12 completed, 6 unknown, 1 recruiting. 5 Phase 3, 4 Phase 2, 3 Not applicable, 3 Phase 4, 2 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 5 | Completed 3, Unknown 2 |
| Phase 2 | 4 | Completed 2, Unknown 2 |
| Not applicable | 3 | Completed 2, Unknown 1 |
| Phase 4 | 3 | Completed 2, Recruiting 1 |
| Phase 1 | 2 | Completed 1, Unknown 1 |
Follow Low Cardiac Output Syndrome: new trials by email Literature Review of Low Cardiac Output Syndrome trials Research Report on Low Cardiac Output Syndrome
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Landiolol in Mitral Valve Surgery Landiolol, Placebo - Cardiac Failure, Low Cardiac Output Syndrome | Phase 4 | Recruiting | Università Vita-Salute San Raffaele | 1500 | 2025-01-28 | 2025-12-29 |
| Patients With Low Cardiac Output Syndrome Undergoing Local Dental Anesthesia Anesthetic infiltration - Low Cardiac Output Syndrome | Not applicable | Completed | University of Sao Paulo General Hospital | 45 | 2023-08-08 | 2026-09-30 |
| Exogenous Ketones for Acutely Decompensated HEart Failure 25g Ketone monoester without added salts, Placebo - Acute Heart Failure, Low Cardiac Output Syndrome | Phase 3 | Unknown | Institute for Clinical and Experimental Medicine | 24 | 2020-12-02 | 2021-01-06 |
| Intraoperative Global Longitudinal Strain and Global Longitudinal Strain Rate as Predictors of Unfavorable Outcome in On-Pump Mitral Surgery Philips QLAB Ultrasound Quantification Software - Mitral Valve Disease, Low Cardiac Output Syndrome | Completed | Scientific Institute San Raffaele | 140 | 2019-10-28 | 2026-05-05 | |
| Autologous Umbilical Cord Blood Treatment of Neonate With CHD Autlogous UCB infusion - Congenital Heart Disease, Brain Injuries | Phase 1 / Phase 2 | Unknown | Sheba Medical Center | 60 | 2019-02-01 | 2021-01-20 |
| Prophylactic Use of Milrinone After Congenital Heart Surgery in Infants Milrinone, Normal saline - Low Cardiac Output Syndrome, Cardiac Surgical Procedures | Phase 3 | Unknown | Shanghai Children's Medical Center | 520 | 2019-02-01 | 2019-01-30 |
| Anesthesia Standard Operating Procedure During On-pump Coronary Artery Bypass Grafting Low opioid anesthesia - Coronary Artery Disease, Low Cardiac Output Syndrome | Not applicable | Unknown | Heart Institute, Ministry of Health of Ukraine | 120 | 2018-12-01 | 2022-08-24 |
| Nitric Oxide During Bypass for Arterial Switch Operation Nitric Oxide - Low Cardiac Output Syndrome, Transposition of Great Vessels | Phase 3 | Completed | Murdoch Childrens Research Institute | 300 | 2018-07-11 | 2024-04-18 |
| Milrinone Versus Dobutamine in Critically Ill Patients Milrinone, Dobutamine - Low Cardiac Output Syndrome, Cardiogenic Shock | Phase 4 | Completed | Ottawa Heart Institute Research Corporation | 192 | 2017-08-30 | 2020-06-30 |
| Prognostic Markers of Inflammation in Infants Undergoing Cardiopulmonary Bypass Single blood draw, Multiple blood draws - Congenital Heart Defect, Cardiopulmonary Bypass | Completed | University of Oklahoma | 38 | 2017-06-04 | 2019-04-30 | |
| Levosimendan in Patients With Left Ventricular Systolic Dysfunction Undergoing Cardiac Surgery On Cardiopulmonary Bypass Levosimendan, Placebo - Coronary Artery Bypass Grafting, Mitral Valve Surgery | Phase 3 | Completed | Tenax Therapeutics, Inc. | 882 | 2014-07-01 | 2018-06-21 |
| Remote Ischemic Preconditioning in High Risk Cardiovascular Surgery Patients Remote ischemic preconditioning stimulus, control - Death, Stroke | Phase 3 | Completed | Queen's University | 429 | 2012-02-01 | 2016-02-05 |
| Outcome of Patients Treated With IABP Intra Aortic Balloon Pump - Acute Coronary Syndrome, Cardiogenic Shock | Unknown | Nanjing Medical University | 1000 | 2012-02-01 | 2020-05-28 | |
| Levosimendan in High Risk Patients Undergoing Cardiac Surgery Levosimendan, placebo - Low Cardiac Output Syndrome | Phase 4 | Completed | Università Vita-Salute San Raffaele | 1000 | 2009-11-01 | 2016-07-22 |
| Two Inodilators Postsurgery in Neonates Milrinone, Levosimendan - Low Cardiac Output Syndrome | Phase 1 / Phase 2 | Completed | Fundacion para la Investigacion Biomedica del Hospital Universitario la Paz | 20 | 2009-11-01 | 2012-04-12 |
| Levosimendan Administration in Neonates With Transposition of the Great Arteries levosimendan, placebo - Low Cardiac Output Syndrome | Phase 2 | Completed | Bambino Gesù Hospital and Research Institute | 63 | 2009-01-01 | 2012-06-26 |
| Levosimendan in Congenital Cardiac Surgery Levosimendan, Milrinone - Congenital Cardiovascular Defects, Low Cardiac Output Syndrome | Not applicable | Completed | Cliniques universitaires Saint-Luc- Université Catholique de Louvain | 50 | 2008-07-01 | 2010-01-26 |
| How Much Cardiac Output is Enough? Low Cardiac Output Syndrome | Completed | Klinikum Ludwigshafen | 600 | 2007-10-01 | 2009-11-25 | |
| Prophylactic Use of Levosimendan Versus Milrinone in Open Heart Surgery in Infants Levosimendan, Milrinone - Low Cardiac Output Syndrome | Phase 2 | Unknown | Ludwig Boltzmann Gesellschaft | 40 | 2007-09-01 | 2007-10-25 |
Cardiac Output, Low (19) · Heart Defects, Congenital (4) · Acute Coronary Syndrome (2) · Coronary Artery Disease (2) · Heart Failure (2) · Shock, Cardiogenic (2) · Transposition of Great Vessels (2) · Atrial Fibrillation (1) · Brain Injuries (1) · Death (1) · Infant, Newborn, Diseases (1) · Inflammation (1) · Ketosis (1) · Myocardial Infarction (1) · Postoperative Complications (1)
Cardiovascular Diseases (19) · Heart Diseases (19) · Pathological Conditions, Signs and Symptoms (19) · Signs and Symptoms (19) · Cardiovascular Abnormalities (5) · Congenital Abnormalities (5) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (5) · Pathologic Processes (5) · Myocardial Ischemia (4) · Vascular Diseases (4) · Infarction (3) · Ischemia (3) · Necrosis (3) · Arterial Occlusive Diseases (2) · Arteriosclerosis (2)
Simendan (6) · Milrinone (5) · Blood Specimen Collection (1) · Dobutamine (1) · Echocardiography (1) · Intra-Aortic Balloon Pumping (1) · N(1)-methyl-2-lysergic acid diethylamide (1) · Nitric Oxide (1) · Saline Solution (1) · Sodium Chloride (1) · landiolol (1)
Università Vita-Salute San Raffaele (2) · Bambino Gesù Hospital and Research Institute (1) · Cliniques universitaires Saint-Luc- Université Catholique de Louvain (1) · Fundacion para la Investigacion Biomedica del Hospital Universitario la Paz (1) · Heart Institute, Ministry of Health of Ukraine (1) · Institute for Clinical and Experimental Medicine (1) · Klinikum Ludwigshafen (1) · Ludwig Boltzmann Gesellschaft (1) · Murdoch Childrens Research Institute (1) · Nanjing Medical University (1) · Ottawa Heart Institute Research Corporation (1) · Queen's University (1) · Scientific Institute San Raffaele (1) · Shanghai Children's Medical Center (1) · Sheba Medical Center (1)
Canada (4) · Italy (4) · Brazil (2) · China (2) · United States (2) · Australia (1) · Austria (1) · Belgium (1) · Czechia (1) · Germany (1) · Indonesia (1) · Israel (1) · Malaysia (1) · Russia (1) · Spain (1)
Adelina Pellicer, PhD (1) · Alberto Zangrillo, MD (1) · Anna Hofer, MD (1) · Benjamin M Hibbert, MD, PhD (1) · Carlos Labrandero, MD (1) · Darrin Payne, MD (1) · Evelyn Lechner, MD (1) · Gerald Tulzer, MD, PHD (1) · Hala Chaaban, MD (1) · Hans Gombotz, MD, PHD (1) · Huiwen Chen, MD, PhD (1) · Joachim Boldt, MD (1)
PMID 15329162, PMID 23228403, PMID 23771484, PMID 25734940, PMID 25989324, PMID 27686343, PMID 27914501, PMID 28316276, PMID 28320259, PMID 29116972, PMID 29200066, PMID 32402931, PMID 34347952, PMID 34376218, PMID 34713704, PMID 35261289, PMID 35263653, PMID 37803334, PMID 41126360