Major Depressive Disorder: Clinical Trials

1087 completed, 219 unknown, 160 recruiting, 104 terminated. 671 Not applicable, 299 Phase 2, 276 Phase 3, 204 Phase 4, 125 Phase 1.

By phase and status

Phase	Trials	Status
Not applicable	671	Completed 375, Unknown 114, Recruiting 85, Terminated 32, Active not recruiting 21, Not yet recruiting 21, Withdrawn 16, Suspended 4, Enrolling by invitation 3
Phase 2	299	Completed 197, Recruiting 28, Terminated 27, Unknown 16, Withdrawn 15, Active not recruiting 10, Not yet recruiting 4, Suspended 2
Phase 3	276	Completed 212, Terminated 20, Recruiting 17, Unknown 10, Active not recruiting 7, Withdrawn 7, Enrolling by invitation 1, Not yet recruiting 1, Suspended 1
Phase 4	204	Completed 132, Unknown 29, Terminated 14, Recruiting 12, Withdrawn 9, Not yet recruiting 5, Active not recruiting 2, Enrolling by invitation 1
Phase 1	125	Completed 91, Unknown 8, Terminated 7, Withdrawn 7, Recruiting 6, Active not recruiting 3, Enrolling by invitation 2, Not yet recruiting 1
Early Phase 1	20	Completed 11, Unknown 3, Active not recruiting 2, Withdrawn 2, Enrolling by invitation 1, Recruiting 1

Follow Major Depressive Disorder: new trials by email Literature Review of Major Depressive Disorder trials Research Report on Major Depressive Disorder

Trials newest first · largest first

Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

Trial	Phase	Status	Sponsor	Enrollment	Start	Updated
Efficacy and Safety of Bupropion Hydrobromide in Adolescents and Children With Major Depressive Disorder bupropion hydrobromide, Placebo - Major Depressive Disorder	Phase 4	Not yet recruiting	Bausch Health Americas, Inc.	246	2027-07-01	2026-09-29
Stony Brook Medicine Anti-Inflammatory Trial Celecoxib, Minocycline - Major Depressive Disorder	Phase 4	Not yet recruiting	Stony Brook University	42	2027-06-01	2026-04-23
A Phase I/II Study of PDC-1421 for Treating Depression in Cancer Patients PDC-1421 Capsule - Major Depressive Disorder	Phase 1 / Phase 2	Not yet recruiting	BioLite, Inc.	12	2027-01-15	2026-04-20
Mild-Intensity Whole Body Hyperthermia (WBH) for Major Depressive Disorder Tocilizumab, Placebo, Whole-Body Hyperthermia - Major Depressive Disorder	Phase 2	Suspended	Massachusetts General Hospital	35	2026-12-01	2025-11-13
Accelerated iTBS for Depression and Suicidality Accelerated Intermittent Theta Burst (aiTBS), Electroconvulsive therapy (ECT) - Major Depressive Disorder, Suicide	Not applicable	Not yet recruiting	University of Iowa	50	2026-12-01	2025-05-20
Multi-site Feasibility of an Integrated Treatment for the Biology and Experience of Depression: The MULTIBED Study Cognitive Behavioral Therapy (CBT), Whole-Body Hyperthermia - Major Depressive Disorder	Not applicable	Not yet recruiting	University of California, San Francisco	60	2026-12-01	2026-10-13
Cortical rTMS as a Treatment for Depression Repetitive Transcranial Magnetic Stimulation - Major Depressive Disorder, Opioid Use Disorder	Not applicable	Recruiting	Baylor College of Medicine	50	2026-11-01	2026-10-13
A Mobile App to Support Mood, Daily Routines and Medication Adherence in Adults With Severe Mental Illness MoodSync, Standard care - Severe Mental Illness, Bipolar Disorder	Not applicable	Not yet recruiting	Alexandria University	60	2026-11-01	2026-10-16
A Mechanistic Study to Assess a Single Dose of CYB003 in Participants With Depression and Anxiety CYB003, Placebo - Depression, Anxiety	Phase 2	Recruiting	Ohio State University	40	2026-11-01	2026-10-20
A Study to Evaluate BMS-986511 in Adults With Major Depressive Disorder BMS-986511, Placebo - Major Depressive Disorder	Phase 2	Not yet recruiting	Bristol-Myers Squibb	200	2026-10-30	2026-09-04
Sensory Synchronized Imaging and Neuromodulation TMS - Major Depressive Disorder	Not applicable	Not yet recruiting	VA Office of Research and Development	250	2026-10-12	2026-10-13
Multimodal MRI Study of Acupuncture's Rapid Antidepressant Mechanisms and Response Prediction in Depression Acupuncture, Sham Acupuncture - Major Depressive Disorder	Not applicable	Not yet recruiting	Second Affiliated Hospital of Tsinghua University	80	2026-10-08	2026-10-07
Predictors of Treatment Outcome in Major Depressive Disorder Major Depressive Disorder		Not yet recruiting	Assiut University	100	2026-10-01	2026-10-01
Intradermal Acupuncture as an Adjunct to SSRI Tapering in Major Depressive Disorder Selective Serotonin Reuptake Inhibitors (SSRIs), Sham Intradermal Acupuncture, Intradermal Acupuncture - Major Depressive Disorder	Not applicable	Not yet recruiting	First People's Hospital of Hangzhou	114	2026-10-01	2026-09-22
PET Biomarker Study for Antidepressant Response Prediction in Major Depressive Disorder brain 18F-FDG PET-CT - Major Depressive Disorder	Not applicable	Not yet recruiting	Central Hospital, Nancy, France	30	2026-09-01	2025-06-05
Study of Electrophysiological Markers of Antidepressants in Major Depressive Disorder Electroretinography (ERG) - Major Depressive Disorder	Not applicable	Not yet recruiting	Centre Psychothérapique de Nancy	108	2026-09-01	2026-03-27
Regulated Stimulation for Optimized Network Activity and Therapeutic Equilibrium Motif XCS System - Major Depressive Disorder	Not applicable	Recruiting	Motif Neurotech, Inc.	20	2026-09-01	2026-10-21
Accelerated Versus Standard Intermittent Theta Burst Stimulation for Major Depressive Disorder Accelerated Intermittent Theta Burst Stimulation, Standard Intermittent Theta Burst Stimulation - Major Depressive Disorder	Not applicable	Recruiting	Military Hospital 175	80	2026-08-27	2026-09-09
Home-Based Wearable rTMS Therapy for Moderate to Severe Depression rTMS-Tiny Treatment, Sham Stimulation - Major Depressive Disorder	Not applicable	Not yet recruiting	Shanghai Mental Health Center	124	2026-08-20	2026-08-20
Enhancing Veteran-Clinical Collaboration in VA PRRCs Collaborative Decision Skills Training, Leveling Up - Schizophrenia, Schizoaffective Disorder	Not applicable	Recruiting	VA Office of Research and Development	119	2026-08-12	2026-08-19

Showing 20 of 1735. Sign in to see all of them.

Narrower conditions

Depressive Disorder, Major (1735)  ·  Depression (578)  ·  Bipolar Disorder (136)  ·  Depressive Disorder, Treatment-Resistant (91)  ·  Depressive Disorder (82)  ·  Anxiety Disorders (66)  ·  Mood Disorders (62)  ·  Schizophrenia (60)  ·  Stress Disorders, Post-Traumatic (49)  ·  Generalized Anxiety Disorder (44)  ·  Psychotic Disorders (34)  ·  Mental Disorders (32)  ·  Suicidal Ideation (32)  ·  Dysthymic Disorder (28)  ·  Suicide (26)

Broader conditions

Mental Disorders (1703)  ·  Mood Disorders (1673)  ·  Depressive Disorder (1653)  ·  Behavior (640)  ·  Behavioral Symptoms (603)  ·  Bipolar and Related Disorders (135)  ·  Pathological Conditions, Signs and Symptoms (121)  ·  Nervous System Diseases (103)  ·  Signs and Symptoms (74)  ·  Schizophrenia Spectrum and Other Psychotic Disorders (69)  ·  Pathologic Processes (55)  ·  Neurologic Manifestations (54)  ·  Trauma and Stressor Related Disorders (50)  ·  Self-Injurious Behavior (47)  ·  Stress Disorders, Traumatic (46)

Interventions

Escitalopram (102)  ·  Ketamine (74)  ·  Transcranial Magnetic Stimulation (66)  ·  Duloxetine Hydrochloride (54)  ·  Vortioxetine (44)  ·  Sertraline (41)  ·  Fluoxetine (40)  ·  Cognitive Behavioral Therapy (37)  ·  Venlafaxine Hydrochloride (31)  ·  Bupropion (30)  ·  Transcranial Direct Current Stimulation (30)  ·  Selective Serotonin Reuptake Inhibitors (28)  ·  Citalopram (27)  ·  Therapeutics (26)  ·  Antidepressive Agents (23)

Sponsors

Massachusetts General Hospital (64)  ·  Eli Lilly and Company (39)  ·  Centre for Addiction and Mental Health (35)  ·  AstraZeneca (29)  ·  H. Lundbeck A/S (29)  ·  New York State Psychiatric Institute (27)  ·  Shanghai Mental Health Center (27)  ·  Forest Laboratories (26)  ·  Mclean Hospital (23)  ·  Stanford University (23)  ·  University of California, Los Angeles (23)  ·  National Institute of Mental Health (NIMH) (18)  ·  Pfizer (18)  ·  Otsuka Pharmaceutical Development & Commercialization, Inc. (17)  ·  University of Texas Southwestern Medical Center (16)

Countries

United States (906)  ·  Canada (190)  ·  China (107)  ·  Germany (68)  ·  France (62)  ·  United Kingdom (51)  ·  Taiwan (39)  ·  South Korea (36)  ·  Spain (36)  ·  Australia (35)  ·  Poland (35)  ·  Finland (32)  ·  Israel (30)  ·  Japan (30)  ·  Bulgaria (28)

Top investigators

Carl Gommoll, MS (8)  ·  Hesheng Liu, Ph.D. (8)  ·  Maurizio Fava, MD (8)  ·  Bret Rutherford, MD (7)  ·  Sanjeev Pathak, MD (6)  ·  Xiaomei Shao, Ph.D (6)

Results publications

PMID 25758058, PMID 24816198, PMID 34817851, PMID 24067192, PMID 24175720, PMID 26474010, PMID 26644956, PMID 26709542, PMID 34183490, PMID 34510411, PMID 27780334, PMID 29140227, PMID 23485955, PMID 23497790, PMID 26644957, PMID 32242018, PMID 21731833, PMID 23106023, PMID 23585997, PMID 23585999, PMID 23673347, PMID 24571916, PMID 24766999, PMID 29523415, PMID 29608461, PMID 31087825, PMID 31818787, PMID 16248986, PMID 16717171, PMID 17573044, PMID 18832427, PMID 20616670, PMID 20816039, PMID 21438794, PMID 22027845, PMID 22106941, PMID 23216998, PMID 23562005, PMID 23672772, PMID 24108148, PMID 24127687, PMID 24175721, PMID 24507016, PMID 25080392, PMID 25083802, PMID 25602163, PMID 25978741, PMID 25980552, PMID 26137355, PMID 26513202

NIH funding

2008 (9), 2018 (5), 2023 (5), 2014 (4), 2019 (4), 2015 (2), P20GM113125 (2), R00MH101235 (2), R01MH101547 (2), R34AT011221 (2), R34MH103568 (2), 1RC1MH088438 (1), 2004 (1), 2009 (1), 2016 (1)