14 terminated. 14 Phase 2, 4 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 14 | Terminated 14 |
| Phase 1 | 4 | Terminated 4 |
Follow Hypoxia: new trials by email Literature Review of Hypoxia trials Research Report on Hypoxia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study of NKT2152, a HIF2α Inhibitor, in Patients With Advanced Clear Cell Renal Cell Carcinoma Oral NKT2152 - ccRCC, Clear Cell Renal Cell Carcinoma | Phase 1 / Phase 2 | Terminated | NiKang Therapeutics, Inc. | 120 | 2021-10-26 | 2025-11-12 |
| A Study of Micro Dose Ambrisentan in Hospitalized Patients With Respiratory Insufficiency Due to COVID-19 Ambrisentan, Placebo - Covid19, Hypoxemia | Phase 2 | Terminated | Noorik Biopharmaceuticals AG | 88 | 2021-02-08 | 2023-03-21 |
| Hyperbaric Oxygen as an Adjuvant Treatment for Patients With Covid-19 Severe Hypoxemia Hyperbaric Oxygen - Covid19 | Phase 2 | Terminated | Asociación Argentina de Medicina Hiperbárica e Investigación | 40 | 2020-07-06 | 2021-01-15 |
| Study to Evaluate the Effect of GBT440 Administered to Subjects With IPF on Supplemental Oxygen at Rest GBT440 - Idiopathic Pulmonary Fibrosis, Hypoxemia | Phase 2 | Terminated | Global Blood Therapeutics | 14 | 2016-11-01 | 2020-08-21 |
| Tumor Hypoxia With HX4 PET in Several Diseases Injection with the hypoxia tracer [18F]HX4, - Prostatic Neoplasms, Esophageal Neoplasms | Phase 2 | Terminated | Maastricht Radiation Oncology | 1 | 2016-05-01 | 2019-03-08 |
| TIBOHCA: Safety, Tolerability and Pharmacokinetics of 2-Iminobiotin (2-IB) After OHCA 2-Iminobiotin - Cardiac Arrest, Hypoxic Ischemic Brain Injury | Phase 1 / Phase 2 | Terminated | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | 21 | 2016-05-01 | 2021-02-18 |
| Study for Treatment of Patients With Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck or Skin TH-4000 (Tarloxotinib) - Metastatic Head-and-neck Squamous-cell Carcinoma | Phase 2 | Terminated | Rain Oncology Inc | 30 | 2015-08-01 | 2023-01-12 |
| Study for Treatment With TH-4000 (Tarloxotinib) in Epidermal Growth Factor Receptor (EGFR) Mutant, T790M-negative Non-small Cell Lung Cancer (NSCLC) Patients TH-4000 (Tarloxotinib) - Non-small Cell Lung Cancer, NSCLC | Phase 2 | Terminated | Rain Oncology Inc | 21 | 2015-06-01 | 2023-01-12 |
| PET CT With HX4 in Cervix Cancer injection with [18F] HX4 and PET imaging - Cervix Cancer | Phase 2 | Terminated | Maastricht Radiation Oncology | 4 | 2014-11-01 | 2019-03-08 |
| Topiramate in Neonates Receiving Whole Body Cooling for Hypoxic Ischemic Encephalopathy Topiramate, Placebo - Hypoxic Ischemic Encephalopathy | Phase 1 / Phase 2 | Terminated | Kristin R Hoffman | 34 | 2013-02-01 | 2024-06-11 |
| Nitroglycerin in Non-small Cell Lung Cancer Nitroglycerin patch - Non Small Cell Lung Cancer (NSCLC) | Phase 2 | Terminated | Maastricht Radiation Oncology | 47 | 2011-12-01 | 2019-02-15 |
| Phase 2 Study of PEG-Intron in Hereditary Hemorrhagic Telangiectasia Pegylated Interferon Alpha2b, Standard care - Anemia, Liver Disease | Phase 2 | Terminated | Mayo Clinic | 10 | 2007-01-01 | 2013-02-22 |
| Intrathecal Baclofen Therapy and Paroxysmal Dysautonomia in Severe Brain-Injured Patients baclofen (drug) - Traumatic Brain Injury, Cerebral Anoxia | Phase 2 | Terminated | University Hospital, Bordeaux | 4 | 2003-03-01 | 2007-06-13 |
| Inhaled Nitric Oxide in Neonates With Elevated A-a DO2 Gradients Not Requiring Mechanical Ventilation nitric oxide for inhalation, Oxygen - Lung Disease, Hypoxemia | Phase 1 / Phase 2 | Terminated | Mallinckrodt | 7 | 2002-05-01 | 2016-10-19 |
COVID-19 (2) · Carcinoma, Non-Small-Cell Lung (2) · Carcinoma, Squamous Cell (2) · Hypoxia-Ischemia, Brain (2) · Acidosis, Respiratory (1) · Anemia (1) · Anemia, Iron-Deficiency (1) · Autonomic Nervous System Diseases (1) · Brain Injuries (1) · Brain Injuries, Traumatic (1) · Brain Neoplasms (1) · Carcinoma, Renal Cell (1) · Coma (1) · Esophageal Neoplasms (1)
Pathological Conditions, Signs and Symptoms (14) · Signs and Symptoms (14) · Signs and Symptoms, Respiratory (14) · Neoplasms (6) · Neoplasms by Site (6) · Respiratory Tract Diseases (6) · Lung Diseases (5) · Brain Diseases (4) · Central Nervous System Diseases (4) · Nervous System Diseases (4) · Carcinoma (3) · Neoplasms by Histologic Type (3) · Neoplasms, Glandular and Epithelial (3) · Urogenital Diseases (3)
3-fluoro-2-(4-((2-nitro-1H-imidazol-1-yl)methyl)-1H-1,2,3-triazol-1-yl)propan-1-ol (2) · Injections (2) · 2-iminobiotin (1) · Baclofen (1) · Endothelium-Dependent Relaxing Factors (1) · Hyperbaric Oxygenation (1) · Inhalation (1) · Magnetic Resonance Spectroscopy (1) · Nitric Oxide (1) · Nitroglycerin (1) · Oxygen (1) · Pharmaceutical Preparations (1) · Propylene Glycol (1) · Standard of Care (1) · Topiramate (1)
Maastricht Radiation Oncology (3) · Rain Oncology Inc (2) · Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) (1) · Asociación Argentina de Medicina Hiperbárica e Investigación (1) · Global Blood Therapeutics (1) · Kristin R Hoffman (1) · Mallinckrodt (1) · Mayo Clinic (1) · NiKang Therapeutics, Inc. (1) · Noorik Biopharmaceuticals AG (1) · University Hospital, Bordeaux (1)
United States (7) · Netherlands (4) · Australia (2) · Argentina (1) · Croatia (1) · France (1) · Spain (1) · United Kingdom (1)
Stephen Liu (2) · Emmanuel Cuny, Professor (1) · Fabrizio Verdini, MD (1) · Janneke Horn, MD, PhD (1) · Karen L Swanson, DO (1) · Kristin R Hoffman, MD (1) · Liliana Jorda-Vargas (1) · Mariana Cannellotto, MD (1) · Mariano Duarte, PhD (1) · Paul Perez, Dr (1) · Philippe Lambin, MD, PhD (1) · Philippe Lambin, Prof. dr. (1) · Philippe Lambin, prof MD PhD (1) · Rok Civljak, MD (1) · Waldemar Carlo, MD (1)