102 completed. 102 Phase 3, 12 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 102 | Completed 102 |
| Phase 2 | 12 | Completed 12 |
Follow Low Back Pain: new trials by email Literature Review of Low Back Pain trials Research Report on Low Back Pain
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Efficacy and Safety in the Combination of Celecoxib / Pregabalin / Vitamin B for Low Back Chronic Pain Celecoxib+Pregabalin+Vitamin B fixed dose, Celecoxib + Vitamin B fixed dose, Pregabalin + Vitamin B fixed dose - Chronic Low-back Pain | Phase 3 | Completed | Laboratorios Silanes S.A. de C.V. | 192 | 2024-04-11 | 2025-04-04 |
| Efficacy and Safety of FIRTECH in Patients With Mild to Moderate Acute Low Back Pain ITP FIRTECH - Low Back Pain | Phase 3 | Completed | Sanofi | 221 | 2021-11-04 | 2025-09-09 |
| BackToBasic: Infliximab in Chronic Low Back Pain and Modic Changes Biosimilar Infliximab, Placebo - Low Back Pain | Phase 3 | Completed | Oslo University Hospital | 128 | 2018-12-12 | 2024-03-08 |
| Spinal Manipulation and Patient Self-Management for Preventing Acute to Chronic Back Pain Supported-Self Management (SSM), Spinal Manipulation Therapy (SMT), SMT + SSM - Acute Pain, Low Back Pain, Mechanical | Phase 3 | Completed | University of Minnesota | 1000 | 2018-11-01 | 2025-10-16 |
| Ibuprofen With or Without Acetaminophen for Low Back Pain Acetaminophen, Ibuprofen 600 mg, Educational intervention - Low Back Pain | Phase 3 | Completed | Montefiore Medical Center | 120 | 2018-10-16 | 2024-02-28 |
| Optimizing Chronic Low Back Pain Exercise Therapies With Cerebral Electrical Stimulation Real transcranial direct current stimulation + therapeutic exercises for back pain, Sham transcranial direct current stimulation + therapeutic exercises for back pain - Low Back Pain, Recurrent, Chronic Low Back Pain | Phase 2 / Phase 3 | Completed | Universidade Federal do Piauí | 60 | 2018-04-10 | 2021-01-19 |
| Clinical Research on the Efficacy of Bosinji on Herniated Intervertebral Disc of Lumbar Spine Bosinji, Loxonine tab., Acupuncture - Lumbar Disc Herniation | Phase 3 | Completed | Kyunghee University Medical Center | 74 | 2017-12-28 | 2020-02-05 |
| Protocol to Monitor the Neurological Development of Infants With Exposure in Utero From Birth to 15 Months in Tanezumab Clinical Studies Investigational medical product (IMP) administered in parent study - Osteoarthritis, Cancer Pain | Phase 3 | Completed | Pfizer | 4 | 2017-11-03 | 2021-06-25 |
| Study to Assess the Efficacy and Safety of Tizaspray® Versus Sirdalud®, in Patients With Acute Low Back Pain Tizaspray® administered intranasally, Sirdalud® 2 mg tablets administered - Low Back Pain | Phase 3 | Completed | MDM S.p.A. | 117 | 2016-10-01 | 2018-01-16 |
| Long Term Safety and Efficacy Study of Tanezumab in Japanese Adult Subjects With Chronic Low Back Pain Celecoxib, Tanezumab 5 mg, Tanezumab 10 mg - Low Back Pain | Phase 3 | Completed | Pfizer | 277 | 2016-05-26 | 2020-08-11 |
| Physiotherapy for Sciatica; Is Earlier Better? Physiotherapy - Sciatica, Low Back Pain | Phase 3 | Completed | Michael Reddington | 80 | 2016-02-01 | 2016-11-10 |
| A Study to Determine the Efficacy and Safety of Fasinumab for the Treatment of Adults With Chronic Low Back Pain Fasinumab, placebo - Low Back Pain | Phase 2 / Phase 3 | Completed | Regeneron Pharmaceuticals | 563 | 2016-01-26 | 2020-06-16 |
| A Phase 3 Study of Tanezumab for Chronic Low Back Pain Placebo to Week 16; tanezumab 5mg SC, Placebo to Week 16, tanezumab 10 mg SC, Tanezumab 5 mg SC - Low Back Pain | Phase 3 | Completed | Pfizer | 1832 | 2015-08-18 | 2020-02-21 |
| Diazepam Use With Standard Management for Acute Low Back Pain Naproxen, Placebo, Diazepam - Low Back Pain | Phase 2 / Phase 3 | Completed | Montefiore Medical Center | 114 | 2015-06-01 | 2018-08-01 |
| A Trial of Cooled Radiofrequency Ablation of Medial Branch Nerves for theTreatment of Lumbar Facet Syndrome Conventional radiofrequency ablation (RFA), Cooled Radiofrequency Ablation (CRFA) - Low Back Pain | Phase 3 | Completed | Northwestern University | 48 | 2015-06-01 | 2018-09-06 |
| Antibiotics In Modic Changes Amoxicillin (Amoksicillintrihydrat), Placebo - Low Back Pain, Modic Changes Type I or II Seen on MRI | Phase 3 | Completed | Oslo University Hospital | 180 | 2015-06-01 | 2021-09-27 |
| Long-Term Safety and Tolerability Study of NKTR-181 in Subjects With Chronic Low Back Pain or Chronic Non-Cancer Pain NKTR-181 BID tablets - Low Back Pain, Chronic Pain | Phase 3 | Completed | Nektar Therapeutics | 638 | 2015-04-14 | 2021-06-22 |
| Efficacy and Safety Study of NKTR-181 in Opioid-Naive Subjects With Low Back Pain NKTR-181 BID tablets, Placebo to match NKTR-181 BID tablets - Low Back Pain, Chronic Pain | Phase 3 | Completed | Nektar Therapeutics | 1189 | 2015-03-11 | 2020-09-16 |
| Placebo-controlled Study to Evaluate Rexlemestrocel-L Alone or Combined With Hyaluronic Acid in Participants With Chronic Low Back Pain Rexlemestrocel-L, Rexlemestrocel-L + HA Mixture, Placebo - Degenerative Disc Disease | Phase 3 | Completed | Mesoblast, Ltd. | 404 | 2015-03-06 | 2022-10-19 |
| The Use of Methylsulfonylmethane (MSM) in the Treatment of Low Back Pain MSM 1000mg twice a day (6000 mgs), Placebo capsules twice a day - Low Back Pain | Phase 3 | Completed | Mike O'Callaghan Military Hospital | 100 | 2015-02-01 | 2024-04-05 |
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Chronic Pain (22) · Back Pain (14) · Pain (13) · Osteoarthritis (12) · Radiculopathy (5) · Bronchiolitis Obliterans Syndrome (4) · Sciatica (4) · Motor Activity (3) · Neuralgia (3) · Arthritis, Rheumatoid (2) · Constipation (2) · Duodenal Ulcer (2) · Intervertebral Disc Displacement (2) · Musculoskeletal Pain (2)
Pathological Conditions, Signs and Symptoms (102) · Signs and Symptoms (102) · Neurologic Manifestations (101) · Pain (89) · Back Pain (88) · Musculoskeletal Diseases (18) · Arthritis (13) · Joint Diseases (13) · Rheumatic Diseases (13) · Nervous System Diseases (11) · Neuromuscular Diseases (10) · Peripheral Nervous System Diseases (10) · Immune System Diseases (6) · Bronchial Diseases (4) · Bronchiolitis (4)
Tapentadol (6) · Oxycodone (5) · Buprenorphine (4) · Celecoxib (4) · Acupuncture Therapy (3) · Ibuprofen (3) · Acetaminophen (2) · Carisoprodol (2) · Duration of Therapy (2) · Esomeprazole (2) · Etoricoxib (2) · Exercise (2) · Methylprednisolone (2) · Naproxen (2) · Saline Solution (2)
BioDelivery Sciences International (5) · Johnson & Johnson Pharmaceutical Research & Development, L.L.C. (5) · Purdue Pharma LP (5) · Pfizer (4) · Kaiser Permanente (3) · Montefiore Medical Center (3) · Teva Branded Pharmaceutical Products R&D, Inc. (3) · AstraZeneca (2) · Charite University, Berlin, Germany (2) · Endo USA Inc., a Keenova Therapeutics Company (2) · Janssen Pharmaceutical K.K. (2) · Meda Pharmaceuticals (2) · Nektar Therapeutics (2) · Organon and Co (2) · Oslo University Hospital (2)
United States (51) · Germany (9) · Japan (8) · South Korea (5) · Canada (4) · France (4) · Italy (4) · Brazil (3) · Norway (3) · Poland (3) · Australia (2) · China (2) · Czechia (2) · Denmark (2) · Hungary (2)
Andrew Finn, PharmD (4) · Benjamin W Friedman, MD, MS (2) · Daniel Cherkin, PhD (2) · Lewis M. Fredane, MD (2) · Naotsugu Oyama (2) · Aage Indahl, Ph.d (1) · Adelfia Urenda-Quezada (1) · Ajay Wasan, M.D., MSc. (1) · Anamaria Jones, PT (1) · Andre M Beer, MD, PhD (1) · Andreas Siegenthaler, Dr Med (1)
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2009 (1), 2014 (1), 2015 (1), K24AT002422 (1), P01AT002048 (1), R01AT000985 (1), U01AT001110 (1), U01AT001908 (1), UL1RR024153 (1)