35 completed, 5 unknown, 1 not yet recruiting, 1 recruiting. 44 Phase 1, 7 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 44 | Completed 35, Unknown 5, Not yet recruiting 1, Recruiting 1, Terminated 1, Withdrawn 1 |
| Phase 2 | 7 | Completed 4, Unknown 2, Recruiting 1 |
Follow Insomnia: new trials by email Literature Review of Insomnia trials Research Report on Insomnia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Mindfulness Meditation for Insomnia Instructed bedtime app-guided mindfulness meditation, Uninstructed app-guided mindfulness meditation, Sleep hygiene education - Sleep Initiation and Maintenance Disorders, Insomnia | Phase 1 / Phase 2 | Recruiting | Brigham and Women's Hospital | 30 | 2026-03-31 | 2026-06-23 |
| Evaluating the Efficacy and Safety of PROSOMNIA Sleep Therapy™ in Patients With Sleep Deprivation and Chronic Insomnia PROSOMNIA Sleep Therapy™ (PSTx), Anesthesia-Induced Sleep Therapy, Diprivan (propofol), Astra-Zeneca - Chronic Insomnia, Sleep Deprivation | Phase 1 | Not yet recruiting | Nyree Penn | 100 | 2025-11-01 | 2025-05-28 |
| A Clinical Study to Evaluate the Drug Interaction Between YZJ-1139 Tablets and Escitalopram Oxalate Tablets YZJ-1139 tablets, Escitalopram oxalate tablets, YZJ-1139 simulated tablets - Insomnia, Central Nervous System | Phase 1 | Completed | Shanghai Haiyan Pharmaceutical Technology Co., Ltd. | 24 | 2024-08-31 | 2026-06-30 |
| A Drug-drug Interaction Study of YZJ-1139 Tablets and Ticagrelor Tablets in Healthy Subjects YZJ-1139 tablets, Ticagrelor Tablets - Insomnia | Phase 1 | Completed | Shanghai Haiyan Pharmaceutical Technology Co., Ltd. | 27 | 2024-08-22 | 2026-06-30 |
| Pharmacokinetics and Safety Study of YZJ-1139 in Subjects With Severe Renal Impairment and Normal Renal Impairment YZJ-1139 - Insomnia, Renal Impairment | Phase 1 | Completed | Shanghai Haiyan Pharmaceutical Technology Co., Ltd. | 16 | 2024-06-03 | 2026-06-30 |
| Pharmacokinetics and Safety Study of YZJ-1139 in Subjects With Mild, Moderate and Normal Hepatic Impairment YZJ-1139 - Insomnia, Hepatic Impairment | Phase 1 | Completed | Shanghai Haiyan Pharmaceutical Technology Co., Ltd. | 24 | 2024-03-22 | 2024-11-04 |
| Investigating the Use of taVNS to Treat Insomnia in Individuals With Breast Cancer (taVNS-insomnia-BC) transauricular Vagus Nerve Stimulation - Breast Cancer, Insomnia | Phase 1 | Completed | University of Alabama at Birmingham | 20 | 2023-09-26 | 2026-06-18 |
| Comparative Pharmacokinetic (PK) Study of Ibuprofen and Diphenhydramine Hydrochloride MR Tablets in Healthy Adults Under Fasting Condition Compound ibuprofen polyrelease tablets, reference 1 (R1): Ibuprofen Tablets (Motrin IB®)reference 2 (R2): Diphenhydramine Hydrochloride Tablets (Benadryl®) - Pain, Insomnia | Phase 1 | Unknown | Overseas Pharmaceuticals, Ltd. | 16 | 2023-04-03 | 2023-02-15 |
| Shugan Jieyu Capsule for Insomnia Patients With Depressive Symptoms Experimental group: Shugan Jieyu Capsule combined with zolpidem, Control group: Placebo combined with zolpidem - Insomnia | Phase 1 | Unknown | Nanfang Hospital, Southern Medical University | 60 | 2022-11-30 | 2023-03-13 |
| The Study of Hemp Oil CBD for Evaluation of Efficacy and Safety in Treatment of Pain, Anxiety and Insomnia Management CBD - CBD, Pain, Chronic | Phase 1 | Unknown | Advanced Pain and Rehab Specialists | 30 | 2021-09-01 | 2021-08-06 |
| Recovering Damaged Cells for Sequelae Caused by COVID-19, SARS-CoV-2 PurWet, FurFat, PurApo - Sequelae of; Infection, Post Infection Glomerulonephritis | Phase 1 / Phase 2 | Unknown | All Natural Medicine Clinic, LLC | 2000 | 2021-03-01 | 2021-05-26 |
| the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics Study of HEC83518 Tablets Food, HEC83518, placebo - Insomnia | Phase 1 | Completed | Sunshine Lake Pharma Co., Ltd. | 57 | 2021-01-18 | 2026-05-01 |
| The Safety, Tolerability, Pharmacokinetics and Pharmacodynamics Study of HEC83518 Tablets in Chinses Healthy Subjects HEC83518 tablets, Placebo - Insomnia | Phase 1 | Completed | Sunshine Lake Pharma Co., Ltd. | 74 | 2020-04-01 | 2026-05-01 |
| PK/PD Study of YZJ-1139 YZJ-1139, Placebo, Zolpidem - Insomnia | Phase 1 | Completed | Shanghai Haiyan Pharmaceutical Technology Co., Ltd. | 20 | 2019-03-07 | 2024-11-12 |
| A Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Single and Multiple Doses of YZJ-1139 in Healthy Participants YZJ-1139, Placebo - Insomnia | Phase 1 | Completed | Shanghai Haiyan Pharmaceutical Technology Co., Ltd. | 104 | 2017-12-01 | 2025-02-10 |
| Repurposing Dexmedetomidine as an Orally Administered Sleep Therapeutic Dexmedetomidine, Saline Placebo - Sleep, Insomnia | Phase 1 / Phase 2 | Completed | Massachusetts General Hospital | 15 | 2016-10-01 | 2019-10-02 |
| Efficacy and Safety Study of Propofol Infusion for Refractory Chronic Primary Insomnia propofol injectable emulsion - Insomnia, Sleep Disorder | Phase 1 | Completed | Life Extension Foundation Inc. | 2 | 2013-06-01 | 2016-08-30 |
| Open-Label Study of Bioavailability of E2006 Tablet Versus Capsule Formulations E2006 - Insomnia | Phase 1 | Completed | Eisai Inc. | 40 | 2012-08-01 | 2013-05-22 |
| A 2-Part Single Dose Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of E2006 E2006 1.0 mg, E2006 2.5 mg, E2006 5.0 mg - Insomnia | Phase 1 | Completed | Eisai Inc. | 122 | 2011-10-05 | 2020-01-18 |
| Gabapentin's Effects on Insomnia in Patients With Recent Concussion Gabapentin - Insomnia | Phase 1 | Completed | State University of New York at Buffalo | 21 | 2011-08-01 | 2023-02-14 |
Showing 20 of 44. Sign in to see all of them.
Sleep Initiation and Maintenance Disorders (44) · Anxiety Disorders (3) · Sleep Deprivation (3) · Sleep Wake Disorders (3) · Chronic Pain (2) · Depression (2) · Pain (2) · Parasomnias (2) · Stress Disorders, Post-Traumatic (2) · Ageusia (1) · Alzheimer Disease (1) · Anosmia (1) · Arthritis, Reactive (1) · Autistic Disorder (1) · Bipolar Disorder (1)
Mental Disorders (44) · Nervous System Diseases (44) · Sleep Disorders, Intrinsic (44) · Dyssomnias (43) · Sleep Wake Disorders (41) · Pathological Conditions, Signs and Symptoms (8) · Neurologic Manifestations (7) · Signs and Symptoms (7) · Behavior (3) · Behavioral Symptoms (2) · Brain Diseases (2) · Central Nervous System Diseases (2) · Chronic Disease (2) · Digestive System Diseases (2) · Disease Attributes (2)
Zolpidem (6) · suvorexant (4) · zopiclone (3) · Eszopiclone (2) · ramelteon (2) · (1-aminomethyl-3,4-dimethylcyclopentyl)acetic acid (1) · Administration, Sublingual (1) · Charcoal (1) · Cognitive Behavioral Therapy (1) · Dexmedetomidine (1) · Diphenhydramine (1) · Electroencephalography (1) · Escitalopram (1) · Ethanol (1) · Exercise (1)
Shanghai Haiyan Pharmaceutical Technology Co., Ltd. (6) · Merck Sharp & Dohme LLC (5) · Eisai Inc. (2) · Eli Lilly and Company (2) · Sunshine Lake Pharma Co., Ltd. (2) · University of Utah (2) · Advanced Pain and Rehab Specialists (1) · All Natural Medicine Clinic, LLC (1) · Brigham and Women's Hospital (1) · Coeruleus Ltd. (1) · Eisai Co., Ltd. (1) · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (1) · GlaxoSmithKline (1) · Life Extension Foundation Inc. (1) · Massachusetts General Hospital (1)
United States (17) · China (10) · Netherlands (4) · United Kingdom (4) · Germany (2) · Israel (2) · Austria (1) · Denmark (1) · Finland (1) · France (1) · Hungary (1) · Japan (1) · Russia (1) · Spain (1) · Sweden (1)
Gavin West, M.D. (2) · Alexandra Evancho, DPT (1) · Annemiek Vermeeren, PhD (1) · Aziz Laurent (1) · Beth A Malow, MD, MS (1) · Bin Zhang, MD & PhD (1) · Claire C. Bourguet, Ph.D. (1) · Deborah Metzger, MD (1) · Dr. Daryl Bendel, MBChB (1) · Dr. Malgorzata Knurowska, MD (1) · Edward A Czinn, M.D. (1) · Eleornora Chiossi, MSc (1) · Fabrice Kramer, MD (1)
PMID 21966064, PMID 22549286, PMID 24587571, PMID 25661282, PMID 26240742, PMID 41107798, PMID 41345210, PMID 41904400, PMID 42482263
K23AT012475 (1), R21NR009080 (1)