4 completed, 3 unknown, 2 not yet recruiting, 1 recruiting. 11 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 11 | Completed 4, Unknown 3, Not yet recruiting 2, Recruiting 1, Suspended 1 |
Follow Heart Septal Defects, Atrial: new trials by email Literature Review of Heart Septal Defects, Atrial trials Research Report on Heart Septal Defects, Atrial
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Novel Echocardiography-Guided Strategy for Percutateous Closure of Atrial Septal Defect Assisted by PannaWire Ultrasound-guided intervention with assistance of specialized instruments, fluoroscopy-guided intervention - Atrial Septal Defect (ASD) | Phase 4 | Not yet recruiting | Chinese Academy of Medical Sciences, Fuwai Hospital | 666 | 2026-03-14 | 2026-03-17 |
| A Multicenter Randomized Controlled Trial of Echocardiography-Guided Atrial Septal Defect Closure Performed in a Mobile Surgical Unit Mobile Surgical Vehicle Echocardiography-guided ASD closure Group, Conventional Operating Room Echocardiography-guided ASD closure Group - ASD - Atrial Septal Defect | Phase 4 | Not yet recruiting | China National Center for Cardiovascular Diseases | 300 | 2025-12-19 | 2025-12-09 |
| Effect of Dexmedetomidine Supplementation to General Anaesthesia in Paediatric Transcatheter Closure of Atrial Septal Defect Dexmedetomidine, Saline (NaCl 0,9 %) (placebo) - Atrial Septal Defect (ASD), Dexmedetomidine | Phase 4 | Recruiting | Alexandria University | 30 | 2024-04-03 | 2024-10-15 |
| Regional Anesthesia Following Pediatric Cardiac Surgery Regional Anesthesia, Wound infiltration, Ropivacaine 0.2% Injectable Solution - Atrial Septal Defect, Ventricular Septal Defect | Phase 4 | Completed | Duke University | 52 | 2023-03-29 | 2025-08-28 |
| COMParison of the EffecT of dEvice Closure in Alleviating Migraine With PFO (COMPETE-2) PFO device closure, Aspirin - Migraine, Patent Foramen Ovale | Phase 4 | Unknown | Chinese Academy of Medical Sciences, Fuwai Hospital | 460 | 2022-10-01 | 2023-01-09 |
| Comparative Effects of Dexmedetomidine and Ketofol for Sedation in Patients Undergoing Trans-esophageal Echocardiography Dexmedetomidine, Ketofol(ketamine+propofol) - Heart Valve Disease, Heart Septal Defects, Atrial | Phase 4 | Completed | Post Graduate Institute of Medical Education and Research, Chandigarh | 50 | 2016-06-01 | 2017-11-06 |
| Comparison of the Local Anaesthetics Articaine and Bupivacaine in Treatment of Acute Sternum Pain After Heart Surgery Articaine hydrochloride 2% solution, Sodium Chloride - Diseases of Mitral Valve, Aortic Valve Disorder | Phase 4 | Suspended | Helsinki University Central Hospital | 36 | 2012-03-01 | 2019-05-07 |
| Device Closure Versus Medical Therapy for Cryptogenic Stroke Patients With High-Risk Patent Foramen Ovale (DEFENSE-PFO) Device closure, Standard medical treatment - Patent Foramen Ovale | Phase 4 | Unknown | Jae-Kwan Song | 210 | 2012-02-01 | 2017-06-29 |
| Clopidogrel For the Prevention of New Onset Migraine Headache Following Transcatheter Closure of Atrial Septal Defects Clopidogrel - Migraine | Phase 4 | Completed | Laval University | 220 | 2008-10-01 | 2019-02-26 |
| PC-Trial: Patent Foramen Ovale and Cryptogenic Embolism Percutaneous closure of patent foramen ovale, Medical antitrhombotic treatment - Embolism, Paradoxical, Heart Septal Defects, Atrial | Phase 4 | Unknown | Foundation for Cardiovascular Research, Zurich | 414 | 2000-02-01 | 2009-05-27 |
| Patent Foramen Ovale in Cryptogenic Stroke Study Warfarin, Aspirin - Ischemic Stroke, Patent Foramen Ovale | Phase 4 | Completed | Columbia University | 630 | 1993-06-01 | 2011-09-15 |
Foramen Ovale, Patent (4) · Migraine Disorders (2) · Aortic Valve Disease (1) · Atrial myxoma, familial (1) · Cerebrovascular Disorders (1) · Embolism, Paradoxical (1) · Emergence Delirium (1) · Fractures, Stress (1) · Heart Septal Defects, Ventricular (1) · Heart Valve Diseases (1) · Ischemic Stroke (1) · Pain, Postoperative (1) · Pain, Procedural (1) · Stroke (1)
Cardiovascular Abnormalities (11) · Cardiovascular Diseases (11) · Congenital Abnormalities (11) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (11) · Heart Defects, Congenital (11) · Heart Diseases (11) · Heart Septal Defects (11) · Nervous System Diseases (5) · Brain Diseases (4) · Central Nervous System Diseases (4) · Neurologic Manifestations (3) · Pathological Conditions, Signs and Symptoms (3) · Signs and Symptoms (3) · Vascular Diseases (3)
Aspirin (2) · Dexmedetomidine (2) · Sodium Chloride (2) · Anesthesia, Conduction (1) · Carticaine (1) · Clopidogrel (1) · Ropivacaine (1) · Solutions (1) · Vascular Closure Devices (1) · Warfarin (1)
Chinese Academy of Medical Sciences, Fuwai Hospital (2) · Alexandria University (1) · China National Center for Cardiovascular Diseases (1) · Columbia University (1) · Duke University (1) · Foundation for Cardiovascular Research, Zurich (1) · Helsinki University Central Hospital (1) · Jae-Kwan Song (1) · Laval University (1) · Post Graduate Institute of Medical Education and Research, Chandigarh (1)
China (3) · United States (2) · Australia (1) · Austria (1) · Belgium (1) · Canada (1) · Egypt (1) · Finland (1) · India (1) · South Korea (1) · Switzerland (1)
Bernhard Meier, MD (1) · Fengwen Zhang, MM (1) · Jae-Kwan Song, MD, PhD (1) · Josep Rodes-Cabau, MD (1) · Lisa M Einhorn, MD (1) · Mihkel Meinberg, MD (1) · Shunichi Homma, MD (1) · Sruthi Sankar (1)
PMID 12045168, PMID 13678932, PMID 15232117, PMID 19380621, PMID 21356042, PMID 23514285, PMID 26551304, PMID 29544871, PMID 32381162, PMID 32965476, PMID 39660641, PMID 41032451
R01NS032525 (1)