13 unknown, 9 completed, 3 recruiting, 2 terminated. 29 Phase 2, 7 Phase 3, 2 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 29 | Unknown 13, Completed 9, Recruiting 3, Terminated 2, Active not recruiting 1, Withdrawn 1 |
| Phase 3 | 7 | Unknown 6, Recruiting 1 |
| Phase 1 | 2 | Recruiting 1, Unknown 1 |
Follow Intracranial Arteriosclerosis: new trials by email Literature Review of Intracranial Arteriosclerosis trials Research Report on Intracranial Arteriosclerosis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Role of GLP1 RA Dulaglutide on Severe Intracranial Atherosclerosis Dulaglutide - Intracranial Atherosclerosis, Stroke, Ischemic | Phase 2 / Phase 3 | Recruiting | National University of Singapore | 130 | 2025-12-17 | 2025-12-23 |
| Rifaximin SSD in Dementia Trial Rifaximin SSD 40 mg IR tablet, Placebo - Dementia Alzheimer Type, Dementia Associated With Cerebrovascular Disease | Phase 1 / Phase 2 | Recruiting | Jasmohan Bajaj | 20 | 2024-12-30 | 2026-04-03 |
| Cannabidiol's Role in Dementia Management Cannabidiol Oil - Dementia, Vascular, Dementia, Mixed | Phase 2 / Phase 3 | Unknown | Hospital Pengajar Universiti Putra Malaysia | 486 | 2024-09-01 | 2024-07-23 |
| Anticoagulation Using Rivaroxaban on Top of Aspirin in Intracranial Atherosclerotic Stenosis Rivaroxaban, Clopidogrel, Aspirin - Ischemic Stroke, Intracranial Atherosclerosis | Phase 2 / Phase 3 | Unknown | The First Affiliated Hospital with Nanjing Medical University | 1180 | 2023-12-30 | 2023-12-21 |
| Colchicine Use in Intracranial Atherosclerotic Disease Colchicine 0.5 MG - ICAD - Intracranial Atherosclerotic Disease | Phase 2 | Recruiting | Chinese University of Hong Kong | 72 | 2022-11-28 | 2026-07-30 |
| Efficacy and Safety of Tian Ma Bian Chun Zhi Gan Tablets in Mild to Moderate Vascular Dementia Tian Ma Bian Chun Zhi Gan Tablets, Placebo - Vascular Dementia, Cognitive Impairment | Phase 2 | Unknown | Dongzhimen Hospital, Beijing | 360 | 2022-05-25 | 2022-11-22 |
| A Study of the Effects of CY6463 in Participants With Alzheimer's Disease With Vascular Pathology CY6463, Placebo - Alzheimer's Disease With Vascular Pathology | Phase 2 | Terminated | Tisento Therapeutics | 12 | 2021-11-02 | 2024-10-30 |
| Trial of PCSK9 Inhibition in Patients with Acute Stroke and Symptomatic Intracranial Atherosclerosis Alirocumab - Intracranial Atherosclerosis, Acute Ischemic Stroke | Phase 2 | Active not recruiting | Chang Gung Memorial Hospital | 60 | 2021-08-01 | 2025-03-26 |
| Dapagliflozin Effect in Cognitive Impairment in Stroke Trial Dapagliflozin 10mg Tab, Statins (Cardiovascular Agents), Platelet Antiaggregant - Stroke, Ischemic, Mild Cognitive Impairment | Phase 2 / Phase 3 | Unknown | Jaime Daniel Mondragon | 270 | 2020-08-01 | 2022-10-04 |
| A Noval Tau Tracer in Young Onset Dementia 18F-PM-PBB3 - Alzheimer's Disease, Vascular Dementia | Phase 1 / Phase 2 | Unknown | Chang Gung Memorial Hospital | 100 | 2020-02-20 | 2020-01-30 |
| Trial of Remote Ischemic Pre-conditioning in Vascular Cognitive Impairment Remote ischemic conditioning - Vascular Dementia, Cerebral Small Vessel Diseases | Phase 2 | Unknown | University of Calgary | 24 | 2019-09-26 | 2022-06-09 |
| Efficacy and Safety of Ferrous Iron on the Prevention of Vascular Cognitive Impairment Among Patients With Cerebral Infarction/TIA (FAVORITE) Ferrous succinate - Vascular Cognitive Impairment, Dementia, Vascular | Phase 2 | Unknown | Beijing Tiantan Hospital | 1006 | 2019-04-01 | 2020-07-13 |
| A Double-Blind, Placebo-Controlled Safety and Efficacy Study of NA-831 N-831(Traneurocin) 10 mg QD, NA-831 (Traneurocin) 20 mg QD, NA-831 (Traneurocin) 40 mg QD - Mild Cognitive Impairment, Alzheimer Disease | Phase 2 | Completed | Biomed Industries, Inc. | 126 | 2018-09-15 | 2020-06-30 |
| Efficacy and Safety of TMBCZG in Mild to Moderate Vascular Dementia TMBCZG, placebo - Vascular Dementia | Phase 2 | Completed | Dongzhimen Hospital, Beijing | 160 | 2017-07-28 | 2021-03-02 |
| Optimized Remote Ischemic Conditioning (RIC) Treatment for Patients With Chronic Cerebral Ischemia Remote ischemic conditioning - Chronic Cerebral Ischemia, Intracranial Atherosclerosis | Phase 2 / Phase 3 | Unknown | Capital Medical University | 600 | 2017-06-01 | 2017-12-05 |
| BAC in Patient With Alzheimer's Disease or Vascular Dementia BAC, BAC Matched Vehicle - Alzheimer's Disease, Vascular Dementia | Phase 2 | Withdrawn | Botanicure Co., Ltd. | 2017-01-30 | 2026-05-20 | |
| A Study to Evaluate Efficacy and Safety of BAC in Patient With Alzheimer's Disease or Vascular Dementia BAC treatment, Matched vehicle - Alzheimer's Disease or Vascular Dementia | Phase 2 | Completed | Charsire Biotechnology Corp. | 80 | 2016-12-01 | 2022-10-13 |
| Perfusion by Arterial Spin Labelling Following Single Dose Tadalafil in Small Vessel Disease (PASTIS) Trial Tadalafil, Placebo, Cognitive functioning tests - Dementia, Vascular | Phase 2 | Completed | St George's, University of London | 55 | 2015-09-01 | 2022-10-27 |
| n-3 PUFA for Vascular Cognitive Aging Omega 3 PUFA, Placebo - Age Related Cognitive Decline, Alzheimer's Disease | Phase 2 | Unknown | Oregon Health and Science University | 102 | 2014-05-01 | 2020-09-04 |
| Symptomatic Treatment of Vascular Cognitive Impairment Galantamine, Methylphenidate, Placebo - Mild Cognitive Impairment (Vascular), Mild Cognitive Disorder (Vascular) | Phase 2 / Phase 3 | Unknown | Amsterdam UMC, location VUmc | 30 | 2014-02-01 | 2016-05-02 |
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Dementia, Vascular (22) · Alzheimer Disease (10) · Dementia (6) · Cognitive Dysfunction (5) · Ischemic Stroke (4) · Stroke (3) · Cardiovascular Diseases (2) · Cerebrovascular Disorders (2) · Heart Diseases (2) · Lewy Body Disease (2) · Memory Disorders (2) · Mixed Dementias (2) · Neurocognitive Disorders (2) · Vascular Diseases (2)
Arterial Occlusive Diseases (29) · Arteriosclerosis (29) · Brain Diseases (29) · Central Nervous System Diseases (29) · Intracranial Arterial Diseases (29) · Nervous System Diseases (29) · Cardiovascular Diseases (27) · Cerebrovascular Disorders (27) · Vascular Diseases (27) · Leukoencephalopathies (22) · Mental Disorders (21) · Neurocognitive Disorders (20) · Dementia (16) · Neurodegenerative Diseases (9)
Aspirin (3) · Clopidogrel (2) · Acetaminophen (1) · Ascorbic Acid (1) · Atorvastatin (1) · Biguanides (1) · Bromocriptine (1) · Cannabidiol (1) · Cardiovascular Agents (1) · Colchicine (1) · Dronabinol (1) · Ergoloid Mesylates (1) · Fish Oils (1) · Galantamine (1) · Hydroxymethylglutaryl-CoA Reductase Inhibitors (1)
Dongzhimen Hospital, Beijing (3) · Chang Gung Memorial Hospital (2) · National Heart, Lung, and Blood Institute (NHLBI) (2) · Amsterdam UMC, location VUmc (1) · Beijing Tiantan Hospital (1) · Biomed Industries, Inc. (1) · Botanicure Co., Ltd. (1) · Capital Medical University (1) · Charsire Biotechnology Corp. (1) · Chinese University of Hong Kong (1) · Hospital Pengajar Universiti Putra Malaysia (1) · Jaime Daniel Mondragon (1) · Jasmohan Bajaj (1) · National Ageing Research Institute, Australia (1) · National University of Singapore (1)
China (7) · United States (5) · Netherlands (2) · Taiwan (2) · Australia (1) · Canada (1) · Hong Kong (1) · Malaysia (1) · Mexico (1) · New Zealand (1) · Singapore (1) · South Korea (1) · United Kingdom (1)
Baojun Wang, Doctor (1) · Benyan Luo, Doctor (1) · Changshan Ai, Master (1) · Curt Furberg (1) · Desheng Zhou, Doctor (1) · Dongdong Yang, Doctor (1) · Duk L. Na, MD. PhD. (1) · Eric Smith, MD (1) · Gene Bowman, ND, MPH (1) · James H. Dwyer, III (1) · Jasmohan Bajaj (1) · Jeremy Dr Isaacs, MRCP PhD (1) · Jia Qian, doctor (1)
PMID 20204386, PMID 23040716, PMID 27266867, PMID 28095900, PMID 28950419, PMID 29016744, PMID 29371333, PMID 29446769, PMID 29559423, PMID 29573529, PMID 30572524, PMID 30934894, PMID 31236801, PMID 31248555, PMID 31535829, PMID 31910895, PMID 32115470, PMID 32144994, PMID 32178931, PMID 32317958, PMID 32352644, PMID 32559474, PMID 32854852, PMID 33030307, PMID 33055122, PMID 33282811, PMID 33894597, PMID 34532852, PMID 34813630, PMID 35080734, PMID 35135037, PMID 35487727, PMID 37565307, PMID 38160357, PMID 38789134, PMID 39088212, PMID 40049590, PMID 42714476
2015 (1), R01AG043398 (1), R01HL038194 (1), U01HL052073 (1)