7 completed, 5 terminated, 3 unknown, 2 not yet recruiting. 14 Not applicable, 2 Phase 2, 1 Phase 1, 1 Phase 3.
Follow Acidosis, Respiratory: new trials by email Literature Review of Acidosis, Respiratory trials Research Report on Acidosis, Respiratory
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Extracorporeal Carbon Dioxide Removal Plus Noninvasive Ventilation in Patients With COPD Not Eligible for Intubation Extracorporeal Carbon Dioxide Removal, Noninvasive Ventilation - Acute Exacerbation of Chronic Obstructive Pulmonary Disease | Not applicable | Not yet recruiting | Hospital del Mar Research Institute (IMIM) | 14 | 2026-09-01 | 2026-08-25 |
| Nasal High Flow Versus Non-invasive Ventilation for Early Treatment of Acute Exacerbation of Chronic Obstructive Pulmonary Disease With Hypercapnic Acidosis Ventilatory support via nasal high flow, Ventilatory support via NIV - Acute Exacerbation of Chronic Obstructive Pulmonary Disease, Hypercapnic Acidosis | Not applicable | Recruiting | University Hospital, Montpellier | 174 | 2026-06-16 | 2026-06-22 |
| Evaluation of the Effects on Carbon Dioxide (paCO2) of a New Oronasal Mask in Patients With Severe COPD Exacerbation Requiring Non-Invasive Mechanical Ventilation OptiNIV, Visairo - COPD, Respiratory Acidosis | Not applicable | Not yet recruiting | IRCCS Azienda Ospedaliero-Universitaria di Bologna | 21 | 2025-08-01 | 2025-07-23 |
| VentilO Prospective Study Clinicians, VenitlO - Mechanical Ventilation Complication, Respiratory Acidosis | Not applicable | Active not recruiting | Laval University | 76 | 2025-04-24 | 2026-11-05 |
| High Flow Oxygen Therapy in Patients Undergoing Bronchoscopy Under Sedation High Flow Oxygen Therapy (HFOT) - Respiratory Failure, Hypercapnic Acidosis | Not applicable | Unknown | Cardarelli Hospital | 100 | 2024-09-01 | 2024-02-13 |
| Clinical Stabilization of Hypercapnia: NIPPV v HVNI High Velocity Nasal Insufflation (HVNI), Noninvasive Positive Pressure Ventilation (NIPPV) - Hypercapnic Respiratory Failure, Chronic Obstructive Pulmonary Disease | Not applicable | Completed | Vapotherm, Inc. | 68 | 2020-11-11 | 2024-08-09 |
| Efficacy of Volume Ventilation in Patients With Acute Respiratory Failure at Risk of Obstructive Apneas or Obesity Hypoventilation AVAPS-AE mode during NIV, S/T mode during NIV - Acute Respiratory Failure, Hypercapnic Respiratory Failure | Not applicable | Terminated | University Hospital, Rouen | 14 | 2019-12-04 | 2026-04-15 |
| Determination of the Dissociation Constant (Ka) of Plasma and Whole Blood in Septic Patients In vitro determination the dissociation constant (Ka) and total amount of non-volatile buffers (Atot) in isolated plasma., In vitro determination the dissociation constant (Ka) and total amount of non-volatile buffers (Atot) in whole blood, Biomolecular analysis of plasma proteins. - Sepsis, Septic Shock | Unknown | Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico | 90 | 2019-06-03 | 2019-06-04 | |
| THRIVE Apneic Ventilation With Standardized Airway Management During General Anesthesia. Apneic ventilation - Apnea, Ventilation Therapy; Complications | Unknown | Copenhagen University Hospital, Rigshospitalet | 36 | 2019-01-08 | 2019-01-23 | |
| High Flow Oxygen in Patients Undergoing Suspension Laryngoscopy Under General Anesthesia Nasal High Flow Oxygen - Laryngoscopy, Apnea | Not applicable | Terminated | CMC Ambroise Paré | 29 | 2018-07-05 | 2026-04-08 |
| Non Carbonic Buffer Power of Critical Ill Patients With Sepsis In vitro determination of non-carbonic buffer power, Classic description of acid-base status - Acid-Base Imbalance, Respiratory Acidosis | Completed | Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico | 36 | 2018-03-07 | 2019-04-25 | |
| Gas Mask and Chronic Obstructive Pulmonary Disease (COPD): New Understanding on the Respiratory Index Impact? measurement of the work of breathing, Gas Mask - Work of Breathing | Not applicable | Completed | Laval University | 9 | 2016-06-01 | 2016-09-29 |
| FIRST-line Support for Assistance in Breathing in Children (FIRST-ABC) Feasibility Study Treatment strategy: Non-invasive respiratory support delivered via high flow nasal cannula, Treatment strategy: Non-invasive respiratory support delivered via continuous positive airway pressure - Hypoxia, Respiratory Acidosis | Phase 2 / Phase 3 | Completed | Great Ormond Street Hospital for Children NHS Foundation Trust | 121 | 2015-11-01 | 2016-12-16 |
| The Gas Mask: the Effects on Respiration! measurement of the work of breathing, Gas mask - Work of Breathing | Not applicable | Completed | Laval University | 15 | 2015-06-01 | 2016-09-29 |
| Efficacy and Safety of Non-invasive Ventilation by Calibrated Leak in the Treatment of Respiratory Acidosis in ICU Non-Invasive Ventilation with Homecare ventilator, Non-Invasive Ventilation with ICU ventilator - Respiratory Acidosis in ICU Patients | Not applicable | Terminated | University Hospital, Grenoble | 7 | 2015-05-27 | 2018-05-14 |
| Treatment of Dyspnea in Do-not-intubate Patients NIV, CPAP, Standard oxygen - Acute Respiratory Failure, Acute on Chronic Respiratory Failure | Terminated | Tufts Medical Center | 400 | 2014-04-01 | 2025-05-13 | |
| Clinical Study to Determine the Optimal Operation Parameters During CO2 Removal With the Abylcap® System Abylcap® System: blood flow (QB): 200mL/min; gas flow (QG):7L/min, Abylcap® System: blood flow (QB): 300mL/min; gas flow (QG):7L/min, Abylcap® System: blood flow (QB): 400mL/min; gas flow (QG):7L/min - ARDS (Acute Respiratory Distress Syndrome), Respiratory Acidosis | Not applicable | Completed | University Hospital, Ghent | 4 | 2014-02-20 | 2022-12-29 |
| Pulmonary Vascular Effects of Respiratory Rate & Carbon Dioxide HLR, EHR - Low Tidal Volume Ventilation, Acute Respiratory Distress Syndrome | Not applicable | Withdrawn | Beth Israel Deaconess Medical Center | 2013-09-01 | 2017-02-27 | |
| Normalizing CO2 in Chronic Hyperventilation by a Novel Breathing Mask: A Pilot Study Partial Rebreathing Mask - Hyperventilation, Chronic Idiopathic Hyperventilation | Not applicable | Completed | University of Aarhus | 6 | 2011-02-01 | 2016-05-19 |
| Inhaled Nitric Oxide in Neonates With Elevated A-a DO2 Gradients Not Requiring Mechanical Ventilation nitric oxide for inhalation, Oxygen - Lung Disease, Hypoxemia | Phase 1 / Phase 2 | Terminated | Mallinckrodt | 7 | 2002-05-01 | 2016-10-19 |
Hypoxia (5) · Respiratory Insufficiency (5) · Alkalosis, Respiratory (3) · Apnea (3) · Dyspnea (3) · Pulmonary Disease, Chronic Obstructive (3) · Acid-Base Imbalance (2) · Hypercapnia (2) · Acidosis (1) · Acute Lung Injury (1) · Critical Illness (1) · Emergencies (1) · Hyperventilation (1) · Hypoventilation (1)
Metabolic Diseases (20) · Nutritional and Metabolic Diseases (20) · Respiration Disorders (20) · Respiratory Tract Diseases (20) · Acidosis (19) · Acid-Base Imbalance (18) · Respiratory Insufficiency (15) · Pathological Conditions, Signs and Symptoms (14) · Signs and Symptoms (11) · Signs and Symptoms, Respiratory (11) · Disease Attributes (5) · Lung Diseases (5) · Pathologic Processes (5) · Alkalosis (3) · Chronic Disease (3)
Noninvasive Ventilation (2) · Respiratory Protective Devices (2) · Endothelium-Dependent Relaxing Factors (1) · Inhalation (1) · Nitric Oxide (1) · Nurse Clinicians (1) · Oxygen (1)
Laval University (3) · Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico (2) · Beth Israel Deaconess Medical Center (1) · CMC Ambroise Paré (1) · Cardarelli Hospital (1) · Copenhagen University Hospital, Rigshospitalet (1) · Great Ormond Street Hospital for Children NHS Foundation Trust (1) · Hospital del Mar Research Institute (IMIM) (1) · IRCCS Azienda Ospedaliero-Universitaria di Bologna (1) · Mallinckrodt (1) · Tufts Medical Center (1) · University Hospital, Ghent (1) · University Hospital, Grenoble (1) · University Hospital, Montpellier (1) · University Hospital, Rouen (1)
Italy (5) · France (4) · United States (4) · Canada (3) · Denmark (2) · Belgium (1) · Czechia (1) · Spain (1) · United Kingdom (1)
Giacomo Grasselli, MD (2) · Thomas Langer, MD (2) · Andrew Meltzer, MD, MS (1) · Anthony Innabi, MBA, RRT-NPS (1) · Antoine Cuvelier, MD, PhD (1) · Antonio M Pesenti, MD (1) · Antonio Pesenti, MD (1) · Christopher W Jones, MD (1) · Cynthia Pfeiffer, MD (1) · Daniel Talmor, MD MPH (1) · David Yamane, MD (1) · Francois Lellouche, Doctorate (1) · Francois Lellouche, PhD (1) · Frantisek Duska, MD (1)
PMID 32071135, PMID 19183804, PMID 28606907, PMID 29866165, PMID 30065082, PMID 36524243, PMID 41711585