67 completed, 15 unknown, 8 recruiting, 6 terminated. 51 Not applicable, 16 Phase 3, 11 Phase 2, 10 Phase 4, 5 Phase 1.
Follow Migraine without Aura: new trials by email Literature Review of Migraine without Aura trials Research Report on Migraine without Aura
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Using Virtual Reality to Teach Mindfulness to People With Migraine ACT therapy delivered by REACT NeuroVR headset - Migraine Disorders, Migraine With Aura | Not applicable | Not yet recruiting | Brigham and Women's Hospital | 160 | 2026-09-30 | 2026-09-30 |
| A Prospective, Open-Label Study Evaluating the Effectiveness of Gepants for Acute Treatment of Migraine in the Emergency Department Rimegepant, Zavegepant - Migraine, Migraine Disease | Phase 1 | Recruiting | University of South Florida | 100 | 2026-09-15 | 2026-10-27 |
| Study of EVO756 in Adults With Migraine EVO756, Dose 1, EVO756, Dose 2, Placebo - Migraine | Phase 2 | Recruiting | Evommune, Inc. | 330 | 2026-07-29 | 2026-10-02 |
| A Comprehensive Digital Care Program for Migraine Management Neuromodulation Wearable Device, Migraine Digital Care Program - Migraine, Migraine With Aura | Not applicable | Enrolling by invitation | Hinge Health, Inc | 140 | 2026-07-09 | 2026-09-17 |
| Preventive Role of Melatonin and Propranolol Administration in Pediatric Migraine Melatonin, Propranolol - Migraine Disorders | Not applicable | Enrolling by invitation | Nishtar Medical University | 60 | 2026-06-10 | 2026-08-03 |
| App-Based Migraine Treatment: The Health enSuite Study Health enSuite Headache - Migraine, Migraine With Aura | Not applicable | Not yet recruiting | IWK Health Centre | 415 | 2026-02-15 | 2026-01-27 |
| Myotensive Extraocular Muscle Techniques Added to Manual Therapy for Migraine Without Aura Myotensive Extraocular Muscle Techniques + Manual Therapy, Standard Manual Therapy - Migraine Without Aura | Not applicable | Not yet recruiting | Facultad de Enfermería, Fisioterapia y Podología (FEFP) | 84 | 2026-01-08 | 2025-11-28 |
| Efficacy and Mechanism of Fu's Subcutaneous Needling Treatment for Migraine Without Aura Fu's Subcutaneous Needling, Flunarizine Hydrochloride - Migraine Without Aura | Phase 1 | Not yet recruiting | Guangzhou University of Chinese Medicine | 60 | 2025-09-01 | 2025-07-16 |
| Healthy Living Partnerships for Veterans With Migraine Intensive Lifestyle Intervention - Migraine, Migraine Disorders | Not applicable | Withdrawn | Wake Forest University Health Sciences | 2025-06-01 | 2025-07-02 | |
| Management of Acute Tinnitus With Migraine Medications Nortriptyline, Topiramate, Paroxetine - Tinnitus | Phase 4 | Suspended | University of California, Irvine | 100 | 2025-06-01 | 2026-10-27 |
| Trial Designs for Evaluating Migraine Treatment Active drug for acute migraine treatment, Placebo Oral Tablet - Migraine With Aura, Migraine Without Aura | Not applicable | Recruiting | University of Aarhus | 128 | 2024-11-13 | 2026-04-13 |
| BE WELL With Migraine: Brain Education and WELLness With Migraine Brain Education and WELLness with Migraine Group A, Brain Education and WELLness with Migraine Group B - Migraine | Not applicable | Recruiting | Wake Forest University Health Sciences | 286 | 2024-07-31 | 2026-06-12 |
| Italian Real-life obServational Study on the effecTiveness, sAfety and Tolerability of Atogepant in Migraine Patients Atogepant 60 mg - Migraine, Migraine With Aura | Active not recruiting | University of Florence | 500 | 2024-05-09 | 2026-01-21 | |
| RimegepAnt effectIvenesS and tolErability as Migraine Preventive Treatment Rimegepant 75 mg - Migraine, Migraine With Aura | Recruiting | University of Florence | 100 | 2024-03-26 | 2026-06-11 | |
| Effectiveness and Tolerability of Eptinezumab Eptinezumab 100 or 300 mg ev - Migraine, Migraine With Aura | Completed | University of Florence | 130 | 2024-03-26 | 2026-06-11 | |
| Mi-Helper Transnasal Cooling for Acute Treatment of Migraine Mi-Helper - Episodic Migraine, Migraine With Aura | Not applicable | Completed | CoolTech LLC | 172 | 2023-11-15 | 2024-09-26 |
| Anisodine Hydrobromide For The Preventive Treatment Of Episodic Migraine Anisodine Hydrobromide, Anisodine Hydrobromide placebo - Migraine Without Aura, Migraine With Aura | Phase 3 | Unknown | Second Affiliated Hospital, Zhejiang University, School of Medicine | 288 | 2023-10-30 | 2024-02-28 |
| Migraine Attack Pain Phase Prediction Study Migraine, Migraine Headache | Active not recruiting | Fundación de Investigación Biomédica - Hospital Universitario de La Princesa | 70 | 2023-10-09 | 2026-09-23 | |
| Responding With Evidence and Access for Childhood Headaches CBT, Amitriptyline - Headache, Headache Disorders | Not applicable | Recruiting | Children's Hospital Medical Center, Cincinnati | 400 | 2023-08-22 | 2026-09-21 |
| Migraine With and Without Aura Characteristics and Response to Remote Electrical Neuromodulation (REN) Treatment Nerivio device - Migraine With Aura, Migraine Without Aura | Completed | Theranica | 31715 | 2023-07-01 | 2025-08-15 |
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Migraine with Aura (74) · Migraine Disorders (67) · Headache (22) · Pain (8) · Headache Disorders (7) · Headache Disorders, Secondary (5) · Headache Disorders, Primary (3) · Brain Diseases (2) · Emergencies (2) · Tension-Type Headache (2) · Agnosia (1) · Aneurysm (1) · Behavior (1) · Central Nervous System Diseases (1)
Central Nervous System Diseases (108) · Nervous System Diseases (108) · Brain Diseases (107) · Headache Disorders, Primary (106) · Headache Disorders (102) · Migraine Disorders (42) · Pathological Conditions, Signs and Symptoms (30) · Signs and Symptoms (28) · Neurologic Manifestations (27) · Pain (16) · Pathologic Processes (3) · Sensation Disorders (3) · Cardiovascular Diseases (2) · Disease Attributes (2) · Vascular Diseases (2)
Topiramate (6) · Dihydroergotamine (5) · Pituitary Adenylate Cyclase-Activating Polypeptide (5) · Cromakalim (4) · rimegepant sulfate (4) · Metoclopramide (3) · Propranolol (3) · Sodium Chloride (3) · Sumatriptan (3) · Acupuncture Therapy (2) · Botulinum Toxins, Type A (2) · Cilostazol (2) · Flunarizine (2) · Nitroglycerin (2) · almotriptan (2)
Danish Headache Center (18) · Satsuma Pharmaceuticals, Inc. (5) · University of Florence (5) · Johnson & Johnson Pharmaceutical Research & Development, L.L.C. (3) · Wake Forest University Health Sciences (3) · Children's Hospital Medical Center, Cincinnati (2) · CoolTech LLC (2) · Glostrup University Hospital, Copenhagen (2) · Kocaeli University (2) · Minster Research Ltd (2) · Norwegian University of Science and Technology (2) · Second Affiliated Hospital, Zhejiang University, School of Medicine (2) · Swedish Medical Center (2) · Theranica (2) · Vastra Gotaland Region (2)
United States (31) · Denmark (24) · China (7) · Italy (7) · Turkey (Türkiye) (7) · France (5) · Spain (5) · Norway (4) · Canada (3) · Sweden (3) · Hungary (2) · Israel (2) · Netherlands (2) · United Kingdom (2) · Austria (1)
Messoud Ashina, Prof. (4) · Detlef Albrecht, MD (3) · Kaiming Liu, MD & PHD (2) · Rebecca E Wells, MD, MPH (2) · Scott Powers, PhD (2) · Alit Stark Inbar, PhD (1) · Ana Beatriz Gago Veiga (1) · Angel L Guerrero Peral, MD, PhD (1) · Annette C Toledano, M.D. (1) · Bradley J Katz, MD (1) · Chuanlong Zhou (1)
PMID 22590713, PMID 23731663, PMID 24524844, PMID 30353868, PMID 30496104, PMID 30879893, PMID 32430657, PMID 11112243, PMID 14982912, PMID 15096395, PMID 15316798, PMID 16135345, PMID 17175134, PMID 18662331, PMID 19222510, PMID 19453963, PMID 20548058, PMID 20974598, PMID 22520687, PMID 23946318, PMID 24030685, PMID 24171782, PMID 24335848, PMID 25744676, PMID 26134103, PMID 26145718, PMID 26603732, PMID 27154997, PMID 27696633, PMID 28241154, PMID 28322750, PMID 28324697, PMID 29310498, PMID 30310310, PMID 31074005, PMID 31104505, PMID 31331265, PMID 31985049, PMID 32213509, PMID 33050719, PMID 33315046, PMID 33567890, PMID 34418951, PMID 34431322, PMID 35957963, PMID 38181724, PMID 38413540, PMID 38850034, PMID 39373843, PMID 39762740
2008 (1), 2014 (1), K23AT008406 (1), R01AT011502 (1), U01AT010132 (1), UL1TR001420 (1)