40 completed, 21 recruiting, 18 unknown, 9 not yet recruiting. 102 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 102 | Completed 40, Recruiting 21, Unknown 18, Not yet recruiting 9, Active not recruiting 4, Terminated 4, Withdrawn 4, Enrolling by invitation 1, Suspended 1 |
Follow Heart Septal Defects: new trials by email Literature Review of Heart Septal Defects trials Research Report on Heart Septal Defects
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| WSO BEAT STROKE Initiative Educational and implementation Neurocardiology tool, No educational or implementation tool will be provided - Stroke, PFO - Patent Foramen Ovale | Not applicable | Not yet recruiting | Luciano A. Sposato | 2400 | 2027-03-01 | 2026-09-18 |
| Dapagliflozin and Right Heart Recovery After ASD Device Closure trans catheter device closure - ASD2(Secundum Atrial Septal Defect) | Not applicable | Not yet recruiting | Assiut University | 70 | 2026-11-01 | 2026-09-17 |
| Comparing Two PFO Closure Devices in Adults With Previous Stroke or TIA PFO Closure procedure - Patent Foramen Ovale, Stroke | Not applicable | Recruiting | Giuseppe Tarantini | 1260 | 2026-07-24 | 2026-10-05 |
| Safety and Efficacy of the Patent Foramen Ovale Suture System for the Closure of Patent Foramen Ovale Patent Foramen Ovale Suture System, Amplatzer PFO Occluder - Patent Foramen Ovale (PFO) | Not applicable | Not yet recruiting | Shenzhen Bihe Medical Co., Ltd | 244 | 2026-06-30 | 2026-07-27 |
| Evaluating Percutaneous Repair Of The Atrial Septum With A Novel PFO Occluder: The PROTEA-PFO OUS Study Recross P3 Occluder (P3O) System - PFO, PFO - Patent Foramen Ovale | Not applicable | Recruiting | Recross Cardio, Inc. | 15 | 2026-06-17 | 2026-07-13 |
| Safety and Efficacy of the AbsnowTM II Absorbable Atrial Septal Defect Closure System for Atrial Septal Defect Closure Therapy Absnow II Absorbable Atrial Septal Defect Occluder System, Cera Atrial Septal Defect Occluder - Atrial Septal Defect | Not applicable | Not yet recruiting | Lifetech Scientific (Shenzhen) Co., Ltd. | 236 | 2026-04-01 | 2026-04-14 |
| IABP for MI-VSD Patients in SCAI SHOCK Stage B Insertion of IABP in SCAI SHOCK stage B - Acute Myocardial Infarction (AMI), Ventricular Septal Defects (VSD) | Not applicable | Not yet recruiting | Qilu Hospital of Shandong University | 100 | 2026-02-28 | 2026-03-19 |
| Bypass Clear Priming VSD Cardiopulmonary Bypass Circuit Reduce Bypass Associated Inflammation? Clear priming of the bypass pump - Ventricular Septal Defect | Not applicable | Not yet recruiting | Seattle Children's Hospital | 60 | 2026-02-25 | 2026-02-06 |
| Utility of the Perclose ProGlide™ Suture-Mediated Closure Device After Cardiologic Procedures Via the Femoral Vein Approach (Eight-Clover) Perclose ProStyle™ Suture-Mediated Closure System, Conventional Hemostasis (Manual Compression or Figure-of-Eight Suture) - Atrial Fibrillation, Atrial Septal Defect | Not applicable | Enrolling by invitation | Ewha Womans University Mokdong Hospital | 200 | 2026-02-02 | 2026-09-18 |
| Effects of PFO Closure on Glymphatic Function and Clinical Symptoms in Patients With Migraine Percutaneous Patent Foramen Ovale Closure, No Intervention - Migraine Disorders, Patent Foramen Ovale | Not applicable | Recruiting | First Affiliated Hospital Xi'an Jiaotong University | 150 | 2026-01-14 | 2026-01-16 |
| Non-Invasive Detection of Pulmonary Right-to-Left Shunts Using the SONAS Ultrasound Device Transcranial Ultrasound Device - Hereditary Haemorrhagic Telangiectasia, PFO - Patent Foramen Ovale | Not applicable | Recruiting | St. Antonius Hospital | 40 | 2026-01-07 | 2026-02-17 |
| Study on the Safety and Effectiveness of a Biodegradable Patent Foramen Ovale Occluder System Active Comparator, Experimental - Cardiovascular Diseases, Cardiovascular Abnormality | Not applicable | Not yet recruiting | Shanghai Lingsi Medical Technology Co., Ltd. | 258 | 2025-12-30 | 2025-12-23 |
| Early Feasibility Study (EFS) Evaluating Percutaneous Repair of the Atrial Septum With a Novel PFO Occluder: The PROTEA-PFO Study Recross P3 Occluder (P3O) System - PFO, PFO - Patent Foramen Ovale | Not applicable | Recruiting | Recross Cardio, Inc. | 30 | 2025-10-09 | 2026-07-27 |
| Beta-blockers for Prevention of Supraventricular Arrhythmia Following PFO Closure Beta-blocker treatment group, Non-treatment group - Atrial Fibrillation, Atrial Flutter | Not applicable | Not yet recruiting | Yonsei University | 350 | 2025-09-01 | 2025-08-14 |
| Investigation of Tetralogy of Fallot in Neonates corrective surgery within 28 days of birth, corrective surgery between 3-6 months of age - Tetralogy of Fallot (TOF), Pulmonary Stenosis | Not applicable | Recruiting | Beijing Anzhen Hospital | 160 | 2025-03-01 | 2026-10-13 |
| Percutaneous Repair for Drug - Resistant Epilepsy by Intervention of Closing the Patent Foramen Ovale（PREDICT-PFO Trial） patent foramen ovale closure - Epilepsy (treatment Refractory) | Not applicable | Recruiting | Sichuan University | 180 | 2025-02-28 | 2025-03-11 |
| Close Obstructive Sleep Apnea (OSA) Trial PFO closure - Obstructive Sleep Apnea, Patent Foramen Ovale | Not applicable | Withdrawn | University of Miami | 2025-02-01 | 2025-03-20 | |
| Standardized Goal-Directed vs. Self-Directed Valsalva Maneuver for the Assessment of Patent Foramen Ovale Experimental: Intervention arm: Goal-Directed Valsalva maneuver, Control - standard of care: Self-Directed Valsalva maneuver - Stroke | Not applicable | Recruiting | Ottawa Heart Institute Research Corporation | 488 | 2025-01-30 | 2026-04-30 |
| High Intensity Interval Training in Patients With a Right Ventricle to Pulmonary Artery Conduit High intensity interval training - Congenital Heart Disease, Truncus Arteriosus | Not applicable | Recruiting | Erasmus Medical Center | 38 | 2025-01-16 | 2026-01-21 |
| Feasibility Study on the VERAFEYE System VERAFEYE System - Atrial Septal Defect, Atrial Fibrillation | Not applicable | Completed | LUMA Vision Ltd. | 18 | 2025-01-09 | 2026-02-10 |
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Foramen Ovale, Patent (54) · Heart Septal Defects, Atrial (33) · Stroke (15) · Heart Septal Defects, Ventricular (14) · Ischemic Stroke (14) · Heart Defects, Congenital (8) · Truncus Arteriosus, Persistent (8) · Migraine Disorders (7) · Atrial Fibrillation (6) · Tetralogy of Fallot (6) · Transposition of Great Vessels (5) · Double Outlet Right Ventricle (4) · Ischemic Attack, Transient (4) · Pulmonary Valve Stenosis (4)
Congenital, Hereditary, and Neonatal Diseases and Abnormalities (102) · Congenital Abnormalities (101) · Heart Diseases (101) · Cardiovascular Abnormalities (100) · Cardiovascular Diseases (99) · Heart Defects, Congenital (94) · Heart Septal Defects, Atrial (46) · Nervous System Diseases (33) · Vascular Diseases (32) · Brain Diseases (31) · Central Nervous System Diseases (31) · Cerebrovascular Disorders (24) · Pathological Conditions, Signs and Symptoms (14) · Pathologic Processes (12)
Aspirin (2) · Clopidogrel (2) · Drug Delivery Systems (2) · Septal Occluder Device (2) · Acetaminophen (1) · Aging (1) · Anesthesia, General (1) · Anesthesia, Local (1) · Angioplasty (1) · Aspirin, Dipyridamole Drug Combination (1) · Blood Specimen Collection (1) · Conversion to Open Surgery (1) · Device Lead Extraction (1) · Dipyridamole (1) · Echocardiography (1)
Abbott Medical Devices (6) · Lifetech Scientific (Shenzhen) Co., Ltd. (6) · W.L.Gore & Associates (6) · Carag AG (3) · Chinese Academy of Medical Sciences, Fuwai Hospital (3) · Cierra (3) · Josep Rodes-Cabau (2) · Recross Cardio, Inc. (2) · University of Miami (2) · pfm medical gmbh (2) · Asan Medical Center (1) · Assiut University (1) · Beijing Anzhen Hospital (1) · Bentong Yu (1) · C. R. Bard (1)
United States (31) · China (17) · Germany (16) · Canada (10) · France (8) · Netherlands (5) · Denmark (4) · Egypt (4) · Italy (4) · South Korea (4) · United Kingdom (4) · Ireland (3) · Switzerland (3) · Serbia (2) · Australia (1)
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PMID 18442545, PMID 19064683, PMID 20484101, PMID 20801925, PMID 22157844, PMID 22313193, PMID 22920912, PMID 24509270, PMID 24762035, PMID 26796197, PMID 27649347, PMID 27966652, PMID 28633478, PMID 28801537, PMID 28874164, PMID 28886621, PMID 28902580, PMID 29090661, PMID 29191325, PMID 29643872, PMID 31133575, PMID 31140194, PMID 31612072, PMID 32847382, PMID 33157063, PMID 33303305, PMID 34455822, PMID 34949392, PMID 35115207, PMID 35818509, PMID 36371488, PMID 37795589, PMID 39227910, PMID 39297855, PMID 39734195, PMID 40014670, PMID 40057986, PMID 40804644, PMID 40939873, PMID 41530892, PMID 41884901, PMID 42083863, PMID 42114665, PMID 42757893, PMID 42781600
2019 (1), 5UL1TR002240-05 (1)