5 completed, 3 unknown, 2 not yet recruiting, 1 recruiting. 12 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 12 | Completed 5, Unknown 3, Not yet recruiting 2, Recruiting 1, Suspended 1 |
Follow Heart Septal Defects: new trials by email Literature Review of Heart Septal Defects trials Research Report on Heart Septal Defects
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Novel Echocardiography-Guided Strategy for Percutateous Closure of Atrial Septal Defect Assisted by PannaWire Ultrasound-guided intervention with assistance of specialized instruments, fluoroscopy-guided intervention - Atrial Septal Defect (ASD) | Phase 4 | Not yet recruiting | Chinese Academy of Medical Sciences, Fuwai Hospital | 666 | 2026-03-14 | 2026-03-17 |
| A Multicenter Randomized Controlled Trial of Echocardiography-Guided Atrial Septal Defect Closure Performed in a Mobile Surgical Unit Mobile Surgical Vehicle Echocardiography-guided ASD closure Group, Conventional Operating Room Echocardiography-guided ASD closure Group - ASD - Atrial Septal Defect | Phase 4 | Not yet recruiting | China National Center for Cardiovascular Diseases | 300 | 2025-12-19 | 2025-12-09 |
| Effect of Dexmedetomidine Supplementation to General Anaesthesia in Paediatric Transcatheter Closure of Atrial Septal Defect Dexmedetomidine, Saline (NaCl 0,9 %) (placebo) - Atrial Septal Defect (ASD), Dexmedetomidine | Phase 4 | Recruiting | Alexandria University | 30 | 2024-04-03 | 2024-10-15 |
| Regional Anesthesia Following Pediatric Cardiac Surgery Regional Anesthesia, Wound infiltration, Ropivacaine 0.2% Injectable Solution - Atrial Septal Defect, Ventricular Septal Defect | Phase 4 | Completed | Duke University | 52 | 2023-03-29 | 2025-08-28 |
| COMParison of the EffecT of dEvice Closure in Alleviating Migraine With PFO (COMPETE-2) PFO device closure, Aspirin - Migraine, Patent Foramen Ovale | Phase 4 | Unknown | Chinese Academy of Medical Sciences, Fuwai Hospital | 460 | 2022-10-01 | 2023-01-09 |
| The Cardiopulmonary Effect of Inhaled Beta-2-agonists on Adult Patients Born With Ventricular Septum Defects. Salbutamol, Norflouran (Placebo Evohaler(R) ) - Ventricular Septal Defect | Phase 4 | Completed | University of Aarhus | 96 | 2016-10-15 | 2018-07-05 |
| Comparative Effects of Dexmedetomidine and Ketofol for Sedation in Patients Undergoing Trans-esophageal Echocardiography Dexmedetomidine, Ketofol(ketamine+propofol) - Heart Valve Disease, Heart Septal Defects, Atrial | Phase 4 | Completed | Post Graduate Institute of Medical Education and Research, Chandigarh | 50 | 2016-06-01 | 2017-11-06 |
| Comparison of the Local Anaesthetics Articaine and Bupivacaine in Treatment of Acute Sternum Pain After Heart Surgery Articaine hydrochloride 2% solution, Sodium Chloride - Diseases of Mitral Valve, Aortic Valve Disorder | Phase 4 | Suspended | Helsinki University Central Hospital | 36 | 2012-03-01 | 2019-05-07 |
| Device Closure Versus Medical Therapy for Cryptogenic Stroke Patients With High-Risk Patent Foramen Ovale (DEFENSE-PFO) Device closure, Standard medical treatment - Patent Foramen Ovale | Phase 4 | Unknown | Jae-Kwan Song | 210 | 2012-02-01 | 2017-06-29 |
| Clopidogrel For the Prevention of New Onset Migraine Headache Following Transcatheter Closure of Atrial Septal Defects Clopidogrel - Migraine | Phase 4 | Completed | Laval University | 220 | 2008-10-01 | 2019-02-26 |
| PC-Trial: Patent Foramen Ovale and Cryptogenic Embolism Percutaneous closure of patent foramen ovale, Medical antitrhombotic treatment - Embolism, Paradoxical, Heart Septal Defects, Atrial | Phase 4 | Unknown | Foundation for Cardiovascular Research, Zurich | 414 | 2000-02-01 | 2009-05-27 |
| Patent Foramen Ovale in Cryptogenic Stroke Study Warfarin, Aspirin - Ischemic Stroke, Patent Foramen Ovale | Phase 4 | Completed | Columbia University | 630 | 1993-06-01 | 2011-09-15 |
Heart Septal Defects, Atrial (8) · Foramen Ovale, Patent (4) · Heart Septal Defects, Ventricular (2) · Migraine Disorders (2) · Aortic Valve Disease (1) · Atrial myxoma, familial (1) · Cerebrovascular Disorders (1) · Embolism, Paradoxical (1) · Emergence Delirium (1) · Fractures, Stress (1) · Heart Defects, Congenital (1) · Heart Valve Diseases (1) · Ischemic Stroke (1) · Pain, Postoperative (1) · Pain, Procedural (1)
Cardiovascular Abnormalities (12) · Cardiovascular Diseases (12) · Congenital Abnormalities (12) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (12) · Heart Diseases (12) · Heart Defects, Congenital (11) · Nervous System Diseases (5) · Brain Diseases (4) · Central Nervous System Diseases (4) · Heart Septal Defects, Atrial (3) · Neurologic Manifestations (3) · Pathological Conditions, Signs and Symptoms (3) · Signs and Symptoms (3) · Vascular Diseases (3)
Aspirin (2) · Dexmedetomidine (2) · Sodium Chloride (2) · Albuterol (1) · Anesthesia, Conduction (1) · Carticaine (1) · Clopidogrel (1) · Ropivacaine (1) · Solutions (1) · Vascular Closure Devices (1) · Warfarin (1)
Chinese Academy of Medical Sciences, Fuwai Hospital (2) · Alexandria University (1) · China National Center for Cardiovascular Diseases (1) · Columbia University (1) · Duke University (1) · Foundation for Cardiovascular Research, Zurich (1) · Helsinki University Central Hospital (1) · Jae-Kwan Song (1) · Laval University (1) · Post Graduate Institute of Medical Education and Research, Chandigarh (1) · University of Aarhus (1)
China (3) · United States (2) · Australia (1) · Austria (1) · Belgium (1) · Canada (1) · Denmark (1) · Egypt (1) · Finland (1) · India (1) · South Korea (1) · Switzerland (1)
Bernhard Meier, MD (1) · Fengwen Zhang, MM (1) · Jae-Kwan Song, MD, PhD (1) · Josep Rodes-Cabau, MD (1) · Lisa M Einhorn, MD (1) · Mihkel Meinberg, MD (1) · Shunichi Homma, MD (1) · Sruthi Sankar (1) · Vibeke E Hjortdal, MD PhD DMSc (1)
PMID 12045168, PMID 13678932, PMID 15232117, PMID 19380621, PMID 21356042, PMID 23514285, PMID 26551304, PMID 29544871, PMID 30233808, PMID 32381162, PMID 32965476, PMID 39660641, PMID 41032451
R01NS032525 (1)