10 completed, 4 unknown, 2 withdrawn, 1 not yet recruiting. 6 Phase 1, 4 Not applicable, 3 Phase 3, 3 Phase 4, 2 Phase 2.
Follow Administration, Sublingual: new trials by email Literature Review of Administration, Sublingual trials Research Report on Administration, Sublingual
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| This Randomized, Clinical Trial Evaluates the Efficacy of Oral Versus Sublingual Vitamin B12 Supplementation in Correcting Early-onset Vitamin B12 Deficiency in Adult Patients Using Proton Pump Inhibitors (PPIs). The Primary Outcome is the Change in Serum Vitamin B12 Levels Over a 6-week Cyanocobalamin 1000 Mcg Oral Tablet, Cyanocobalamin 1000 Mcg Sublingual Tablet, Proton Pump Inhibitor therapy only - Hypovitaminosis b 12 | Phase 3 | Not yet recruiting | Tanta University | 23 | 2026-12-30 | 2025-05-13 |
| Efficacy of Sublingual 5-MeO-DMT for Reducing Anxiety and Depression in MCI Sublingual administration, Electroencephalography, Biochemical mesurements - Mild Cognitive Impairment, Anxiety State | Phase 1 / Phase 2 | Completed | Biomind Labs Inc. | 20 | 2024-12-15 | 2025-04-09 |
| Safety and Efficacy of Zolpidem in the Long-Term Treatment of Insomnia Sublingual Tablet - Chronic Insomnia | Phase 3 | Unknown | EMS | 358 | 2024-06-01 | 2023-09-07 |
| Sublingual Melatonin for Anxiety and Pain in Elective Gynecologic Surgery Melatonin 3 mg Sublingual, Melatonin 6 mg Sublingual - Anxiety, Postoperative Pain | Not applicable | Completed | Benha University | 96 | 2024-01-15 | 2025-06-11 |
| Proportional Dose of Sublingual Fentanyl Tablet Based on Daily Opioid Requirement Intravenous Infusion, Sublingual Tablet - Cancer Pain, Breakthrough Pain | Not applicable | Withdrawn | Seoul National University | 2022-12-01 | 2023-08-07 | |
| DSUVIA Early Evaluation of Pain Trial Sufentanil 30 MCG Sublingual Tablet, standard care pain treatment - Traumatic Injury | Phase 3 | Completed | Frank Guyette | 150 | 2022-08-05 | 2025-04-30 |
| Melatonin Versus Hydroxizin for Pre Operative Anxiety in Elderly Patients With Hip Fracture Melatonin 5 MG Sublingual Tablet, Hydroxyzine - Preoperative Anxiety | Not applicable | Unknown | Mongi Slim Hospital | 50 | 2022-03-01 | 2022-02-04 |
| The Impact of Sublingual Sufentanil on Postoperative Pain and Analgesic Requirements in Spine Surgery Patients Sublingual Tablet - Spine Fusion, Pain, Postoperative | Phase 4 | Completed | Brigham and Women's Hospital | 199 | 2020-12-01 | 2025-03-30 |
| Safety, Tolerability and Pharmacokinetics of Y-2(Edaravone And Borneol) Sublingual Tablet Y-2(Edaravone And Borneol) Sublingual Tablet - Stroke, Acute, Intracranial Hemorrhages | Phase 1 | Unknown | Yantai YenePharma Co., Ltd. | 24 | 2018-10-25 | 2020-02-17 |
| Evaluating MED2005 & Nitrostat Bioavailability MED2005, Nitrostat 0.6Mg Sublingual Tablet, Nitro Pohl - Erectile Dysfunction | Phase 1 | Completed | Futura Medical Developments Ltd. | 40 | 2017-11-15 | 2019-07-05 |
| Esophageal Food Impaction Nitrostat 0.4Mg Sublingual Tablet - Esophageal Food Bolus Obstruction | Phase 4 | Completed | HealthPartners Institute | 20 | 2017-08-25 | 2023-02-08 |
| Pharmacokinetics of Nicotine Sublingual Tablets Versus Nicorette Lozenge in Healthy Smokers Sublingual tablet 4 mg versus Nicorette Lozenge 4mg - Tobacco Use Disorder, Cigarette Smoking | Phase 1 | Completed | Friends Research Institute, Inc. | 24 | 2017-05-25 | 2017-12-04 |
| The Effects of Buprenorphine on Responses to Verbal Tasks Buprenorphine 0.2 MG Sublingual Tablet, Placebo, Buprenorphine 0.4 MG Sublingual Tablet - Basic Science | Early Phase 1 | Completed | University of Chicago | 48 | 2013-09-01 | 2019-08-01 |
| Driving Performance After Middle of the Night Administration of 3.5 mg Zolpidem Tartrate Sublingual Tablet zopiclone, zolpidem tartrate sublingual tablet, Placebo (sublingual tablet) - Insomnia | Phase 1 | Completed | Transcept Pharmaceuticals | 40 | 2010-06-01 | 2012-02-14 |
| Study to Evaluate Subclinical Atherosclerosis (an Early Sign of Heart Disease) in Healthy Adult Immigrant Asian Indians Flow Mediated Doppler (FMD), Nitroglycerin 0.4 mg sublingual - Healthy | Not applicable | Withdrawn | Northwell Health | 2010-04-01 | 2013-06-12 | |
| Transfer From Methadone to Buprenorphine Maintenance Treatment Using Buprenorphine Patches Buprenorphine patch and sublingual tablets - Heroin Addiction | Phase 4 | Unknown | Psychiatric University Hospital, Zurich | 10 | 2008-08-01 | 2008-09-10 |
| Study of Nighttime Dosing of Sublingual Tizanidine (12 mg) in Multiple Sclerosis (MS) Patients With Significant Spasticity Tizanidine (sublingual or oral) - Muscle Spasticity | Phase 1 / Phase 2 | Completed | Teva GTC | 20 | 2006-12-01 | 2009-01-21 |
Anxiety Disorders (2) · Pain, Postoperative (2) · Sleep Initiation and Maintenance Disorders (2) · Agnosia (1) · Breakthrough Pain (1) · Cancer Pain (1) · Cigarette Smoking (1) · Cognitive Dysfunction (1) · Depression (1) · Erectile Dysfunction (1) · Heroin Dependence (1) · Hip Fractures (1) · Intracranial Hemorrhages (1) · Multiple Sclerosis (1) · Muscle Spasticity (1)
Benha University (1) · Biomind Labs Inc. (1) · Brigham and Women's Hospital (1) · EMS (1) · Frank Guyette (1) · Friends Research Institute, Inc. (1) · Futura Medical Developments Ltd. (1) · HealthPartners Institute (1) · Mongi Slim Hospital (1) · Northwell Health (1) · Psychiatric University Hospital, Zurich (1) · Seoul National University (1) · Tanta University (1) · Teva GTC (1) · Transcept Pharmaceuticals (1)
United States (6) · Argentina (1) · Brazil (1) · Egypt (1) · Israel (1) · Netherlands (1) · Switzerland (1) · United Kingdom (1)
Annemiek Vermeeren, PhD (1) · Arnon Karni, MD (1) · Frank J Vocci, Ph.D. (1) · Harriet de Wit, Ph.D. (1) · Jason Sperry, MD (1) · Jee Youn Moon, MD, PhD (1) · Jerome Jaffe, M.D. (1) · Lukas Boesch, PhD (1) · Martin A. Bruno, PhD (1) · Rajiv Jauhar, MD (1) · Richard D. Urman, MD (1) · Rudolf Stohler, MD (1) · Sam Stellpflug, MD (1) · Samuel Israel, Israel (1)