33 completed, 15 unknown, 11 recruiting, 11 terminated. 28 Not applicable, 10 Phase 2, 10 Phase 4, 8 Phase 3, 4 Phase 1.
Follow Cardio-Renal Syndrome: new trials by email Literature Review of Cardio-Renal Syndrome trials Research Report on Cardio-Renal Syndrome
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Optimised Cardiovascular and Renal Protection in Patients With Chronic Kidney Disease and Cardiovascular Disease Multidisciplinary Cardio-Renal Care - Chronic Kidney Disease, Heart Failure With Preserved Ejection Fraction (HFPEF) | Not applicable | Recruiting | Odense University Hospital | 500 | 2026-10-01 | 2026-10-15 |
| Cardiorenal Syndrome: Characteristics and Prognostic Impact in Advanced Heart Failure Cardiorenal syndrome follow-up - Advanced Heart Failure, Cardiorenal Syndrome | Not applicable | Not yet recruiting | Hospices Civils de Lyon | 100 | 2026-09-01 | 2026-07-01 |
| Monitoring of the Sympathetic/Vagal Balance Through Multiparametric Analysis of Heart Rate Variability (HRV) HOLTER ECG monitoring - Diabete Type 2, Heart Failure | Active not recruiting | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | 150 | 2026-05-20 | 2026-09-04 | |
| Spironolactone Alternate Dosing vs Finerenone in Elevated Potassium - K Safety Study Finerenone, Spironolactone (drug) - Heart Failure, Diabetic Kidney Disease | Phase 4 | Not yet recruiting | Hospital de Messejana Dr. Carlos Alberto Studart Gomes | 60 | 2026-04-01 | 2026-05-13 |
| Efficacy and Safety of Compression Boots in Patients With Acute Decompensated Heart Failure. Pulsatile Compression Boots (PCB) - Acute Decompensated Heart Failure (ADHF) | Not applicable | Not yet recruiting | Odense University Hospital | 100 | 2026-01-01 | 2026-01-29 |
| Dapagliflozin for Cardio-renal Protection After ICU Discharge Dapagliflozin 10 MG Oral Tablet [Farxiga], One tablet of placebo of dapagliflozin 10 mg - Heart Failure and Chronic Kidney Disease Post-ICU | Phase 3 | Recruiting | Assistance Publique - Hôpitaux de Paris | 600 | 2025-12-02 | 2026-02-23 |
| French AKI Registry (FAKIR): A Multicenter Study on the In-Hospital Management and Outcomes of Severe Acute Kidney Injury in Nephrology Units Acute Kidney Injury, Kidney Failure Chronic | Not yet recruiting | University Hospital, Strasbourg, France | 750 | 2025-11-01 | 2025-08-14 | |
| Feasibility of the SCD in Cardiorenal Syndrome Patients Awaiting LVAD Selective Cytopheretic Device - Acute on Chronic Systolic Congestive Heart Failure, Cardiorenal Syndrome | Not applicable | Recruiting | SeaStar Medical | 20 | 2025-10-02 | 2026-03-31 |
| Screening of Predictive Biomarkers for Cardiorenal Syndrome This is an observational Study. - Cardiorenal Syndrome (CRS) | Recruiting | Haiyan Pan | 150 | 2025-09-15 | 2026-02-27 | |
| Exercise Rehabilitation for Cardiorenal Syndrome in HFrEF Patients Standardized Basic Drug Therapy for HFrEF with Chronic Kidney Dysfunction, Home-based Personalized Exercise Rehabilitation - Cardiorenal Syndrome | Not applicable | Recruiting | Haiyan Pan | 60 | 2025-09-15 | 2026-02-27 |
| SCD for CRS in Congestive Heart Failure (CHF) (No Left Ventricular Assist Device) Selective Cytopheretic Device - Heart Failure, Chronic Systolic Heart Failure | Not applicable | Suspended | Lenar Yessayan | 10 | 2025-09-01 | 2024-09-27 |
| The Role of intraABDOminal Pressure and Point Of Care UltraSound to Guide Decongestive Therapy in Heart Failure Furosemide 20 Milligrams - Acute Heart Failure, Congestive Heart Failure | Phase 3 | Recruiting | Instituto de Investigación Sanitaria Aragón | 168 | 2025-03-10 | 2025-06-06 |
| The Treatment Effects of Empagliflozin on Renal Outcomes in Cardiorenal Syndrome Type 1 Empagliflozin 10 MG, Placebo - Empagliflozin in Cardiorenal Syndrome Type 1 | Phase 2 / Phase 3 | Recruiting | Chulalongkorn University | 200 | 2025-03-01 | 2026-06-16 |
| Evaluation of the Impact of Interventional Treatments for Symptomatic, Severe Tricuspid Valve Insufficiency on Renal Integrity and Function, as Well as on Physical Function and Activity in Older Adults. Transcatheter edge-to-edge repair (TEER) - Tricuspid Regurgitation, Tricuspid Valve Insufficiency | Recruiting | Robert Bosch Medical Center | 100 | 2025-02-01 | 2026-03-11 | |
| Effects of a Supervised Training Program on Functional Capacity in Patients With HF and Cardiorenal Syndrome Supervised aerobic plus strength training - Heart Failure, Cardiorenal Syndrome | Not applicable | Not yet recruiting | Fundación para la Investigación del Hospital Clínico de Valencia | 26 | 2024-10-08 | 2024-10-15 |
| Venous Ultrasound Guided Organ Decongestion in Patients Hospitalized with Acute Decompensated Heart Failure VExUS guided decongestion - Cardiorenal Syndrome, Heart Failure | Not applicable | Recruiting | Oslo University Hospital | 180 | 2024-09-16 | 2024-12-03 |
| Cardio-Renal Registry Observation - End Stage Renal Disease, Cardio-Renal Syndrome | Recruiting | Queen Mary University of London | 60000 | 2024-08-01 | 2026-01-07 | |
| Feasibility Study to Support Cardiorenal Function in Acute Decompensated Heart Failure With Diuretic Resistance ModulHeart Support - Heart Failure, Acute Decompensated Heart Failure | Not applicable | Unknown | Puzzle Medical Devices Inc. | 5 | 2024-08-01 | 2024-06-17 |
| Sodium-Glucose Cotransporter-2 Inhibitor for Acute Cardiorenal Syndrome: A Feasibility Study Dapagliflozin - Cardiorenal Syndrome | Phase 2 | Completed | Yale University | 30 | 2024-05-30 | 2026-08-13 |
| Diuretics Alone vs. Aortix Endovascular Device for Acute Heart Failure Aortix System - Heart Failure, Cardiorenal Syndrome | Not applicable | Recruiting | Procyrion | 320 | 2023-08-23 | 2026-08-25 |
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Heart Failure (30) · Renal Insufficiency, Chronic (13) · Renal Insufficiency (10) · Acute Kidney Injury (9) · Edema (4) · Coronary Artery Disease (3) · Heart Diseases (3) · Heart Failure, Diastolic (3) · Heart Failure, Systolic (3) · Hyperemia (3) · Kidney Failure, Chronic (3) · Metabolic Syndrome (3) · Cardiovascular Diseases (2) · Kidney Diseases (2)
Female Urogenital Diseases (82) · Female Urogenital Diseases and Pregnancy Complications (82) · Male Urogenital Diseases (82) · Urogenital Diseases (82) · Urologic Diseases (82) · Cardiovascular Diseases (80) · Kidney Diseases (80) · Heart Diseases (79) · Renal Insufficiency (72) · Heart Failure (52) · Pathological Conditions, Signs and Symptoms (25) · Pathologic Processes (20) · Chronic Disease (16) · Disease Attributes (16) · Vascular Diseases (11)
Spironolactone (6) · Simendan (4) · Dobutamine (3) · Furosemide (3) · Ultrafiltration (3) · dapagliflozin (3) · Cardiac Surgical Procedures (2) · Chlorthalidone (2) · Diet (2) · Isosorbide Dinitrate (2) · Milrinone (2) · Natriuretic Peptide, Brain (2) · Saline Solution, Hypertonic (2) · iodixanol (2) · Acetazolamide (1)
Hospices Civils de Lyon (4) · Chinese PLA General Hospital (3) · Assiut University (2) · Guangdong Provincial People's Hospital (2) · Haiyan Pan (2) · Hospital Civil de Guadalajara (2) · Odense University Hospital (2) · Procyrion (2) · Triomed AB (2) · University of Giessen (2) · 3ive Labs (1) · Ain Shams University (1) · Ankara University (1) · Aspirus Heart and Vascular Institute-Research and Education (1) · Assistance Publique - Hôpitaux de Paris (1)
United States (17) · China (7) · France (7) · Germany (7) · Canada (3) · Italy (3) · Mexico (3) · Netherlands (3) · Sweden (3) · United Kingdom (3) · Australia (2) · Belgium (2) · Denmark (2) · Georgia (2) · Norway (2)
Dai Yun Chen, MD (2) · Horng H. Chen, M.D. (2) · Shiqun Chen, MS (2) · Abdallah I. Kelany, MD (1) · Abinet Aklilu (1) · Alex Parker, MD (1) · Alexander Kharlamov, M.D. (1) · Alexander Perrish, M.D. (1) · Alexandre Mebazaa, MD-PHD (1) · Anitha Vijayan, M.D. (1) · Ann-Cathrine Johansson, MD, PhD (1) · Branko Braam, MD, PhD (1) · Carlo AJ Gaillard, MD, PhD (1)
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R01HL084155 (1), R44HL170779 (1), U01HL084904 (1)