22 completed, 7 terminated, 6 unknown, 3 recruiting. 42 Phase 3, 6 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 42 | Completed 22, Terminated 7, Unknown 6, Recruiting 3, Withdrawn 2, Active not recruiting 1, Not yet recruiting 1 |
| Phase 2 | 6 | Completed 5, Recruiting 1 |
Follow Intraoperative Complications: new trials by email Literature Review of Intraoperative Complications trials Research Report on Intraoperative Complications
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Tranexamic Acid to Reduce Blood Loss After Varus Derotation Osteotomy Tranexamic Acid (IV), Placebo - Cerebral Palsy, Hip Surgery Corrective | Phase 3 | Not yet recruiting | Murdoch Childrens Research Institute | 52 | 2026-11-01 | 2026-10-14 |
| Phase 3 Trial of Reltodecacog Alfa (VMX-C001) vs Usual Pharmacological Care in Patients Taking a FXa Direct Oral Anticoagulant Who Require Urgent Surgery With or Without Heparin. Reltodecacog alfa, Usual Pharmacological Care - Blood Loss, Surgical, Coagulation Disorder | Phase 3 | Recruiting | VarmX B.V. | 800 | 2026-08-18 | 2026-10-14 |
| Decreasing Postoperative Blood Loss and Seizures by Timing of Intravenous Tranexamic Acid 2 Pilot Trial Before CPB Tranexamic Acid, After CPB Tranexamic Acid, Before CPB Placebo - Bleeding, Surgical Blood Loss | Phase 3 | Unknown | Hamilton Health Sciences Corporation | 40 | 2025-01-01 | 2024-10-02 |
| Epinephrine in Irrigation Fluid for Visualization During Ankle Surgery Epinephrine, Normal Saline irrigation fluid - Intraoperative Bleeding | Phase 3 | Withdrawn | The Guthrie Clinic | 2024-08-01 | 2024-10-15 | |
| Tranexamic Acid for Reduction of Transfusion in Abdominal Surgery Tranexamic Acid, Placebo - Surgical Blood Loss, Transfusion-dependent Anemia | Phase 3 | Completed | Ulrich Ronellenfitsch, MD | 892 | 2024-06-17 | 2026-10-07 |
| The Effect of Adding Either Propofol or Ketamine to Magnesium and Lidocaine Infusions in Nasal Surgeries. Intravenous Infusion of propofol, lidocaine, Magnesium sulfate, Intravenous infusion of ketamine, lidocaine, Magnesium sulfate, Intravenous infusion of dexmedetomidine, lidocaine, Magnesium sulfate - Intraoperative Bleeding | Phase 2 / Phase 3 | Recruiting | Ain Shams University | 90 | 2024-06-15 | 2024-10-09 |
| MisOpRostol Effect on Second Trimester Abortion Blood Loss Misoprostol 400mcg buccal, Placebo - Blood Loss, Surgical, Second Trimester Abortion | Phase 3 | Terminated | Stanford University | 7 | 2024-02-08 | 2025-08-24 |
| THRIVE Feasibility Trial Anesthetic technique Propofol TIVA, Anesthetic technique inhaled agent - Surgery--Complications, Anesthesia Complication | Phase 3 | Completed | Washington University School of Medicine | 300 | 2022-09-29 | 2023-11-24 |
| Tranexamic Acid During Excisional Burn Surgery Tranexamic acid, Placebo - Burns, Blood Loss, Surgical | Phase 3 | Unknown | Maasstad Hospital | 96 | 2021-12-01 | 2024-03-13 |
| The Cryopreserved vs. Liquid Platelets Trial Cryopreserved platelets, Liquid-stored platelets - Surgical Blood Loss, Hemorrhage | Phase 3 | Active not recruiting | Australian and New Zealand Intensive Care Research Centre | 388 | 2021-08-17 | 2025-01-03 |
| Tranexamic Acid Versus Misoprostol in Reducing Blood Loss in Cesarean Section in Primigravida Tranexamic acid, Misoprostol 200mcg Tab - Cesarean Section Complications, Blood Loss, Surgical | Phase 3 | Completed | Cairo University | 200 | 2021-01-01 | 2022-07-22 |
| A Phase III Study of Hemofence for Hemostasis in Patients With Uncontrolled Exudative Hemorrhage During Spinal Or Orthopedic Surgery Hemofence, Floseal hemostatic matrix - Surgical Hemorrhage | Phase 3 | Completed | BMI Korea | 172 | 2020-12-03 | 2026-09-17 |
| DEPOSITION - Decreasing Postoperative Blood Loss by Topical vs. Intravenous Tranexamic Acid in Open Cardiac Surgery Tranexamic Acid - Bleeding, Surgical Blood Loss | Phase 3 | Terminated | Population Health Research Institute | 3242 | 2019-09-17 | 2026-10-26 |
| Effect of TXA on Blood Loss in Reverse Total Shoulder Arthroplasty Tranexamic Acid, Normal Saline - Shoulder Arthritis, Blood Loss, Surgical | Phase 3 | Withdrawn | University of Kansas Medical Center | 2019-05-01 | 2024-10-15 | |
| Effect of Rectal Misoprostol in Reducing Intra-operative Blood Loss During Myomectomy Misoprostol - Blood Loss, Surgical, Uterine Myoma | Phase 3 | Completed | Pak Emirates Military Hospital | 200 | 2019-03-04 | 2021-11-05 |
| Use of Tranexamic Acid in Liposculpture Tranexamic acid - Blood Loss, Surgical | Phase 2 / Phase 3 | Completed | Total Definer Research Group | 141 | 2019-01-17 | 2020-06-12 |
| Tranexamic Acid in Adult Spinal Deformity Surgery Tranexamic Acid 100 MG/ML, Placebo - Spinal Deformity, Degenerative Lumbar Spinal Stenosis | Phase 3 | Recruiting | Hospital for Special Surgery, New York | 100 | 2018-07-11 | 2026-04-28 |
| Hemostatic Effect of Intrauterine Instillation Of Tranexamic Acid In Hysteroscopic Myomectomy Topical application Tranexamic acid, Placebo (Normal saline) - Surgical Blood Loss, Fibroid | Phase 3 | Unknown | Ain Shams University | 80 | 2017-08-01 | 2017-06-29 |
| Non-inferiority Trial of Oral Tranexamic Acid vs. Intravenous Tranexamic Acid in Joint Replacement Surgery Tranexamic Acid (Oral), Tranexamic Acid (Intravenous) - Osteoarthritis, Blood Loss, Surgical | Phase 3 | Unknown | The New England Baptist Hospital | 118 | 2015-04-01 | 2016-03-22 |
| Epidural Anesthesia Within an Enhanced Recovery Pathway in Reducing Pain in Patients Undergoing Gynecologic Surgery Epidural analgesia, Intraoperative Complication Management and Prevention, Pain Therapy - Intraoperative Complication, Malignant Female Reproductive System Neoplasm | Phase 3 | Completed | University of Wisconsin, Madison | 104 | 2015-03-17 | 2023-09-06 |
Showing 20 of 42. Sign in to see all of them.
Blood Loss, Surgical (36) · Hemorrhage (12) · Postoperative Hemorrhage (5) · Osteoarthritis (3) · Hypovolemia (2) · Pain, Postoperative (2) · Postoperative Complications (2) · Seizures (2) · Arthritis (1) · Blood Coagulation Disorders (1) · Burns (1) · Cerebral Palsy (1) · Coronary Artery Disease (1) · Depression (1)
Pathological Conditions, Signs and Symptoms (42) · Pathologic Processes (41) · Hemorrhage (24) · Signs and Symptoms (6) · Neurologic Manifestations (5) · Postoperative Complications (5) · Nervous System Diseases (4) · Arthritis (3) · Cardiovascular Diseases (3) · Joint Diseases (3) · Musculoskeletal Diseases (3) · Rheumatic Diseases (3) · Vascular Diseases (3) · Hematologic Diseases (2)
Tranexamic Acid (13) · Aprotinin (4) · Fibrinogen (3) · Misoprostol (3) · Saline Solution (3) · Sodium Chloride (3) · Adrenal Cortex Hormones (1) · Analgesia (1) · Analgesia, Epidural (1) · Anesthesia, Epidural (1) · Antifibrinolytic Agents (1) · Control Groups (1) · Dexmedetomidine (1) · Epinephrine (1) · Fibrin Tissue Adhesive (1)
Bayer (4) · Ain Shams University (2) · Fresenius Kabi Japan (2) · Rush University Medical Center (2) · Austin Health (1) · Australian and New Zealand Intensive Care Research Centre (1) · BMI Korea (1) · CSL Behring (1) · Cairo University (1) · Corewell Health East (1) · CryoLife, Inc. (1) · Ethicon, Inc. (1) · Hadassah Medical Organization (1) · Hamilton Health Sciences Corporation (1) · Hospital Universitari de Bellvitge (1)
United States (17) · Canada (8) · Germany (6) · Australia (5) · France (4) · Japan (4) · Spain (4) · United Kingdom (4) · Austria (3) · Belgium (3) · Denmark (3) · Italy (3) · Netherlands (3) · Czechia (2) · Egypt (2)
Akiyoshi Namiki, MD, PhD (2) · Andre Lamy, MD (2) · Ahmed Khairyy Makled, MD (1) · Amgad Said Abu-Gamra, MD (1) · Antoni Sabate, MD (1) · Brett R Levine, MD (1) · Erich Rutz, MD, PhD (1) · Hajer Giuma Soliman, M.B.B.CH (1) · Han Jo Kim, MD (1) · Ian Witterick, MD FRCSC (1) · James Hart, MD (1) · Kenneth Bauer, MD (1) · Kevin Baker, PhD (1) · Lisa Barroilhet (1)
PMID 10565650, PMID 11411248, PMID 11679600, PMID 18480196, PMID 19247742, PMID 19397502, PMID 19930626, PMID 22054656, PMID 23739984, PMID 26880105, PMID 27317703, PMID 27774838, PMID 28990201, PMID 30146969, PMID 30462259, PMID 30908754, PMID 36600425, PMID 37068889, PMID 37919695, PMID 38587333, PMID 39095919, PMID 39152310, PMID 39425234, PMID 41360717, PMID 41950401
2005 (2), 2004 (1), 2023 (1)