19 completed, 8 unknown, 6 recruiting, 6 terminated. 19 Not applicable, 7 Phase 4, 5 Phase 2, 2 Phase 1, 1 Phase 3.
Follow Heart Valve Disease: new trials by email Literature Review of Heart Valve Disease trials Research Report on Heart Valve Disease
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Serratus Posterior Superior Intercostal Plane Block in Minimally Invasive Cardiac Surgery Serratus Posterior Superior Intercostal Plane Block With Bupivacaine, Serratus Posterior Superior Intercostal Plane Block With Saline - Heart Valve Disease, Postoperative Pain | Not applicable | Recruiting | Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital | 90 | 2026-05-16 | 2026-05-19 |
| The Study Tests if Preoperative Dental Screening is Superior to no Preoperative Dental Screening in Improving the Outcome of Patients Undergoing Surgical Cardiac Valve Replacement or Transcatheter Cardiac Valve Implantation. Preoperative dental screening, No preoperative dental screening - Infective Endocarditis (IE), Heart Valve Disease | Not applicable | Recruiting | Region Skane | 1300 | 2026-05-06 | 2026-05-19 |
| LLM-Based Intelligent Health Management Assistant in Life-Cycle Health Management of Cardiac Surgery Patients LLM-Based Intelligent Health Management Assistant - Coronary Artery Bypass Grafting, Heart Valve Disease | Not applicable | Not yet recruiting | Beijing Anzhen Hospital | 500 | 2026-05-01 | 2026-04-13 |
| Warfarin Effects on Male Fertility After Cardiac Surgery Semen analysis, sperm DNA fragmentation and hormonal evaluation - Male Infertility, Heart Valve Disease | Not yet recruiting | Città di Lecce Hospital, GVM Care & Research | 90 | 2026-02-01 | 2026-01-09 | |
| Cohort Observing Mechanisms, Progression and Sequelae of Valvular Heart Disease Heart Valve Disease, Mitral Valve (MV) Regurgitation | Recruiting | Second Affiliated Hospital, Zhejiang University, School of Medicine | 10000 | 2025-06-01 | 2025-12-05 | |
| The TRICURE EU Pivotal Study Transcatheter Tricuspid Valve Replacement - Tricuspid Valve Regurgitation, Heart Valve Disease | Not applicable | Recruiting | TRiCares | 80 | 2024-08-29 | 2026-04-15 |
| Enhanced Valves Interventions and Safe AI Generated End Results Medical imaging analysis via artificial intelligence algorithms - Heart Valve Disease, TAVI | Recruiting | Montreal Heart Institute | 21000 | 2024-05-01 | 2025-10-09 | |
| Validation of Naevia Medical in Valvulopathies Clinical decision support system (software) - Heart Valve Disease | Completed | Dilemma Solutions S.L. | 106 | 2024-03-27 | 2025-12-31 | |
| CTSN Embolic Protection Trial CardioGard Embolic Protection Cannula, Standard Aortic Cannula - Delirium, Ischemic Stroke | Not applicable | Active not recruiting | Icahn School of Medicine at Mount Sinai | 842 | 2023-09-18 | 2026-10-02 |
| Structural Heart and Valve Network PROSPECTIVE Registry Mitral Valve Regurgitation, Heart Failure | Withdrawn | National Heart, Lung, and Blood Institute (NHLBI) | 2023-01-10 | 2023-01-12 | ||
| Safety and Performance of the Trialign Percutaneous Tricuspid Valve Annuloplasty System (PTVAS) Mitralign Percutaneous Tricuspid Valve Annuloplasty System (PTVAS) - Chronic Symptomatic Functional Tricuspid Regurgitation, Tricuspid Valve Insufficiency | Not applicable | Unknown | Mitralign, Inc. | 60 | 2017-05-22 | 2018-02-07 |
| High Dose Vitamin C in Cardiac Surgery Patients Ascorbic Acid, Placebo - Disorder of Vitamin C, Atrial Fibrillation | Phase 1 | Terminated | Virginia Commonwealth University | 6 | 2017-01-01 | 2019-06-24 |
| Effects of Hyperoxia on Open Heart Surgery Fraction of inspired oxygen 40%, Fraction of inspired oxygen 100% - Heart Valve Disease, Coronary (Artery) Disease | Not applicable | Unknown | Istanbul University | 100 | 2016-12-01 | 2017-01-06 |
| Comparative Effects of Dexmedetomidine and Ketofol for Sedation in Patients Undergoing Trans-esophageal Echocardiography Dexmedetomidine, Ketofol(ketamine+propofol) - Heart Valve Disease, Heart Septal Defects, Atrial | Phase 4 | Completed | Post Graduate Institute of Medical Education and Research, Chandigarh | 50 | 2016-06-01 | 2017-11-06 |
| Valve Leaflet Motion in Sutureless Bioprosthetic Aortic Valves 4-dimensional volume-rendered computed tomography - Aortic Valve Stenosis, Heart Valve Disease | Not applicable | Completed | Karolinska University Hospital | 47 | 2016-01-01 | 2016-07-11 |
| Frailty and Cognitive Function Assessment of TAVI Patients Cognitive fuction, quality of life - Quality of Life, Aortic Valve Stenosis | Phase 4 | Unknown | Hungarian Institute of Cardiology | 100 | 2015-11-01 | 2016-01-08 |
| Early Feasibility of the Mitralign Percutaneous Tricuspid Valve Annuloplasty System (PTVAS) Also Known as TriAlign™. Mitralign Percutaneous Tricuspid Valve Annuloplasty System (PTVAS) - Chronic Symptomatic Functional Tricuspid Regurgitation, Tricuspid Valve Insufficiency | Not applicable | Unknown | Mitralign, Inc. | 30 | 2015-11-01 | 2017-10-27 |
| Aortic Replacement Using Individualised Regenerative Allografts - ARISE (the "Surveillance") Decellularized human heart valves - Heart Valve Disease | Completed | corlife | 144 | 2015-09-01 | 2020-06-02 | |
| Early Feasibility Study of the CardiAQ™ TMVI System (Transfemoral and Transapical DS) CardiAQ TMVI System (Transapical & Transfemoral DS) - Mitral Insufficiency, Heart Valve Disease | Not applicable | Withdrawn | Edwards Lifesciences | 2015-08-01 | 2016-03-31 | |
| Magnetic Resonance Imaging and Fibrosis Heart Valve Disease, Ventricular Function | Completed | Linkoeping University | 60 | 2015-06-01 | 2021-02-21 |
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Heart Valve Diseases (45) · Coronary Artery Disease (6) · Aortic Valve Stenosis (5) · Tricuspid Valve Insufficiency (5) · Atrial Fibrillation (4) · Cardiovascular Diseases (4) · Heart Defects, Congenital (4) · Mitral Valve Insufficiency (4) · Heart Diseases (3) · Thromboembolism (3) · Delirium (2) · Pulmonary Embolism (2) · Acute Kidney Injury (1) · Aneurysm (1) · Aortic Aneurysm (1)
Heart Diseases (42) · Cardiovascular Diseases (41) · Vascular Diseases (13) · Pathological Conditions, Signs and Symptoms (11) · Pathologic Processes (7) · Arterial Occlusive Diseases (6) · Arteriosclerosis (6) · Coronary Disease (6) · Myocardial Ischemia (6) · Cardiovascular Abnormalities (5) · Congenital Abnormalities (5) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (5) · Embolism and Thrombosis (5) · Signs and Symptoms (5) · Ventricular Outflow Obstruction (5)
Simcor (2) · Simvastatin (2) · Warfarin (2) · Activities of Daily Living (1) · Adrenergic beta-Antagonists (1) · Ascorbic Acid (1) · Bupivacaine (1) · Cardiac Surgical Procedures (1) · Dexmedetomidine (1) · Fibrinogen (1) · Hand Strength (1) · Mental Status and Dementia Tests (1) · Metoprolol (1) · Phytic Acid (1) · Propofol (1)
On-X Life Technologies, Inc. (3) · Edwards Lifesciences (2) · Mitralign, Inc. (2) · Sun Yat-sen University (2) · University of California, Irvine (2) · Yonsei University (2) · corlife (2) · Abbott Medical Devices (1) · Beijing Anzhen Hospital (1) · Chinese Academy of Medical Sciences, Fuwai Hospital (1) · Chinese PLA General Hospital (1) · Città di Lecce Hospital, GVM Care & Research (1) · Copenhagen University Hospital, Rigshospitalet (1) · Dilemma Solutions S.L. (1) · Emory University (1)
United States (13) · China (9) · Germany (6) · Canada (5) · Italy (5) · Netherlands (5) · Spain (4) · Sweden (4) · Belgium (3) · France (3) · Turkey (Türkiye) (3) · United Kingdom (3) · Denmark (2) · India (2) · Switzerland (2)
Axel Haverich, Prof. Dr. (2) · Jeffrey C Milliken, MD (2) · Jing-song Ou, MD,PhD (2) · Samir Sarikouch, PD Dr. (2) · Alexander Iribarne, MD (1) · Alfredo Trento, MD (1) · Ann-Dorthe Zwisler, MD, Ph.d. (1) · Annetine C. Gelijns, PhD (1) · Charles Brown, MD (1) · Christian Hassager, MD, DMSc (1) · Christopher Meduri, MD, MPH (1) · Donald F Brophy, PharmD (1) · Eric Jamieson, MD (1) · Esko Ruokonen, MD,PhD (1)
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