60 completed, 20 unknown, 12 recruiting, 9 terminated. 43 Not applicable, 19 Phase 2, 16 Phase 3, 10 Phase 4, 5 Phase 1.
Follow Migraine with Aura: new trials by email Literature Review of Migraine with Aura trials Research Report on Migraine with Aura
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Efficacy of Rimegepant 75 mg for the Acute Treatment of Migraine: a Bayesian Individual Participant Data Meta-analysis Standardized to Defined Target Populations Rimegepant, Placebo - Migraine | Active not recruiting | Pfizer | 1 | 2026-10-12 | 2026-10-30 | |
| Using Virtual Reality to Teach Mindfulness to People With Migraine ACT therapy delivered by REACT NeuroVR headset - Migraine Disorders, Migraine With Aura | Not applicable | Not yet recruiting | Brigham and Women's Hospital | 160 | 2026-09-30 | 2026-09-30 |
| A Prospective, Open-Label Study Evaluating the Effectiveness of Gepants for Acute Treatment of Migraine in the Emergency Department Rimegepant, Zavegepant - Migraine, Migraine Disease | Phase 1 | Recruiting | University of South Florida | 100 | 2026-09-15 | 2026-10-27 |
| Study of EVO756 in Adults With Migraine EVO756, Dose 1, EVO756, Dose 2, Placebo - Migraine | Phase 2 | Recruiting | Evommune, Inc. | 330 | 2026-07-29 | 2026-11-04 |
| A Comprehensive Digital Care Program for Migraine Management Neuromodulation Wearable Device, Migraine Digital Care Program - Migraine, Migraine With Aura | Not applicable | Enrolling by invitation | Hinge Health, Inc | 140 | 2026-07-09 | 2026-09-17 |
| Preventive Role of Melatonin and Propranolol Administration in Pediatric Migraine Melatonin, Propranolol - Migraine Disorders | Not applicable | Enrolling by invitation | Nishtar Medical University | 60 | 2026-06-10 | 2026-08-03 |
| App-Based Migraine Treatment: The Health enSuite Study Health enSuite Headache - Migraine, Migraine With Aura | Not applicable | Active not recruiting | IWK Health Centre | 415 | 2026-02-15 | 2026-11-05 |
| Induction of Migraine Attacks With Aura Using Pituitary Adenylate Cyclase Activating Polypeptide-38 Pituitary Adenylate Cyclase Activating Polypeptide-38 (PACAP-38), Placebo - Migraine With Aura, Migraine Aura | Not applicable | Not yet recruiting | Danish Headache Center | 21 | 2026-02-01 | 2026-01-15 |
| The Sequestration of Holistic Stress Management Techniques for Adults Holistic Medicine (HM) - Stress, Job, PTSD | Not applicable | Withdrawn | Goddess Zena I. Jones | 2026-01-26 | 2026-02-04 | |
| Neurogenetic And Hemodynamic Of Migraine Aura And Pfo Intervention - Migraine With Aura | Recruiting | Azienda Usl di Bologna | 240 | 2025-11-24 | 2026-02-11 | |
| Comparative Effectiveness of Migraine Preventive Medications: The APT Comparison Study Atogepant 60 mg, Propranolol 160 mg, Topiramate 100 mg - Migraine | Phase 4 | Recruiting | Mayo Clinic | 1335 | 2025-07-09 | 2026-10-19 |
| Induction of Migraine Attacks With Aura Using Calcitonin Gene-Related Peptide Calcitonin-gene related peptide (CGRP), Placebo - Migraine Aura, Migraine With Aura | Not applicable | Recruiting | Danish Headache Center | 21 | 2025-06-27 | 2025-08-06 |
| Healthy Living Partnerships for Veterans With Migraine Intensive Lifestyle Intervention - Migraine, Migraine Disorders | Not applicable | Withdrawn | Wake Forest University Health Sciences | 2025-06-01 | 2025-07-02 | |
| Trial Designs for Evaluating Migraine Treatment Active drug for acute migraine treatment, Placebo Oral Tablet - Migraine With Aura, Migraine Without Aura | Not applicable | Recruiting | University of Aarhus | 128 | 2024-11-13 | 2026-04-13 |
| BE WELL With Migraine: Brain Education and WELLness With Migraine Brain Education and WELLness with Migraine Group A, Brain Education and WELLness with Migraine Group B - Migraine | Not applicable | Recruiting | Wake Forest University Health Sciences | 286 | 2024-07-31 | 2026-06-12 |
| Italian Real-life obServational Study on the effecTiveness, sAfety and Tolerability of Atogepant in Migraine Patients Atogepant 60 mg - Migraine, Migraine With Aura | Active not recruiting | University of Florence | 500 | 2024-05-09 | 2026-01-21 | |
| RimegepAnt effectIvenesS and tolErability as Migraine Preventive Treatment Rimegepant 75 mg - Migraine, Migraine With Aura | Recruiting | University of Florence | 100 | 2024-03-26 | 2026-06-11 | |
| Effectiveness and Tolerability of Eptinezumab Eptinezumab 100 or 300 mg ev - Migraine, Migraine With Aura | Completed | University of Florence | 130 | 2024-03-26 | 2026-06-11 | |
| Real-world Effectiveness and Tolerability of Triptans-Ditans-Gepants (TRIDIGEP) Patients with migraine treated with triptans, Lasmiditan or Gepants - Migraine, Migraine Disorders | Unknown | Hospital Clínico Universitario de Valladolid | 1500 | 2023-12-04 | 2024-02-21 | |
| Mi-Helper Transnasal Cooling for Acute Treatment of Migraine Mi-Helper - Episodic Migraine, Migraine With Aura | Not applicable | Completed | CoolTech LLC | 172 | 2023-11-15 | 2024-09-26 |
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Migraine Disorders (75) · Migraine without Aura (74) · Headache (22) · Epilepsy (10) · Headache Disorders (7) · Pain (6) · Foramen Ovale, Patent (5) · Headache Disorders, Secondary (5) · Brain Diseases (2) · CADASIL (2) · Emergencies (2) · Headache Disorders, Primary (2) · Tension-Type Headache (2) · Agnosia (1)
Central Nervous System Diseases (114) · Nervous System Diseases (114) · Brain Diseases (112) · Headache Disorders, Primary (112) · Headache Disorders (107) · Migraine Disorders (39) · Pathological Conditions, Signs and Symptoms (31) · Signs and Symptoms (27) · Neurologic Manifestations (26) · Pain (17) · Cardiovascular Diseases (9) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (7) · Congenital Abnormalities (6) · Cardiovascular Abnormalities (5) · Heart Defects, Congenital (5)
Topiramate (9) · Dihydroergotamine (5) · rimegepant sulfate (5) · Propranolol (4) · Metoclopramide (3) · tonabersat (3) · Calcitonin Gene-Related Peptide (2) · Cilostazol (2) · Nitroglycerin (2) · Sildenafil Citrate (2) · Sumatriptan (2) · Tryptamines (2) · almotriptan (2) · atogepant (2) · erenumab (2)
Danish Headache Center (10) · Satsuma Pharmaceuticals, Inc. (5) · University of Florence (5) · Glostrup University Hospital, Copenhagen (3) · Johnson & Johnson Pharmaceutical Research & Development, L.L.C. (3) · Minster Research Ltd (3) · Swedish Medical Center (3) · Wake Forest University Health Sciences (3) · Charite University, Berlin, Germany (2) · Children's Hospital Medical Center, Cincinnati (2) · CoolTech LLC (2) · Herlev Hospital (2) · Hospital Clínico Universitario de Valladolid (2) · Kocaeli University (2) · Monarch Medical Research (2)
United States (40) · Denmark (20) · Italy (9) · France (6) · Canada (5) · Germany (5) · Spain (5) · Turkey (Türkiye) (5) · Norway (4) · China (3) · Netherlands (3) · Sweden (3) · United Kingdom (3) · Hungary (2) · Israel (2)
Detlef Albrecht, MD (3) · Cindy J. Fuller, Ph.D. (2) · Donald W Lewis, MD (2) · Jill T. Jesurum, Ph.D. (2) · Kaiming Liu, MD & PHD (2) · Messoud Ashina, Prof. (2) · Rebecca E Wells, MD, MPH (2) · Scott Powers, PhD (2) · Alain Viguier, PH (1) · Alan M. Haltiner, Ph.D. (1) · Alit Stark Inbar, PhD (1)
PMID 30496104, PMID 22590713, PMID 23731663, PMID 24524844, PMID 30353868, PMID 30879893, PMID 32430657, PMID 10449117, PMID 11112243, PMID 14982912, PMID 15096395, PMID 15316798, PMID 16135345, PMID 16450381, PMID 16611468, PMID 17175134, PMID 18662331, PMID 19222510, PMID 19453963, PMID 19570717, PMID 20206581, PMID 20548058, PMID 20816413, PMID 20974598, PMID 21833737, PMID 22322311, PMID 22517281, PMID 22520687, PMID 23766355, PMID 23946318, PMID 24030685, PMID 24045571, PMID 24142848, PMID 24335848, PMID 24554619, PMID 25744676, PMID 26134103, PMID 26145718, PMID 26467451, PMID 26603732, PMID 26908949, PMID 27154997, PMID 27696633, PMID 28322750, PMID 28324697, PMID 28521762, PMID 29310498, PMID 30134739, PMID 30296840, PMID 30310310
2008 (1), 2014 (1), 2016 (1), 2017 (1), K23AT008406 (1), R01AT011502 (1), U01AT010132 (1), UL1TR001420 (1)