60 completed, 21 recruiting, 18 unknown, 15 not yet recruiting. 54 Not applicable, 21 Phase 2, 12 Phase 1, 10 Phase 4, 9 Phase 3.
Follow Trigeminal Neuralgia: new trials by email Literature Review of Trigeminal Neuralgia trials Research Report on Trigeminal Neuralgia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Twenty-five Years of Advanced RadioTherapy at San Raffaele Hospital Advanced radiotherapy techniques - Malignant Tumor, Benign Neoplasm | Not yet recruiting | IRCCS San Raffaele | 10000 | 2026-11-15 | 2026-10-29 | |
| RP-008 in Combination With Daily Oral Varenicline for the Treatment of Trigeminal Neuralgia RP-008, Varenicline tartrate - Trigeminal Neuralgia | Phase 1 / Phase 2 | Recruiting | Kriya Therapeutics, Inc. | 24 | 2026-09-10 | 2026-10-23 |
| Clinical Efficacy and Peripheral Ultrasound Mechanism of Trigger Point Bloodletting Therapy for Primary Trigeminal Neuralgia Trigger Point Bloodletting Therapy, Carbamazepine - Trigeminal Neuralgia (TN) | Not applicable | Not yet recruiting | Beijing Hospital of Traditional Chinese Medicine | 60 | 2026-08-31 | 2026-08-06 |
| Efficacy and Safety of Oral Antiviral Therapy for Idiopathic Trigeminal Neuralgia Intervention：Drug: Carbamazepine, Intervention：Drug: Carbamazepine + Acyclovir, Intervention：Drug: Carbamazepine + Celecoxib - Idiopathic Trigeminal Neuralgia | Not applicable | Not yet recruiting | Beijing Tiantan Hospital | 165 | 2026-08-31 | 2026-06-29 |
| Management of Arachnoid Nerve Tethering in Trigeminal Neuralagia Arachnoid nerve detethering - Trigeminal Neuralgia | Not applicable | Not yet recruiting | Assiut University | 23 | 2026-08-31 | 2026-09-10 |
| High-intensity Laser Therapy Versus Low Level Laser Therapy in the Treatment of Trigeminal Neuralgia 1064 nm Nd-YAG Laser, 940 nm Diode laser - Trigeminal Neuralgia | Not applicable | Not yet recruiting | Alexandria University | 38 | 2026-05-15 | 2026-05-15 |
| Identification of Possible Trigeminal Neuralgia Completion of the IDTN Questionnaire - Trigeminal Neuralgia (TN), Orofacial Pain | Not yet recruiting | University College, London | 250 | 2026-04-01 | 2026-03-23 | |
| Resting-State fMRI Study of Functional Connectivity After Gamma Knife Radiosurgery in Trigeminal Neuralgia Resting-State Functional MRI - Trigeminal Neuralgia | Not applicable | Not yet recruiting | Assistance Publique Hopitaux De Marseille | 28 | 2026-04-01 | 2026-01-21 |
| The Alternative Effects of Electroacupuncture in the Treatment of Trigeminal Neuralgia Carbarmazepine, Sham Electroacupuncture, Carbarmazepine Placebo - Trigeminal Neuralgia | Not applicable | Not yet recruiting | Yuanyuan Wu | 126 | 2026-03-01 | 2026-03-05 |
| Risk Factors for Recurrence of Trigeminal Neuralgia After Percutaneous Balloon Compression Percutaneous Balloon Compression - Trigeminal Neuralgia | Not yet recruiting | Second Xiangya Hospital of Central South University | 700 | 2025-12-15 | 2025-11-20 | |
| Post-Operative Trigeminal Pain After Microvascular Decompression for Trigeminal Neuralgia Trigeminal Neuralgia, Microvascular Decompression Surgery | Not yet recruiting | Rutgers, The State University of New Jersey | 100 | 2025-12-12 | 2025-10-14 | |
| Efficacy and Safety of Irregular Pulsed Radiofrequency (Sluijter-Teixera Poisson) Versus Regular Pulsed Radiofrequency to the Gasserian Ganglion for Treatment of Primary Trigeminal Neuralgia Irregular pulsed Radiofrequency, Regular pulsed Radiofrequency - Trigeminal Neuralgia | Not applicable | Not yet recruiting | Sohag University | 62 | 2025-12-01 | 2025-12-31 |
| Prospective Register Study to Assess Eligibility for and Efficacy of Surgical Treatment in Patients With nEuRovascular Conflict Trigeminal Neuralgia, Tic Douloureux | Not yet recruiting | Gerrit A Schubert | 5001 | 2025-10-01 | 2025-08-21 | |
| Ultra-Early Gamma Knife Stereotactic Radiosurgery for TN GK SRS - Trigeminal Neuralgia (TN) | Phase 2 | Recruiting | University of Alberta | 80 | 2025-07-30 | 2026-10-23 |
| The Synergism and Attenuation Effects of Electroacupuncture in the Treatment of Trigeminal Neuralgia CBZ placebo, CBZ, Electroacupuncture - Trigeminal Neuralgia | Not applicable | Not yet recruiting | Yuanyuan Wu | 28 | 2025-07-20 | 2025-07-20 |
| Comparison of Two Types of Radiofrequency Treatment for Trigeminal Neuralgia Conventional Gasserian Ganglion Radiofrequency, Peripheral Pulsed Radiofrequency - Trigeminal Neuralgia, Tic Douloureux | Not applicable | Not yet recruiting | Mesut Bakır | 60 | 2025-06-15 | 2025-06-10 |
| Comparison b/w Carbamazepine vs Oxcarbazepine in Treatment of Trigeminal Neuralgia Carbamazepine, oxcarbazepine - Trigeminal Neuralgia | Not applicable | Active not recruiting | Abbasi Shaheed Hospital | 122 | 2025-05-20 | 2025-11-26 |
| Intravenous Lacosamide for the Treatment of Acute Pain in Trigeminal Neuralgia Lacosamide - Trigeminal Neuralgia | Recruiting | Hospital Universitari de Bellvitge | 20 | 2025-04-21 | 2026-09-15 | |
| Esketamine Combined Pulsed Radiofrequency for Acute/Subacute Zoster-associated Trigeminal Neuralgia Esketamine group, PRF group - Zoster; Herpes, Trigeminal Neuralgia (Etiology) | Not applicable | Recruiting | Beijing Tiantan Hospital | 174 | 2025-04-01 | 2025-04-27 |
| Sphenopalatine Ganglion Pulsed Radiofrequency Treatment Outcomes Pulsed Radiofrequency of the Sphenopalatine Ganglion - Migraine Disorders, Facial Pain Disorder, Cluster Headache, Trigeminal Neuralgia, Trigeminal Autonomic Cephalalgias | Not applicable | Completed | Ankara City Hospital Bilkent | 55 | 2025-03-20 | 2026-03-18 |
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Neuralgia (13) · Facial Pain (12) · Pain (6) · Cluster Headache (5) · Glossopharyngeal Nerve Diseases (4) · Headache Disorders (4) · Neuralgia, Postherpetic (4) · Agnosia (3) · Arteriovenous Malformations (3) · Chronic Pain (3) · Complex Regional Pain Syndromes (3) · Migraine Disorders (3) · Multiple Sclerosis (3) · Aneurysm (2)
Facial Nerve Diseases (139) · Mouth Diseases (139) · Nervous System Diseases (139) · Stomatognathic Diseases (139) · Cranial Nerve Diseases (138) · Facial Neuralgia (137) · Trigeminal Nerve Diseases (137) · Pathological Conditions, Signs and Symptoms (38) · Signs and Symptoms (36) · Neurologic Manifestations (35) · Pain (24) · Neuromuscular Diseases (18) · Peripheral Nervous System Diseases (17) · Central Nervous System Diseases (15) · Brain Diseases (13)
Carbamazepine (7) · Botulinum Toxins, Type A (6) · Oxcarbazepine (5) · vixotrigine (5) · Pulsed Radiofrequency Treatment (4) · Radiosurgery (4) · Lidocaine (3) · Prolactin-Releasing Hormone (3) · Sodium Chloride (3) · Control Groups (2) · Electroacupuncture (2) · Lamotrigine (2) · Watchful Waiting (2) · 2-chloro-4-(1-(4-fluorophenyl)-2,5-dimethyl-1H-imidazol-4-ylethynyl)pyridine (1) · Acupuncture Therapy (1)
Beijing Tiantan Hospital (7) · Biogen (6) · Danish Headache Center (6) · Stanford University (4) · Assiut University (3) · Diskapi Teaching and Research Hospital (3) · University Health Network, Toronto (3) · University of Minnesota (3) · Alexandria University (2) · IRCCS San Raffaele (2) · Noema Pharma AG (2) · Norwegian University of Science and Technology (2) · Postgraduate Institute of Dental Sciences Rohtak (2) · Sohag University (2) · St. Olavs Hospital (2)
United States (34) · China (17) · Turkey (Türkiye) (9) · United Kingdom (9) · Canada (7) · Egypt (7) · Denmark (5) · Italy (5) · Germany (3) · Norway (3) · Pakistan (3) · Spain (3) · France (2) · Greece (2) · India (2)
Clara Choi (3) · Fang Luo, M.D. (3) · Scott Soltys (3) · Ahmed A Bessar, MD, PhD (2) · Erling A Tronvik, PhD, MD (2) · Mojgan Hodaie, MD, MSc (2) · Abdelrady S Ibrahim, M.D. (1) · Anand Mahadevan, MD (1) · Andrei Fodor, MD (1) · Asgeir S Jakola, MD PhD (1) · Athanasia Tsaroucha, Assoc. Prof. (1) · Athos Patsalides, MD, MPH (1) · Bifa Fan, MD (1)
PMID 11704310, PMID 12128137, PMID 16436823, PMID 17258129, PMID 18077952, PMID 18164488, PMID 18981841, PMID 19039051, PMID 20227216, PMID 20419329, PMID 21116663, PMID 21422774, PMID 21621166, PMID 22151211, PMID 24215306, PMID 24745706, PMID 26392096, PMID 27320780, PMID 27335883, PMID 28216232, PMID 28708043, PMID 29439707, PMID 30086682, PMID 30587219, PMID 30832577, PMID 30954936, PMID 31335643, PMID 31342515, PMID 31491821, PMID 31571339, PMID 31786660, PMID 32484754, PMID 32536001, PMID 32580883, PMID 33134025, PMID 33249870, PMID 33400432, PMID 3363593, PMID 33851065, PMID 34049739, PMID 34087549, PMID 34341037, PMID 34380093, PMID 35469443, PMID 35692557, PMID 36075299, PMID 36184668, PMID 36402970, PMID 36570809, PMID 36800644
2016 (3), 2014 (1), 2015 (1), K23NS050485 (1)