1006 completed, 370 unknown, 209 recruiting, 112 terminated. 682 Not applicable, 377 Phase 2, 199 Phase 1, 103 Phase 4, 97 Phase 3.
Follow Fatty Liver: new trials by email Literature Review of Fatty Liver trials Research Report on Fatty Liver
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Liver Steatosis in Pediatric CD Patients Gluten-free diet - Celiac Disease in Children, Non-Alcoholic Fatty Liver Disease | Recruiting | University of Palermo | 91 | 2027-11-01 | 2026-05-01 | |
| SGLT2 Inhibitors as a Novel Treatment for Pediatric Non-Alcoholic Fatty Liver Disease Empagliflozin 10 MG, Placebo Oral Tablet - Non-Alcoholic Fatty Liver Disease, NAFLD | Phase 2 | Not yet recruiting | Justin Ryder | 40 | 2027-05-01 | 2026-01-20 |
| Human Models of Selective Insulin Resistance: Pancreatic Clamp Insulin human, Octreotide Acetate, Glucagon - Insulin Resistance, Hyperinsulinemia | Phase 1 | Not yet recruiting | Columbia University | 36 | 2027-01-01 | 2026-02-06 |
| Diagnosis and Quantification of Hepatic Steatosis Using Near-infrared Spectroscopy Near-infrared spectrometer - Hepatic Transplantation, Steatohepatitis | Not applicable | Not yet recruiting | Assistance Publique Hopitaux De Marseille | 90 | 2027-01-01 | 2026-09-23 |
| RE and Probiotics in MAFLD/NAFLD physical exercise programme, probiotics supplementation, Placebo - NASH, NAFLD | Not applicable | Not yet recruiting | Nicolaus Copernicus University | 180 | 2026-11-10 | 2026-10-21 |
| Trial to Evaluate ALN-CIDEB in Adults With Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) ALN-CIDEB, Placebo - Metabolic Dysfunction-Associated Steatotic Liver Disease, MASLD | Phase 3 | Not yet recruiting | Regeneron Pharmaceuticals | 1500 | 2026-11-06 | 2026-10-02 |
| DDI Study of ECC0509 With Metformin, Midazolam, and Caffeine ECC0509, Metformin, Caffeine - Steatohepatitis, Nonalcoholic, Osteo Arthritis | Phase 1 | Not yet recruiting | Eccogene | 40 | 2026-11-01 | 2026-10-14 |
| GLP-1 RA on Alcohol Consumption, Metabolism and Liver Parameters in Patients With Obesity and Fatty Liver Disease Semaglutide, Weight reduction recommendations (nutritional and exercise) - Adiposity, Fatty Liver | Not applicable | Not yet recruiting | Insel Gruppe AG, University Hospital Bern | 64 | 2026-11-01 | 2026-08-19 |
| Lifestyle, Dietary Patterns, and Cardiometabolic Risk in Metabolic Dysfunction-Associated Steatotic Liver Disease Among People Living With HIV Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD), HIV Infections | Not yet recruiting | Assiut University | 250 | 2026-11-01 | 2026-10-06 | |
| Chinese Overweight/Obesity Cohort: Metabolic & Comorbidity Risks No intervention; observational assessment only - Obesity & Overweight, Diabetes Mellitus, Type 2 | Not yet recruiting | Shanxi Bethune Hospital | 25974 | 2026-11-01 | 2026-10-21 | |
| Ultrasound Biomarkers for Assessing Eligibility and Response to Resmetirom Therapy Metabolic Dysfunction-steatohepatitis (MASH) | Not yet recruiting | Radnet Management, Inc. | 524 | 2026-10-01 | 2026-10-06 | |
| Wearable Patch Ultrasound Probe for Diagnosis of Liver Stiffness Wearable Patch-Type Ultrasound Probe, Transient Elastography (FibroScan) - Liver Fibrosis, Liver Cirrhosis | Not yet recruiting | Second Affiliated Hospital of Xi'an Jiaotong University | 150 | 2026-10-01 | 2026-07-21 | |
| Metabolic Flux Analysis in Metabolic Dysfunction-Associated Steatotic Liver Disease Bariatric surgery, Stable isotope tracer infusion, MRI/MRE - Metabolic Dysfunction-Associated Steatotic Liver Disease, Metabolic Dysfunction-Associated Steatohepatitis | Not applicable | Not yet recruiting | Vanderbilt University Medical Center | 20 | 2026-10-01 | 2026-08-12 |
| Impact of Overt and Subclinical Hypothyroidism on Liver Fibrosis in Patients With MASLD Metabolic Dysfunction-Associated Steatotic Liver Disease, Non-Alcoholic Fatty Liver Disease | Not yet recruiting | Assiut University | 120 | 2026-10-01 | 2026-09-18 | |
| Hypothyroidism and Liver Fibrosis Severity in MASLD Metabolic Dysfunction-Associated Steatotic Liver Disease, Hypothyroidism | Not yet recruiting | Assiut University | 85 | 2026-10-01 | 2026-08-28 | |
| The Effects of 5-methyltetrahydrofolate Supplementation in Patients With Metabolic Dysfunction-Associated Steatotic Liver Disease 5-methyltetrahydrofolate (5-MTHF), placebo group - Nonalcoholic Fatty Liver Disease, Nonalcoholic Fatty Liver Disease (NAFLD) | Not applicable | Not yet recruiting | Tabriz University of Medical Sciences | 44 | 2026-09-30 | 2026-07-31 |
| Nutritional Indices and Inflammatory Markers in MASLD Liver Fibrosis, Malnutrition | Not yet recruiting | Assiut University | 180 | 2026-09-20 | 2026-09-22 | |
| Efficacy and Safety of Mazdutide in Patients With Type 2 Diabetes Mellitus and Moderate to Severe Nonalcoholic Fatty Liver Disease Previously Treated With Semaglutide Mazdutide(Dual GLP-1R/GCGR Agonist), Semaglutide (1 Mg Dose) - Type 2 Diabetes Mellitus (T2DM), Nonalcoholic Fatty Liver Disease (NAFLD) With History of Diabetes Melitus | Not applicable | Not yet recruiting | Tianjin Medical University | 72 | 2026-09-15 | 2026-07-20 |
| Misocholic Tablets for Non-Viral Elevated Liver Enzymes Misocholic Tab, Placebo, Silymarin (Silybum marianum) - Alcohol-Related Liver Disease, Drug-Induced Liver Injury | Phase 3 | Not yet recruiting | Hanoi Medical University | 60 | 2026-09-15 | 2026-09-22 |
| A Single-Dose Pharmacokinetic Study of HRS-4729 Injection in Healthy Participants and Patients With Renal Impairment HRS-4729 - Overweight/Obesity, Metabolic Dysfunction-associated Steatotic Liver Disease/Steatohepatitis (MASLD/MASH) | Phase 1 | Recruiting | Fujian Shengdi Pharmaceutical Co., Ltd. | 32 | 2026-09-09 | 2026-09-16 |
Showing 20 of 1931. Sign in to see all of them.
Non-alcoholic Fatty Liver Disease (1596) · Obesity (285) · Liver Cirrhosis (170) · Diabetes Mellitus, Type 2 (163) · Metabolic Syndrome (126) · Insulin Resistance (123) · Liver Diseases (110) · Fibrosis (106) · Diabetes Mellitus (94) · Overweight (60) · Motor Activity (47) · Cardiovascular Diseases (44) · Dyslipidemias (43) · Inflammation (40)
Digestive System Diseases (1912) · Liver Diseases (1821) · Nutritional and Metabolic Diseases (668) · Pathological Conditions, Signs and Symptoms (653) · Metabolic Diseases (470) · Glucose Metabolism Disorders (421) · Signs and Symptoms (375) · Body Weight (355) · Nutrition Disorders (353) · Overnutrition (348) · Pathologic Processes (340) · Overweight (288) · Endocrine System Diseases (281) · Hyperinsulinism (219)
Exercise (47) · Metformin (31) · Pioglitazone (27) · Diet (25) · Vitamin E (25) · semaglutide (23) · Bariatric Surgery (21) · empagliflozin (21) · Diet, Mediterranean (19) · Blood Specimen Collection (15) · Diet Therapy (14) · Diet, Fat-Restricted (14) · Magnetic Resonance Imaging (13) · Probiotics (13) · Ultrasonography (13)
Assiut University (29) · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (22) · Cairo University (19) · Massachusetts General Hospital (17) · AstraZeneca (16) · Gilead Sciences (16) · Novo Nordisk A/S (15) · Pfizer (15) · University of California, San Diego (15) · Columbia University (14) · University of Aarhus (14) · Azienda Ospedaliera Specializzata in Gastroenterologia Saverio de Bellis (13) · Chinese University of Hong Kong (13) · Maastricht University Medical Center (13) · Tanta University (13)
United States (627) · China (171) · United Kingdom (139) · France (125) · Italy (117) · Canada (106) · Germany (97) · Spain (93) · Egypt (79) · South Korea (75) · Israel (73) · Puerto Rico (70) · Belgium (61) · Australia (60) · Denmark (59)
Stephen Harrison, MD (7) · Joshua R Cook, MD, PhD (6) · Raika Jamali, M.D. (5) · Ali Ismail, lecturer (4) · Ali MA Ismail, lecturer (4) · Claude B Sirlin, MD (4)
PMID 36318027, PMID 40434633, PMID 33307033, PMID 36750244, PMID 37786277, PMID 40568349, PMID 42014131, PMID 18820647, PMID 26707365, PMID 30639779, PMID 32027858, PMID 33454241, PMID 39326675, PMID 17081293, PMID 18086506, PMID 19827166, PMID 20427778, PMID 21520200, PMID 21618575, PMID 22338037, PMID 22431131, PMID 23396737, PMID 24042449, PMID 24187469, PMID 24360972, PMID 24740208, PMID 24743428, PMID 25040896, PMID 26511519, PMID 26602219, PMID 28039099, PMID 28346567, PMID 28545937, PMID 29990488, PMID 30221912, PMID 30779990, PMID 31235380, PMID 31271665, PMID 31301251, PMID 32044314, PMID 32147362, PMID 32278004, PMID 32360804, PMID 32674604, PMID 33210751, PMID 33293204, PMID 33344496, PMID 33584535, PMID 33657443, PMID 33666272
2019 (13), 2016 (12), 2017 (9), 2018 (9), 2023 (7), U01DK061730 (6), U01DK061728 (5), R01HD040787 (4), U01DK061732 (4), U01DK061737 (4), 2025 (3), K12DK133995 (3), P30DK063608 (3), U01DK061713 (3), U01DK061718 (3)