64 completed, 19 unknown, 13 not yet recruiting, 12 withdrawn. 133 Phase 1, 52 Phase 2.
Follow Ischemic Stroke: new trials by email Literature Review of Ischemic Stroke trials Research Report on Ischemic Stroke
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| ARTEMIS: UC-MSCs After Mechanical Thrombectomy for Acute Ischemic Stroke Allogeneic Umbilical Cord-Derived Mesenchymal Stromal Cells (UC-MSCs), Standard Stroke Care Including Mechanical Thrombectomy - Acute Ischemic Stroke | Phase 1 | Not yet recruiting | Royan Stem Cell Technology Company | 10 | 2026-11-20 | 2026-11-03 |
| Safely Quenching Complement in Stroke Survivors Pegcetacoplan Injection [Empaveli] - Acute Ischemic Stroke, Cerebral Infarction | Phase 1 | Not yet recruiting | Columbia University | 20 | 2026-10-01 | 2026-04-29 |
| A Phase 1b Study to Assess the Safety and Tolerability of AB126 Neural Exosomes in Patients With Moderate to Severe Acute Ischemic Stroke AB126 Neural Exosomes Intravenous Injection, AB126 Placebo - Acute Ischemic Stroke | Phase 1 | Not yet recruiting | Aruna Bio, Inc. | 20 | 2026-10-01 | 2026-09-10 |
| Investigating Central Contributions to Fatigue Using Non-invasive Brain Stimulation Transcranial alternating current stimulation (tACS), Sham treatment - Stroke, Cerebrovascular Accident (CVA) | Phase 1 / Phase 2 | Not yet recruiting | Vrije Universiteit Brussel | 120 | 2026-09-01 | 2026-05-29 |
| Safety, Dose-Finding, and Efficacy of Transcranial Pulse Stimulation for Post-Stroke Neurorehabilitation Required Field - Ischemic Stroke | Phase 1 / Phase 2 | Enrolling by invitation | Taipei Hospital, Ministry of Health and Welfare | 9 | 2026-08-20 | 2026-08-25 |
| Intra-Arterial Magnesium Therapy After Mechanical Thrombectomy in Acute Ischemic Stroke Magnesium sulfate - Acute Ischemic Stroke | Phase 1 | Recruiting | Baylor College of Medicine | 30 | 2026-07-01 | 2026-10-01 |
| A Phase I Trial of Umbilical Cord Mesenchymal Stromal Cells for Acute Ischemic Stroke Placebo of Human Umbilical Cord Mesenchymal Stromal Cells Injection, Human Umbilical Cord Mesenchymal Stem Cells Injection - Acute Ischemic Stroke, AIS | Phase 1 | Not yet recruiting | BOE Technology Group Co., Ltd. | 35 | 2026-06-30 | 2026-06-05 |
| Human Placenta-derived 3D Mesenchymal Stem Cells(Guojianqingke) Human Placenta-derived 3D Mesenchymal Stem Cells (Guojiangqingke) - Acute Ischemic Stroke | Phase 1 / Phase 2 | Recruiting | Chinese PLA General Hospital | 24 | 2026-06-01 | 2026-06-09 |
| Anisodine Hydrobromide for Patients With Acute Ischemic Stroke Undergoing Endovascular Therapy (HEAL) Anisodine Hydrobromide - Acute Ischemic Stroke | Phase 1 | Active not recruiting | Capital Medical University | 92 | 2026-04-28 | 2026-08-24 |
| A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of LWP779 in Healthy Participants LWP779, Placebo of LWP779 - Ischemic Stroke | Phase 1 | Recruiting | Longwood Pharmaceuticals (Hangzhou) Co., Ltd. | 76 | 2026-03-13 | 2026-03-20 |
| Psychedelic Healing: Adjunct Therapy Harnessing Opened Malleability Psilocybin (Usona Institute) - Stroke, Chronic Stroke | Phase 1 | Recruiting | Johns Hopkins University | 20 | 2026-02-09 | 2026-02-13 |
| Safety and Efficacy of Human Adipose-Derived Stem Cell Exosomes in Acute Ischemic Stroke Human Adipose-Derived Stem Cell Exosomes, Placebo - Acute Ischemic Stroke | Phase 1 / Phase 2 | Not yet recruiting | Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine | 60 | 2026-01-31 | 2026-02-10 |
| A Study of B2065 in Patients With Acute Ischemic Stroke B2065, Placebo - Acute Ischemic Stroke | Phase 1 / Phase 2 | Recruiting | Tasly Pharmaceutical Group Co., Ltd | 54 | 2025-12-31 | 2026-08-13 |
| Exploratory Study of Intranasal Administration of Human Umbilical Cord Mesenchymal Stem Cell-Derived Extracellular Vesicles for the Treatment of Ischemic Stroke Intranasal Administration of Human Umbilical Cord Mesenchymal Stem Cell-Derived Small Extracellular Vesicles (hUC-MSC-sEV-001) Therapy - Ischemic Stroke | Phase 1 | Not yet recruiting | Zhujiang Hospital | 9 | 2025-12-01 | 2025-11-18 |
| The Safety and Efficacy of NouvSoma001 in Ischemic Stroke extracellular vesicles derived from human induced neural stem cell for intravenous injection, a placebo of extracellular vesicles derived from human induced neural stem cell for intravenous injection - Ischemic Stroke | Phase 1 | Recruiting | Wei Wang | 69 | 2025-11-30 | 2026-01-21 |
| Study of BB-025, Alone and After BB-031, in Healthy Volunteers BB-025, BB-031 - Pharmacodynamics, Pharmacokinetics | Phase 1 | Completed | Basking Biosciences, Inc. | 72 | 2025-11-05 | 2026-04-06 |
| Human Induced Neural Stem Cell-derived Exosomes for Treating Acute Ischemic Stroke iNSC-EV01, Placebo - Ischemic Stroke, Acute | Phase 1 / Phase 2 | Not yet recruiting | Xuanwu Hospital, Beijing | 38 | 2025-10-01 | 2025-08-27 |
| RK-4 Intracalvariosseous Injection in Treatment of Acute Large Hemispheric Infarction RK-4 injection - Transcranial Bone Marrow Injection, RK-4 | Phase 1 / Phase 2 | Not yet recruiting | Neurodawn Pharmaceutical Co., Ltd. | 18 | 2025-09-20 | 2025-09-30 |
| Intra-arterial Selective Hypothermic Magnesium Sulfate Infusion in Combination With Endovascular Thrombectomy in Acute Ischemic Stroke Endovascular thrombectomy combination with selective intra-arterial hypothermic magnesium sulfate infusion (350 ml)., Endovascular thrombectomy combination with selective intra-arterial hypothermic magnesium sulfate infusion (500 ml)., Endovascular thrombectomy combination with selective intra-arterial hypothermic magnesium sulfate infusion (650 ml). - Acute Ischemic Stroke | Phase 1 / Phase 2 | Enrolling by invitation | Capital Medical University | 42 | 2025-09-15 | 2026-08-13 |
| Safety Of A Second Dose Of Tenecteplase In Selected Acute Ischemic Stroke Patients Not Responding To The First Dose Tenecteplase (TNK) (0.25 mg/kg, to maximum of 25mg) - Acute Ischemic Stroke | Phase 1 | Not yet recruiting | Memorial Hermann Health System | 20 | 2025-07-01 | 2025-06-05 |
Showing 20 of 133. Sign in to see all of them.
Stroke (41) · Ischemia (6) · Infarction, Middle Cerebral Artery (5) · Brain Ischemia (4) · Hemorrhagic Stroke (4) · Cerebral Hemorrhage (3) · Cerebral Infarction (3) · Paresis (3) · Reperfusion Injury (3) · Aphasia, Broca (2) · Brain Edema (2) · Brain Infarction (2) · Bronchiolitis Obliterans Syndrome (2) · Cerebral Palsy (2)
Central Nervous System Diseases (133) · Cerebrovascular Disorders (133) · Nervous System Diseases (133) · Vascular Diseases (133) · Brain Diseases (132) · Cardiovascular Diseases (132) · Stroke (92) · Pathological Conditions, Signs and Symptoms (28) · Pathologic Processes (19) · Signs and Symptoms (12) · Brain Ischemia (8) · Infarction (8) · Necrosis (8) · Ischemia (7) · Neurologic Manifestations (7)
Aspirin (6) · Sodium Chloride (5) · Injections (4) · Verapamil (3) · AER-271 (2) · Clopidogrel (2) · Dimethyl Fumarate (2) · Magnesium Sulfate (2) · Ticagrelor (2) · Tissue Plasminogen Activator (2) · Transcranial Direct Current Stimulation (2) · 3-n-butylphthalide (1) · Acetaminophen (1) · Albumins (1) · BMS-986141 (1)
Capital Medical University (5) · Xuanwu Hospital, Beijing (4) · China Medical University Hospital (3) · Justin Fraser (3) · The University of Texas Health Science Center, Houston (3) · Baylor College of Medicine (2) · Changzhou Qianhong Bio-pharma Co., Ltd. (2) · Columbia University (2) · Daiichi Sankyo (2) · H. Lundbeck A/S (2) · ImaRx Therapeutics (2) · Shin Poong Pharmaceutical Co. Ltd. (2) · Tianjin Huanhu Hospital (2) · University of California, San Diego (2) · Zhujiang Hospital (2)
United States (49) · China (37) · France (8) · Taiwan (7) · Australia (5) · United Kingdom (5) · Germany (4) · South Korea (4) · Spain (4) · Canada (2) · Finland (2) · Indonesia (2) · Iran (2) · Israel (2) · Netherlands (2)
Juan Li, Doctor (2) · Shinn-Zong Lin, M.D.;PhD. (2) · Alex King, MD (1) · Andrea Comenducci, MD (1) · Andrei Alexandrov, MD (1) · Andrew D. Barreto, MD (1) · Antony J. Furlan, MD (1) · Bei Hu, MD (1) · Beverly C Walters, MD (1) · Brian Mehling, MD (1) · Brian Silver, MD (1) · Carlos Molina Cateriano, MD (1) · Carolin I Dohle, MD (1)
PMID 39545461, PMID 16282547, PMID 16336965, PMID 16574922, PMID 16908730, PMID 18468545, PMID 19570514, PMID 19609078, PMID 19717023, PMID 20966420, PMID 21350210, PMID 21786299, PMID 22198979, PMID 22223235, PMID 22474060, PMID 22659021, PMID 22738918, PMID 23197640, PMID 23370205, PMID 24193798, PMID 24610327, PMID 25530442, PMID 25671797, PMID 26671426, PMID 26704258, PMID 27130637, PMID 27168844, PMID 27256670, PMID 29626135, PMID 29752869, PMID 30497166, PMID 31349978, PMID 31495331, PMID 32106339, PMID 34174279, PMID 35613802, PMID 35900437, PMID 36642931, PMID 36908619, PMID 37104115, PMID 37311758, PMID 37338893, PMID 38267188, PMID 38414067, PMID 38804212, PMID 39403266, PMID 40517620, PMID 40889891, PMID 40921621, PMID 41277536
2015 (1), 2018 (1), P50NS044148 (1), P50NS044227 (1), R21DC009876 (1), R21HD060978 (1), R44NS071657 (1)