62 completed, 17 recruiting, 17 unknown, 16 terminated. 44 Not applicable, 20 Phase 2, 19 Phase 3, 9 Phase 1, 6 Phase 4.
Follow Cluster Headache: new trials by email Literature Review of Cluster Headache trials Research Report on Cluster Headache
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Pivotal Clinical Study to Evaluate the MySalvia System for the Treatment of Resistant Migraine Neurostimulator - Resistant Migraine, Chronic Migraine Headache | Not applicable | Recruiting | Salvia BioElectronics | 150 | 2026-12-01 | 2026-08-28 |
| Efficacy, Safety and Tolerability of Low Sodium Oxybate for Nocturnal Cluster Headache Attacks Low Sodium Oxybate, Placebo - Chronic Cluster Headache | Phase 2 | Not yet recruiting | Leiden University Medical Center | 52 | 2026-12-01 | 2026-08-25 |
| Zavegepant Intranasal Spray for the Acute Treatment of Episodic Cluster Headache Zavegepant 20 mg - Cluster Headache | Phase 2 | Not yet recruiting | The University of Texas Health Science Center, Houston | 40 | 2026-10-01 | 2026-10-02 |
| Italian Trigeminal Autonomic Cephalalgias Assessment Study Trigeminal Autonomic Cephalalgias, Cluster Headache | Recruiting | Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta | 800 | 2026-09-15 | 2026-09-22 | |
| High- vs Standard-Dose Intravenous Magnesium for Acute Headache Magnesium Sulfate 2 grams, Magnesium Sulfate 4 G, Paracetamol 1 g - Acute Headache, Migraine | Not applicable | Recruiting | University of Monastir | 300 | 2026-06-01 | 2026-08-21 |
| A First-in-human Study to Assess the Initial Safety, Tolerability, and Effectiveness of the ONSS Bilateral Occipital Nerve Field Stimulation System for the Prophylactic Treatment of Chronic Cluster Headache in Difficult-to-treat Subjects. Occipital Nerve Stimulation System - Chronic Cluster Headache | Not applicable | Recruiting | Man and Science, SA | 10 | 2026-05-18 | 2026-08-27 |
| Yogabased Movements for Primary Headaches (Migraine and/or Cluster Headache) - YOURHEAD Intervention yoga based exercises - Cluster Headache - Episodic and Chronic, Migraine Headache | Not applicable | Recruiting | Karolinska Institutet | 80 | 2026-05-01 | 2026-09-23 |
| Response to Combined Trigeminal and Occipital Nerve Stimulation for the Preventive Treatment in Chronic Cluster Headache The Salvia PRIMUS implantable neurostimulator System - Chronic Cluster Headache | Not applicable | Recruiting | Salvia BioElectronics | 10 | 2026-04-13 | 2026-07-16 |
| Yogabased Movements for Primary Headaches (Migraine and/or Cluster Headache) - YOURHEAD - a Pilot Study Intervention yogabased movements - Cluster Headache - Episodic and Chronic, Migraine Headache | Not applicable | Active not recruiting | Karolinska Institutet | 20 | 2026-01-01 | 2026-09-23 |
| Osteopathic Manual Therapy (OMT) and Brain Structure and Function in Primary Headache Patients: A Pilot Study Osteopathic Manipulative Therapy - Primary Headaches (Migraines, Tension, Cluster Headaches) | Not applicable | Completed | Edward Via Virginia College of Osteopathic Medicine | 31 | 2025-08-05 | 2026-05-06 |
| Pulsed Radiofrequency Combined With Platelet-Rich Plasma Applied to the Sphenopalatine Ganglion in Treating Episodic Cluster Headache Cluster Headache, Pain Management | Not yet recruiting | Beijing Tiantan Hospital | 242 | 2025-05-01 | 2025-03-24 | |
| LSD to Improve Cluster Headache Impact Trial LSD tartrate, Placebo - Chronic Cluster Headache | Phase 2 | Recruiting | Radboud University Medical Center | 65 | 2025-04-16 | 2025-04-15 |
| Sphenopalatine Ganglion Pulsed Radiofrequency Treatment Outcomes Pulsed Radiofrequency of the Sphenopalatine Ganglion - Migraine Disorders, Facial Pain Disorder, Cluster Headache, Trigeminal Neuralgia, Trigeminal Autonomic Cephalalgias | Not applicable | Completed | Ankara City Hospital Bilkent | 55 | 2025-03-20 | 2026-03-18 |
| Efficacy of Light Therapy in Treatment of Chronic Cluster Headache use of Luminettes ® with active light emission, use of Luminettes ® with a light emission presumed to have no therapeutic effect - Cluster Headache | Not applicable | Recruiting | Assistance Publique Hopitaux De Marseille | 48 | 2025-02-06 | 2025-03-17 |
| SPG Pulsed Radiofrequency for Chronic Cluster Headache PRF, NB - Headache, Cluster | Not applicable | Recruiting | Beijing Tiantan Hospital | 108 | 2025-01-24 | 2025-01-27 |
| nVNS for the Prevention and Treatment of Primary Headache Transcutaneous auricular vagus nerve stimulation - Primary Headache, Migraine in Adolescence | Not applicable | Recruiting | Nanfang Hospital, Southern Medical University | 15 | 2024-12-05 | 2025-08-12 |
| A Close Examination of Patient Experiences in Cluster Headache Clinical Research Cluster Headache | Unknown | Power Life Sciences Inc. | 500 | 2024-08-01 | 2023-08-07 | |
| Personalised Process-based Psychological Interventions for Paediatric Headaches PBT Personalised - Primary Headaches (Includes Migraines, Tension, Cluster Headaches) | Not applicable | Completed | Royal Holloway University | 5 | 2024-02-09 | 2026-08-18 |
| Refractory Chronic Cluster Headache: Exploring the Potential of Repetitive Transcranial Magnetic Stimulation Repetitive Transcranial Magnetic Stimulation, Sham Stimulation - Refractory Chronic Cluster Headache | Not applicable | Completed | Hospital Universitario La Paz | 8 | 2023-12-21 | 2025-04-08 |
| Civamide Nasal Solution for Cluster Headache Civamide nasal solution 0.01% - Episodic Cluster Headache | Phase 3 | Unknown | Winston Laboratories | 180 | 2023-11-01 | 2021-04-23 |
Showing 20 of 122. Sign in to see all of them.
Migraine Disorders (23) · Headache (17) · Trigeminal Autonomic Cephalalgias (11) · Tension-Type Headache (8) · Headache Disorders (7) · Headache Disorders, Primary (5) · Trigeminal Neuralgia (5) · Bronchiolitis Obliterans Syndrome (4) · Pain (4) · Paroxysmal Hemicrania (4) · Chronic Pain (3) · Facial Pain (3) · Fibromyalgia (3) · Agnosia (2)
Central Nervous System Diseases (121) · Nervous System Diseases (121) · Brain Diseases (120) · Headache Disorders, Primary (117) · Headache Disorders (115) · Trigeminal Autonomic Cephalalgias (111) · Pathological Conditions, Signs and Symptoms (34) · Signs and Symptoms (30) · Neurologic Manifestations (28) · Pain (22) · Cranial Nerve Diseases (8) · Disease Attributes (8) · Facial Nerve Diseases (8) · Mouth Diseases (8) · Pathologic Processes (8)
Sodium Chloride (4) · Actigraphy (3) · Botulinum Toxins, Type A (3) · Saline Solution (3) · Verapamil (3) · fremanezumab (3) · galcanezumab (3) · Blood Specimen Collection (2) · Ketamine (2) · Lysergic Acid Diethylamide (2) · Magnesium Sulfate (2) · Methylprednisolone (2) · Psilocybin (2) · Sumatriptan (2) · Surveys and Questionnaires (2)
Autonomic Technologies, Inc. (6) · Danish Headache Center (6) · Leiden University Medical Center (5) · Norwegian University of Science and Technology (5) · The University of Texas Health Science Center, Houston (5) · Assistance Publique Hopitaux De Marseille (4) · Beijing Tiantan Hospital (3) · Centre Hospitalier Universitaire de Nice (3) · ElectroCore INC (3) · Eli Lilly and Company (3) · Salvia BioElectronics (3) · Teva Branded Pharmaceutical Products R&D, Inc. (3) · Thomas Jefferson University (3) · University Hospital, Ghent (3) · Winston Laboratories (3)
United States (38) · Denmark (19) · Germany (18) · United Kingdom (18) · France (16) · Netherlands (15) · Belgium (14) · Italy (14) · Spain (14) · Finland (9) · Norway (8) · Canada (7) · Sweden (7) · China (5) · Australia (4)
Mark J Burish, MD, PhD (2) · Abraham A. Ashkenazi, M.D. (1) · Alexander D Nesbitt, BM BCh MRCP (1) · Amir Radfar, M.D,MPH (1) · Anuj Bhatia, MD FRCPC (1) · Arne May, MD, PhD (1) · Athos Patsalides, MD, MPH (1) · Brett Faine, PharmD (1) · Carrie Robertson, MD (1) · Charly Gaul, Dr med (1)
PMID 31246132, PMID 34146510, PMID 38162453, PMID 16128874, PMID 19461827, PMID 19936616, PMID 21903477, PMID 22113647, PMID 23369112, PMID 23598371, PMID 25623151, PMID 26232105, PMID 27102120, PMID 27593728, PMID 29082824, PMID 29483892, PMID 29987329, PMID 30470143, PMID 30886069, PMID 30904875, PMID 31291515, PMID 31701891, PMID 32050782, PMID 32446809, PMID 32583902, PMID 32962406, PMID 34267550, PMID 34822741, PMID 35361224, PMID 35633025, PMID 35720061, PMID 36268950, PMID 36620891, PMID 36739508, PMID 37024948, PMID 37143998, PMID 37865755, PMID 38127692, PMID 38376015, PMID 38581739, PMID 38819614, PMID 39703191, PMID 39948510, PMID 40074270, PMID 40252664, PMID 40388178, PMID 40526384, PMID 40563725, PMID 40990636, PMID 41430107
2016 (4), 2015 (2), 2018 (2), 2004 (1), 2014 (1), 2019 (1), 2023 (1)