9 recruiting, 5 not yet recruiting, 5 unknown, 3 completed. 25 Early Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Early Phase 1 | 25 | Recruiting 9, Not yet recruiting 5, Unknown 5, Completed 3, Terminated 3 |
Follow Epilepsy: new trials by email Literature Review of Epilepsy trials Research Report on Epilepsy
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Cholinergic Enhancement of Theta COBENFY KarXT (50/20 mg), Control - Epilepsy, Seizures | Early Phase 1 | Not yet recruiting | University of Texas Southwestern Medical Center | 50 | 2026-12-01 | 2026-09-29 |
| Translational Recording and Characterization of Epilepsy Signals Using Subgaleal EEG During Standard-of-care SEEG Monitoring EEG Record only - Epilepsy (Treatment Refractory) | Early Phase 1 | Not yet recruiting | Adraxe Corp. | 15 | 2026-10-15 | 2026-09-16 |
| Human Cognition During Surgery: Stimulation-based and Cholinergic Modulation Cobenfy KarXT pill (50/20 mg), Placebo - Epilepsy, Essential Tremor | Early Phase 1 | Not yet recruiting | University of Texas Southwestern Medical Center | 30 | 2026-10-01 | 2026-07-23 |
| The Safety and Efficacy Evaluation of Everolimus as an Adjunctive Treatment for Focal Refractory Epilepsy Everolimus - Epilepsy, Drug Resistant | Early Phase 1 | Recruiting | Xuanwu Hospital, Beijing | 5 | 2026-07-01 | 2026-04-07 |
| Cenobamate in the Intensive Care Unit Cenobamate - Epilepsy, Neurologic Disorder | Early Phase 1 | Not yet recruiting | Brigham and Women's Hospital | 10 | 2026-06-01 | 2026-03-30 |
| Optimizing Therapy in Epilepsy Using Seizure Forecasts Via EEG and Wearables UNEEG SubQ device, seizure forecasts, nasal diazepam, Preventative Medication (PM) - Focal Epilepsy, Generalized Seizure | Early Phase 1 | Recruiting | Mayo Clinic | 12 | 2026-01-20 | 2026-09-25 |
| A Study to Evaluate the Safety and Pharmacokinetics of RC001 in Children With Dravet Syndrome RC001 injection-Dose Escalation Cohort, RC001 injection-Fixed Dose Cohort - Dravet Syndrome (DS) | Early Phase 1 | Recruiting | Second Affiliated Hospital of Guangzhou Medical University | 8 | 2025-12-22 | 2026-06-30 |
| Exploratory Study of UX-GIP001 Cell Therapy in Adult Patients With Drug-Resistant Unilateral Mesial Temporal Lobe Epilepsy (MTLE) UX-GIP001 - Epilepsy, MTLE | Early Phase 1 | Recruiting | Second Affiliated Hospital, Zhejiang University, School of Medicine | 6 | 2025-11-10 | 2026-04-22 |
| Effect of Rose Odor Exposure on Ictal Apnea 2-phenylethanol rose scent - Epilepsy, Sudden Unexpected Death in Epilepsy | Early Phase 1 | Recruiting | Vanderbilt University Medical Center | 40 | 2025-07-01 | 2026-06-11 |
| Sirolomus Adjuvant Treatment of Focal Refractory Epilepsy (SATFRE) Sirolimus - Epilepsy, Drug Resistant | Early Phase 1 | Recruiting | Xuanwu Hospital, Beijing | 15 | 2024-12-23 | 2024-12-31 |
| Allogenic Adipose-derived Mesenchymal Stem Cells(AMSCs) for Epilepsy During Deep Brain Stimulation(DBS) Surgery AMSCs - Epilepsy | Early Phase 1 | Terminated | Mayo Clinic | 1 | 2024-12-23 | 2026-09-08 |
| Propranolol Adjuvant Treatment of Focal Refractory Epilepsy (PATFRE) Propranolol - Epilepsy, Drug Resistant | Early Phase 1 | Not yet recruiting | Xuanwu Hospital, Beijing | 15 | 2024-12-05 | 2024-12-10 |
| The Role of Vitamin D in Neuroinflammatory on Drug Resistant Epilepsy Cholecalciferol, Placebo - Drug Resistant Epilepsy | Early Phase 1 | Unknown | DINA KEUMALA SARI | 70 | 2024-01-19 | 2024-02-14 |
| Induced Pluripotent Stem Cell Derived Exosomes Nasal Drops for the Treatment of Refractory Focal Epilepsy iPSC-Exos - Refractory Focal Epilepsy | Early Phase 1 | Unknown | Peking Union Medical College Hospital | 34 | 2023-06-05 | 2023-06-07 |
| Sodium-Glucose Cotransporter-2 Inhibitors: A Potential Novel Treatment for Epilepsy Empagliflozin 25 mg, Placebo - Epilepsy | Early Phase 1 | Unknown | Washington University School of Medicine | 18 | 2022-08-17 | 2022-08-23 |
| Sodium Lactate Infusion in GLUT1DS Patients sodiumlactate - GLUT1 Deficiency Syndrome, GLUT1DS1 | Early Phase 1 | Completed | Radboud University Medical Center | 2 | 2022-05-20 | 2022-11-23 |
| Tolerability and Activity of Brivaracetam (BRV) in Patients With Diffuse Gliomas Brivaracetam - Brain Tumor | Early Phase 1 | Terminated | University of Rochester | 3 | 2022-05-17 | 2026-06-03 |
| Optimization of Deep Brain Stimulation Parameters in Patients With Medically Refractory Epilepsy Physician-Selected Settings Stimulation, Optimized Settings Stimulation, DBS Setting Optimization - Refractory Epilepsy, Deep Brain Stimulation | Early Phase 1 | Recruiting | University of Minnesota | 30 | 2021-07-01 | 2026-10-16 |
| Localizing Epileptic Networks Using MRI and iEEG 3T Magnetic Resonance Imaging, Intracranial electroencephalography recordings, 7T Magnetic Resonance Imaging - Epilepsy, Epilepsy Intractable | Early Phase 1 | Recruiting | University of Pennsylvania | 290 | 2021-03-01 | 2026-02-13 |
| CBD Cannabis Extract: Pharmacokinetic Studies cannabidiol extract - Epilepsy | Early Phase 1 | Completed | University of Mississippi, Oxford | 10 | 2021-02-01 | 2024-11-20 |
Showing 20 of 25. Sign in to see all of them.
Drug Resistant Epilepsy (8) · Seizures (5) · Memory Disorders (3) · Cognitive Dysfunction (2) · Epilepsies, Partial (2) · Brain Injuries, Traumatic (1) · Brain Neoplasms (1) · Dystonia 18 (1) · Epilepsies, Myoclonic (1) · Epilepsy, Temporal Lobe (1) · Essential Tremor (1) · Generalized Epilepsy With Febrile Seizures Plus, Type 2 (1) · Glut1 Deficiency Syndrome (1) · Hyperlactatemia (1)
Brain Diseases (25) · Central Nervous System Diseases (25) · Nervous System Diseases (24) · Pathological Conditions, Signs and Symptoms (7) · Signs and Symptoms (6) · Neurologic Manifestations (5) · Epileptic Syndromes (3) · Neurobehavioral Manifestations (3) · Cognition Disorders (2) · Mental Disorders (2) · Neurocognitive Disorders (2) · Brain Injuries (1) · Central Nervous System Neoplasms (1) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (1)
Cannabidiol (1) · Cenobamate (1) · Cholecalciferol (1) · Everolimus (1) · Patient Education as Topic (1) · Phenytoin (1) · Propranolol (1) · Scopolamine (1) · Sirolimus (1) · Topiramate (1) · Vagus Nerve Stimulation (1) · Vitamin D (1) · brivaracetam (1) · empagliflozin (1)
University of Texas Southwestern Medical Center (3) · Xuanwu Hospital, Beijing (3) · Beijing Pins Medical Co., Ltd (2) · Mayo Clinic (2) · University of Pennsylvania (2) · Adraxe Corp. (1) · Brigham and Women's Hospital (1) · DINA KEUMALA SARI (1) · National Institute of Neurological Disorders and Stroke (NINDS) (1) · Peking Union Medical College Hospital (1) · Radboud University Medical Center (1) · Second Affiliated Hospital of Guangzhou Medical University (1) · Second Affiliated Hospital, Zhejiang University, School of Medicine (1) · University of Minnesota (1) · University of Mississippi, Oxford (1)
United States (14) · China (7) · Indonesia (1) · Netherlands (1)
Liankun Ren, MD (3) · Bradley C Lega, MD (2) · Zhuo Huang, PhD (2) · Benjamin Brinkmann, PhD (1) · Bill Gurley, Ph. D. (1) · Bradley C Lega, MC (1) · Dina K. Sari, SpGK(K), Prof.Dr.dr. (1) · Gregory A Worrell, MD, PhD (1) · Irene H Dustin, C.R.N.P. (1) · Jamie J Van Gompel, MD (1) · Jong Woo Lee, MD, PhD (1) · Junming Zhu, Doctor (1) · Kathryn A Davis, MD, MSTR (1) · Kwee L Thio (1) · Marc A Dichter, MD, PhD (1)
PMID 20204561, PMID 21749363, PMID 26724101, PMID 26800377, PMID 27179600, PMID 28538134, PMID 29114823, PMID 29262425, PMID 29540584, PMID 29701252, PMID 30100226, PMID 30250864, PMID 30374683, PMID 30687209, PMID 30791225, PMID 30921490, PMID 31052254, PMID 31152723, PMID 31161980, PMID 31212965, PMID 31313338, PMID 32471438, PMID 41613983
R01NS125250 (1), UG3NS123066-02 (1)