10 completed, 4 terminated, 2 unknown, 1 recruiting. 17 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 17 | Completed 10, Terminated 4, Unknown 2, Recruiting 1 |
Follow Hyponatremia: new trials by email Literature Review of Hyponatremia trials Research Report on Hyponatremia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| CReep and Maintenance flUid Sodium Chloride ADministration rEduction in cRitically Ill adultS Glucose 5% for fluid creep, NaCl 0.9% (normal saline) for fluid creep, PlasmaLyte as maintenance fluid - Critical Care, Intensive Care, Fluid Accumulation | Phase 4 | Recruiting | University Hospital, Antwerp | 640 | 2025-10-07 | 2026-02-03 |
| Effects of the SGLT2 Inhibitor Empagliflozin in Patients With Euvolemic and Hypervolemic Hyponatremia Empagliflozin 25 MG, Placebo - Hyponatremia, SIADH | Phase 4 | Completed | University Hospital, Basel, Switzerland | 113 | 2021-02-04 | 2026-09-22 |
| Early Sodium Intake in Preterm Newborns Sodium < 1mEq/kg/day, Sodium 5mEq/kg/day - Hyponatremia, Premature | Phase 4 | Completed | Hospital del Niño "Dr. Federico Gomez Santos" | 52 | 2018-03-30 | 2020-04-21 |
| Intravenous Fluids in Hospitalised Children Plasmalyte Glucos 50 mg/mL, 0.45% saline in 5% dextrose - Hypokalemia, Hyponatremia | Phase 4 | Completed | University of Oulu | 660 | 2016-10-03 | 2019-08-22 |
| Tolvaptan for Advanced or Refractory Heart Failure Tolvaptan, Standard of care diuretic therapy - Heart Failure, Hyponatremia | Phase 4 | Terminated | University of Calgary | 9 | 2016-10-01 | 2020-07-27 |
| Efficacy and Safety of Rapid Intermittent Compared With Slow Continuous Correction in Severe Hyponatremia Patients 3% hypertonic saline - Hyponatremia Symptomatic | Phase 4 | Completed | Seoul National University Hospital | 178 | 2016-08-01 | 2020-04-09 |
| Regional Tolvaptan Registry Tolvaptan, No intervention - Decompensated Heart Failure, Hyponatremia | Phase 4 | Unknown | Cardiology Research UBC | 25 | 2016-05-01 | 2018-08-10 |
| Tolvaptan for Hyponatremia in Cirrhotic Patients With Ascites Tolvaptan, placebo - Hyponatremia, Ascites | Phase 4 | Unknown | Konkuk University Medical Center | 105 | 2012-11-01 | 2012-10-30 |
| Post Transjugular Intrahepatic Portosystemic Shunt (Tips) Albumine Infusion to Prevent Hepatic Encephalopathy Albumin - Hepatic Encephalopathy | Phase 4 | Completed | University of Roma La Sapienza | 20 | 2012-09-01 | 2013-12-17 |
| Effect of Samsca on Control of Hyponatremia and Extracellular Fluid in Cirrhotic Patients With Ascites Tolvaptan, Placebo - Hyponatremia and Extracellular Fluid in Cirrhotic | Phase 4 | Terminated | Korea Otsuka Pharmaceutical Co., Ltd. | 74 | 2012-04-01 | 2022-03-04 |
| Tolvaptan to Reduce Length of Stay in Hospitalized Patients With Cirrhosis and Hyponatremia Tolvaptan, Placebo, Hepatic Encephalopathy Assessment - Hyponatremia | Phase 4 | Terminated | NYU Langone Health | 2 | 2012-03-01 | 2017-12-11 |
| Tolvaptan in Hyponatremic Cancer Patients Tolvaptan, Placebo - Advanced Cancers | Phase 4 | Completed | M.D. Anderson Cancer Center | 52 | 2011-05-01 | 2020-09-23 |
| Effect of Midodrine and Albumine in the Prevention of Complications in Cirrhotic Patients Awaiting Liver Transplantation albumin, Midodrine, Placebo - Renal Failure, Hyponatremia | Phase 4 | Completed | Hospital Clinic of Barcelona | 199 | 2008-08-01 | 2016-08-18 |
| Use of Conivaptan (Vaprisol) for Hyponatremic Neuro-ICU Patients Conivaptan - Hyponatremia | Phase 4 | Terminated | Northwestern University | 6 | 2008-08-01 | 2022-03-28 |
| Pico-Salax Colonic Preparation Study: Quantifying Electrolyte and Volume Status Changes Pico-Salax - Hemodynamics, Hyponatremia | Phase 4 | Completed | Queen's University | 20 | 2008-07-01 | 2015-09-22 |
| A Study of Multiple Dosing Regimens of IV Conivaptan in Subjects With Euvolemic or Hypervolemic Hyponatremia Conivaptan, placebo - Hyponatremia, Euvolemia | Phase 4 | Completed | Cumberland Pharmaceuticals | 121 | 2007-01-01 | 2014-05-15 |
| Introduction of Hypo-osmolar ORS for Routine Use Hypo-osmolar ORS - Diarrhoea | Phase 4 | Completed | International Centre for Diarrhoeal Disease Research, Bangladesh | 75000 | 2002-12-01 | 2022-02-11 |
Fibrosis (2) · Hepatic Encephalopathy (2) · Renal Insufficiency (2) · Acute Kidney Injury (1) · Ascites (1) · Critical Illness (1) · Dehydration (1) · Diabetes Insipidus (1) · Diarrhea (1) · Edema (1) · Gastrointestinal Hemorrhage (1) · Heart Failure (1) · Hypernatremia (1) · Hypokalemia (1)
Metabolic Diseases (17) · Nutritional and Metabolic Diseases (17) · Water-Electrolyte Imbalance (17) · Pathological Conditions, Signs and Symptoms (7) · Female Urogenital Diseases and Pregnancy Complications (5) · Pathologic Processes (5) · Urogenital Diseases (5) · Digestive System Diseases (4) · Female Urogenital Diseases (4) · Kidney Diseases (4) · Liver Diseases (4) · Male Urogenital Diseases (4) · Nervous System Diseases (4) · Urologic Diseases (4) · Brain Diseases (3)
Tolvaptan (6) · Albumins (2) · Glucose (2) · conivaptan (2) · Midodrine (1) · Pico-Salax (1) · Plasmalyte A (1) · Saline Solution (1) · Saline Solution, Hypertonic (1) · Serum Albumin, Human (1) · Sodium Chloride (1) · Sugars (1) · empagliflozin (1)
Cardiology Research UBC (1) · Cumberland Pharmaceuticals (1) · Hospital Clinic of Barcelona (1) · Hospital del Niño "Dr. Federico Gomez Santos" (1) · International Centre for Diarrhoeal Disease Research, Bangladesh (1) · Konkuk University Medical Center (1) · Korea Otsuka Pharmaceutical Co., Ltd. (1) · M.D. Anderson Cancer Center (1) · NYU Langone Health (1) · Northwestern University (1) · Queen's University (1) · Seoul National University Hospital (1) · University Hospital, Antwerp (1) · University Hospital, Basel, Switzerland (1) · University of Calgary (1)
Canada (3) · South Korea (3) · United States (3) · Bangladesh (1) · Belgium (1) · Finland (1) · Germany (1) · India (1) · Israel (1) · Mexico (1) · Netherlands (1) · Spain (1) · Switzerland (1)
Abdulla K. Salahudeen, MD (1) · Andrew M Naidech, MD, MSPH (1) · Art Wheeler, MD (1) · Ben D Valdes, MD (1) · Carlos Sanchez, MD (1) · Jonathan Howlett, MD (1) · Julie Refardt, MD (1) · June Sung Lee, MD, PhD (1) · Lawrence Hookey, MD (1) · Niels Van Regenmortel, MD, PhD (1) · Nur H Alam, MD (1) · Samuel Sigal, MD (1) · Sean Virani, MD, MSc, MPH, FRCPC (1) · Seon Ha Baek, PhD (1)
PMID 20568023, PMID 24569125, PMID 28356136, PMID 30138685, PMID 33104176, PMID 33104189
2025 (1)