4 completed, 4 terminated, 1 recruiting, 1 withdrawn. 10 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 10 | Completed 4, Terminated 4, Recruiting 1, Withdrawn 1 |
Follow Fluid Overload: new trials by email Literature Review of Fluid Overload trials Research Report on Fluid Overload
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Comparing Natriuretic Effects of ER Torsemide to IR Torsemide in Patients With Heart Failure Extended Release Torsemide Tablets, Immedate Release Torsemide Tablets - Heart Failure, Edema | Phase 4 | Withdrawn | Sarfez Pharmaceuticals, Inc. | 2025-05-01 | 2026-09-28 | |
| Controlled Fluid Removal in Critical Ill Patients With Fluid Overload in the Intensive Care Unit. Furosemide, Isotonic saline - Fluid Overload | Phase 4 | Recruiting | Morten H. Bestle | 1000 | 2020-08-17 | 2026-06-03 |
| Compare the Diuretic Effect With Furosemide vs Furosemide and Albumin Combined in Cirrhotic Patients Furosemide Injection, Albumin Human - Cirrhosis, Liver, Volume Overload | Phase 4 | Terminated | Rush University Medical Center | 21 | 2019-12-19 | 2025-09-16 |
| Diuretic Effect of Metolazone Pre-dosing Versus Concurrent Dosing Metolazone 60 minutes prior to furosemide, Metolazone concurrently with furosemide - Fluid Overload, Heart Failure Acute | Phase 4 | Terminated | University of Maryland, Baltimore | 3 | 2019-01-01 | 2021-10-22 |
| The Effect of Vitamin C, Thiamine and Hydrocortisone on Clinical Course and Outcome in Patients With Severe Sepsis and Septic Shock Vitamin C, Hydrocortisone, Thiamine - Sepsis, Septic Shock | Phase 4 | Terminated | University Medical Centre Ljubljana | 5 | 2017-09-26 | 2019-02-19 |
| TOnicity of Perioperative Maintenance SoluTions NaCl 0.9% in Glucose 5% + 40mmol/L Potassium, Glucion 5% - Thoracic Diseases, Water-Electrolyte Imbalance | Phase 4 | Completed | Niels Van Regenmortel | 70 | 2017-03-09 | 2018-08-14 |
| Forced Fluid Removal in High Risk Acute Kidney Injury Furosemide (Furix), Continuous renal replacement therapy (CRRT), Resuscitation - Acute Kidney Injury, Fluid Overload | Phase 4 | Terminated | Nordsjaellands Hospital | 21 | 2015-10-01 | 2017-07-06 |
| Fluid Mobilization in Hospitalized Patients With Acute Kidney Injury (100 ml of Albumin 25%) - Hypotension During Dialysis, Fluid Overload | Phase 4 | Completed | University of California, San Diego | 65 | 2015-06-03 | 2020-08-24 |
| Crystalloids Versus Colloids During Surgery Lactated Ringer's Solution, Hydroxyethylstarch 6% 130/0.4 - Fluid Overload, Postoperative Complications | Phase 4 | Completed | Medical University of Vienna | 1109 | 2006-09-01 | 2018-01-10 |
| The Optimization of Blood Pressure and Fluid Status Control With Eight-Polar Bioelectrical Impedance Analysis Bioelectrical impedance-guide dry weight reduction - Hypertension, Fluid Overload | Phase 4 | Completed | Taipei Veterans General Hospital, Taiwan | 132 | 2006-09-01 | 2009-02-27 |
Edema (10) · Critical Illness (2) · Acute Kidney Injury (1) · Heart Diseases (1) · Heart Failure (1) · Hypernatremia (1) · Hypertension (1) · Liver Cirrhosis (1) · Postoperative Complications (1) · Renal Insufficiency, Chronic (1) · Sepsis (1) · Shock, Septic (1) · Thoracic Diseases (1) · Water-Electrolyte Imbalance (1)
Pathological Conditions, Signs and Symptoms (10) · Signs and Symptoms (10) · Pathologic Processes (5) · Disease Attributes (3) · Cardiovascular Diseases (2) · Female Urogenital Diseases (2) · Female Urogenital Diseases and Pregnancy Complications (2) · Kidney Diseases (2) · Male Urogenital Diseases (2) · Metabolic Diseases (2) · Nutritional and Metabolic Diseases (2) · Renal Insufficiency (2) · Urogenital Diseases (2) · Urologic Diseases (2) · Chronic Disease (1)
Furosemide (4) · Sodium Chloride (2) · Adrenal Cortex Hormones (1) · Albumins (1) · Ascorbic Acid (1) · Continuous Renal Replacement Therapy (1) · Glucose (1) · Hydrocortisone (1) · Hydroxyethyl Starch Derivatives (1) · Metolazone (1) · Potassium (1) · Resuscitation (1) · Ringer's Lactate (1) · Saline Solution (1) · Serum Albumin, Human (1)
Medical University of Vienna (1) · Morten H. Bestle (1) · Niels Van Regenmortel (1) · Nordsjaellands Hospital (1) · Rush University Medical Center (1) · Sarfez Pharmaceuticals, Inc. (1) · Taipei Veterans General Hospital, Taiwan (1) · University Medical Centre Ljubljana (1) · University of California, San Diego (1) · University of Maryland, Baltimore (1)
United States (3) · Denmark (2) · Australia (1) · Austria (1) · Belgium (1) · Czechia (1) · Finland (1) · Iceland (1) · Lithuania (1) · Netherlands (1) · Norway (1) · Slovenia (1) · Switzerland (1) · Taiwan (1)
Anders Perner, Md, Ph D (1) · Brent Reed, PharmD (1) · Edith Fleischmann, M.D., Ph.D. (1) · Jens-Ulrik Jensen, MD, Ph D (1) · Jinn-Yang Chen, MD, PhD (1) · Lance Lance Lineberger, PharmD (1) · Michael Ibsen, MD, Ph D (1) · Morten Bestle, MD (1) · Morten H Bestle, MD, Ph D (1) · Rasmus E Berthelsen, MD (1) · Ravindra L Mehta, MD (1) · Salim Shah, PhD, JD (1) · Sebastian Stefanovic, MD (1)
PMID 28438182, PMID 29664109, PMID 31627889, PMID 32825817, PMID 33407747, PMID 35898170, PMID 37691474, PMID 38622671
2015 (1), 2019 (1)