5 completed, 2 withdrawn, 1 not yet recruiting. 8 Early Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Early Phase 1 | 8 | Completed 5, Withdrawn 2, Not yet recruiting 1 |
Follow Heart Valve Diseases: new trials by email Literature Review of Heart Valve Diseases trials Research Report on Heart Valve Diseases
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Understanding the Metabolic and Functional Derangement of Primary Mitral Regurgitation: a Feasibility Study Using Carbon 11(C-11) Acetate Cardiac Positron Emission Tomography Magnetic Resonance Imaging (PET-MRI) [11C] acetate - Mitral Valve Regurgitation | Early Phase 1 | Withdrawn | University of Alabama at Birmingham | 2027-06-01 | 2025-01-24 | |
| A Trial of HRS-1893 in Healthy Volunteers HRS-1893 - Hypertrophic Cardiomyopathy | Early Phase 1 | Completed | Atridia Pty Ltd. | 20 | 2025-06-25 | 2025-11-18 |
| A Multicenter, Prospective, Randomized Controlled Trial to Evaluate the Efficacy of PCSK-9 Inhibitors in Delaying the Progression of Calcified Aortic Valve Disease The Group A received PCSK9 inhibitor plus statin therapy - Aortic Stenosis, PCSK9 Inhibitor | Early Phase 1 | Not yet recruiting | Nanfang Hospital, Southern Medical University | 316 | 2025-06-01 | 2025-05-30 |
| Prevalence of Transthyretin Cardiac Amyloidosis in Clinically Significant Aortic Stenosis 99mTc-PYP - Aortic Stenosis, Transthyretin Amyloidosis | Early Phase 1 | Completed | Mayo Clinic | 4 | 2023-07-14 | 2024-08-07 |
| Pressure Assessment to Improve Outcomes After TAVR: a Registry Eplerenone - Hypertension, Aortic Stenosis, Calcific | Early Phase 1 | Completed | North Florida Foundation for Research and Education | 12 | 2019-06-03 | 2020-05-28 |
| Early Aortic Valve Lipoprotein(a) Lowering Trial Extended release Niacin, Placebo Comparator - Aortic Stenosis and Lipoprotein(a) Levels | Early Phase 1 | Withdrawn | George Thanassoulis | 2014-05-01 | 2023-10-25 | |
| Sevoflurane's Effect on Mitral Valve Annular Velocity in Cardiac Surgery Sevoflurane dosage titration - Valvular Heart Disease | Early Phase 1 | Completed | Konkuk University Medical Center | 20 | 2009-05-01 | 2015-02-24 |
| Randomised Ischaemic Mitral Evaluation (RIME) Trial CABG + Mitral valve annuloplasty, CABG - Mitral Regurgitation, Coronary Artery Disease | Early Phase 1 | Completed | Imperial College London | 73 | 2007-01-01 | 2023-03-28 |
Aortic Valve Stenosis (4) · Mitral Valve Insufficiency (2) · Amyloidosis, Hereditary, Transthyretin-Related (1) · Aortic Valve, Calcification of (1) · Cardiomyopathy, Hypertrophic (1) · Coronary Artery Disease (1) · Hypertension (1)
Cardiovascular Diseases (8) · Heart Diseases (8) · Aortic Valve Disease (5) · Ventricular Outflow Obstruction (4) · Vascular Diseases (2) · Aortic Stenosis, Subvalvular (1) · Aortic Valve Stenosis (1) · Arterial Occlusive Diseases (1) · Arteriosclerosis (1) · Cardiomyopathies (1) · Coronary Disease (1) · Myocardial Ischemia (1)
Eplerenone (1) · Mitral Valve Annuloplasty (1) · Sevoflurane (1) · Technetium Tc 99m Pyrophosphate (1) · carbon-11 acetate (1)
Atridia Pty Ltd. (1) · George Thanassoulis (1) · Imperial College London (1) · Konkuk University Medical Center (1) · Mayo Clinic (1) · Nanfang Hospital, Southern Medical University (1) · North Florida Foundation for Research and Education (1) · University of Alabama at Birmingham (1)
United States (2) · Australia (1) · Canada (1) · Poland (1) · South Korea (1) · United Kingdom (1)
Anthony Bavry, MD (1) · John R Pepper, MChir, FRCS (1) · K. M. John Chan, FRCS CTh (1) · Marcus Flather, MBBS, FRCP (1) · Omar F Abou Ezzeddine, MD (1) · Pradeep Bhambhvani, MD (1) · Tae-Yop Kim, MD PhD (1)