428 completed, 107 unknown, 50 terminated, 49 recruiting. 258 Not applicable, 89 Phase 3, 89 Phase 4, 76 Phase 2, 23 Phase 1.
Follow Water-Electrolyte Imbalance: new trials by email Literature Review of Water-Electrolyte Imbalance trials Research Report on Water-Electrolyte Imbalance
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Finerenone for AKI: a Multicenter, Randomized, Placebo-Controlled Feasibility Pilot Trial Finerenone (BAY94-8862 ) 10 mg, Placebo - Acute Kidney Injury, Renal Insufficiency,Chronic | Not applicable | Not yet recruiting | Jean-Maxime Côté | 72 | 2027-01-01 | 2026-08-20 |
| Can Changes in Dialysate Sodium Concentration Improve Blood Pressure and Endothelial Function in Chronic HD Patients? Low-Sodium Dialysate (133 mmol/L), Standard-Sodium Dialysate (139 mmol/L) - Dialysis Dependent Chronic Kidney Disease, Dialysis Patients | Not applicable | Not yet recruiting | Gødstrup Hospital | 25 | 2026-11-01 | 2026-09-15 |
| Personalised Nutritional Care in Older Patients With Pancreatic Ductal Adenocarcinoma Experimental: Personalised nutritional care delivered by a trained dietitian - Pancreatic Cancer | Not applicable | Not yet recruiting | Inna Chen, MD | 250 | 2026-11-01 | 2026-09-16 |
| Effects of Increased Water Intake on Hormonal Response, Hydration Status, and Physical Function in Low-drinking Older Adults Water - Dehydrated, Water-Electrolyte Imbalance, Malnutrition, Dehydration (Physiology) | Not applicable | Not yet recruiting | Polytechnic University of Santarém | 38 | 2026-11-01 | 2026-10-23 |
| Ondansetron to Prevent Oral Rehydration Failure in Children With Cholera Ondansetron, Standard Cholera Care - Cholera (Disorder) | Phase 2 | Not yet recruiting | Public Interest Science Center | 120 | 2026-10-20 | 2026-10-19 |
| Ionized Calcium as a Severity Marker in Septic Shock Patients Sepsis, Septic Shock | Not yet recruiting | Assiut University | 160 | 2026-10-01 | 2026-09-10 | |
| Rapid Rehydration for Severe Hypernatremia Intravenous Dextrose 5% solution - Hypernatremia | Phase 2 | Not yet recruiting | Columbia University | 80 | 2026-10-01 | 2026-08-24 |
| Safety of a Healthy Plant-based Diet With Higher Potassium Content, Compared to a Healthy Plant-based Diet With Limited Potassium Content in Patients With Chronic Kidney Disease: A Pilot Study Healthy plant-based diet (healthy-PBD), Potassium-restricted plant-based diet - Hyperkalemia, Chronic Kidney Disease (Stages 4 and 5) | Not applicable | Recruiting | Karolinska Institutet | 30 | 2026-09-29 | 2026-10-02 |
| A Two-Part, Open-Label, Phase 3 Study Evaluating the Efficacy and Safety of WS016 for the Treatment of Hyperkalemia WS016 - Hyperkalemia | Phase 3 | Recruiting | Waterstone Pharmaceutical (Wuhan) Co., LTD. | 300 | 2026-09-25 | 2026-10-20 |
| Hydration Intervention to Decrease Side Effects Associated With GLP - 1 RA Therapy Hydration Plus, Control - Obesity & Overweight, Type 2 Diabetes | Not applicable | Recruiting | State University of New York at Buffalo | 30 | 2026-09-24 | 2026-10-02 |
| The GranStone Trial empagliflozin (Jardiance) 25 mg, Losartan 100 mg - Paraffinoma, Granuloma, Foreign-Body | Phase 2 / Phase 3 | Not yet recruiting | Martin Blomberg Jensen | 100 | 2026-09-01 | 2026-09-18 |
| Liberalizing Potassium Restrictions in Patients Receiving Hemodialysis Liberalized Potassium Diet, Low Potassium Diet - End Stage Kidney Disease (ESKD), Hemodialysis | Not applicable | Not yet recruiting | University of Ontario Institute of Technology | 148 | 2026-08-01 | 2026-08-19 |
| Validation of a Wearable Bioimpedance Sensor for Hydration Monitoring Bioimpedance sensor - Dehydration, Hypovolemia | Not yet recruiting | Mode Sensors AS | 60 | 2026-08-01 | 2026-06-17 | |
| Effects of Minimally vs. Ultra-Processed Diets on Potassium (K) Handling in CKD Low-potassium, ultra-processed diet, Low-potassium, minimally processed diet, Normal potassium-rich, minimally processed diet - Chronic Kidney Disease | Not applicable | Not yet recruiting | University of Alberta | 48 | 2026-07-01 | 2026-02-05 |
| Hydration & Female Life Stages placebo beverage, electrolyte beverage - Dehydration, Menstruation | Not applicable | Recruiting | PepsiCo Global R&D | 72 | 2026-06-29 | 2026-09-21 |
| The Role of Carbohydrate Blends and Electrolytes on Physical and Mental Performance During Cycling in the Heat Water (Placebo), Carbohydrate Milk Permeate sports drink, 6% Sports drink - Hydration, Dehydration (Physiology) | Not applicable | Not yet recruiting | Arizona State University | 14 | 2026-06-22 | 2026-06-22 |
| Radiofrequency Ablation Versus Adrenalectomy for Adenoma in Patients With Primary Aldosteronism and Hypertension RFA -radiofrequency ablation, Adrenalectomy - Primary Aldosteronism Due to Conn Adenoma, Radiofrequency Ablation Treatment | Not applicable | Recruiting | University Hospital, Toulouse | 134 | 2026-06-05 | 2026-06-11 |
| NIRAF-Guided Parathyroid Identification During Thyroidectomy Wearable Near-Infrared Autofluorescence Imaging System - Hypocalcemia, Hypoparathyroidism | Not applicable | Not yet recruiting | Ss. Cyril and Methodius University of Skopje | 280 | 2026-06-01 | 2026-06-01 |
| Assessing the Effects of Cool Roofs on Indoor Environments and Health in Tavua, Fiji Cool roof - Resting Heart Rate, Blood Glucose Control | Not applicable | Not yet recruiting | Aditi Bunker | 800 | 2026-05-18 | 2026-05-18 |
| Balanced Crystalloid vs Normal Saline in Pediatric Acute Gastroenteritis Gastroenteritis Acute, Dehydration | Recruiting | Aydin Adnan Menderes University | 180 | 2026-05-15 | 2026-05-28 |
Showing 20 of 713. Sign in to see all of them.
Dehydration (192) · Hyponatremia (155) · Hyperkalemia (132) · Hypocalcemia (94) · Renal Insufficiency, Chronic (55) · Hypercalcemia (50) · Hypernatremia (47) · Inappropriate ADH Syndrome (41) · Hypokalemia (38) · Heart Failure (25) · Hypoparathyroidism (25) · Diabetes Insipidus (23) · Hypertension (23) · Edema (21) · Water Intoxication (19)
Nutritional and Metabolic Diseases (713) · Metabolic Diseases (706) · Pathological Conditions, Signs and Symptoms (363) · Pathologic Processes (323) · Endocrine System Diseases (159) · Calcium Metabolism Disorders (139) · Urogenital Diseases (136) · Female Urogenital Diseases and Pregnancy Complications (134) · Female Urogenital Diseases (127) · Male Urogenital Diseases (127) · Urologic Diseases (125) · Kidney Diseases (115) · Nervous System Diseases (94) · Signs and Symptoms (90)
sodium zirconium cyclosilicate (29) · Tolvaptan (27) · Sodium Chloride (20) · Water (18) · patiromer (18) · Saline Solution (17) · Glucose (12) · Spironolactone (12) · Suspensions (11) · conivaptan (11) · Calcitriol (9) · Cholecalciferol (8) · Vitamin D (8) · Blood Specimen Collection (7) · Calcium (7)
AstraZeneca (29) · University Hospital, Basel, Switzerland (17) · Arizona State University (11) · Cumberland Pharmaceuticals (9) · Otsuka Pharmaceutical Development & Commercialization, Inc. (9) · ZS Pharma, Inc. (8) · Amgen (7) · Mode Sensors AS (7) · Relypsa, Inc. (7) · University of Cologne (7) · Sanofi (6) · Assistance Publique - Hôpitaux de Paris (5) · Baxter Healthcare Corporation (5) · Columbia University (5) · M.D. Anderson Cancer Center (5)
United States (242) · Germany (48) · Canada (47) · France (47) · Italy (43) · Spain (43) · United Kingdom (36) · Denmark (32) · China (31) · Switzerland (30) · Belgium (25) · Poland (25) · Israel (24) · Sweden (22) · Turkey (Türkiye) (22)
Art Wheeler, MD (9) · Volker Burst, MD (6) · Henrik Rasmussen, MD, PhD (5) · Sigve N Aas, PhD (5) · Collin Tukuitonga, Sir. Dr. (3) · George Harb, MD, MPH (3) · Henrik Rasmussen, MD (3) · Julian Platon, MD, PhD (3) · Mirjam Christ-Crain, Prof. Dr. med. (3) · Adam Ogna, MD (2) · Ann Dandurand, MD (2)
PMID 32588430, PMID 33107592, PMID 40668552, PMID 17105757, PMID 18035553, PMID 18424759, PMID 18557726, PMID 19066739, PMID 20236866, PMID 22027579, PMID 24569125, PMID 25151571, PMID 28356136, PMID 31791288, PMID 33957864, PMID 10824078, PMID 12605179, PMID 12873814, PMID 14582032, PMID 15070956, PMID 15817862, PMID 15829535, PMID 17021267, PMID 17284531, PMID 17556706, PMID 17913972, PMID 17992382, PMID 18272864, PMID 18382267, PMID 18414066, PMID 18477658, PMID 18508290, PMID 18589451, PMID 19117033, PMID 19523575, PMID 19562574, PMID 19570764, PMID 19805455, PMID 19931753, PMID 20007307, PMID 20185637, PMID 20345336, PMID 20405264, PMID 20508186, PMID 20568023, PMID 20634018, PMID 20658124, PMID 20668885, PMID 20837883, PMID 20846604
2019 (5), 2023 (5), 2025 (5), 2017 (4), 2018 (3), R01CA212147 (3), 2016 (2), K12HD043494 (2), R01AI047040 (2), R01AI054843 (2), R44AG042990 (2), 2008 (1), 2009 (1), 2014 (1), 2015 (1)