336 completed. 336 Phase 2, 55 Phase 1, 49 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 336 | Completed 336 |
| Phase 1 | 55 | Completed 55 |
| Phase 3 | 49 | Completed 49 |
Follow Heart Failure: new trials by email Literature Review of Heart Failure trials Research Report on Heart Failure
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Dose-finding Study of JMKX003142 in Treatment of Cardiac Edema JMKX003142 Injection, JMKX003142 placebo - Cardiac Edema | Phase 2 | Completed | Jemincare | 160 | 2025-07-09 | 2026-08-06 |
| Effects of Dapagliflozin, Semaglutide, and Their Combination in Heart Failure Patients With Prosthetic Heart Valves semaglutide, Dapagliflozin (10mg Tab) - Heart Failure, Heart Valve Prosthesis | Phase 2 | Completed | Kafrelsheikh University | 160 | 2025-06-02 | 2026-05-29 |
| Mangafodipir - an Intracellular Contrast Agent for Magnetic Resonance Imaging (MRI): Measuring Manganese Uptake Rate in Heart Failure Patients With Preserved Ejection Fraction (HFpEF) Patients. Gadoteric acid, Mangafodipir trisodium injection - Heart Failure With Preserved Ejection Fraction (HFPEF) | Phase 2 | Completed | IC TARGETS AS | 44 | 2024-11-22 | 2026-01-08 |
| Allopurinol Improves Heart Function in African Americans With Resistant Hypertension Allopurinol - Heart Failure Preserved Ejection Fraction, Resistant Hypertension | Phase 2 | Completed | VA Office of Research and Development | 40 | 2024-09-30 | 2026-09-04 |
| Effect of Extended Release Torsemide in Patients With Congestive Heart Failure and Overactive Bladder Extended release torsemide, Immediate release torsemide, Extended release torsemide placebo - Heart Failure, Overactive Bladder | Phase 2 | Completed | Sarfez Pharmaceuticals, Inc. | 24 | 2024-06-15 | 2026-03-12 |
| Sodium-Glucose Cotransporter-2 Inhibitor for Acute Cardiorenal Syndrome: A Feasibility Study Dapagliflozin - Cardiorenal Syndrome | Phase 2 | Completed | Yale University | 30 | 2024-05-30 | 2026-08-13 |
| Ketones in Heart Failure With Reduced Ejection Fraction ketone ester, placebo - Heart Failure With Reduced Ejection Fraction | Phase 2 | Completed | Duke University | 25 | 2024-03-06 | 2026-09-03 |
| To Evaluate the Safety, Tolerability and Efficacy of R2R01 Combined With SOC as Compared to SOC Alone in Outpatients With Worsening Heart Failure (WHF) Placebo, R2R01 - Heart Failure, Worsening Heart Failure (WHF) | Phase 2 | Completed | River 2 Renal Corp. | 33 | 2024-03-01 | 2026-06-22 |
| A Study to Assess Safety & Effectiveness of Tovinontrine in Chronic Heart Failure With Reduced Ejection Fraction (Cycle-1-REF) Tovinontrine (CRD-750), Placebo - Heart Failure, Heart Failure With Reduced Ejection Fraction | Phase 2 | Completed | Cardurion Pharmaceuticals, Inc. | 557 | 2024-02-13 | 2026-09-01 |
| Safety & Effectiveness of Tovinontrine in Chronic Heart Failure With Preserved Ejection Fraction (Cycle-2-PEF) Tovinontrine (CRD-750), Placebo - Heart Failure, Heart Failure Preserved Ejection Fraction | Phase 2 | Completed | Cardurion Pharmaceuticals, Inc. | 303 | 2024-02-13 | 2026-09-01 |
| Evaluate Efficacy, Safety and Tolerability of JTT-861 in Subjects With Heart Failure With Reduced Ejection Fraction JTT-861 Capsules, Placebo Capsules - Chronic Heart Failure | Phase 2 | Completed | Akros Pharma Inc. | 314 | 2023-12-20 | 2026-09-24 |
| A Randomised, Controlled Trial of a Low-energy Diet for Improving Functional Status in Heart Failure With PRESERVED Ejection Fraction Preserved Ejection Fraction Low calorie meal replacement plan, Cardiovascular magnetic resonance (CMR) imaging and magnetic resonance spectroscopy, Transthoracic echocardiography - Heart Failure With Preserved Ejection Fraction, Heart Failure, Diastolic | Phase 2 / Phase 3 | Completed | University of Leicester | 66 | 2023-12-05 | 2026-07-22 |
| A Study of Ultra High Dose Diuretics to Treat Heart Failure Bumetanide, Furosemide - Heart Failure; With Decompensation | Phase 2 | Completed | Mayo Clinic | 20 | 2023-11-27 | 2026-01-14 |
| Effect of Empagliflozin 10 vs 25 mg on LV Remodeling in Diabetic Patients With Anterior STEMI With Reduced LVEF Empagliflozin 10 MG [Jardiance], empagliflozin (Jardiance) 25 mg - Diabete Mellitus, Heart Failure | Phase 2 | Completed | Ain Shams University | 200 | 2023-07-12 | 2025-09-12 |
| Furoscix in Heart Failure Patients With Diuretic Resistance Furoscix, Diuretic Therapy - Heart Failure | Phase 2 | Completed | University of Texas Southwestern Medical Center | 70 | 2023-06-02 | 2025-07-16 |
| A Study of AZD3427 in Participants With Heart Failure and Pulmonary Hypertension Group 2 AZD3427, Placebo - Pulmonary Hypertension (World Health Organization Group 2), Heart Failure | Phase 2 | Completed | AstraZeneca | 260 | 2023-04-24 | 2026-10-27 |
| Hemodynamic Effects of Modulating Circulating Ketone Bodies With 1,3-butanediol 1,3-Butanediol, Placebo - Heart Failure | Phase 2 | Completed | Aarhus University Hospital | 12 | 2023-04-01 | 2024-03-22 |
| A Dose-ranging Trial of OPC-131461 in Cardiac Edema (Congestive Heart Failure [CHF]) OPC 131461 10mg group, OPC 131461 5mg group, OPC 131461 2mg group - Cardiac Edema (CHF) | Phase 2 | Completed | Otsuka Pharmaceutical Co., Ltd. | 157 | 2023-01-10 | 2025-10-20 |
| Effect of Diuretics Withdrawal in Chronic Heart Failure With Reduced Ejection Fraction Diuretics withdrawal, Diuretics maintenance - Heart Failure, Electric Impedance | Phase 2 | Completed | Maimónides Biomedical Research Institute of Córdoba | 98 | 2022-12-19 | 2024-11-04 |
| Use of a Novel SUBCUTaneous Preparation of Furosemide to Facilitate Early Supported Discharge of Patients With Heart Failure SQIN-Furosemide, SQIN-Infusor - Heart Failure | Phase 2 | Completed | NHS Greater Glasgow and Clyde | 172 | 2022-11-17 | 2026-03-30 |
Showing 20 of 336. Sign in to see all of them.
Cardiomyopathy, Dilated (15) · Heart Failure, Diastolic (15) · Diabetes Mellitus (12) · Heart Failure, Systolic (12) · Cardiomyopathies (11) · Cardiovascular Diseases (11) · Inflammation (10) · Renal Insufficiency (10) · Heart Diseases (8) · Myocardial Ischemia (8) · Myocardial Infarction (7) · Diabetes Mellitus, Type 2 (6) · Anemia (5) · Coronary Artery Disease (5)
Heart Diseases (328) · Cardiovascular Diseases (325) · Pathological Conditions, Signs and Symptoms (66) · Pathologic Processes (43) · Vascular Diseases (39) · Nutritional and Metabolic Diseases (30) · Metabolic Diseases (28) · Signs and Symptoms (24) · Endocrine System Diseases (21) · Glucose Metabolism Disorders (20) · Respiratory Tract Diseases (20) · Myocardial Ischemia (19) · Female Urogenital Diseases (18) · Female Urogenital Diseases and Pregnancy Complications (18)
Furosemide (10) · Natriuretic Peptide, Brain (10) · Sodium Chloride (9) · Interleukin 1 Receptor Antagonist Protein (7) · Spironolactone (7) · Sodium Nitrite (6) · Allopurinol (5) · Metformin (5) · omecamtiv mecarbil (5) · Sildenafil Citrate (4) · Tolvaptan (4) · alagebrium (4) · dapagliflozin (4) · empagliflozin (4) · sacubitril and valsartan sodium hydrate drug combination (4)
Bayer (11) · Mayo Clinic (8) · Boston Scientific Corporation (7) · Bristol-Myers Squibb (7) · Duke University (7) · Novartis Pharmaceuticals (7) · University of Aarhus (7) · University of Pennsylvania (7) · Virginia Commonwealth University (7) · AstraZeneca (6) · Cytokinetics (5) · Synvista Therapeutics, Inc (4) · University of Washington (4) · scPharmaceuticals, Inc. (4) · Amgen (3)
United States (180) · Germany (50) · Poland (36) · Netherlands (33) · Canada (31) · United Kingdom (30) · Denmark (26) · Italy (24) · Czechia (19) · Spain (18) · Hungary (16) · Japan (16) · Australia (15) · Bulgaria (15) · Belgium (14)
Eugene Braunwald, MD (4) · Horng H. Chen, M.D. (4) · Antonio Abbate, MD, PhD (3) · Benjamin Van Tassell, PharmD (3) · Benjamin W Van Tassell, PharmD (3) · Julio A Chirinos, MD, PhD (3) · Rainer P Hambrecht, MD (3) · Adrian Hernandez, MD (2) · Andrew R Coggan, PhD (2) · Anne R Cappola, MD,ScM (2)
PMID 33107592, PMID 22936827, PMID 24107588, PMID 31168885, PMID 32150314, PMID 35079778, PMID 38365073, PMID 40938666, PMID 10618557, PMID 10723976, PMID 10843268, PMID 10999979, PMID 11176729, PMID 11561221, PMID 11755290, PMID 11832662, PMID 11911756, PMID 12016627, PMID 12140801, PMID 12140805, PMID 12151474, PMID 14563591, PMID 15152059, PMID 15319045, PMID 15704055, PMID 15739984, PMID 15795361, PMID 15812741, PMID 16796497, PMID 17543634, PMID 17923351, PMID 17992382, PMID 18195176, PMID 18534276, PMID 18549913, PMID 18553028, PMID 18599344, PMID 18760123, PMID 18760668, PMID 19007589, PMID 19095138, PMID 19204305, PMID 19327618, PMID 19329178, PMID 19464414, PMID 19567409, PMID 19679246, PMID 19808265, PMID 19919976, PMID 19920054
2016 (6), 2023 (5), P01HL076611 (5), R01HL084155 (4), UL1RR024150 (4), 2014 (3), U10HL084904 (3), 2005 (2), 2017 (2), 2018 (2), 2019 (2), R01HL128526 (2), R61HL146390 (2), U01HL088942 (2), UL1TR000135 (2)