55 terminated. 55 Phase 3, 12 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 55 | Terminated 55 |
| Phase 2 | 12 | Terminated 12 |
Follow Heart Failure: new trials by email Literature Review of Heart Failure trials Research Report on Heart Failure
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Research Study to Look at How Ziltivekimab Works Compared to Placebo in People With Heart Failure and Inflammation Ziltivekimab, Placebo - Heart Failure | Phase 3 | Terminated | Novo Nordisk A/S | 4874 | 2023-05-08 | 2026-10-01 |
| Immunosuppressive Treatment in Chronic Virus-Negative Inflammatory Cardiomyopathy Mycophenolate Mofetil, Prednisolone, Mycophenolate Mofetil Placebo - Inflammatory Cardiomyopathy | Phase 2 / Phase 3 | Terminated | LMU Klinikum | 9 | 2023-03-28 | 2025-07-25 |
| Ertugliflozin to Reduce Arrhythmic Burden in ICD/CRT patientS (ERASe-Trial) - a Phase III Study Ertugliflozin 5 mg, Placebo 5mg - Heart Failure With Reduced Ejection Fraction, Heart Failure With Mid Range Ejection Fraction | Phase 3 | Terminated | Medical University of Graz | 55 | 2021-06-24 | 2025-06-03 |
| A Mobile Application to Promote Self-management and Improve Outcomes in Heart Failure Sodium intervention, Clinical worsening intervention, Educational content - Heart Failure | Phase 3 | Terminated | University of Michigan | 62 | 2021-06-14 | 2026-09-17 |
| COLchicine to Prevent Sympathetic Denervation After an Acute Myocardial Infarction Colchicine - Myocardial Infarction, Acute | Phase 2 / Phase 3 | Terminated | University Hospital, Montpellier | 54 | 2020-12-04 | 2026-06-12 |
| Ozone Therapy in Refractory Ischemic Heart Disease. Ozone, Oxygen - Ischemic Heart Disease | Phase 2 / Phase 3 | Terminated | Bernardino Clavo, MD, PhD | 1 | 2020-02-26 | 2022-04-04 |
| The Impact of Low Flow Nocturnal Oxygen Therapy on Hospital Admissions and Mortality in Patients With Heart Failure and Central Sleep Apnea Oxygen, Room Air - Heart Failure, Central Sleep Apnea | Phase 3 | Terminated | Brigham and Women's Hospital | 98 | 2019-04-15 | 2023-08-01 |
| Iron in Patients With Cardiovascular Disease Ferric carboxymaltose, Saline - Cardiovascular Diseases, Anemia, Iron-deficiency | Phase 3 | Terminated | Dr. med. Mahir Karakas | 8 | 2019-02-28 | 2023-12-27 |
| Spironolactone in the Treatment of Heart Failure Experimental: Spironolactone, Placebo Comparator - Heart Failure with Mid-range Ejection Fraction, Heart Failure with Preserved Ejection Fraction | Phase 3 | Terminated | Charite University, Berlin, Germany | 743 | 2018-11-01 | 2025-03-28 |
| Administration of Prothrombin Complex Concentrate vs. Standard Transfusion During/After Heart Transplantation Kcentra, Frozen Plasma Product, Human - Heart Disease End Stage, Heart Failureļ¼Congestive | Phase 3 | Terminated | University of Maryland, Baltimore | 14 | 2018-07-11 | 2025-05-23 |
| Effect of Sotagliflozin on Cardiovascular Events in Participants With Type 2 Diabetes Post Worsening Heart Failure (SOLOIST-WHF Trial) Sotagliflozin, Placebo - Heart Failure, Type 2 Diabetes Mellitus | Phase 3 | Terminated | Lexicon Pharmaceuticals | 1222 | 2018-06-15 | 2022-10-28 |
| A Study of ARRY-371797 (PF-07265803) in Patients With Symptomatic Dilated Cardiomyopathy Due to a Lamin A/C Gene Mutation ARRY-371797 (PF-07265803), Placebo - Dilated Cardiomyopathy, Lamin A/C Gene Mutation | Phase 3 | Terminated | Pfizer | 77 | 2018-04-17 | 2024-01-09 |
| Clinical Utility of Subcutaneous Furosemide in Patients Presenting With Early Signs of Fluid Overload sc2Wear Furosemide Infusor - Heart Failure | Phase 2 / Phase 3 | Terminated | Steward St. Elizabeth's Medical Center of Boston, Inc. | 9 | 2018-04-05 | 2022-10-13 |
| Effect of Sotagliflozin on Cardiovascular and Renal Events in Participants With Type 2 Diabetes and Moderate Renal Impairment Who Are at Cardiovascular Risk Sotagliflozin, Placebo - Heart Failure, Type 2 Diabetes Mellitus | Phase 3 | Terminated | Lexicon Pharmaceuticals | 10584 | 2017-12-19 | 2022-10-28 |
| High-Flow-Therapy for the Treatment of Cheyne-Stokes-Respiration in Chronic Heart Failure Oxygen, Placebo - Heart Failureļ¼Congestive | Phase 3 | Terminated | Heart and Diabetes Center North-Rhine Westfalia | 14 | 2017-02-02 | 2018-09-26 |
| Prevention of Hemorrhage After Implantation of Mechanical Circulatory Support Prophylactic treatment with Wilfactin - Heart Failure | Phase 3 | Terminated | University Hospital, Lille | 31 | 2016-01-20 | 2019-07-11 |
| International Study to Determine if AdreView Heart Function Scan Can be Used to Identify Patients With Mild or Moderate Heart Failure (HF) That Benefit From Implanted Medical Device Iobenguane I -123 Injection, Implantable Cardioverter Defibrillator, Thyroid blocking - Heart Failure | Phase 3 | Terminated | GE Healthcare | 395 | 2015-12-30 | 2019-05-22 |
| Metolazone As Early Add On Therapy For Acute Decompensated Heart Failure (MELT-HF)--A Single Center Pilot Study. Experimental: Placebo, Experimental: Metolazone - Acute Decompensated Heart Failure | Phase 3 | Terminated | Aultman Health Foundation | 147 | 2015-10-01 | 2019-02-15 |
| Effect of Eleclazine (GS-6615) on Exercise Capacity in Subjects With Symptomatic Hypertrophic Cardiomyopathy Eleclazine, Placebo - Hypertrophic Cardiomyopathy | Phase 2 / Phase 3 | Terminated | Gilead Sciences | 172 | 2015-02-05 | 2018-09-24 |
| OneShot Renal Denervation Registry OneShot Ablation System - Hypertension, Heart Failure | Phase 2 / Phase 3 | Terminated | Medtronic Endovascular | 51 | 2014-07-01 | 2015-09-02 |
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Anemia (3) · Cardiomyopathy, Dilated (3) · Diabetes Mellitus, Type 2 (3) · Heart Diseases (3) · Heart Failure, Systolic (3) · Hypertension (3) · Atrial Fibrillation (2) · Breast Neoplasms (2) · Cardiomyopathies (2) · Cardiovascular Diseases (2) · Diabetes Mellitus (2) · Heart Failure, Diastolic (2) · Hypertension, Pulmonary (2) · Iron Deficiencies (2)
Cardiovascular Diseases (53) · Heart Diseases (52) · Vascular Diseases (10) · Pathological Conditions, Signs and Symptoms (9) · Pathologic Processes (8) · Nutritional and Metabolic Diseases (7) · Metabolic Diseases (6) · Respiratory Tract Diseases (6) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (5) · Arrhythmias, Cardiac (4) · Endocrine System Diseases (4) · Genetic Diseases, Inborn (4) · Glucose Metabolism Disorders (4) · Myocardial Ischemia (4)
Metoprolol (3) · Oxygen (3) · (2S,3R,4R,5S,6R)-2-(4-chloro-3-(4-ethoxybenzyl)phenyl)-6-(methylthio)tetrahydro-2H-pyran-3,4,5-triol (2) · Defibrillators, Implantable (2) · Enoximone (2) · Simendan (2) · Sodium Chloride (2) · ferric carboxymaltose (2) · 3-Iodobenzylguanidine (1) · ARRY-371797 (1) · Acetazolamide (1) · Amiodarone (1) · Atenolol (1) · Buspirone (1) · Cardiac Resynchronization Therapy (1)
Gilead Sciences (3) · CardioKinetix, Inc (2) · Lexicon Pharmaceuticals (2) · AHEPA University Hospital (1) · Amgen (1) · Aultman Health Foundation (1) · Bernardino Clavo, MD, PhD (1) · BioControl Medical (1) · Biotronik, Inc. (1) · Boston Scientific Corporation (1) · Brigham and Women's Hospital (1) · Carelon Research (1) · Charite University, Berlin, Germany (1) · Columbia University (1) · Dr. med. Mahir Karakas (1)
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Suman Wason, MD (2) · Andre Denault, Prof. (1) · Andrea D'Armini, Prof. (1) · Arthur J. Moss, M.D. (1) · Benjamin JW Chow, MD, FRCPC (1) · Bernardino Clavo, MD, PhD (1) · Burkert Pieske, Prof. MD (1) · Celestina Amador, MD, PhD (1) · Dirk von Lewinski, Assoc-Prof. (1) · Douglas L. Mann, MD (1) · Eugene Braunwald, MD (1) · Fabrizio Oliva, MD (1) · Flora S Siami, MPH (1)
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