61 completed, 27 unknown, 13 recruiting, 11 terminated. 54 Not applicable, 10 Phase 4, 5 Phase 2, 4 Phase 3, 3 Phase 1.
Follow Fluid Overload: new trials by email Literature Review of Fluid Overload trials Research Report on Fluid Overload
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Using Bioimpedance Analysis to Monitor Fluid Status in Children Bioimpedance device - Fluid Overload | Recruiting | St. Jude Children's Research Hospital | 30 | 2026-11-01 | 2026-10-26 | |
| Volume Removal Intolerance During Net Ultrafiltration in Acute Kidney Injury Patients Acute Kidney Injury, Fluid Overload | Recruiting | Hospital Las Higueras | 128 | 2026-07-06 | 2026-07-08 | |
| Electric Cardiometry-Guided Standard Versus Restricted Fluid Therapy In Robotic Prostaectomy Liberal Fluid Therapy, Restricted Fluid Therapy - Prostate Cancer, Surgery | Not applicable | Recruiting | Nazmy Edward Seif | 90 | 2026-06-05 | 2026-06-08 |
| The FILTRATE Trial: High-Rate Ultrafiltration for Intravascular Congestion High-rate ultrafiltration, Standard fluid removal - End Stage Chronic Renal Failure, Congestive Heart Failure (CHF) | Not applicable | Recruiting | Universidad Autonoma de Nuevo Leon | 70 | 2026-06-04 | 2026-07-15 |
| Concordance and Discordance in the Assessment of Volume Status in Home Dialysis Patients: A Comparison of Modified Medical Research Council Dyspnea Scale, Physical Exam, and Point of Care Ultrasound (POCUS) point-of-care ultrasound (POCUS), specifically lung ultrasound (LUS), Modified Medical Research Council (mMRC) Dyspnea scale, Physical Exam - Fluid Overload, POCUS | Not applicable | Active not recruiting | Indiana University | 90 | 2026-01-09 | 2026-08-27 |
| Timing of Renal Replacement Therapy in the Critically Ill Patients CRRT - Acute Kidney Injury, Uremia | Recruiting | Karolinska University Hospital | 50000 | 2025-11-01 | 2025-09-03 | |
| Timing and Dose of Fluid Deresuscitation in Critically Ill Patients Fluid Overload, Critical Care, Intensive Care | Recruiting | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | 150 | 2025-10-15 | 2026-01-21 | |
| Proactive Hemodynamic Management During Cytoreductive Surgery and HIPEC Assisted Fluid Management, Goal Directed Fluid Therapy (GDT) - Ovarian Cancer, Hemodynamic Instability | Not applicable | Recruiting | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | 52 | 2025-09-01 | 2026-05-11 |
| Comparing Natriuretic Effects of ER Torsemide to IR Torsemide in Patients With Heart Failure Extended Release Torsemide Tablets, Immedate Release Torsemide Tablets - Heart Failure, Edema | Phase 4 | Withdrawn | Sarfez Pharmaceuticals, Inc. | 2025-05-01 | 2026-09-28 | |
| Assessment of Worldwide Acute Kidney Injury Epidemiology in Neonates 2.0 Acute Kidney Injury, Fluid Overload | Enrolling by invitation | Indiana University | 8000 | 2025-03-01 | 2026-10-28 | |
| Naturally Controlled Decongestion Using Renal Independent System in ADHF Patients, a European Registry AquaPass - Chronic Heart Failure, Fluid Overload | Not applicable | Unknown | AquaPass Medical Ltd. | 30 | 2025-02-01 | 2024-05-06 |
| Investigation of Novel and Established Therapies in a Human Intravenous Lipopolysaccharide Model of Sepsis Imatinib, Compound sodium lactate solution - Sepsis, Fluid Overload | Phase 1 / Phase 2 | Unknown | Belfast Health and Social Care Trust | 65 | 2024-12-01 | 2024-10-04 |
| Muscle and Subcutaneous Tissue Variation by Ultrasound and Impedance Linked to Fluid Balance in ICU Patients Ultrasound and Bioelectrical Impedance Analysis for Muscle Thickness and Fluid Balance Assessment Translation - Weakness Acquired in the ICU, Muscle Wasting | Recruiting | Dr F Duprez | 40 | 2024-10-21 | 2024-11-20 | |
| The Efficient PICU Fluid Care Evaluation Strict adherence to European guidelines - Respiratory Insufficiency Requiring Mechanical Ventilation, Fluid Overload | Not applicable | Unknown | Radboud University Medical Center | 90 | 2024-10-01 | 2024-10-16 |
| Inferior Vena Cava Collapsibility Index Guide for Preoperative Fluid Therapy in Preeclampsia fluid therapy, 300 ml of crystalloid Ringer's solution. - Pre-Eclampsia, Hypotension | Not applicable | Unknown | Ain Shams University | 90 | 2024-08-15 | 2024-10-29 |
| Fluid Status and Body Composition Analysis by Bioelectrical Impedance in Patients After Cardiac Surgery (FLUBIACS) Bioelectrical impedance - Cardiopulmonary Disease, Fluid Overload | Unknown | University Medical Centre Ljubljana | 150 | 2024-07-01 | 2024-07-12 | |
| Macrohemodynamic Impact of Fluid Removal With Net Ultrafiltration in Patients With Continuous Renal Replacement Therapy Macrohemodynamic parameters - Fluid Removal, Critically Ill | Unknown | Hospices Civils de Lyon | 60 | 2024-06-01 | 2024-05-22 | |
| Role of Active Deresuscitation After Resuscitation: Furosemide Injection, Metolazone Tablets - Fluid Overload, Critical Illness | Phase 2 | Unknown | Unity Health Toronto | 120 | 2024-05-01 | 2024-03-22 |
| Pharmacokinetics and Pharmacodynamics of Subcutaneous vs Intravenous Furosemide in Healthy Volunteers SCP-111, Furosemide USP - Heart Failure, Fluid Overload | Phase 1 | Completed | scPharmaceuticals, Inc. | 21 | 2024-04-19 | 2026-03-30 |
| Evaluating Fluid Responsiveness in ICU Patients Using VTI and Trendelenburg Positioning Trendelenburg positioning VTI - Shock, Fluid Overload | Not applicable | Unknown | Lenox Hill Hospital | 400 | 2024-04-01 | 2024-05-16 |
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Edema (120) · Acute Kidney Injury (18) · Critical Illness (13) · Heart Failure (8) · Hypovolemia (7) · Postoperative Complications (7) · Sepsis (7) · Renal Insufficiency, Chronic (4) · Shock (4) · Hypertension (3) · Hypotension (3) · Respiratory Insufficiency (3) · Cardiac Output, Low (2) · Coronary Artery Disease (2) · Disease (2)
Pathological Conditions, Signs and Symptoms (120) · Signs and Symptoms (120) · Pathologic Processes (47) · Urogenital Diseases (27) · Female Urogenital Diseases and Pregnancy Complications (26) · Cardiovascular Diseases (25) · Female Urogenital Diseases (24) · Male Urogenital Diseases (24) · Kidney Diseases (23) · Urologic Diseases (23) · Renal Insufficiency (21) · Disease Attributes (19) · Heart Diseases (17) · Infections (10) · Vascular Diseases (10)
Furosemide (7) · Crystalloid Solutions (3) · Ringer's Lactate (3) · Blood Specimen Collection (2) · Continuous Renal Replacement Therapy (2) · Control Groups (2) · Echocardiography (2) · Fluid Therapy (2) · Metolazone (2) · Sodium Chloride (2) · Ultrasonography (2) · Water-Electrolyte Balance (2) · Adrenal Cortex Hormones (1) · Albumins (1) · Anesthesia, General (1)
Hospices Civils de Lyon (5) · Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) (4) · Indiana University (3) · Medical University of Vienna (3) · Nuwellis, Inc. (3) · Amsterdam UMC, location VUmc (2) · Bakirkoy Dr. Sadi Konuk Research and Training Hospital (2) · Belfast Health and Social Care Trust (2) · Centre hospitalier de l'Université de Montréal (CHUM) (2) · Hopital Louis Pradel (2) · Hospital Civil de Guadalajara (2) · Hospital de Clinicas de Porto Alegre (2) · Nordsjaellands Hospital (2) · Tanta University (2) · University Medical Centre Ljubljana (2)
United States (20) · France (14) · Netherlands (9) · Denmark (8) · Canada (7) · Sweden (7) · Italy (6) · Mexico (6) · Egypt (5) · United Kingdom (5) · Belgium (4) · Brazil (4) · Germany (4) · Turkey (Türkiye) (4) · Austria (3)
Abdelkarim ALoweidi, consultant (1) · Alan Chiem, MD MPH (1) · Alper Azak, Asist Prof (1) · Amy Lee, MD (1) · Ana Carolina P Antonio, MD, PhD (1) · Anders Perner, Md, Ph D (1) · Andre Lamy, MD (1) · Andrew Stasic, MD (1) · Anoop D Shah, MBBS, PhD (1) · Apatsara Saokaew, MD (1) · Ashgan R Aly, M.D. (1) · Barbara Kabon, MD (1) · Bernd Stegmayr, MD, PhD (1) · Birgitte Brandstrup, PhD (1)
PMID 11254839, PMID 11794169, PMID 12234829, PMID 12475851, PMID 15034650, PMID 15286557, PMID 15375649, PMID 1599111, PMID 16424713, PMID 17285286, PMID 17316468, PMID 17427526, PMID 17508199, PMID 18533029, PMID 19758300, PMID 20863929, PMID 21307764, PMID 22580944, PMID 22656677, PMID 22710266, PMID 23043910, PMID 23075459, PMID 23247571, PMID 23263578, PMID 23326767, PMID 24116747, PMID 24170232, PMID 24171518, PMID 24188480, PMID 24478870, PMID 24495437, PMID 24842135, PMID 24886171, PMID 25432557, PMID 25563826, PMID 25581632, PMID 26206387, PMID 26989397, PMID 27207178, PMID 27592046, PMID 27801521, PMID 27922547, PMID 27922878, PMID 27940452, PMID 28029449, PMID 28130687, PMID 28438182, PMID 28575331, PMID 28719887, PMID 28742783
2009 (1), 2015 (1), 2019 (1), 2023 (1), R01DK128100 (1)