96 completed, 23 unknown, 17 terminated, 10 recruiting. 36 Not applicable, 32 Phase 3, 17 Phase 4, 13 Phase 2, 4 Phase 1.
Follow Hyponatremia: new trials by email Literature Review of Hyponatremia trials Research Report on Hyponatremia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effect of Protein Supplementation and Fluid Restriction on Plasma Sodium Levels in Patients Undergoing Pituitary Surgery Fluid restriction, Dietary protein supplementation, Standard post-operative care - Hyponatremia, Pituitary Surgery | Not applicable | Recruiting | University Hospital, Basel, Switzerland | 282 | 2026-01-20 | 2026-02-03 |
| CReep and Maintenance flUid Sodium Chloride ADministration rEduction in cRitically Ill adultS Glucose 5% for fluid creep, NaCl 0.9% (normal saline) for fluid creep, PlasmaLyte as maintenance fluid - Critical Care, Intensive Care, Fluid Accumulation | Phase 4 | Recruiting | University Hospital, Antwerp | 640 | 2025-10-07 | 2026-02-03 |
| Natriuresis-guided Depletion After Cardiac Surgery Furosemide intravenous titration based on natriuresis, Furosemide intravenous titration based on clinical examination - Cardiac Surgery, Diuresis | Not applicable | Recruiting | Centre Hospitalier Universitaire, Amiens | 102 | 2025-06-25 | 2026-01-21 |
| Protein Supplementation in Hyponatremia Due to the Syndrome of Inappropriate Antidiuresis Moltein PURE Protein Powder, Fluid restriction - Hyponatremia, Syndrome of Inappropriate Antidiuresis | Not applicable | Recruiting | University Hospital, Basel, Switzerland | 70 | 2025-04-14 | 2025-07-10 |
| Systematic Use of DDAVP to Prevent Serum Sodium Overcorrection in Severe Hyponatremia DDAVP, Standard hyponatremia treatment - Hyponatremia | Phase 3 | Recruiting | Assistance Publique - Hôpitaux de Paris | 260 | 2024-12-17 | 2025-05-23 |
| Analysis of the Epidemiology, Clinical Presentation and Therapy as Well as Therapy-associated Risk of Demyelination Syndrome in Patients With Profound Hyponatremia in the Emergency Department Hyponatremia | Completed | University of Cologne | 1000 | 2024-11-01 | 2026-04-30 | |
| Urea for Treatment of Hyponatremia in Patients With SIAD Unresponsive to Fluid Restriction urea - SIAD - Syndrome of Inappropriate Antidiuresis | Not applicable | Recruiting | University of Turin, Italy | 20 | 2024-09-12 | 2026-04-14 |
| Saline Infusion Test in Hyponatremia Isotonic saline infusion - Hyponatremia | Not yet recruiting | University Hospital, Akershus | 100 | 2024-07-01 | 2024-07-12 | |
| Validation of New Diagnostic Indices to Simplify Hyponatremia Therapy Assessment in Patients on Thiazide Diuretics Standard Care, aSID/ChU Guided Therapy - Thiazide Associated Hyponatremia | Not applicable | Recruiting | University Hospital, Basel, Switzerland | 136 | 2024-05-06 | 2026-02-11 |
| Low-dose Tolvaptan for Inpatient Hyponatraemia. Tolvaptan - Hyponatremia, SIADH | Unknown | King's College Hospital NHS Trust | 180 | 2024-03-15 | 2024-03-08 | |
| Effects of Intravenous [Pyr1]Apelin-13 on Healthy Volunteers With Artificially Induced SIAD Placebo, Apelin Low Dose, Apelin High Dose - SIAD - Syndrome of Inappropriate Antidiuresis, Hyponatremia | Not applicable | Completed | University Hospital, Basel, Switzerland | 15 | 2024-03-01 | 2025-03-30 |
| Mortality and Neurologic Outcomes in Rapid vs. Slow Hyponatremia Correction Rapid sodium correction, Slow sodium correction - Hyponatremia, Hospitalisation | Completed | Hospital Italiano de Buenos Aires | 2037 | 2024-03-01 | 2024-11-05 | |
| Hyponatremia Volume Status Analysis by Point-of-care Ultrasound Measurement of sodium levels - Hyponatremia, Water-Electrolyte Imbalance | Active not recruiting | Universidad Veracruzana | 80 | 2023-10-01 | 2024-11-19 | |
| Plasma Sodium and Sodium Administration in the ICU Hypernatremia, Hyponatremia | Unknown | University Hospital, Linkoeping | 200 | 2023-09-04 | 2023-09-26 | |
| Hyponatremia - Complications, Prognosis, Epidemiology in Finnish Tertiary Care Hyponatremia, Osmotic Demyelination Syndrome | Active not recruiting | University of Turku | 10000 | 2023-09-01 | 2026-02-24 | |
| Regulation of Extracellular Sodium in End Stage Renal Disease Upon Volume and Electrolyte Challenges Water administration, NaCl-Administration - Hyponatremia | Not applicable | Recruiting | University of Cologne | 60 | 2023-07-01 | 2025-09-17 |
| Comparison of Isotonic Versus Hypotonic Fluids in Neonates for Maintenance Fluid Therapy After Surgery Isotonic Saline with Dextrose - Hyponatremia, Hypernatremia | Not applicable | Completed | Rawalpindi Medical College | 84 | 2023-01-01 | 2024-07-03 |
| Evaluation of Volume and Electrolyte Balance in Hyponatremia Treatment - a Prospective Observational Trial Patients - Non-hypervolemic Hyponatremia | Recruiting | University of Cologne | 50 | 2022-10-15 | 2025-09-11 | |
| Study of Changes in CSF Ionic Composition After Aneurysmal Meningeal Hemorrhage Concurrent evaluation of blood and CSF ionograms to determine if there is a correlation between CSF change and the development of hyoponatremia between day 0 and day 14. - Subarachnoid Hemorrhage | Unknown | Hospices Civils de Lyon | 80 | 2022-10-01 | 2023-07-12 | |
| Urinary Prostaglandin as a Potential Predictive Marker for Thiazide-induced Hyponatremia Data and biosample collection - Thiazide-induced Hyponatremia (TIH) | Recruiting | University Hospital, Basel, Switzerland | 232 | 2022-09-26 | 2025-07-01 |
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Inappropriate ADH Syndrome (30) · Diabetes Insipidus (14) · Edema (10) · Hypernatremia (9) · Heart Failure (7) · Water-Electrolyte Imbalance (7) · Fibrosis (5) · Metabolic Diseases (4) · Hepatic Encephalopathy (3) · Hypovolemia (3) · Liver Cirrhosis (3) · Renal Insufficiency (3) · Subarachnoid Hemorrhage (3) · Ascites (2)
Nutritional and Metabolic Diseases (155) · Metabolic Diseases (151) · Water-Electrolyte Imbalance (148) · Nervous System Diseases (44) · Endocrine System Diseases (40) · Pathological Conditions, Signs and Symptoms (40) · Brain Diseases (39) · Central Nervous System Diseases (39) · Pituitary Diseases (37) · Hypothalamic Diseases (32) · Pathologic Processes (26) · Female Urogenital Diseases and Pregnancy Complications (20) · Urogenital Diseases (20) · Female Urogenital Diseases (19) · Male Urogenital Diseases (19)
Tolvaptan (23) · conivaptan (11) · Sodium Chloride (7) · satavaptan (6) · Glucose (5) · Saline Solution (4) · Urea (4) · empagliflozin (4) · Saline Solution, Hypertonic (3) · Standard of Care (3) · Albumins (2) · Blood Specimen Collection (2) · Deamino Arginine Vasopressin (2) · Plasmalyte A (2) · Tablets (2)
University Hospital, Basel, Switzerland (13) · Cumberland Pharmaceuticals (9) · Otsuka Pharmaceutical Development & Commercialization, Inc. (8) · Sanofi (6) · University of Cologne (6) · Otsuka Pharmaceutical Europe Ltd (3) · CardioKine Inc. (2) · Hospices Civils de Lyon (2) · Hospital General de Niños Pedro de Elizalde (2) · Hospital Italiano de Buenos Aires (2) · Hospital Nacional Profesor Alejandro Posadas (2) · Karolinska University Hospital (2) · Thomas Jefferson University (2) · University Hospital, Caen (2) · University Hospital, Linkoeping (2)
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Art Wheeler, MD (9) · Volker Burst, MD (5) · Mirjam Christ-Crain, Prof. Dr. med. (3) · Ann Dandurand, MD (2) · Bruno Allolio, MD (2) · Gregor Lindner, M.D. (2) · Mirjam Christ-Crain, Prof. MD (2) · Abdulla K. Salahudeen, MD (1) · Ahmed ELbadawy, MD (1) · Andrew M Naidech, MD, MSPH (1) · Andrew S Little, MD (1) · Aris Nikas (1)
PMID 17105757, PMID 22027579, PMID 24569125, PMID 25151571, PMID 28356136, PMID 10824078, PMID 15829535, PMID 17913972, PMID 17992382, PMID 18272864, PMID 18477658, PMID 18508290, PMID 19523575, PMID 20185637, PMID 20345336, PMID 20568023, PMID 20668885, PMID 21199833, PMID 22007013, PMID 22243938, PMID 23912284, PMID 24148616, PMID 24246119, PMID 24906029, PMID 24944242, PMID 25066025, PMID 25472864, PMID 25683094, PMID 25751673, PMID 25915455, PMID 27156756, PMID 27777873, PMID 28174217, PMID 29422070, PMID 29871886, PMID 30138685, PMID 30180806, PMID 30396772, PMID 30462243, PMID 30882872, PMID 31221280, PMID 3309659, PMID 33104176, PMID 33104189, PMID 33306187, PMID 34412521, PMID 34552947, PMID 34693505, PMID 34926496, PMID 36396331
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