recruiting | Hacettepe University | 90 | 2026-10-20 | 2026-11-06 | |
| Exercise Self-Efficacy, Body Composition, and Physical Activity in Men With Hypogonadism Hypogonadism, Male, Body Composition | Recruiting | Hacettepe University | 45 | 2026-10-20 | 2026-11-09 | |
| Safety and Efficacy of Weekly Testosterone Cypionate Auto-Injector in Men With Hypogonadism Testosterone Cypionate 75 mg, Testosterone cypionate 50 mg, Testosterone cypionate 100 mg - Male Hypogonadism | Phase 3 | Recruiting | Amneal Pharmaceuticals, LLC | 190 | 2026-09-28 | 2026-10-27 |
| AIM-TEST: Microbiome-Targeted Nutrition for Functional Secondary Hypogonadism Fixed-Formula Microbiome-Targeted Oral Nutritional Supplement, Matched Oral Placebo - Hypogonadism, Male, Secondary Hypogonadism | Not applicable | Enrolling by invitation | Varol TUNALI | 112 | 2026-08-15 | 2026-09-29 |
| Effect of Testosterone on Elderly Frail Men With Testosterone Deficiency Nebido (Testosterone Undecanoate) - Frail Elderly Patients, Hypogonadal Males | Phase 2 | Not yet recruiting | Rune Skovgaard Rasmussen | 96 | 2026-08-01 | 2026-05-06 |
| Gonadotropin Therapy in Idiopathic Hypogonadal Non-Obstructive No intervention, hCG + FSH therapy - APHRODITE Group | Not applicable | Not yet recruiting | Indira IVF Hospital Pvt Ltd | 860 | 2026-07-17 | 2026-04-20 |
| A Multiple Baseline Feasibility Trial of Social Management Training for People With Sex Chromosome Aneuploidies Social Management Training - Sex Chromosome Disorders | Phase 1 | Recruiting | University of Oslo | 30 | 2026-06-01 | 2026-07-22 |
| Anthropometric, Functional and Lifestyle Factors Associated With Testosterone Levels in Middle-Aged Men Observational Assessment - Testosterone Deficiency, Male Hypogonadism | Recruiting | Andijan State Medical Institute | 600 | 2026-06-01 | 2026-08-25 | |
| Intratesticular Artery Resistive Index Changes After Varicocelectomy Microscopic Sub-inguinal Varicocelectomy - Varicocele, Male Infertility | Not applicable | Not yet recruiting | Assiut University | 40 | 2026-05-01 | 2026-04-08 |
| Clinical Evaluation of Subcutaneous Testosterone Implants in Men With Symptomatic Hypogonadism Subcutaneous Testosterone Implants - Male Hypogonadism, Testosterone Deficiency | Phase 2 | Not yet recruiting | University of Sao Paulo | 30 | 2026-03-01 | 2026-03-30 |
| Male Experiences With Intra Cytoplasmic Sperm Injection (ICSI) and Reduced Sperm Quality Psychological Experience in Fertility Treatment, Hypogonadism | Recruiting | Peter Humaidan | 400 | 2026-02-13 | 2026-04-22 | |
| Ambulatory Blood Pressure Monitoring (ABPM) Study in Hypogonadal Men Testosterone Cypionate Injection 200 mg/mL - Hypogonadism, Male | Phase 4 | Not yet recruiting | Azurity Pharmaceuticals | 144 | 2026-02-01 | 2026-01-09 |
| Kisspeptin Administration Subcutaneously to Patients With Hypothalamic Amenorrhea kisspeptin 112-121 - Hypothalamic Amenorrhea, Hypogonadotropic Hypogonadism | Phase 2 | Recruiting | Stephanie B. Seminara, MD | 20 | 2025-12-09 | 2026-07-13 |
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Eunuchism (75) · Klinefelter Syndrome (47) · Obesity (25) · Kallmann Syndrome (23) · Sexual Infantilism (23) · Turner Syndrome (19) · Metabolic Syndrome (17) · Erectile Dysfunction (15) · Insulin Resistance (14) · Diabetes Mellitus (13) · Diabetes Mellitus, Type 2 (13) · Endocrine System Diseases (13) · Infertility (13) · Infertility, Male (13)
Gonadal Disorders (423) · Endocrine System Diseases (422) · Urogenital Diseases (154) · Male Urogenital Diseases (149) · Female Urogenital Diseases (107) · Female Urogenital Diseases and Pregnancy Complications (107) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (103) · Congenital Abnormalities (98) · Urogenital Abnormalities (98) · Disorders of Sex Development (95) · Genetic Diseases, Inborn (82) · Pathological Conditions, Signs and Symptoms (80) · Nutritional and Metabolic Diseases (74) · Genital Diseases (68)
Testosterone (98) · testosterone undecanoate (40) · Testosterone Propionate (27) · Enclomiphene (17) · Gonadotropin-Releasing Hormone (17) · Chorionic Gonadotropin (13) · testosterone enanthate (13) · testosterone 17 beta-cypionate (11) · Anastrozole (9) · Estradiol (8) · Clomiphene (7) · Sodium Chloride (7) · Dutasteride (5) · Exenatide (5) · Natesto (5)
Repros Therapeutics Inc. (16) · Massachusetts General Hospital (15) · University of Colorado, Denver (12) · Clarus Therapeutics, Inc. (11) · Gulhane School of Medicine (11) · University of Aarhus (9) · Acerus Pharmaceuticals Corporation (7) · Bayer (7) · Rhythm Pharmaceuticals, Inc. (7) · University of Washington (7) · VA Office of Research and Development (7) · Baylor College of Medicine (6) · Eli Lilly and Company (6) · Stephanie B. Seminara, MD (6) · Antares Pharma Inc. (5)
United States (242) · Denmark (30) · United Kingdom (24) · Italy (20) · Germany (17) · Turkey (Türkiye) (16) · Canada (12) · France (11) · Netherlands (9) · China (8) · Spain (8) · Brazil (6) · Russia (6) · Australia (5) · South Korea (5)
David Meeker, MD (6) · Stephanie B Seminara, MD (6) · Ronald Swerdloff, MD (5) · Stephanie Seminara, MD (5) · Abraham Morgentaler, MD (4) · Ranjith Ramasamy, MD (4) · Sandeep Dhindsa, MD (4) · Anthony DelConte, MD (3) · Joseph S Podolski (3) · Natalie D Shaw, M.D. (3) · Shanlee M Davis, MD (3)
PMID 38224135, PMID 28981994, PMID 31132118, PMID 32034419, PMID 36978128, PMID 21209029, PMID 21474786, PMID 23643382, PMID 27992261, PMID 29669934, PMID 32542985, PMID 32870266, PMID 35027909, PMID 36272969, PMID 38606384, PMID 38852333, PMID 10664066, PMID 11502778, PMID 11531930, PMID 11788640, PMID 11836290, PMID 12213860, PMID 12788881, PMID 14573733, PMID 15230699, PMID 15613419, PMID 16291975, PMID 16352669, PMID 16606836, PMID 16757106, PMID 16764984, PMID 16801584, PMID 16882745, PMID 17074994, PMID 17334928, PMID 17371886, PMID 17510436, PMID 17535868, PMID 17635942, PMID 17761590, PMID 17959774, PMID 17983892, PMID 18073301, PMID 18077826, PMID 18270253, PMID 18272894, PMID 18445673, PMID 18567642, PMID 18996225, PMID 19021638
U54HD028138 (4), 2009 (2), 2017 (2), K23HD045386 (2), UL1TR001082 (2), 2005 (1), 2008 (1), 2014 (1), 2015 (1), 2016 (1), 2018 (1), 2023 (1), I01CX001665 (1), I01RX001449 (1), K12HD057022 (1)