51 completed, 5 recruiting, 1 active not recruiting, 1 not yet recruiting. 33 Phase 1, 10 Phase 2, 6 Not applicable, 6 Phase 3, 4 Phase 4.
Follow this drug Literature Review of Probenecid trials Research Report on Probenecid
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study to Assess the Effects of Probenecid on the Pharmacokinetics of Mirdametinib and Its Metabolites in Healthy Participants Mirdametinib, Probenecid - Healthy | Phase 1 | Recruiting | Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany | 17 | 2026-09-25 | 2026-10-09 |
| Drug-drug Interactions Studies of VC005 Tablets in Healthy Adult Subjects VC005 and verapamil, VC005 and probenecid, VC005 and metformin - Healthy Adult Participants | Phase 1 | Not yet recruiting | Jiangsu vcare pharmaceutical technology co., LTD | 84 | 2026-09-20 | 2026-09-01 |
| Efficacy of Probenecid on Cluster Seizures During Anti Seizure Medication Withdrawal in Presurgical Focal Epilepsy Video-EEG Monitoring Probenecid, Placebo - Focal Epilepsy | Phase 2 | Recruiting | Fondation Ophtalmologique Adolphe de Rothschild | 600 | 2026-08-24 | 2026-10-05 |
| A Clinical Study of MK-8527 in Healthy Participants (MK-8527-021) MK-8527, Probenecid, Itraconazole - Healthy | Phase 1 | Active not recruiting | Merck Sharp & Dohme LLC | 44 | 2026-06-30 | 2026-09-03 |
| Pharmacokinetics of Sulopenem Etzadroxil Plus Probenecid in Adolescents sulopenem etzadroxil and probenecid - Pharmacokinetics After Oral Intake | Phase 1 | Recruiting | Iterum Therapeutics, International Limited | 12 | 2026-04-01 | 2026-03-27 |
| Probenecid Administration for Alcohol Craving and Consumption Probenecid Oral Tablet, Placebo Oral Tablet - Alcohol Use Disorder (AUD), Alcohol Consumption | Phase 2 | Recruiting | Brown University | 120 | 2026-03-14 | 2026-03-17 |
| A Study to Learn About How the Study Medicines Called Itraconazole and Probenecid Change How the Body Processes PF-07220060 PF-07220060, Itraconazole, Probenecid - Healthy Adults | Phase 1 | Completed | Pfizer | 25 | 2025-09-22 | 2026-04-03 |
| A Study in Healthy People to Test How 2 Different Formulations of BI 690517 Are Taken up in the Body and How Probenecid Influences the Amount of BI 690517 in the Blood BI 690517 formulation 1, BI 690517 formulation 2, Probenecid - Healthy | Phase 1 | Completed | Boehringer Ingelheim | 15 | 2024-11-13 | 2025-01-09 |
| A Relative Bioavailability Study With a Novel PanCytoVir™ Oral Suspension (100 mg/ml) PanCytoVir™ 100 mg/mL oral suspension, Probenecid 500 mg - Relative Bioavailability | Phase 1 | Completed | TrippBio, Inc. | 14 | 2024-09-01 | 2024-11-21 |
| A Study to Assess the Effect of Povorcitinib on Digoxin, Rosuvastatin, and Metformin Pharmacokinetics and the Effect of Probenecid on Povorcitinib Pharmacokinetics When Administered Orally to Healthy Adult Participants Digoxin, Rosuvastatin, Metformin - Healthy Participants | Phase 1 | Completed | Incyte Corporation | 71 | 2024-06-19 | 2025-02-06 |
| Biodistribution and Pathophysiology Study of 11C-para-aminobenzoic Acid 11C-para-aminobenzoic acid PET/CT, Probenecid - Renal Excretion, Bacterial Infections | Completed | Johns Hopkins University | 13 | 2023-12-22 | 2025-12-12 | |
| Novel Use of Probenecid to Alleviate Symptoms of Opioid Withdrawal Probenecid - Chronic Pain, Drug Dependence of Morphine Type | Phase 2 | Recruiting | University of Calgary | 40 | 2023-10-31 | 2026-05-01 |
| Phase 1 Study of the Pharmacokinetics of Amoxicillin in Pregnancy Amoxicillin - Pregnancy Related | Phase 1 | Completed | University of Alabama at Birmingham | 13 | 2023-08-29 | 2025-12-17 |
| Drug-durg Interaction of ZSP1273 With Digoxin, Rosuvastatin,Itraconazole and Probenecid Digoxin, Rosuvastatin, ZSP1273 - Drug Drug Interaction | Phase 1 | Completed | Guangdong Raynovent Biotech Co., Ltd | 49 | 2023-07-10 | 2024-01-29 |
| Oral Sulopenem Versus Amoxicillin/Clavulanate for Uncomplicated Urinary Tract Infection in Adult Women Sulopenem etzadroxil/probenecid, Amoxicillin/clavulanate - Urinary Tract Infections, Cystitis | Phase 3 | Completed | Iterum Therapeutics, International Limited | 2229 | 2022-10-18 | 2024-11-20 |
| Study of AT-527 in Subjects With Normal and Impaired Renal Function AT-527, AT-527 and Probenecid - Healthy Volunteer, Renal Impairment | Phase 1 | Completed | Atea Pharmaceuticals, Inc. | 36 | 2022-10-17 | 2024-07-31 |
| A Study to Evaluate the Efficacy of PanCytoVir™ for the Treatment of Non-Hospitalized Patients With COVID-19 Infection PanCytoVir™ (probenecid), Placebo - COVID-19 | Phase 2 | Completed | TrippBio, Inc. | 75 | 2022-07-12 | 2023-08-25 |
| Pharmacokinetic Drug-Drug Interaction Study to Identify Biomarkers of Kidney Transporters MetFORMIN Oral Solution, Cimetidine 400 MG, Furosemide Oral Liquid Product - Interaction, Endogenous Biomarkers | Early Phase 1 | Completed | Washington State University | 16 | 2022-04-11 | 2025-08-08 |
| Effects of Rifampicin and Probenecid On The Pharmacokinetic Profile Of Rongliflozin In Healthy Subjects Rongliflozin, Rifampin, Probenecid - Type 2 Diabetes Mellitus | Phase 1 | Completed | Sunshine Lake Pharma Co., Ltd. | 28 | 2022-02-21 | 2023-03-01 |
| AV-101 Alone and in Combination With Probenecid in Healthy Subjects AV-101, Probenecid - Drug Drug Interaction | Phase 1 | Unknown | VistaGen Therapeutics, Inc. | 24 | 2021-12-23 | 2022-03-15 |
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HIV Infections (8) · Acquired Immunodeficiency Syndrome (6) · Cytomegalovirus Retinitis (5) · Cytomegalovirus Infections (4) · Diabetes Mellitus, Type 2 (3) · Obesity (3) · Retinitis (3) · Alcoholism (2) · Bacterial Infections (2) · AIDS-Related Complex (1) · AIDS-Related Opportunistic Infections (1) · Alcohol Drinking (1) · Brain Injuries (1) · Breast Neoplasms (1) · COVID-19 (1)
Iterum Therapeutics, International Limited (6) · National Institute of Allergy and Infectious Diseases (NIAID) (6) · Boehringer Ingelheim (3) · Brigham and Women's Hospital (2) · Brown University (2) · Gilead Sciences (2) · Pfizer (2) · TrippBio, Inc. (2) · VA Office of Research and Development (2) · Akebia Therapeutics (1) · Atea Pharmaceuticals, Inc. (1) · CSPC ZhongQi Pharmaceutical Technology Co., Ltd. (1) · Children's Hospital Medical Center, Cincinnati (1) · Daiichi Sankyo (1) · Eli Lilly and Company (1)
United States (40) · Germany (6) · Canada (4) · China (4) · United Kingdom (3) · Estonia (2) · Georgia (2) · Hungary (2) · India (2) · Latvia (2) · Bulgaria (1) · France (1) · Poland (1) · Thailand (1)
David E Martin, PharmD (2) · Ann K Rosenthal, MD (1) · Anthony R Godfrey, Pharm.D. (1) · BG Petty (1) · Barker DE (1) · Bassel F Shneker, MD (1) · Brandon T Gufford, PharmD, PhD (1) · Carolina Haass-Koffler, PharmD, PhD (1) · Carolina L Haass-Koffler, PHARMD, PHD (1)
PMID 10628898, PMID 10934667, PMID 11744606, PMID 18559644, PMID 19637952, PMID 21849262, PMID 23006736, PMID 24491572, PMID 26612873, PMID 28686657, PMID 29742587, PMID 29914924, PMID 31535696, PMID 35061234, PMID 35226304, PMID 35392963, PMID 36068705, PMID 36069202, PMID 36264536, PMID 37515194, PMID 37596428, PMID 39472130, PMID 40153540, PMID 40401788, PMID 40552968
2017 (2), 2016 (1), I01CX001968 (1), R01HD081299 (1), R01HL105440 (1), R01HL131829 (1), R01NS069247 (1), R15GM072526 (1), R21DK071223 (1)