151 completed, 68 unknown, 54 recruiting, 33 terminated. 372 Phase 2, 65 Phase 3, 52 Phase 1.
Follow Ischemic Stroke: new trials by email Literature Review of Ischemic Stroke trials Research Report on Ischemic Stroke
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| CC-101 (f/k/a NR1) Neural Stem Cell Transplantation for Adults With Chronic Ischemic Stroke CC-101 (f/k/a NR1) Intracerebral Transplantation, Tacrolimus, Sham Surgical Control - Chronic Ischemic Stroke | Phase 2 | Not yet recruiting | Clarion Cells, Inc. | 36 | 2027-01-01 | 2026-07-17 |
| A Phase II Clinical Study of LT3001 for Injection in the Treatment of Acute Ischemic Stroke LT3001 Drug:high dose, LT3001 Drug: low dose, Placebo - Acute Ischemic Stroke | Phase 2 | Not yet recruiting | Shanghai Pharmaceuticals Holding Co., Ltd | 300 | 2026-12-01 | 2026-10-19 |
| A Multicenter, Three-Arm, Open-Label, Endpoint-Blinded Randomized Controlled Trial to Evaluate the Optimal Duration of Early Tirofiban After Intravenous Thrombolysis in Acute Ischemic Stroke Tirofiban Injection, No Interventions - Acute Ischemic Stroke | Phase 2 / Phase 3 | Not yet recruiting | Xinqiao Hospital of Chongqing | 1482 | 2026-11-19 | 2026-09-25 |
| Glucagon-like Peptide-1 Receptor Agonists for Endovascular Stroke Thrombectomy Semaglutide - Ischemic Stroke | Phase 2 | Not yet recruiting | Population Health Research Institute | 100 | 2026-10-31 | 2026-09-24 |
| A Phase 2a Study to Evaluate the Dose-response, Safety, Tolerability, Efficacy, and Population Pharmacokinetics of Intravenous NTS-521 Infusions in the Early Recovery Treatment From Acute Ischemic Stroke NTS-521, Placebo Control - Acute Ischemic Stroke | Phase 2 | Not yet recruiting | NeuroTrauma Sciences, LLC | 140 | 2026-10-31 | 2026-08-03 |
| The Efficacy and Safety of HRS-4029 in Acute Ischemic Stroke Patients HRS-4029, Placebo - Acute Ischemic Stroke | Phase 2 | Not yet recruiting | Beijing Suncadia Pharmaceuticals Co., Ltd | 340 | 2026-10-01 | 2026-10-02 |
| Reduction of SystemiC Inflammation After Ischemic Stroke by Intravenous DNase Administration (ReSCInD) Dornase Alfa, Isotonic Saline Solution - Ischemic Stroke, Inflammatory Response | Phase 2 | Recruiting | Ludwig-Maximilians - University of Munich | 36 | 2026-10-01 | 2026-09-11 |
| A Study to Evaluate the Intracranial Arterial Recanalization With Multiple Doses of LT3001 Drug Product in AIS Participant LT3001 Drug Product - Acute Ischemic Stroke | Phase 2 | Recruiting | Lumosa Therapeutics Co., Ltd. | 10 | 2026-10-01 | 2026-10-22 |
| Infarct Growth After Intravenous Tocilizumab in Adults With Acute Ischemic Stroke Undergoing Endovascular Thrombectomy - ILLUMINATE Tociliuzumab, Placebo - Acute Ischemic Stroke | Phase 2 / Phase 3 | Not yet recruiting | Oslo University Hospital | 156 | 2026-09-21 | 2026-10-13 |
| Tirzepatide in Thrombectomy-Treated Acute Ischemic Stroke: A Randomized Trial Tirzepatide, Standard Medical Care (SMC) - Acute Ischemic Stroke (AIS) | Phase 2 / Phase 3 | Not yet recruiting | yifang zhu | 726 | 2026-09-20 | 2026-10-01 |
| Anisodine Hydrobromide for Patients With Acute Ischemic Stroke Undergoing Endovascular Therapy (HEAL-2) Anisodine Hydrobromide, Anisodine Hydrobromide Placebo - Acute Ischemic Stroke | Phase 2 | Recruiting | Capital Medical University | 204 | 2026-09-06 | 2026-10-13 |
| Cerebrolysin After Reperfusion in Extended-window EndoVascular Thrombectomy Cerebrolysin, Normal saline placebo - Acute Ischemic Stroke | Phase 2 | Not yet recruiting | Chang Gung Memorial Hospital | 100 | 2026-09-01 | 2026-08-11 |
| A Study of Probiotics in Patients With Acute Ischemic Stroke probiotic supplement OMNi-BiOTiC® SR-9, Matching Placebo - Ischemic Stroke | Phase 2 | Not yet recruiting | Capital Medical University | 220 | 2026-09-01 | 2026-06-17 |
| Investigating Central Contributions to Fatigue Using Non-invasive Brain Stimulation Transcranial alternating current stimulation (tACS), Sham treatment - Stroke, Cerebrovascular Accident (CVA) | Phase 1 / Phase 2 | Not yet recruiting | Vrije Universiteit Brussel | 120 | 2026-09-01 | 2026-05-29 |
| Glenzocimab in Anterior Stroke With Large Ischemic Core Eligible for Endovascular Therapy glenzocimab, placebo - Acute Ischemic Stroke | Phase 2 / Phase 3 | Withdrawn | Fondation Ophtalmologique Adolphe de Rothschild | 2026-09-01 | 2026-09-09 | |
| A Phase 2b Trial of Lesion Network Mapping-Guided cTBS for Motor Recovery After Acute Ischemic Stroke LNM-navigated cTBS, Sham cTBS - Ischemic Stroke | Phase 2 | Not yet recruiting | Beijing Tiantan Hospital | 60 | 2026-08-26 | 2026-08-18 |
| Safety, Dose-Finding, and Efficacy of Transcranial Pulse Stimulation for Post-Stroke Neurorehabilitation Required Field - Ischemic Stroke | Phase 1 / Phase 2 | Enrolling by invitation | Taipei Hospital, Ministry of Health and Welfare | 9 | 2026-08-20 | 2026-08-25 |
| Safety and Efficacy of J147 in Acute Ischemic Stroke J147 Emulsion for Injection, Placebo - Acute Ischemic Stroke | Phase 2 | Recruiting | Abrexa Pharmaceuticals, Inc. | 196 | 2026-07-22 | 2026-08-24 |
| Fructose for Acute Ischemic Stroke 10% Fructose Injection - Acute Ischemic Stroke | Phase 2 | Active not recruiting | Ji Xunming,MD,PhD | 46 | 2026-06-05 | 2026-06-18 |
| Spatiotemporal Evolution of Traditional Chinese Medicine Mechanisms in Acute Ischemic Stroke Treated With Dengzhan Xixin and Dengzhan Shengmai Dengzhan Shengmai - Erigeron breviscapus sequential intervention, corresponding control group sequential intervention - Ischemic Strokes, Traditional Chinese Medicine (TCM) | Phase 2 / Phase 3 | Not yet recruiting | Guangdong Provincial Hospital of Traditional Chinese Medicine | 358 | 2026-06-01 | 2026-05-18 |
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Stroke (129) · Ischemia (14) · Cerebrovascular Disorders (13) · Cerebral Infarction (11) · Hemorrhagic Stroke (9) · Thrombosis (9) · Brain Diseases (8) · Hypothermia (8) · Brain Infarction (7) · Intracranial Hemorrhages (7) · Central Nervous System Diseases (6) · Ischemic Attack, Transient (6) · Cerebral Hemorrhage (5) · cyclopia sequence (5)
Cardiovascular Diseases (368) · Nervous System Diseases (368) · Vascular Diseases (368) · Central Nervous System Diseases (366) · Brain Diseases (364) · Cerebrovascular Disorders (359) · Stroke (243) · Pathological Conditions, Signs and Symptoms (71) · Pathologic Processes (57) · Infarction (23) · Necrosis (23) · Brain Ischemia (22) · Ischemia (21) · Signs and Symptoms (19) · Hemorrhage (13)
Aspirin (17) · Tenecteplase (15) · Tissue Plasminogen Activator (15) · Sodium Chloride (14) · Tirofiban (10) · Clopidogrel (8) · Injections (8) · Standard of Care (7) · Minocycline (6) · Saline Solution (6) · TNK-tissue plasminogen activator (5) · Atorvastatin (4) · Edaravone (4) · Eptifibatide (4) · Rivaroxaban (4)
Beijing Tiantan Hospital (15) · Capital Medical University (12) · General Hospital of Shenyang Military Region (7) · Xiang Luo (6) · Xijing Hospital (6) · University Hospital Heidelberg (5) · Xuanwu Hospital, Beijing (5) · Chang Gung Memorial Hospital (4) · Christina Kruuse (4) · Lumosa Therapeutics Co., Ltd. (4) · Neuroscience Trials Australia (4) · University of California, Los Angeles (4) · Assistance Publique - Hôpitaux de Paris (3) · Biogen (3) · Dongzhimen Hospital, Beijing (3)
China (107) · United States (101) · Germany (32) · France (24) · Australia (21) · Canada (21) · Spain (20) · South Korea (18) · United Kingdom (16) · Belgium (13) · Taiwan (13) · Japan (10) · Austria (9) · Denmark (8) · Czechia (7)
Sven Poli, Dr. med. (5) · Xiang Luo (4) · Gang Zhao, MD (3) · Yongjun Wang, MD (3) · Andrea Comenducci, MD (2) · Brian Buck (2) · Bruce Campbell (2) · Christina R Kruuse, MD, PhD (2) · Christopher Chen, BMBCh, MRCP, FAMS, FRCPE (2) · Gang Zhao, M.D. (2) · Gary K Steinberg, MD, PhD (2) · Jong Sung Kim, MD, Phd (2) · Mahesh Kate (2)
PMID 25671797, PMID 34906976, PMID 36289001, PMID 16574919, PMID 19233036, PMID 19834014, PMID 20185783, PMID 20651267, PMID 22435369, PMID 22474060, PMID 22738918, PMID 23418571, PMID 25378424, PMID 25677596, PMID 25726502, PMID 26898852, PMID 29694815, PMID 31662037, PMID 32414889, PMID 33408145, PMID 33464335, PMID 35017305, PMID 36878701, PMID 38502892, PMID 38648030, PMID 39772606, PMID 39869712, PMID 40497495, PMID 41392086, PMID 41446320, PMID 42044230, PMID 9186381, PMID 10718099, PMID 11519775, PMID 12750546, PMID 15569863, PMID 15692126, PMID 16282547, PMID 16336965, PMID 16574922, PMID 16614616, PMID 16908730, PMID 18296121, PMID 18468545, PMID 18790527, PMID 18815396, PMID 19236467, PMID 19570514, PMID 19640572, PMID 19837031
2016 (4), 2015 (2), 2018 (2), 2019 (2), 1UG3NS134619-01A1 (1), 2017 (1), 2023 (1), P50NS044148 (1), P50NS044227 (1), P50NS044283 (1), P50NS049060 (1), P50NS051343 (1), R01HL080107 (1), R01NS042607 (1), R01NS050192 (1)