8 completed, 5 terminated. 13 Phase 2, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 13 | Completed 8, Terminated 5 |
| Phase 3 | 1 | Completed 1 |
Follow alagebrium: new trials by email Literature Review of alagebrium trials Research Report on alagebrium
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effects of Exercise Training and AGE-crosslink Breaker on Cardiovascular Structure and Function Alt-711, Physical exercise training - Cardiovascular Disease, Aging | Phase 2 / Phase 3 | Completed | Radboud University Medical Center | 48 | 2008-11-01 | 2013-09-09 |
| Safety & Efficacy of ALT-711 (Alagebrium) in Chronic Heart Failure ALT-711, Placebo - Chronic Heart Failure | Phase 2 | Terminated | Synvista Therapeutics, Inc | 100 | 2008-08-01 | 2009-01-30 |
| The Effect of Exercise and Alagebrium on the Diastolic Function of the Heart Aerobic Exercise Training, Alagebrium (generic: ALT-711), Tai Chi and/or Yoga Training - Ventricular Function | Phase 2 | Completed | University of Texas Southwestern Medical Center | 62 | 2008-07-01 | 2020-08-07 |
| Beginning a Randomized Evaluation of the AGE Breaker Alagebrium in Diastolic Heart Failure (BREAK-DHF-I) alagebrium, placebo - Diastolic Heart Failure | Phase 2 | Terminated | Synvista Therapeutics, Inc | 160 | 2008-03-01 | 2009-01-30 |
| A Randomized Double-Blind, Placebo-Controlled, Multiple-Dose Study to Evaluate the Effects of Alagebrium on Exercise in Subjects With Diastolic Heart Failure Alagebrium - Diastolic Heart Failure | Phase 2 | Terminated | Cardiovascular Clinical Sciences Inc | 134 | 2007-12-01 | 2013-08-01 |
| Study of Alagebrium in Patients With Insulin-Dependent Type 1 Diabetes and Microalbuminuria Alagebrium, Placebo - Diabetes Mellitus, Type 1, Diabetic Nephropathy | Phase 2 | Terminated | Synvista Therapeutics, Inc | 80 | 2007-11-01 | 2009-01-30 |
| The BENEFICIAL Study: Evaluating the Efficacy and Safety of Alagebrium (ALT-711) in Patients With Chronic Heart Failure ALT-711, Placebo - Heart Failure | Phase 2 | Completed | Synvista Therapeutics, Inc | 100 | 2007-08-01 | 2010-01-13 |
| The STRETCH Study: Distensibility on Endothelial-Dependent Vasoreactivity in Subjects With Systolic Hypertension ALT-711 (alagebrium chloride) - Cardiovascular Disease | Phase 2 | Completed | Synvista Therapeutics, Inc | 70 | 2006-02-01 | 2006-03-22 |
| Systolic Pressure Efficacy and Safety Trial of Alagebrium (SPECTRA) alagebrium chloride (ALT-711) - Hypertension | Phase 2 | Terminated | Synvista Therapeutics, Inc | 392 | 2004-03-01 | 2010-02-08 |
| STRETCH Study: Effect of Distensibility on Endothelial-Dependent Vasoreactivity in Patients With ISH ALT-711 (alagebrium chloride) - Cardiovascular Disease | Phase 2 | Completed | Synvista Therapeutics, Inc | 25 | 2004-02-01 | 2009-08-27 |
| The DIAMOND Study: Distensibility Improvement And Remodeling in Diastolic Heart Failure ALT-711 - Heart Failure, Congestive, Dyspnea | Phase 2 | Completed | Synvista Therapeutics, Inc | 20 | 2002-07-01 | 2009-09-02 |
| The SAPPHIRE Study (Systolic And Pulse Pressure Hemodynamic Improvement By Restoring Elasticity) ALT-711 - Hypertension | Phase 2 | Completed | Synvista Therapeutics, Inc | 450 | 2001-10-01 | 2010-03-26 |
| The SILVER Study: Systolic Hypertension Interaction With Left Ventricular Remodeling ALT-711 - Hypertension, Hypertrophy, Left Ventricular | Phase 2 | Completed | Synvista Therapeutics, Inc | 180 | 2001-08-01 | 2009-07-29 |
Heart Failure (4) · Cardiovascular Diseases (3) · Hypertension (3) · Heart Failure, Diastolic (2) · Motor Activity (2) · Diabetes Mellitus, Type 1 (1) · Diabetic Nephropathies (1) · Dyspnea (1) · Hypertrophy, Left Ventricular (1) · Isolated Systolic Hypertension (1) · Pulmonary Edema (1)
Synvista Therapeutics, Inc (10) · Cardiovascular Clinical Sciences Inc (1) · Radboud University Medical Center (1) · University of Texas Southwestern Medical Center (1)
United States (7) · Netherlands (2) · Australia (1) · Denmark (1)
Milan Kovacevic, MD, PhD (3) · Susan Zieman, MD, PhD (2) · Adriaan A Voors, MD, PhD (1) · Benjamin D Levine, M.D. (1) · Bertram Pitt, MD (1) · Dalane W Kitzman, MD (1) · Maria TE Hopman, MD, PhD (1) · Mark E Cooper, MBBS, PhD (1) · Michael R Zile, MD (1)
PMID 20100811, PMID 21669961, PMID 24130005, PMID 24400341
R01AG017479 (1)