6 completed, 4 terminated, 3 unknown, 1 no longer available. 6 Phase 3, 3 Not applicable, 2 Phase 1, 1 Phase 2, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 6 | Terminated 3, Completed 1, Recruiting 1, Unknown 1 |
| Not applicable | 3 | Completed 2, Unknown 1 |
| Phase 1 | 2 | Completed 1, Terminated 1 |
| Phase 2 | 1 | Unknown 1 |
| Phase 4 | 1 | Completed 1 |
Follow Aprotinin: new trials by email Literature Review of Aprotinin trials Research Report on Aprotinin
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Clinical Trial With Aprotinin in the Acute Respiratory Distress Syndrome Treatment Aprotinin (inhaled), Placebo (Sodium Chloride) - Acute Respiratory Distress Syndrome (ARDS) | Phase 3 | Recruiting | Fundacion del Hospital Nacional de Paraplejicos para la Investigacion y la Integracion | 156 | 2026-06-18 | 2026-07-15 |
| An Open Non-comparative Study of the Efficacy and Safety of Aprotinin in Patients Hospitalized With COVID-19 Aprotinin - COVID-19 | Not applicable | Unknown | Aviron LLC | 30 | 2020-06-11 | 2020-08-26 |
| Fibrin Sealant for Cholangiotomy Closure Study Tisseel, Baxter (Aprotinin and Fibrinogen), Control - Common Bile Duct Gall Stones, Infection | Phase 2 | Unknown | Lasarettet i Enköping | 200 | 2009-01-01 | 2015-09-09 |
| Effects of Aprotinin During Cardiac Surgery/Long Term Death Rates Aprotinin, Amicar - Cardiac Surgery | Completed | State University of New York - Upstate Medical University | 462 | 2007-09-01 | 2016-04-19 | |
| Phase I Study of Aprotinin in Advanced Breast Cancer Aprotinin - Metastatic Breast Cancer | Phase 1 | Terminated | Dartmouth-Hitchcock Medical Center | 18 | 2006-07-01 | 2009-08-04 |
| Effect of Aprotinin on Transfusion Requirements in Patients Undergoing Elective Spinal Fusion Surgery Trasylol (Aprotinin, BAYA0128), Placebo - Blood Loss, Surgical, Postoperative Hemorrhage | Phase 3 | Terminated | Bayer | 54 | 2006-02-27 | 2019-06-04 |
| Efficacy and Safety of Aprotinin on Transfusion Requirements in Patients Undergoing Radical or Total Cystectomy Trasylol (Aprotinin, BAYA0128), Placebo - Blood Loss, Surgical, Postoperative Hemorrhage | Phase 3 | Terminated | Bayer | 57 | 2005-12-01 | 2014-12-17 |
| Study to Investigate the Effect of Aprotinin of Transfusion Requirements in Patients Undergoing Surgical Procedures for Lung or Esophageal Cancer Trasylol (Aprotinin, BAYA0128), Placebo - Blood Loss, Surgical | Phase 3 | Terminated | Bayer | 104 | 2005-12-01 | 2014-12-09 |
| Can Aprotinin Reduce Pancreatitis After Scoliosis Surgery Aprotinin - Pancreatitis | Phase 1 | Completed | Nemours Children's Clinic | 120 | 2005-03-01 | 2010-10-14 |
| Effect of Aprotinin on Transfusion Requirements and Blood Loss in Patients Undergoing Elective Primary Total Hip Replacement Trasylol (Aprotinin, BAYA0128), Placebo - Blood Loss, Surgical | Phase 3 | Completed | Bayer | 359 | 2005-02-01 | 2014-12-30 |
| Comparison of Aprotinin and Tranexamic Acid in Routine Cardiac Surgery aprotinin or tranexamic acid - Bleeding and Cardiac Surgery, Allogeneic Blood Transfusion | Phase 3 | Unknown | German Heart Center | 220 | 2005-01-01 | 2006-11-07 |
| Assess Efficacy and Safety of TachoComb H vs. Standard Surgical Treatment (i.e. Suturing) in Patients Undergoing Prostatectomy (TC-017-AU) Human fibrinogen/thrombin and bovine aprotinin (TachoComb H) - Control of Local Bleeding in Patients Undergoing Prostatectomy. | Phase 4 | Completed | Nycomed | 120 | 2004-05-01 | 2012-05-07 |
| Different Regimen of Aprotinine(Trasylol) Administration in Patients Receiving Antiplatelet Therapy With Clopidogrel (Plavix) Aprotinine - Coronary Artery Disease | Not applicable | Completed | Oslo University Hospital | 400 | 2004-03-01 | 2011-07-06 |
| Investigation of Leukocyte Trafficking Into Skin Blisters During Cardiopulmonary Bypass Aprotinin - Ischemic Heart Disease, Angina Pectoris | Not applicable | Completed | Imperial College London | 24 | 2003-01-01 | 2015-05-28 |
| Aprotinin US Special Access Protocol Aprotinin (Trasylol, BAYA0128) - Postoperative Hemorrhage | No longer available | Bayer | 2014-06-23 |
Blood Loss, Surgical (4) · Postoperative Hemorrhage (3) · Hemorrhage (2) · Angina Pectoris (1) · Breast Neoplasms (1) · COVID-19 (1) · Coronary Artery Disease (1) · Gallstones (1) · Infections (1) · Inflammation (1) · Myocardial Ischemia (1) · Pancreatitis (1) · Pneumonia (1) · Respiratory Distress Syndrome (1)
Bayer (5) · Aviron LLC (1) · Dartmouth-Hitchcock Medical Center (1) · Fundacion del Hospital Nacional de Paraplejicos para la Investigacion y la Integracion (1) · German Heart Center (1) · Imperial College London (1) · Lasarettet i Enköping (1) · Nemours Children's Clinic (1) · Nycomed (1) · Oslo University Hospital (1) · State University of New York - Upstate Medical University (1)
United States (7) · Germany (4) · Canada (3) · Spain (3) · United Kingdom (3) · Belgium (2) · Denmark (2) · France (2) · Sweden (2) · Australia (1) · Austria (1) · Netherlands (1) · Puerto Rico (1) · Russia (1)
Elena Simakina, MD (1) · Gabriel Sandblom, Assoc Prof (1) · Gary N Schwartz, MD (1) · Kenneth M Taylor, MD, FRCS (1) · Nancy A Nussmeier, MD (1) · Wulf Dietrich, MD, PhD (1)
PMID 18931201, PMID 21127274, PMID 34129409
2005 (2), 2025 (1)