17 terminated. 17 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 17 | Terminated 17 |
Follow Epilepsy: new trials by email Literature Review of Epilepsy trials Research Report on Epilepsy
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Efficacy and Safety of Perampanel in the Treatment of Refractory Status Epilepticus Perampanel - Refractory Status Epilepticus | Phase 4 | Terminated | Wayne State University | 1 | 2025-10-10 | 2025-10-14 |
| Perampanel Titration and Cognitive Effects Perampanel 1 week titration, Perampanel 2 week titration, Perampanel 4mg - Epilepsy | Phase 4 | Terminated | Kimford Jay Meador | 29 | 2021-10-20 | 2024-06-06 |
| Perampanel for the Reduction of Seizure Frequency in Patients With High-grade Glioma and Focal Epilepsy Anticonvulsant Agent, Perampanel, Quality-of-Life Assessment - Intractable Epilepsy, Malignant Glioma | Phase 4 | Terminated | Mayo Clinic | 4 | 2020-12-04 | 2023-06-22 |
| Changing Agendas on Sleep, Treatment and Learning in Epilepsy Carbamazepine, Levetiracetam, Parent based sleep (PBS) intervention - Rolandic Epilepsy | Phase 4 | Terminated | King's College London | 5 | 2019-08-02 | 2020-11-02 |
| Perampanel for Treatment of Adults With Refractory Focal Epilepsy : a Pilot Study. perampanel - Epilepsy | Phase 4 | Terminated | Mid-Atlantic Epilepsy and Sleep Center, LLC | 8 | 2015-11-01 | 2017-08-29 |
| Sphenopalatine Ganglion Nerve Block vs. Elavil for Treatment of Transformed Migraines SPG Block with 5% Lidocaine gel, Amitriptyline - Transformed Migraine, Chronic Daily Headache | Phase 4 | Terminated | Rutgers, The State University of New Jersey | 10 | 2014-05-01 | 2026-06-23 |
| An Open Label Study to Evaluate the Effects of Ezogabine/Retigabine Added to Existing Anti-epileptic Drug(s) on Urinary Voiding Function in Subjects With Partial Onset Seizures ezogabine/retigabine - Epilepsy | Phase 4 | Terminated | GlaxoSmithKline | 10 | 2013-03-27 | 2020-12-04 |
| Dose-Optimization, Adjunctive Treatment Study of Ezogabine/Retigabine Immediate Release in Partial-onset Seizures Ezogabine/Retigabine IR, Placebo - Seizures | Phase 4 | Terminated | GlaxoSmithKline | 6 | 2012-12-19 | 2020-12-30 |
| Effect on Anxiety in Partial Epilepsy Patients Treated With Pregabalin Pregabalin - Epilepsy, Complex Partial | Phase 4 | Terminated | Northeast Regional Epilepsy Group | 4 | 2010-04-01 | 2017-09-14 |
| A Study to Evaluate the Safety and Tolerability and Explore the Efficacy of Zonisamide as add-on Therapy in Elderly Patients With Refractory Partial Seizures Zonisamide at targeted daily doses of 100-500 mg/day, Placebo administered to match targeted daily doses of 100-500 mg/day - Epilepsy | Phase 4 | Terminated | Eisai Limited | 41 | 2008-11-01 | 2016-01-08 |
| Lexapro for Major Depression in Patients With Epilepsy Lexapro - Major Depression, Epilepsy | Phase 4 | Terminated | Weill Medical College of Cornell University | 26 | 2007-10-01 | 2018-07-11 |
| Pregabalin In Partial Seizures (PREPS): An Open-Label, Multicenter Add On Therapy Trial Pregabalin - Partial Seizures | Phase 4 | Terminated | Pfizer's Upjohn has merged with Mylan to form Viatris Inc. | 136 | 2007-03-01 | 2021-01-25 |
| Evaluating the Transporter Protein Inhibitor Probenecid In Patients With Epilepsy phenytoin, phenytoin and probenecid - Epilepsy | Phase 4 | Terminated | Jim McAuley | 8 | 2006-03-01 | 2013-05-14 |
| Study Comparing Best Medical Practice With or Without VNS Therapy in Pharmacoresistant Partial Epilepsy Patients Vagal Nerve Simulation (VNS) Therapy, Best Medical Practive - Epilepsy, Partial Epilepsy | Phase 4 | Terminated | Cyberonics, Inc. | 122 | 2006-02-01 | 2015-01-26 |
| Efficacy and Safety of an add-on Treatment With Zonisamide in Adults With Focal Epileptic Seizures With or Without Secondary Generalization Zonegran - Epilepsy | Phase 4 | Terminated | Eisai GmbH | 157 | 2005-05-01 | 2014-06-27 |
| Effectiveness Study Comparing Treatment With Drug(s) or Adjunctive VNS Therapy for Pharmacoresistant Partial Seizures Vagus Nerve Stimulation Therapy - Epilepsies, Partial | Phase 4 | Terminated | Cyberonics, Inc. | 360 | 2005-02-01 | 2006-02-22 |
| Trial to Assess Vagus Nerve Stimulation Therapy vs. Anti-Epileptic Drug (AED) Treatment in Children With Refractory Seizures Vagus Nerve Stimulation (VNS) Therapy, Anti-Epileptic Drug (AED) - Epilepsy | Phase 4 | Terminated | Cyberonics, Inc. | 134 | 2004-10-01 | 2014-06-26 |
Epilepsies, Partial (4) · Seizures (4) · Depressive Disorder, Major (1) · Drug Resistant Epilepsy (1) · Epilepsy, Complex Partial (1) · Epilepsy, Rolandic (1) · Epilepsy, Temporal Lobe (1) · Glioma (1) · Headache Disorders (1) · Migraine Disorders (1) · Status Epilepticus (1) · Urinary Retention (1) · Vascular Headaches (1)
Brain Diseases (17) · Central Nervous System Diseases (17) · Nervous System Diseases (17) · Neurologic Manifestations (4) · Pathological Conditions, Signs and Symptoms (4) · Signs and Symptoms (4) · Epilepsies, Partial (3) · Epileptic Syndromes (2) · Cardiovascular Diseases (1) · Cerebrovascular Disorders (1) · Depressive Disorder (1) · Female Urogenital Diseases (1) · Female Urogenital Diseases and Pregnancy Complications (1) · Headache Disorders, Primary (1)
perampanel (4) · Anticonvulsants (2) · Pregabalin (2) · Therapeutics (2) · ezogabine (2) · Amitriptyline (1) · Carbamazepine (1) · Escitalopram (1) · Levetiracetam (1) · Methods (1) · Phenytoin (1) · Probenecid (1) · Vagus Nerve Stimulation (1) · Zonisamide (1)
Cyberonics, Inc. (3) · GlaxoSmithKline (2) · Eisai GmbH (1) · Eisai Limited (1) · Jim McAuley (1) · Kimford Jay Meador (1) · King's College London (1) · Mayo Clinic (1) · Mid-Atlantic Epilepsy and Sleep Center, LLC (1) · Northeast Regional Epilepsy Group (1) · Pfizer's Upjohn has merged with Mylan to form Viatris Inc. (1) · Rutgers, The State University of New Jersey (1) · Wayne State University (1) · Weill Medical College of Cornell University (1)
United States (11) · Germany (4) · United Kingdom (4) · Belgium (2) · France (2) · Italy (2) · Netherlands (2) · Poland (2) · Sweden (2) · Austria (1) · Canada (1) · Greece (1) · Hungary (1) · Mexico (1) · Norway (1)
Bassel F Shneker, MD (1) · Carol C Base, RN, MS (1) · Christian Elger (1) · Evan Fertig, MD (1) · James H Kocsis, MD (1) · James W McAuley, PhD (1) · Joanna Segieth (1) · Kimford Meador, MD (1) · Mark Bunker, PharmD (1) · Maysaa Basha, MD (1) · Pavel Klein, M.B,B.Chir. (1) · Phillippe Ryvlin, MD (1) · Sophie Leyman, MD (1)
2005 (1), 2018 (1)